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| | pfkA | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (436 aa) |
| | Daes_0032 | PFAM: iron-containing alcohol dehydrogenase; KEGG: dma:DMR_20960 dehydrogenase. (389 aa) |
| | Daes_0042 | KEGG: dsa:Desal_1479 acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. (159 aa) |
| | fumC | Fumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa) |
| | Daes_0076 | PFAM: Transketolase domain-containing protein; KEGG: glo:Glov_0795 transketolase domain protein. (273 aa) |
| | Daes_0077 | KEGG: glo:Glov_0796 transketolase central region; PFAM: Transketolase central region; Transketolase domain-containing protein; SMART: Transketolase central region. (312 aa) |
| | Daes_0080 | Radical SAM domain protein; KEGG: dma:DMR_p1_00270 cobalamin vitamin B12-binding domain/radical SAM domain protein; PFAM: Radical SAM domain protein; cobalamin B12-binding domain protein; SMART: Elongator protein 3/MiaB/NifB. (492 aa) |
| | Daes_0102 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: neu:NE1688 D-isomer specific 2-hydroxyacid dehydrogenase. (308 aa) |
| | Daes_0119 | KEGG: dvm:DvMF_2339 pyruvate, water dikinase; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region. (860 aa) |
| | Daes_0128 | KEGG: dvl:Dvul_0174 pyruvate, water dikinase; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region. (868 aa) |
| | Daes_0189 | PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; KEGG: dma:DMR_27100 phosphohexose mutase. (455 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (296 aa) |
| | acsA | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa) |
| | aroA | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (267 aa) |
| | Daes_0284 | PFAM: phosphoglucose isomerase (PGI); KEGG: dsa:Desal_3771 phosphoglucose isomerase (PGI). (446 aa) |
| | ispDF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). (418 aa) |
| | Daes_0383 | PFAM: phosphofructokinase; KEGG: dde:Dde_1589 diphosphate--fructose-6-phosphate 1-phosphotransferase. (441 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa) |
| | Daes_0512 | KEGG: sna:Snas_2763 NmrA family protein. (287 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (243 aa) |
| | Daes_0542 | PFAM: AMP-dependent synthetase and ligase; KEGG: dvu:DVU2250 AMP-binding protein. (545 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (283 aa) |
| | Daes_0636 | KEGG: dde:Dde_3034 L-serine ammonia-lyase; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain. (406 aa) |
| | Daes_0653 | KEGG: dsa:Desal_3192 asparaginase/glutaminase; PFAM: Asparaginase/glutaminase; SMART: Asparaginase/glutaminase. (334 aa) |
| | Daes_0658 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); KEGG: dma:DMR_33050 phosphoserine phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase. (404 aa) |
| | Daes_0665 | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (639 aa) |
| | Daes_0687 | PFAM: aminotransferase class I and II; KEGG: dsa:Desal_3407 aspartate aminotransferase. (396 aa) |
| | Daes_0700 | PFAM: asparagine synthase; glutamine amidotransferase class-II; manually curated; KEGG: mag:amb0119 asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (631 aa) |
| | Daes_0705 | KEGG: pna:Pnap_2465 proline dehydrogenase; PFAM: Proline dehydrogenase. (318 aa) |
| | Daes_0709 | KEGG: gur:Gura_4090 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; cobalamin B12-binding domain protein; SMART: Elongator protein 3/MiaB/NifB. (667 aa) |
| | Daes_0715 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); KEGG: nde:NIDE2699 asparagine synthase; PFAM: asparagine synthase. (630 aa) |
| | Daes_0716 | Manually curated; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); KEGG: nde:NIDE2699 asparagine synthase; PFAM: asparagine synthase; glutamine amidotransferase class-II. (626 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (393 aa) |
| | Daes_0746 | KEGG: dsa:Desal_0251 uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrinogen III synthase HEM4; Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (506 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (234 aa) |
| | gpsA | PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: dsa:Desal_0748 glycerol-3-phosphate dehydrogenase (NAD(P)(+)); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (330 aa) |
