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| | tsf | Translation elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (204 aa) |
| | rpsB | COGs: COG0052 Ribosomal protein S2; InterPro IPR018130:IPR001865:IPR005706; KEGG: swo:Swol_0882 ribosomal protein S2; PFAM: ribosomal protein S2; SPTR: Q0AYK4 30S ribosomal protein S2; TIGRFAM: ribosomal protein S2; PFAM: Ribosomal protein S2; TIGRFAM: ribosomal protein S2, bacterial type; Belongs to the universal ribosomal protein uS2 family. (232 aa) |
| | Slip_0985 | KEGG: swo:Swol_0881 hypothetical protein; SPTR: Q0AYK5 Putative uncharacterized protein. (150 aa) |
| | Slip_0982 | RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; COGs: COG1191 DNA-directed RNA polymerase specialized sigma subunit; InterProIPR000943:IPR007627:IPR007624:IPR007630:IPR 014284:IPR012845:IPR013325:IPR013324:IPR011991; KEGG: swo:Swol_0878 putative RNA polymerase sigma factor; PFAM: sigma-70 region 4 domain protein; sigma-70 region 2 domain protein; sigma-70 region 3 domain protein; SPTR: Q0AYK8 RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 3; Sigma-70 regi [...] (258 aa) |
| | rplS | Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (126 aa) |
| | Slip_0908 | Conserved hypothetical protein; COGs: COG1837 RNA-binding protein (contains KH domain); InterPro IPR009019:IPR004088; KEGG: ckr:CKR_1299 hypothetical protein; SPTR: B9E1H5 Putative uncharacterized protein; Belongs to the UPF0109 family. (76 aa) |
| | rpsP | COGs: COG0228 Ribosomal protein S16; InterPro IPR000307:IPR020592; KEGG: swo:Swol_1497 30S ribosomal protein S16; PFAM: ribosomal protein S16; SPTR: Q0AWV4 30S ribosomal protein S16; TIGRFAM: ribosomal protein S16; PFAM: Ribosomal protein S16; TIGRFAM: ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (90 aa) |
| | rpmB | COGs: COG0227 Ribosomal protein L28; InterPro IPR001383; KEGG: swo:Swol_0757 50S ribosomal protein L28; PFAM: ribosomal protein L28; SPTR: Q0AYX5 50S ribosomal protein L28; TIGRFAM: ribosomal protein L28; PFAM: Ribosomal L28 family; TIGRFAM: ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (62 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (315 aa) |
| | def | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (153 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (798 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (65 aa) |
| | Slip_0844 | COGs: COG1293 RNA-binding protein homologous to eukaryotic snRNP; InterPro IPR008616:IPR008532; KEGG: swo:Swol_1275 RNA-binding protein-like protein; PFAM: Fibronectin-binding A domain protein; protein of unknown function DUF814; SPTR: Q0AXH0 RNA-binding protein-like protein; PFAM: Domain of unknown function (DUF814); Fibronectin-binding protein A N-terminus (FbpA). (602 aa) |
| | pyrR | Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (183 aa) |
| | Slip_0834 | COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: swo:Swol_0965 glycosyl transferase, group 1; PFAM: glycosyl transferase group 1; SPTR: Q0AYC4 1,2-diacylglycerol 3-glucosyltransferase; PFAM: Glycosyl transferases group 1. (402 aa) |
| | Slip_0828 | COGs: COG3830 ACT domain-containing protein; InterPro IPR002912; KEGG: pth:PTH_0988 hypothetical protein; PFAM: amino acid-binding ACT domain protein; SPTR: C0GHW5 ACT domain-containing protein; PFAM: ACT domain; Belongs to the UPF0237 family. (94 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (926 aa) |
| | Slip_0808 | RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (256 aa) |
| | Slip_0807 | RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (241 aa) |
| | murA | UDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (417 aa) |
| | murC | UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (461 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (372 aa) |
| | murD | UDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (456 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide-transferas e; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (324 aa) |
