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murC murC Slip_2381 Slip_2381 murA-3 murA-3 murA-2 murA-2 Slip_2275 Slip_2275 murI murI Slip_2005 Slip_2005 Slip_1856 Slip_1856 murJ-2 murJ-2 Slip_1396 Slip_1396 Slip_1372 Slip_1372 ddl ddl Slip_1100 Slip_1100 murB murB Slip_1041 Slip_1041 uppP uppP Slip_1012 Slip_1012 Slip_0908 Slip_0908 murA murA murG murG Slip_0794 Slip_0794 murD murD mraY mraY murF murF murE murE Slip_0721 Slip_0721 rodA rodA Slip_0692 Slip_0692 Slip_0689 Slip_0689 Slip_0688 Slip_0688 Slip_0524 Slip_0524 Slip_0446 Slip_0446 murJ murJ glmU glmU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
murCUDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (461 aa)
Slip_2381COGs: COG1847 RNA-binding protein; InterPro IPR001374:IPR004044; KEGG: swo:Swol_2573 single-stranded nucleic acid binding R3H; PFAM: single-stranded nucleic acid binding R3H domain protein; KH type 2 domain protein; SMART: single-stranded nucleic acid binding R3H domain protein; SPTR: Q0ATU4 Single-stranded nucleic acid binding R3H; PFAM: R3H domain. (209 aa)
murA-3UDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (415 aa)
murA-2UDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (434 aa)
Slip_2275Cell shape determining protein, MreB/Mrl family; COGs: COG1077 Actin-like ATPase involved in cell morphogenesis; InterPro IPR004753; KEGG: swo:Swol_2374 rod shape-determining protein Mbl; PFAM: cell shape determining protein MreB/Mrl; SPTR: Q0AUE1 Rod shape-determining protein MreB; TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: MreB/Mbl protein; TIGRFAM: cell shape determining protein, MreB/Mrl family. (342 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (273 aa)
Slip_2005Dynamin family protein; InterPro IPR001401; KEGG: sfu:Sfum_2910 dynamin family protein; PFAM: Dynamin family protein; SPTR: A0LMD5 Dynamin family protein; PFAM: Dynamin family. (577 aa)
Slip_1856Protein of unknown function UPF0052 and CofD; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (330 aa)
murJ-2Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (523 aa)
Slip_1396Serine-type D-Ala-D-Ala carboxypeptidase; COGs: COG1686 D-alanyl-D-alanine carboxypeptidase; InterProIPR012338:IPR015956:IPR001967:IPR012907:IPR 018044; KEGG: chy:CHY_2101 D-alanyl-D-alanine carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; PRIAM: Serine-type D-Ala-D-Ala carboxypeptidase; SPTR: Q3AAB4 D-alanyl-D-alanine carboxypeptidase; PFAM: D-alanyl-D-alanine carboxypeptidase; Penicillin-binding protein 5, C-terminal domain; Belongs to the peptidase S11 family. (427 aa)
Slip_1372Penicillin-binding protein, 1A family; COGs: COG0744 Membrane carboxypeptidase (penicillin-binding protein); InterPro IPR012338:IPR001264:IPR001460:IPR011816; KEGG: swo:Swol_0921 penicillin-binding protein; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; SPTR: Q0AYG7 Penicillin-binding protein; TIGRFAM: penicillin-binding protein, 1A family; PFAM: Penicillin binding protein transpeptidase domain; Transglycosylase; TIGRFAM: penicillin-binding protein 1B; penicillin-binding protein, 1A family. (646 aa)
ddlD-alanine/D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (314 aa)
Slip_1100Penicillin-binding protein, 1A family; COGs: COG0744 Membrane carboxypeptidase (penicillin-binding protein); InterPro IPR001264:IPR001460:IPR011816:IPR012338; KEGG: drm:Dred_1803 1A family penicillin-binding protein; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; SPTR: A4J5H5 Penicillin-binding protein, 1A family; TIGRFAM: penicillin-binding protein, 1A family; PFAM: Penicillin binding protein transpeptidase domain; Transglycosylase; TIGRFAM: penicillin-binding protein, 1A family. (697 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (299 aa)
Slip_1041COGs: COG1426 conserved hypothetical protein; KEGG: swo:Swol_1263 hypothetical protein; SPTR: Q0AXI2 Putative uncharacterized protein; manually curated. (286 aa)
uppPUndecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (259 aa)