| | hemL | KEGG: dba:Dbac_3003 glutamate-1-semialdehyde-2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III. (419 aa) |
| | Daes_0791 | PFAM: FAD linked oxidase domain protein; KEGG: dsa:Desal_0210 D-lactate dehydrogenase (cytochrome). (465 aa) |
| | Daes_0792 | PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; KEGG: dma:DMR_07460 iron-sulfur binding protein. (380 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (318 aa) |
| | mqnB | Futalosine nucleosidase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (232 aa) |
| | Daes_0801 | PFAM: Polyprenyl synthetase; KEGG: dsa:Desal_0763 dimethylallyltranstransferase; Belongs to the FPP/GGPP synthase family. (322 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (998 aa) |
| | ilvD | TIGRFAM: dihydroxy-acid dehydratase; KEGG: dsa:Desal_3776 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | Daes_0827 | Catalase; KEGG: mba:Mbar_A0814 catalase; PFAM: Catalase related subgroup; Catalase domain protein; Belongs to the catalase family. (505 aa) |
| | Daes_0872 | PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: msv:Mesil_0745 agmatinase; Belongs to the arginase family. (279 aa) |
| | Daes_0874 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; KEGG: dsa:Desal_2931 riboflavin biosynthesis protein RibF; SMART: Riboflavin kinase; Belongs to the ribF family. (332 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (312 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (288 aa) |
| | Daes_0893 | PFAM: Saccharopine dehydrogenase; KEGG: dba:Dbac_2320 saccharopine dehydrogenase. (396 aa) |
| | Daes_0910 | PFAM: Polyprenyl synthetase; KEGG: dsa:Desal_0739 polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (297 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (633 aa) |
| | ispH | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (282 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (253 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (387 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: dba:Dbac_2816 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (208 aa) |
| | Daes_0948 | KEGG: dma:DMR_05280 indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (256 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (337 aa) |
| | Daes_0950 | KEGG: dsa:Desal_3059 glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I. (190 aa) |
| | Daes_0951 | KEGG: dsa:Desal_3060 anthranilate synthase; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein. (485 aa) |
| | Daes_0952 | PFAM: Prephenate dehydrogenase; KEGG: dsa:Desal_3061 prephenate dehydrogenase. (256 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (452 aa) |
| | Daes_0954 | TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; Chorismate mutase, type II; KEGG: dvl:Dvul_2475 chorismate mutase; SMART: Chorismate mutase. (367 aa) |
| | Daes_0955 | PFAM: 3-dehydroquinate synthase; KEGG: dsa:Desal_3064 3-dehydroquinate synthase. (327 aa) |
| | aroA-3 | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (265 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (389 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (125 aa) |
| | panC | Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa) |
| | Daes_0973 | KEGG: tra:Trad_0749 phosphoglucomutase, alpha-D-glucose phosphate-specific; TIGRFAM: phosphoglucomutase, alpha-D-glucose phosphate-specific; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase. (556 aa) |
| | Daes_0976 | KEGG: dsa:Desal_3030 STE24 endopeptidase; PFAM: peptidase M48 Ste24p. (412 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (351 aa) |
| | Daes_1012 | KEGG: sfu:Sfum_0649 pyruvate, water dikinase; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region. (866 aa) |
| | Daes_1042 | TIGRFAM: citrate synthase I; KEGG: dba:Dbac_1476 citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (441 aa) |
| | plsY | Protein of unknown function DUF205; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (196 aa) |
| | Daes_1049 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: dsa:Desal_1457 IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme formylation region. (424 aa) |
| | Daes_1068 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: dvl:Dvul_0348 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain. (1200 aa) |