| | murF | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate/ D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (459 aa) |
| | murE | UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (493 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (592 aa) |
| | hisS | COGs: COG0124 Histidyl-tRNA synthetase; InterProIPR004154:IPR004516:IPR002314:IPR015807:IPR 006195; KEGG: swo:Swol_0811 histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; PRIAM: Histidine--tRNA ligase; SPTR: Q0AYS2 Histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase. (421 aa) |
| | Slip_0762 | COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: rmr:Rmar_2613 glycosyl transferase group 1; PFAM: glycosyl transferase group 1; SPTR: D0MFZ7 Glycosyl transferase group 1; PFAM: Glycosyl transferases group 1; Mannose-6-phosphate isomerase. (453 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (405 aa) |
| | Slip_0721 | Penicillin-binding protein, 1A family; COGs: COG0744 Membrane carboxypeptidase (penicillin-binding protein); InterPro IPR012338:IPR001264:IPR001460:IPR011816; KEGG: swo:Swol_1109 peptidoglycan glycosyltransferase; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; SPTR: Q0AXY5 Peptidoglycan glycosyltransferase; TIGRFAM: penicillin-binding protein, 1A family; PFAM: Penicillin binding protein transpeptidase domain; Transglycosylase; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; penicillin-binding protei [...] (784 aa) |
| | Slip_0714 | COGs: COG1184 Translation initiation factor 2B subunit eIF-2B alpha/beta/delta family; InterPro IPR000649; KEGG: dka:DKAM_0459 translation initiation factor IF-2B subunit delta; PFAM: initiation factor 2B related; SPTR: B8D3V4 Putative ribulose-1,5-bisphosphate isomerase; PFAM: Initiation factor 2 subunit family; Belongs to the eIF-2B alpha/beta/delta subunits family. (285 aa) |
| | rpmA | COGs: COG0211 Ribosomal protein L27; InterPro IPR001684:IPR018261; KEGG: swo:Swol_1611 50S ribosomal protein L27; PFAM: ribosomal protein L27; SPTR: Q0AWJ2 50S ribosomal protein L27; TIGRFAM: ribosomal protein L27; PFAM: Ribosomal L27 protein; TIGRFAM: ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (97 aa) |
| | rplU | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa) |
| | fusA | Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...] (669 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (884 aa) |
| | Slip_0647 | COGs: COG3330 conserved hypothetical protein; KEGG: adg:Adeg_0430 hypothetical protein; SPTR: C9RBF6 Putative uncharacterized protein. (217 aa) |
| | Slip_0646 | Domain of unknown function DUF1957; COGs: COG1543 conserved hypothetical protein; InterPro IPR011330:IPR004300:IPR015293; KEGG: pth:PTH_2228 hypothetical protein; PFAM: Domain of unknown function DUF1957; glycoside hydrolase family 57; SPTR: A5D025 Uncharacterized conserved protein; PFAM: Domain of unknown function (DUF1957); Glycosyl hydrolase family 57. (530 aa) |
| | hisZ | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (386 aa) |
| | sigI | Putative RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; Belongs to the sigma-70 factor family. SigI subfamily. (240 aa) |
| | lgt | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (248 aa) |
| | Slip_0538 | COGs: COG0180 Tryptophanyl-tRNA synthetase; InterPro IPR002306:IPR001412:IPR014729:IPR002305; KEGG: hmo:HM1_1883 tryptophanyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase class Ib; PRIAM: Tryptophan--tRNA ligase; SPTR: B0TFC4 Tryptophanyl-tRNA synthetase; TIGRFAM: tryptophanyl-tRNA synthetase; PFAM: tRNA synthetases class I (W and Y); TIGRFAM: tryptophanyl-tRNA synthetase. (327 aa) |
| | Slip_0527 | RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; COGs: COG1191 DNA-directed RNA polymerase specialized sigma subunit; InterProIPR014322:IPR014284:IPR000943:IPR011991:IPR 013325:IPR013324:IPR007627:IPR007624:IPR007630; KEGG: swo:Swol_0615 sigma 28 (flagella/sporulation); PFAM: sigma-70 region 4 domain protein; sigma-70 region 2 domain protein; sigma-70 region 3 domain protein; SPTR: Q0AZB0 RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 3; Sigma-70 r [...] (248 aa) |