Slip_1012Serine-type D-Ala-D-Ala carboxypeptidase; COGs: COG1686 D-alanyl-D-alanine carboxypeptidase; InterPro IPR001967:IPR018044:IPR012338:IPR015956; KEGG: swo:Swol_0909 serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; PRIAM: Serine-type D-Ala-D-Ala carboxypeptidase; SPTR: Q0AYH9 Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: D-alanyl-D-alanine carboxypeptidase; Penicillin-binding protein 5, C-terminal domain; Belongs to the peptidase S11 family. (401 aa)
Slip_0908Conserved hypothetical protein; COGs: COG1837 RNA-binding protein (contains KH domain); InterPro IPR009019:IPR004088; KEGG: ckr:CKR_1299 hypothetical protein; SPTR: B9E1H5 Putative uncharacterized protein; Belongs to the UPF0109 family. (76 aa)
murAUDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (417 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (372 aa)
Slip_0794COGs: COG0772 Bacterial cell division membrane protein; InterPro IPR006162:IPR018365:IPR001182:IPR013437; KEGG: swo:Swol_0825 cell cycle protein; PFAM: cell cycle protein; SPTR: Q0AYQ9 Cell cycle protein; TIGRFAM: cell division protein FtsW; PFAM: Cell cycle protein; TIGRFAM: rod shape-determining protein RodA; stage V sporulation protein E; cell division protein FtsW; Belongs to the SEDS family. (364 aa)
murDUDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (456 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide-transferas e; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (324 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate/ D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (459 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (493 aa)
Slip_0721Penicillin-binding protein, 1A family; COGs: COG0744 Membrane carboxypeptidase (penicillin-binding protein); InterPro IPR012338:IPR001264:IPR001460:IPR011816; KEGG: swo:Swol_1109 peptidoglycan glycosyltransferase; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; SPTR: Q0AXY5 Peptidoglycan glycosyltransferase; TIGRFAM: penicillin-binding protein, 1A family; PFAM: Penicillin binding protein transpeptidase domain; Transglycosylase; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; penicillin-binding protei [...] (784 aa)
rodARod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (378 aa)
Slip_0692Rod shape-determining protein MreD; InterPro IPR017225:IPR007227; KEGG: swo:Swol_1639 hypothetical protein; SPTR: Q0AWG6 Putative uncharacterized protein; TIGRFAM: rod shape-determining protein MreD; PFAM: rod shape-determining protein MreD; TIGRFAM: rod shape-determining protein MreD. (165 aa)
Slip_0689Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. (274 aa)
Slip_0688Cell shape determining protein, MreB/Mrl family; COGs: COG1077 Actin-like ATPase involved in cell morphogenesis; InterPro IPR004753; KEGG: swo:Swol_1641 rod shape-determining protein MreB; PFAM: cell shape determining protein MreB/Mrl; SPTR: Q0AWG4 Rod shape-determining protein MreB; TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: MreB/Mbl protein; TIGRFAM: cell shape determining protein, MreB/Mrl family. (340 aa)
Slip_0524Serine-type D-Ala-D-Ala carboxypeptidase; COGs: COG1686 D-alanyl-D-alanine carboxypeptidase; InterProIPR012338:IPR015956:IPR001967:IPR012907:IPR 018044; KEGG: swo:Swol_0612 serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; PRIAM: Serine-type D-Ala-D-Ala carboxypeptidase; SPTR: Q0AZB3 Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: D-alanyl-D-alanine carboxypeptidase; Penicillin-binding protein 5, C-terminal domain; Belongs to the peptidase S11 family. (381 aa)
Slip_0446KEGG: swo:Swol_0594 hypothetical protein; SPTR: Q0AZD1 Putative uncharacterized protein; PFAM: Glycosyl transferase family 4. (278 aa)
murJIntegral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (528 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (462 aa)
Your Current Organism:
Syntrophothermus lipocalidus
NCBI taxonomy Id: 643648
Other names: S. lipocalidus DSM 12680, Syntrophothermus lipocalidus DSM 12680, Syntrophothermus lipocalidus TGB-C1, Syntrophothermus lipocalidus str. DSM 12680, Syntrophothermus lipocalidus strain DSM 12680
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