| | Daes_1070 | PFAM: FAD linked oxidase domain protein; KEGG: drt:Dret_1038 FAD linked oxidase domain protein. (464 aa) |
| | Daes_1071 | PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; KEGG: dvm:DvMF_1863 protein of unknown function DUF224 cysteine-rich region domain protein. (426 aa) |
| | Daes_1137 | PFAM: peptidase C45 acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; KEGG: tra:Trad_0058 peptidase C45 acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase. (377 aa) |
| | glcB | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (719 aa) |
| | Daes_1192 | PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; KEGG: dsa:Desal_2676 pyruvate, water dikinase. (819 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (471 aa) |
| | Daes_1223 | KEGG: dsa:Desal_2029 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (482 aa) |
| | purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: dsa:Desal_2021 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (298 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (188 aa) |
| | Daes_1238 | UbiD family decarboxylase; KEGG: dsa:Desal_2281 carboxylyase-related protein; TIGRFAM: UbiD family decarboxylase; PFAM: Carboxylyase-related protein; Belongs to the UbiD family. (614 aa) |
| | Daes_1252 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (300 aa) |
| | argG | TIGRFAM: argininosuccinate synthase; KEGG: dsa:Desal_1785 argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (410 aa) |
| | argH | KEGG: dvm:DvMF_0048 argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase. (462 aa) |
| | Daes_1260 | PFAM: Nucleotidyl transferase; KEGG: dsa:Desal_1798 nucleotidyl transferase. (290 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (184 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa) |
| | Daes_1314 | PFAM: aminotransferase class IV; KEGG: dsa:Desal_2302 aminotransferase class IV. (313 aa) |
| | Daes_1317 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (293 aa) |
| | Daes_1318 | KEGG: dsa:Desal_1645 dTDP-glucose 4,6-dehydratase; TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (338 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (213 aa) |
| | Daes_1381 | PFAM: iron-containing alcohol dehydrogenase; KEGG: dsa:Desal_1318 iron-containing alcohol dehydrogenase. (398 aa) |
| | Daes_1384 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: dvl:Dvul_0348 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain. (1168 aa) |
| | Daes_1428 | Glucokinase; KEGG: dde:Dde_1461 glucokinase; PFAM: Glucokinase; Belongs to the bacterial glucokinase family. (316 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (160 aa) |
| | Daes_1438 | TIGRFAM: proposed homoserine kinase; phosphonopyruvate decarboxylase-related protein; KEGG: dsa:Desal_2441 proposed homoserine kinase; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein. (399 aa) |
| | Daes_1439 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; KEGG: dsa:Desal_2440 homoserine dehydrogenase. (432 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa) |
| | Daes_1447 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain-containing protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: dvm:DvMF_0184 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (567 aa) |
| | Daes_1448 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; KEGG: drt:Dret_0516 pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein. (276 aa) |
| | Daes_1451 | PFAM: Acetyl-CoA carboxylase, alpha subunit, conserved region; KEGG: dsa:Desal_2328 acetyl-CoA carboxylase. (748 aa) |
| | Daes_1468 | KEGG: dsa:Desal_2262 phosphoribosylformylglycinamidine synthase. (271 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (265 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | argD | KEGG: dsa:Desal_1626 acetylornithine aminotransferase; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (404 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (222 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (457 aa) |
| | Daes_1537 | TIGRFAM: siroheme synthase; KEGG: dma:DMR_16440 bifunctional precorrin-2 oxidase/chelatase family protein. (225 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (412 aa) |