| | Slip_0524 | Serine-type D-Ala-D-Ala carboxypeptidase; COGs: COG1686 D-alanyl-D-alanine carboxypeptidase; InterProIPR012338:IPR015956:IPR001967:IPR012907:IPR 018044; KEGG: swo:Swol_0612 serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; PRIAM: Serine-type D-Ala-D-Ala carboxypeptidase; SPTR: Q0AZB3 Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: D-alanyl-D-alanine carboxypeptidase; Penicillin-binding protein 5, C-terminal domain; Belongs to the peptidase S11 family. (381 aa) |
| | glgA | Glycogen/starch synthase, ADP-glucose type; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (484 aa) |
| | Slip_0514 | COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: dae:Dtox_0787 glycosyl transferase group 1; PFAM: glycosyl transferase group 1; SPTR: C8W232 Glycosyl transferase group 1; PFAM: Starch synthase catalytic domain; Glycosyl transferases group 1. (421 aa) |
| | gatB | glutamyl-tRNA(Gln) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (484 aa) |
| | gatA | glutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (484 aa) |
| | gatC | glutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (95 aa) |
| | Slip_0446 | KEGG: swo:Swol_0594 hypothetical protein; SPTR: Q0AZD1 Putative uncharacterized protein; PFAM: Glycosyl transferase family 4. (278 aa) |
| | Slip_0445 | COGs: COG0463 Glycosyltransferase involved in cell wall biogenesis; InterPro IPR001173; KEGG: swo:Swol_0593 glycosyl transferase family protein; PFAM: glycosyl transferase family 2; SPTR: Q0AZD2 Glycosyltransferase, group 2 family; PFAM: Glycosyl transferase family 2. (224 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (138 aa) |
| | efp | Translation elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (185 aa) |
| | Slip_0393 | RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (235 aa) |
| | mltG | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (340 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (877 aa) |
| | murJ | Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (528 aa) |
| | Slip_0175 | DegT/DnrJ/EryC1/StrS aminotransferase; COGs: COG0399 pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; InterPro IPR000653:IPR015424:IPR015421:IPR015422; KEGG: gwc:GWCH70_3253 DegT/DnrJ/EryC1/StrS aminotransferase; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase; SPTR: C5D944 DegT/DnrJ/EryC1/StrS aminotransferase; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase family; Belongs to the DegT/DnrJ/EryC1 family. (380 aa) |
| | Slip_0172 | Undecaprenyl-phosphate galactose phosphotransferase; COGs: COG2148 Sugar transferase involved in lipopolysaccharide synthesis; InterPro IPR003362; KEGG: dtu:Dtur_0586 undecaprenyl-phosphate galactose phosphotransferase; PFAM: sugar transferase; PRIAM: Undecaprenyl-phosphate galactose phosphotransferase; SPTR: B8DZE1 Undecaprenyl-phosphate galactose phosphotransferase; PFAM: Bacterial sugar transferase. (223 aa) |
| | Slip_0167 | COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: cpy:Cphy_3501 glycosyl transferase group 1; PFAM: glycosyl transferase group 1; SPTR: B0N0E8 Putative uncharacterized protein; PFAM: Glycosyl transferases group 1. (412 aa) |
| | Slip_0166 | COGs: COG0463 Glycosyltransferase involved in cell wall biogenesis; InterPro IPR001173; KEGG: cpi:Cpin_1085 glycosyl transferase family 2; PFAM: glycosyl transferase family 2; SPTR: Q7P738 Glycosyltransferase; PFAM: Glycosyl transferase family 2. (342 aa) |
| | Slip_0165 | COGs: COG0381 UDP-N-acetylglucosamine 2-epimerase; InterPro IPR003331; KEGG: sha:SH0394 capsular polysaccharide synthesis enzyme CapG; PFAM: UDP-N-acetylglucosamine 2-epimerase; PRIAM: UDP-N-acetylglucosamine 2-epimerase; SPTR: C6JQH6 UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase. (376 aa) |
