STRINGSTRING
Daes_0189 Daes_0189 Daes_0414 Daes_0414 cpdA cpdA purN purN purL purL prs prs Daes_0971 Daes_0971 Daes_0973 Daes_0973 Daes_1049 Daes_1049 purA purA purF purF purC purC Daes_1275 Daes_1275 Daes_1412 Daes_1412 gpt gpt Daes_1434 Daes_1434 Daes_1454 Daes_1454 Daes_1468 Daes_1468 apt apt ndk ndk adk adk Daes_1547 Daes_1547 Daes_1649 Daes_1649 surE surE Daes_1813 Daes_1813 Daes_2072 Daes_2072 Daes_2085 Daes_2085 Daes_2109 Daes_2109 gmk gmk guaA guaA guaB guaB Daes_2498 Daes_2498 Daes_2508 Daes_2508 Daes_2552 Daes_2552 Daes_2586 Daes_2586 ppnP ppnP Daes_2670 Daes_2670 purM purM Daes_2770 Daes_2770 Daes_2988 Daes_2988 Daes_3035 Daes_3035 Daes_3051 Daes_3051 Daes_3096 Daes_3096 Daes_3129 Daes_3129 cysC cysC Daes_3249 Daes_3249 purE purE purD purD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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Daes_0189PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; KEGG: dma:DMR_27100 phosphohexose mutase. (455 aa)
Daes_0414KEGG: mhu:Mhun_0729 metal dependent phosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. (565 aa)
cpdAMetallophosphoesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (282 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (234 aa)
purLPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (998 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (312 aa)
Daes_0971KEGG: dde:Dde_3016 anaerobic ribonucleoside triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone domain protein. (686 aa)
Daes_0973KEGG: tra:Trad_0749 phosphoglucomutase, alpha-D-glucose phosphate-specific; TIGRFAM: phosphoglucomutase, alpha-D-glucose phosphate-specific; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase. (556 aa)
Daes_1049Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: dsa:Desal_1457 IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme formylation region. (424 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (471 aa)
purCTIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: dsa:Desal_2021 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (298 aa)
Daes_1275KEGG: tbi:Tbis_1432 adenosine deaminase; PFAM: adenosine/AMP deaminase. (294 aa)
Daes_1412PFAM: PfkB domain protein; KEGG: dsa:Desal_2501 PfkB domain protein. (311 aa)
gptXanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (160 aa)
Daes_1434TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; KEGG: caa:Caka_1760 deoxyguanosinetriphosphate triphosphohydrolase; SMART: metal-dependent phosphohydrolase HD region; Belongs to the dGTPase family. Type 2 subfamily. (424 aa)
Daes_1454CHASE2 domain protein; KEGG: dma:DMR_40230 putative adenylate cyclase; PFAM: CHASE2 domain protein; adenylyl cyclase class-3/4/guanylyl cyclase; SMART: adenylyl cyclase class-3/4/guanylyl cyclase. (741 aa)
Daes_1468KEGG: dsa:Desal_2262 phosphoribosylformylglycinamidine synthase. (271 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (173 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (222 aa)
Daes_1547PFAM: histidine triad (HIT) protein; KEGG: drt:Dret_1342 histidine triad (HIT) protein. (162 aa)
Daes_1649PFAM: glutamine amidotransferase class-II; KEGG: dde:Dde_1864 glucosamine 6-phosphate synthetase-like. (265 aa)
surEStationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (253 aa)
Daes_1813PFAM: adenylate cyclase; KEGG: dde:Dde_2101 adenylate cyclase. (198 aa)
Daes_2072RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (726 aa)
Daes_2085Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (274 aa)
Daes_2109MazG family protein; KEGG: dde:Dde_2453 nucleoside triphosphate pyrophosphohydrolase; TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase. (266 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (213 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (514 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa)
Daes_2498KEGG: dvl:Dvul_2681 anaerobic ribonucleoside triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone domain protein. (685 aa)
Daes_2508KEGG: dsa:Desal_3228 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa)
Daes_2552PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; manually curated; KEGG: tgr:Tgr7_2890 pyruvate kinase; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa)
Daes_2586PFAM: 5'-Nucleotidase domain-containing protein; metallophosphoesterase; KEGG: dal:Dalk_5285 5'-nucleotidase domain protein; Belongs to the 5'-nucleotidase family. (575 aa)
ppnPProtein of unknown function DUF1255; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (104 aa)
Daes_2670Adenylate cyclase; KEGG: dsa:Desal_0704 putative adenylate cyclase; PFAM: adenylate cyclase class-I; pentapeptide repeat protein. (1291 aa)
purMTIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; KEGG: dsa:Desal_3132 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (353 aa)
Daes_2770TIGRFAM: pyruvate kinase; KEGG: dvl:Dvul_0731 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (485 aa)
Daes_2988Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (202 aa)
Daes_3035TIGRFAM: sulfate adenylyltransferase; KEGG: dde:Dde_2265 sulfate adenylyltransferase; PFAM: ATP-sulfurylase. (426 aa)
Daes_3051PFAM: glutamine amidotransferase class-I; KEGG: dap:Dacet_2818 glutamine amidotransferase class-I. (240 aa)
Daes_3096Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (748 aa)
Daes_3129TIGRFAM: hypoxanthine phosphoribosyltransferase; KEGG: dsa:Desal_3658 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (177 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (199 aa)
Daes_3249PFAM: molybdopterin dehydrogenase FAD-binding; CO dehydrogenase flavoprotein domain protein; KEGG: dat:HRM2_37990 two-component fusion protein (N:molybdopterin dehydrogenase, FAD-binding domain-C:carbon monoxide dehydrogenase medium chain). (282 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
purDTIGRFAM: phosphoribosylamine/glycine ligase; KEGG: dsa:Desal_3434 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (425 aa)
Your Current Organism:
Pseudodesulfovibrio aespoeensis
NCBI taxonomy Id: 643562
Other names: Desulfovibrio aespoeensis Aspo-2, Desulfovibrio aespoeensis DSM 10631, P. aespoeensis Aspo-2, Pseudodesulfovibrio aespoeensis Aspo-2, Pseudodesulfovibrio aespoeensis DSM 10631
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