| | Daes_1551 | KEGG: dsa:Desal_1952 LL-diaminopimelate aminotransferase; TIGRFAM: LL-diaminopimelate aminotransferase; PFAM: aminotransferase class I and II. (388 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | pgk | KEGG: dsa:Desal_1935 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (400 aa) |
| | Daes_1560 | PFAM: NUDIX hydrolase; KEGG: dvm:DvMF_0346 NUDIX hydrolase. (179 aa) |
| | Daes_1561 | PFAM: inositol monophosphatase; KEGG: dsa:Desal_1932 inositol monophosphatase. (263 aa) |
| | Daes_1564 | KEGG: dsa:Desal_1927 glycine cleavage system T protein; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel. (360 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (152 aa) |
| | Daes_1605 | KEGG: tle:Tlet_1722 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (439 aa) |
| | Daes_1649 | PFAM: glutamine amidotransferase class-II; KEGG: dde:Dde_1864 glucosamine 6-phosphate synthetase-like. (265 aa) |
| | Daes_1679 | PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilizing protein; PEP-utilising protein mobile region; KEGG: dsa:Desal_2037 pyruvate phosphate dikinase PEP/pyruvate-binding. (1196 aa) |
| | sucD | ATP-grasp domain protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (692 aa) |
| | Daes_1695 | PFAM: amino acid-binding ACT domain protein; KEGG: app:CAP2UW1_0275 acetolactate synthase 1 regulatory subunit. (92 aa) |
| | Daes_1696 | KEGG: dvl:Dvul_2624 acetolactate synthase catalytic subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein. (557 aa) |
| | Daes_1697 | PFAM: NAD(P)H dehydrogenase (quinone); KEGG: gur:Gura_0096 NAD(P)H dehydrogenase (quinone). (199 aa) |
| | Daes_1706 | KEGG: dma:DMR_17120 cysteine synthase A; TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa) |
| | Daes_1707 | KEGG: dma:DMR_17130 serine acetyltransferase. (306 aa) |
| | Daes_1743 | KEGG: dsa:Desal_1997 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (410 aa) |
| | Daes_1744 | KEGG: dsa:Desal_1998 putative alpha-isopropylmalate/homocitrate synthase family transferase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (534 aa) |
| | Daes_1746 | SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: dsa:Desal_1910 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (327 aa) |
| | surE | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (253 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa) |
| | Daes_1774 | KEGG: dsa:Desal_2397 acetolactate synthase 3 regulatory subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. (163 aa) |
| | Daes_1775 | KEGG: dsa:Desal_2398 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein. (563 aa) |
| | miaA | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (323 aa) |
| | gpmI | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (509 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (259 aa) |
| | fbp | PFAM: Inositol phosphatase/fructose-16-bisphosphatase; KEGG: dsa:Desal_1815 fructose-1,6-bisphosphatase. (343 aa) |
| | Daes_1903 | L-serine ammonia-lyase; KEGG: drt:Dret_2251 serine dehydratase alpha chain; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (453 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | leuC | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (511 aa) |
| | Daes_1913 | KEGG: dsa:Desal_1581 CDP-diacylglycerol/serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (252 aa) |
| | psd | Phosphatidylserine decarboxylase related protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (215 aa) |
| | gpmA | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa) |
| | Daes_1930 | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (296 aa) |
| | Daes_1954 | PFAM: ferredoxin-dependent glutamate synthase; KEGG: dsa:Desal_3279 ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (544 aa) |
| | Daes_1968 | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: bbt:BBta_5657 putative short-chain dehydrogenase/reductase family protein. (259 aa) |
| | Daes_1970 | KEGG: geo:Geob_0664 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (356 aa) |
| | Daes_1972 | Transketolase domain-containing protein; KEGG: mag:amb0067 putative transketolase C-terminal section; PFAM: Transketolase domain-containing protein; Transketolase central region; SMART: Transketolase central region. (308 aa) |
| | Daes_1973 | Transketolase domain-containing protein; KEGG: mag:amb0066 putative transketolase N-terminal section; manually curated; PFAM: Transketolase domain-containing protein. (282 aa) |