| | Slip_0163 | Polysaccharide biosynthesis protein CapD; COGs: COG1086 nucleoside-diphosphate sugar epimerase; InterPro IPR016040:IPR003869:IPR013692; KEGG: drm:Dred_3033 polysaccharide biosynthesis protein CapD; PFAM: polysaccharide biosynthesis protein CapD; Polysaccharide biosynthesis domain protein; SPTR: A4J8Y3 Polysaccharide biosynthesis protein CapD; PFAM: Polysaccharide biosynthesis protein; Polysaccharide biosynthesis protein C-terminal. (357 aa) |
| | Slip_0162 | COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: bfr:BF1109 putative glycosyltransferase; PFAM: glycosyl transferase group 1; SPTR: Q9RGI9 Putative glycosyltransferase; PFAM: Glycosyl transferases group 1. (403 aa) |
| | Slip_0161 | Polysaccharide biosynthesis protein CapD; COGs: COG1086 nucleoside-diphosphate sugar epimerase; InterPro IPR016040:IPR003869; KEGG: swo:Swol_0128 hypothetical protein; PFAM: polysaccharide biosynthesis protein CapD; SPTR: Q0B0M1 Putative uncharacterized protein; manually curated; PFAM: Polysaccharide biosynthesis protein. (611 aa) |
| | Slip_0153 | Membrane bound O-acyl transferase MBOAT family protein; COGs: COG1696 membrane protein involved in D-alanine export; InterPro IPR004299; KEGG: azc:AZC_2811 membrane bound O-acyl transferase; PFAM: membrane bound O-acyl transferase MBOAT family protein; SPTR: C5ELZ0 Alginate O-acetylation protein algI; PFAM: MBOAT family; Belongs to the membrane-bound acyltransferase family. (410 aa) |
| | lysS | COGs: COG1190 Lysyl-tRNA synthetase (class II); InterProIPR006195:IPR018149:IPR016027:IPR012340:IPR 004365:IPR004364:IPR002313; KEGG: swo:Swol_0116 lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; SPTR: Q0B0N3 Lysyl-tRNA synthetase; TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial; lysyl-tRNA synthetase-related protein GenX; Belongs to the class-II aminoacyl-tRNA synthetase family. (487 aa) |
| | Slip_0118 | COGs: COG1098 RNA binding protein (contains ribosomal protein S1 domain); InterPro IPR003029:IPR016027:IPR012340; KEGG: swo:Swol_0089 RNA binding S1; PFAM: RNA binding S1 domain protein; SPTR: Q0B0Q8 RNA binding S1; PFAM: S1 RNA binding domain. (127 aa) |
| | Slip_0116 | RNA polymerase, sigma-24 subunit, ECF subfamily; InterPro IPR000792:IPR016032:IPR011991:IPR013249; KEGG: pth:PTH_0187 DNA-binding HTH domain-containing proteins; PFAM: Sigma-70 region 4 type 2; SPTR: A5D5W8 DNA-binding HTH domain-containing proteins; PFAM: Sigma-70, region 4. (82 aa) |
| | pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (191 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (462 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (646 aa) |
| | Slip_0048 | COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: swo:Swol_0042 DNA polymerase III, delta prime subunit; SPTR: Q0B0V3 DNA polymerase III, delta prime subunit. (320 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (517 aa) |
| | Slip_0030 | Glutamine--scyllo-inositol transaminase; COGs: COG0399 pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; InterPro IPR000653:IPR015424:IPR015421:IPR015422; KEGG: dae:Dtox_1135 glutamine--scyllo-inositol transaminase; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase; PRIAM: Glutamine--scyllo-inositol transaminase; SPTR: C8W4F3 Glutamine--scyllo-inositol transaminase; manually curated; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase family; Belongs to the DegT/DnrJ/EryC1 family. (362 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (423 aa) |
| | Slip_0002 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (382 aa) |
| | Slip_2254 | RNA polymerase, sigma-24 subunit, ECF subfamily; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterProIPR013325:IPR013324:IPR016371:IPR014218:IPR 014284:IPR011991:IPR007627:IPR013249:IPR000792:IPR000943; KEGG: swo:Swol_2351 RNA polymerase factor sigma-70; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; SPTR: Q0AUG2 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-H factor; RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, [...] (217 aa) |