| | Daes_1991 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (289 aa) |
| | hisH-2 | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (224 aa) |
| | aroA-4 | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (263 aa) |
| | Daes_2061 | PFAM: aminotransferase class I and II; KEGG: dsa:Desal_1473 putative transcriptional regulator, GntR family. (392 aa) |
| | Daes_2063 | KEGG: dma:DMR_34310 L-tartrate dehydratase beta subunit; TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate beta region. (183 aa) |
| | Daes_2064 | TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; KEGG: dma:DMR_34300 fumarate hydratase; PFAM: Fe-S type hydro-lyase tartrate/fumarate alpha region. (279 aa) |
| | Daes_2065 | KEGG: dba:Dbac_3064 fumarate reductase iron-sulfur subunit; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein. (245 aa) |
| | Daes_2066 | TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; KEGG: dsa:Desal_0721 fumarate reductase flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (611 aa) |
| | Daes_2067 | PFAM: succinate dehydrogenase cytochrome b subunit; KEGG: dba:Dbac_3066 fumarate reductase respiratory complex transmembrane subunit. (216 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (354 aa) |
| | Daes_2080 | KEGG: dvl:Dvul_1016 acetyl-CoA carboxylase; PFAM: Acetyl-CoA carboxylase, alpha subunit, conserved region. (755 aa) |
| | Daes_2081 | Pyruvate carboxylase; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; biotin carboxylase domain protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: dma:DMR_12700 acetyl-CoA carboxylase biotin carboxylase subunit; SMART: biotin carboxylase domain protein. (472 aa) |
| | Daes_2085 | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (274 aa) |
| | Daes_2087 | PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: dsa:Desal_1529 pyruvate ferredoxin/flavodoxin oxidoreductase. (200 aa) |
| | Daes_2088 | PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; KEGG: dsa:Desal_1528 2-oxoglutarate ferredoxin oxidoreductase subunit beta. (283 aa) |
| | Daes_2089 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: dsa:Desal_1527 2-oxoglutarate ferredoxin oxidoreductase subunit alpha. (381 aa) |
| | Daes_2090 | Hypothetical protein; KEGG: drt:Dret_1403 4Fe-4S ferredoxin iron-sulfur binding domain protein. (90 aa) |
| | Daes_2106 | TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; KEGG: drt:Dret_0269 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase. (475 aa) |
| | Daes_2107 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (190 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa) |
| | gcvPA | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (444 aa) |
| | Daes_2164 | PFAM: Glycine cleavage system P-protein-like; KEGG: dsa:Desal_2996 glycine dehydrogenase subunit 2. (480 aa) |
| | Daes_2165 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: dsa:Desal_2997 FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (453 aa) |
| | Daes_2174 | KEGG: dma:DMR_37970 acyltransferase; PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase. (241 aa) |
| | Daes_2184 | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (236 aa) |
| | Daes_2185 | PFAM: phosphatidate cytidylyltransferase; KEGG: dsa:Desal_1254 phosphatidate cytidylyltransferase; Belongs to the CDS family. (266 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (414 aa) |
| | Daes_2204 | KEGG: dba:Dbac_2391 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (397 aa) |
| | Daes_2205 | KEGG: dsa:Desal_1241 porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (326 aa) |
| | Daes_2206 | KEGG: dsa:Desal_1240 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (389 aa) |
| | Daes_2209 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: dsa:Desal_1238 ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (216 aa) |
| | Daes_2212 | Aldehyde Dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1004 aa) |
| | mqnD | Protein of unknown function DUF178; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (296 aa) |
| | mqnE | Radical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (364 aa) |
| | mqnC | Radical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (391 aa) |
| | mqnA | Protein of unknown function DUF178; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (273 aa) |
| | Daes_2336 | TIGRFAM: phosphonopyruvate decarboxylase-related protein; KEGG: dak:DaAHT2_2657 phosphonopyruvate decarboxylase-related protein; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein. (441 aa) |
| | Daes_2350 | KEGG: dsa:Desal_2862 cysteine synthase; TIGRFAM: cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Cysteinyl-tRNA synthetase class Ia. (771 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (419 aa) |
| | Daes_2365 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: chy:CHY_2698 D-3-phosphoglycerate dehydrogenase. (394 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (356 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: dsa:Desal_1557 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. (244 aa) |
| | hisB | KEGG: dsa:Desal_1555 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa) |
| | Daes_2493 | PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase; KEGG: dvl:Dvul_0528 FMN-dependent alpha-hydroxy acid dehydrogenase. (340 aa) |
| | Daes_2508 | KEGG: dsa:Desal_3228 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa) |
| | Daes_2544 | KEGG: rsq:Rsph17025_4020 ribulose bisphosphate carboxylase; PFAM: ribulose bisphosphate carboxylase large chain; Ribulose bisphosphate carboxylase, large subunit-like; Belongs to the RuBisCO large chain family. (463 aa) |
| | Daes_2546 | TIGRFAM: fructose-1,6-bisphosphatase, class II; KEGG: dba:Dbac_1866 fructose 1,6-bisphosphatase II; PFAM: GlpX family protein. (329 aa) |
| | Daes_2549 | SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: drt:Dret_1397 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa) |
| | Daes_2550 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: dma:DMR_38890 ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (252 aa) |
| | Daes_2551 | Fructose-bisphosphate aldolase, class II, Calvin cycle subtype; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (357 aa) |
| | Daes_2552 | PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; manually curated; KEGG: tgr:Tgr7_2890 pyruvate kinase; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa) |
| | pgk-2 | KEGG: nhl:Nhal_3448 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (390 aa) |
| | Daes_2554 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (671 aa) |
| | Daes_2586 | PFAM: 5'-Nucleotidase domain-containing protein; metallophosphoesterase; KEGG: dal:Dalk_5285 5'-nucleotidase domain protein; Belongs to the 5'-nucleotidase family. (575 aa) |
| | ppnP | Protein of unknown function DUF1255; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (104 aa) |
| | Daes_2594 | Threonine aldolase; KEGG: dsa:Desal_1078 aromatic amino acid beta-eliminating lyase/threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase. (343 aa) |
| | metE | 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (761 aa) |
| | Daes_2676 | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (447 aa) |
| | Daes_2678 | KEGG: dsa:Desal_1093 isocitrate dehydrogenase (NADP(+)); PFAM: isocitrate/isopropylmalate dehydrogenase. (380 aa) |
| | Daes_2688 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: dal:Dalk_2294 glyoxylate reductase. (343 aa) |
| | Daes_2689 | Glycerate kinase; KEGG: dvm:DvMF_2801 hydroxypyruvate reductase; PFAM: MOFRL domain protein. (459 aa) |
| | Daes_2707 | PFAM: glycosyl transferase group 1; Starch synthase catalytic domain-containing protein; KEGG: dds:Ddes_0470 glycosyl transferase group 1. (428 aa) |
| | Daes_2708 | Alpha-amylase; KEGG: lip:LI0331 alpha-amylase; PFAM: glycoside hydrolase family 57. (399 aa) |
| | Daes_2709 | TIGRFAM: alpha-glucan phosphorylase; KEGG: sat:SYN_00879 glycogen synthase/glycogen phosphorylase; PFAM: glycogen synthase; glycosyl transferase family 35. (1412 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (217 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; KEGG: dsa:Desal_3132 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (353 aa) |
| | Daes_2770 | TIGRFAM: pyruvate kinase; KEGG: dvl:Dvul_0731 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (485 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | Daes_2796 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (352 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (465 aa) |
| | Daes_2813 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (377 aa) |