| | cysS | COGs: COG0215 Cysteinyl-tRNA synthetase; InterProIPR009080:IPR015803:IPR002308:IPR014729:IPR 015273; KEGG: pth:PTH_0295 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; PRIAM: Cysteine--tRNA ligase; SPTR: A5D5M0 Cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (539 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (484 aa) |
| | murA-2 | UDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (434 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (355 aa) |
| | rpmE | Ribosomal protein L31; Binds the 23S rRNA. (67 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (418 aa) |
| | Slip_2315 | Methicillin resistance protein; COGs: COG2348 Uncharacterized protein involved in methicillin resistance; InterPro IPR016181:IPR003447; KEGG: swo:Swol_2417 methicillin resistance protein; PFAM: Methicillin resistance protein; SPTR: Q0AU98 Methicillin resistance protein; PFAM: FemAB family. (370 aa) |
| | Slip_2318 | KEGG: swo:Swol_2420 hypothetical protein; SPTR: Q0AU95 Putative uncharacterized protein; PFAM: DNA-directed RNA polymerase delta subunit. (70 aa) |
| | argS | COGs: COG0018 Arginyl-tRNA synthetase; InterProIPR009080:IPR005148:IPR015945:IPR001278:IPR 014729:IPR008909:IPR001412; KEGG: swo:Swol_2421 arginyl-tRNA synthetase; PFAM: Arginyl-tRNA synthetase, class Ic, core; arginyl tRNA synthetase domain protein; DALR anticodon binding domain protein; PRIAM: Arginine--tRNA ligase; SPTR: Q0AU94 Arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R); TIGRFAM: arginyl-tRNA synthetase. (559 aa) |
| | glnS | COGs: COG0008 Glutamyl- and glutaminyl-tRNA synthetase; InterProIPR011035:IPR020060:IPR004514:IPR020061:IPR 020056:IPR020058:IPR020059:IPR001412; KEGG: pth:PTH_2867 glutaminyl-tRNA synthetase; PFAM: Glutamyl/glutaminyl-tRNA synthetase, class Ic, catalytic domain; Glutamyl/glutaminyl-tRNA synthetase, class Ic, anti-codon binding domain; SPTR: A5CY90 Glutamyl-and glutaminyl-tRNA synthetases; TIGRFAM: glutaminyl-tRNA synthetase; PFAM: tRNA synthetases class I (E and Q), catalytic domain; tRNA synthetases class I (E and Q), anti-codon binding domain; TIGRFAM: glutaminyl-tRNA synthetase; gl [...] (561 aa) |
| | murA-3 | UDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (415 aa) |
| | rplI | Ribosomal protein L9; Binds to the 23S rRNA. (148 aa) |
| | rpsR | Ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (74 aa) |
| | rpsF | Ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (97 aa) |
| | Slip_2366 | COGs: COG3276 Selenocysteine-specific translation elongation factor; InterProIPR009000:IPR009001:IPR000795:IPR005225:IPR 004535:IPR011991:IPR004161:IPR015190:IPR015191; KEGG: swo:Swol_2560 selenocysteine-specific translation elongation factor; PFAM: protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; Elongation factor SelB winged helix 2; Elongation factor SelB winged helix 3; SPTR: Q0ATV7 Selenocysteine-specific translation elongation factor SelB; TIGRFAM: selenocysteine-specific translation elongation factor; small GTP-binding protein; PFAM: Elongation factor [...] (636 aa) |
| | selA | L-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (466 aa) |
| | rpmH | Ribosomal protein L34; InterPro IPR000271; KEGG: mrd:Mrad2831_3505 ribosomal protein L34; PFAM: ribosomal protein L34; SPTR: B1LUP6 50S ribosomal protein L34; TIGRFAM: ribosomal protein L34; manually curated; PFAM: Ribosomal protein L34; TIGRFAM: ribosomal protein L34, bacterial type; Belongs to the bacterial ribosomal protein bL34 family. (44 aa) |
| | lepA | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (601 aa) |
| | rpsT | Ribosomal protein S20; Binds directly to 16S ribosomal RNA. (90 aa) |
| | Slip_1664 | COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372:IPR008921:IPR005790; KEGG: swo:Swol_1588 DNA polymerase III delta subunit-like protein; PFAM: DNA polymerase III delta; SPTR: Q0AWL4 DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit. (328 aa) |