| | Daes_2816 | TIGRFAM: riboflavin synthase, alpha subunit; KEGG: dba:Dbac_0061 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein. (225 aa) |
| | ribBA | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (406 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (155 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (310 aa) |
| | aroK-2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (178 aa) |
| | Daes_2857 | KEGG: dat:HRM2_37910 HisC3; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II. (377 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (396 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa) |
| | Daes_2948 | KEGG: dde:Dde_2060 alpha,alpha-trehalose-phosphate synthase (UDP-forming); PFAM: glycosyl transferase family 20. (490 aa) |
| | Daes_2960 | PFAM: ketose-bisphosphate aldolase class-II; KEGG: dal:Dalk_5159 ketose-bisphosphate aldolase class-II. (422 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa) |
| | hisC | KEGG: dsa:Desal_0178 histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa) |
| | Daes_3035 | TIGRFAM: sulfate adenylyltransferase; KEGG: dde:Dde_2265 sulfate adenylyltransferase; PFAM: ATP-sulfurylase. (426 aa) |
| | Daes_3036 | PFAM: Chorismate mutase, type II; EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); KEGG: dsa:Desal_0227 5-enolpyruvylshikimate-3-phosphate synthase-like protein. (584 aa) |
| | Daes_3038 | KEGG: dma:DMR_39020 aconitate hydratase; TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain-containing protein. (648 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (124 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (292 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (413 aa) |
| | Daes_3091 | KEGG: dvl:Dvul_2015 4-hydroxybenzoate polyprenyltransferase, putative; TIGRFAM: 4-hydroxybenzoate polyprenyltransferase; PFAM: UbiA prenyltransferase; Belongs to the UbiA prenyltransferase family. (287 aa) |
| | Daes_3129 | TIGRFAM: hypoxanthine phosphoribosyltransferase; KEGG: dsa:Desal_3658 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (177 aa) |
| | Daes_3130 | PFAM: GCN5-related N-acetyltransferase; KEGG: dde:Dde_2113 acetyltransferase; Belongs to the acetyltransferase family. (152 aa) |
| | Daes_3132 | PFAM: homocysteine S-methyltransferase; dihydropteroate synthase DHPS; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: dsa:Desal_3661 homocysteine S-methyltransferase. (803 aa) |
| | Daes_3137 | KEGG: drt:Dret_0852 ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. (146 aa) |
| | Daes_3138 | TIGRFAM: transketolase; PFAM: Transketolase domain-containing protein; Transketolase central region; KEGG: dsa:Desal_3668 transketolase; SMART: Transketolase central region; Belongs to the transketolase family. (655 aa) |
| | Daes_3139 | TIGRFAM: fructose-1,6-bisphosphatase, class II; KEGG: dsa:Desal_3575 fructose 1,6-bisphosphatase II; PFAM: GlpX family protein. (328 aa) |
| | Daes_3167 | PFAM: Acyl transferase; KEGG: dsa:Desal_3757 acyl transferase. (308 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | Daes_3197 | S-adenosylhomocysteine deaminase; KEGG: dsa:Desal_0018 amidohydrolase; PFAM: amidohydrolase. (385 aa) |
| | Daes_3239 | KEGG: ppd:Ppro_1523 phosphopantetheine-binding. (77 aa) |
| | Daes_3270 | KEGG: slt:Slit_2897 dTDP-4-dehydrorhamnose 3,5-epimerase; PFAM: dTDP-4-dehydrorhamnose 35-epimerase related. (183 aa) |
| | Daes_3309 | KEGG: dsa:Desal_3603 asparagine synthase (glutamine-hydrolyzing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase. (654 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa) |
| | purD | TIGRFAM: phosphoribosylamine/glycine ligase; KEGG: dsa:Desal_3434 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (425 aa) |
| | Daes_3334 | PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: dsa:Desal_3823 pyruvate ferredoxin/flavodoxin oxidoreductase. (180 aa) |
| | Daes_3335 | PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; KEGG: dvm:DvMF_2056 thiamine pyrophosphate protein domain protein TPP-binding. (256 aa) |
| | Daes_3336 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: dsa:Desal_3825 2-ketoisovalerate ferredoxin reductase. (360 aa) |
| | Daes_3337 | KEGG: dsa:Desal_3826 4Fe-4S ferredoxin iron-sulfur binding domain protein. (79 aa) |