| | leuS | COGs: COG0495 Leucyl-tRNA synthetase; InterProIPR002302:IPR015413:IPR013155:IPR014729:IPR 009008:IPR009080:IPR001412; KEGG: mta:Moth_0568 leucyl-tRNA synthetase; PFAM: tRNA synthetase valyl/leucyl anticodon-binding; tRNA synthetase class I (M); SPTR: Q0AWK4 Leucyl-tRNA synthetase; TIGRFAM: leucyl-tRNA synthetase; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family; Belongs to the class-I aminoacyl-tRNA synthetase family. (825 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (871 aa) |
| | Slip_1703 | Tryptophan RNA-binding attenuator protein; InterPro IPR000824:IPR016031; KEGG: swo:Swol_2042 transcription attenuation protein MtrB; PFAM: tryptophan RNA-binding attenuator protein; SPTR: Q0AVB8 Transcription attenuation protein MtrB; PFAM: Tryptophan RNA-binding attenuator protein. (75 aa) |
| | Slip_1704 | COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR004013:IPR011708:IPR004365:IPR016195:IPR 016027:IPR003141:IPR004805; KEGG: swo:Swol_2043 DNA polymerase III DnaE; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: phosphoesterase PHP domain protein; SPTR: Q0AVB7 DNA-directed DNA polymerase; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain; Bacterial DNA polymerase III alpha subunit; OB-fold nucleic acid binding domain; TIGRFAM: DNA-directed DNA polymerase III (polc). (1131 aa) |
| | Slip_1723 | PHP domain protein; COGs: COG1796 DNA polymerase IV (family X); InterProIPR002008:IPR004013:IPR010996:IPR016195:IPR 002054:IPR003141; KEGG: swo:Swol_1105 DNA-dependent DNA polymerase family X protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; DNA polymerase X; SPTR: Q0AXY9 DNA-dependent DNA polymerase family X; PFAM: PHP domain. (558 aa) |
| | smpB | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (152 aa) |
| | Slip_1854 | COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; InterPro IPR000394:IPR007046:IPR007634; KEGG: swo:Swol_0265 sigma-54 (RpoN); PFAM: sigma-54 DNA-binding domain protein; sigma-54 factor core-binding region; sigma-54 factor; SPTR: Q0B091 Sigma-54 (RpoN); TIGRFAM: RNA polymerase sigma-54 factor, RpoN; PFAM: Sigma-54 factor, Activator interacting domain (AID); Sigma-54 factor, core binding domain; Sigma-54, DNA binding domain; TIGRFAM: RNA polymerase sigma-54 factor. (461 aa) |
| | prfB | Hypothetical protein; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (371 aa) |
| | Slip_1951 | COGs: COG0381 UDP-N-acetylglucosamine 2-epimerase; InterPro IPR003331; KEGG: swo:Swol_0184 UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase; PRIAM: UDP-N-acetylglucosamine 2-epimerase; SPTR: Q0B0G8 UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (371 aa) |
| | Slip_1965 | RNA polymerase, sigma-24 subunit, ECF subfamily; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterProIPR014284:IPR013325:IPR013324:IPR000838:IPR 007627:IPR013249; KEGG: swo:Swol_0132 ECF subfamily RNA polymerase sigma-24 factor; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; SPTR: Q0B0L7 RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor RpoE; RNA polymerase sigma factor, sigma-70 family. (193 aa) |
| | Slip_1980 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (571 aa) |
| | Slip_2019 | COGs: COG0539 Ribosomal protein S1; InterPro IPR016027:IPR003029; KEGG: pth:PTH_2479 RNA-binding protein; SPTR: A5CZC9 Hypothetical RNA-binding protein. (258 aa) |
| | Slip_2041 | DnaB domain protein helicase domain protein; COGs: COG0358 DNA primase; InterProIPR002694:IPR006154:IPR007694:IPR013264:IPR 006171; KEGG: sal:Sala_0980 DNA primase; PFAM: DnaB domain protein helicase domain protein; TOPRIM domain protein; DNA primase catalytic core domain; SMART: Toprim sub domain protein; SPTR: A3YYA9 DNA primase; PFAM: Toprim domain; CHC2 zinc finger; DnaB-like helicase C terminal domain; TIGRFAM: DNA primase, catalytic core. (800 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (273 aa) |
| | Slip_2141 | COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR004805:IPR016195:IPR003141:IPR004013:IPR 011708:IPR004365; KEGG: sth:STH1885 DNA polymerase III alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: phosphoesterase PHP domain protein; SPTR: Q67N73 Error-prone DNA polymerase; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain; Bacterial DNA polymerase III alpha subunit; TIGRFAM: DNA-directed DNA polymerase III (polc). (1031 aa) |
| | Slip_2143 | UMUC domain protein DNA-repair protein; COGs: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; InterPro IPR017963:IPR001126; KEGG: tte:TTE0254 nucleotidyltransferase/DNA polymerase involved in DNA repair; PFAM: UMUC domain protein DNA-repair protein; SPTR: C1WS49 Nucleotidyltransferase/DNA polymerase involved in DNA repair; manually curated; PFAM: impB/mucB/samB family. (403 aa) |
| | rplC | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (212 aa) |
| | rpsI | COGs: COG0103 Ribosomal protein S9; InterPro IPR020568:IPR014721:IPR000754:IPR020574; KEGG: swo:Swol_2297 ribosomal protein S9; PFAM: ribosomal protein S9; SPTR: Q0AUL6 30S ribosomal protein S9; PFAM: Ribosomal protein S9/S16; Belongs to the universal ribosomal protein uS9 family. (130 aa) |
| | rplM | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (144 aa) |
| | rplQ | COGs: COG0203 Ribosomal protein L17; InterPro IPR000456; KEGG: tpd:Teth39_0403 ribosomal protein L17; PFAM: ribosomal protein L17; SPTR: C6Q9K7 50S ribosomal protein L17; TIGRFAM: ribosomal protein L17; PFAM: Ribosomal protein L17; TIGRFAM: ribosomal protein L17. (112 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (315 aa) |
| | rpsD | Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (209 aa) |
| | rpsK | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (130 aa) |
| | rpsM | 30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (123 aa) |
| | rpmJ | Ribosomal protein L36; InterPro IPR000473; KEGG: mta:Moth_2435 50S ribosomal protein L36P; PFAM: ribosomal protein L36; SPTR: Q2RFS2 50S ribosomal protein L36; TIGRFAM: ribosomal protein L36; PFAM: Ribosomal protein L36; TIGRFAM: ribosomal protein L36, bacterial type; Belongs to the bacterial ribosomal protein bL36 family. (37 aa) |
| | infA | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa) |
| | Slip_2214 | KEGG: cth:Cthe_2926 hypothetical protein; SPTR: A3DJJ5 Putative uncharacterized protein. (100 aa) |
| | rplO | Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa) |
| | rpmD | COGs: COG1841 Ribosomal protein L30/L7E; InterPro IPR016082:IPR005996:IPR000517; KEGG: swo:Swol_2315 ribosomal protein L30; PFAM: ribosomal protein L30; SPTR: Q0AUJ8 50S ribosomal protein L30; TIGRFAM: ribosomal protein L30; PFAM: Ribosomal protein L30p/L7e; TIGRFAM: ribosomal protein L30, bacterial/organelle. (61 aa) |
| | rpsE | Ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (167 aa) |
| | rplR | Ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (121 aa) |
| | rplF | Ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (179 aa) |
| | rpsH | Ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa) |
| | rpsZ | Ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa) |
| | rplE | Ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa) |
| | rplX | Ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (106 aa) |
| | rplN | Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rpsQ | 30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (90 aa) |
| | rpmC | Ribosomal protein L29; InterPro IPR001854:IPR018254; KEGG: tpd:Teth39_0382 50S ribosomal protein L29; PFAM: ribosomal protein L29; SPTR: C6PEE6 Ribosomal protein L29; TIGRFAM: ribosomal protein L29; PFAM: Ribosomal L29 protein; TIGRFAM: ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (68 aa) |
| | rplP | Ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (144 aa) |
| | rpsC | Ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (222 aa) |
| | rplV | Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (113 aa) |
| | rpsS | Ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (94 aa) |
| | rplB | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (274 aa) |
| | rplW | Ribosomal protein L25/L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (95 aa) |
| | rplD | Ribosomal protein L4/L1e; Forms part of the polypeptide exit tunnel. (208 aa) |
| | rplK | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (140 aa) |
| | rplA | Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (233 aa) |
| | rplJ | Ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (174 aa) |
| | rplL | Ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (126 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1139 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1152 aa) |
| | Slip_2243 | InterPro IPR004038; KEGG: mta:Moth_2466 50S ribosomal protein L7AE; PFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45; SPTR: Q2RFP1 LSU ribosomal protein L7AE; PFAM: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. (82 aa) |
| | rpsL | Ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (126 aa) |
| | rpsG | Ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | fusA-2 | Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...] (694 aa) |
| | tuf | Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (400 aa) |
| | rpsJ | Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (195 aa) |
| | rpmG | COGs: COG0267 Ribosomal protein L33; InterPro IPR001705; KEGG: swo:Swol_2349 ribosomal protein L33; PFAM: ribosomal protein L33; SPTR: Q0AUG4 50S ribosomal protein L33; TIGRFAM: ribosomal protein L33; PFAM: Ribosomal protein L33; TIGRFAM: ribosomal protein L33, bacterial type; Belongs to the bacterial ribosomal protein bL33 family. (81 aa) |
| | glyQ | COGs: COG0752 Glycyl-tRNA synthetase alpha subunit; InterPro IPR006194:IPR002310; KEGG: swo:Swol_1516 glycyl-tRNA synthetase subunit alpha; PFAM: glycyl-tRNA synthetase alpha subunit; PRIAM: Glycine--tRNA ligase; SPTR: Q0AWT5 Glycyl-tRNA synthetase alpha subunit; TIGRFAM: glycyl-tRNA synthetase, alpha subunit; PFAM: Glycyl-tRNA synthetase alpha subunit; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, alpha subunit. (300 aa) |
| | rpsU | Ribosomal protein S21; InterPro IPR001911:IPR018278; KEGG: swo:Swol_1573 30S ribosomal protein S21; PFAM: ribosomal protein S21; SPTR: Q0AWM8 30S ribosomal protein S21; TIGRFAM: ribosomal protein S21; PFAM: Ribosomal protein S21; TIGRFAM: ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (59 aa) |
| | glyS | COGs: COG0751 Glycyl-tRNA synthetase beta subunit; InterPro IPR006194:IPR002311:IPR008909:IPR015944; KEGG: swo:Swol_1515 glycine--tRNA ligase; PFAM: glycyl-tRNA synthetase beta subunit; DALR anticodon binding domain protein; PRIAM: Glycine--tRNA ligase; SPTR: Q0AWT6 Glycyl-tRNA synthetase beta subunit; TIGRFAM: glycyl-tRNA synthetase, beta subunit; PFAM: Glycyl-tRNA synthetase beta subunit; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, beta subunit. (688 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (595 aa) |
| | sigA | RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (361 aa) |
| | Slip_1600 | KEGG: swo:Swol_0119 hypothetical protein; SPTR: Q0B0N0 Putative uncharacterized protein. (85 aa) |
| | murJ-2 | Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (523 aa) |
| | Slip_1510 | DNA polymerase LigD, polymerase domain protein; COGs: COG3285 eukaryotic-type DNA primase; InterPro IPR002755:IPR014145; KEGG: mta:Moth_2082 hypothetical protein; PFAM: DNA primase small subunit; SPTR: Q2RGR4 Putative uncharacterized protein; TIGRFAM: DNA polymerase LigD, polymerase domain protein; TIGRFAM: DNA ligase D; DNA polymerase LigD, polymerase domain. (300 aa) |
| | Slip_1506 | COGs: COG0463 Glycosyltransferase involved in cell wall biogenesis; InterPro IPR007267:IPR001173:IPR013838; KEGG: swo:Swol_1908 cell wall biosynthesis glycosyltransferase-like protein; PFAM: glycosyl transferase family 2; GtrA family protein; SPTR: Q0AVP9 Glycosyltransferases involved in cell wall biogenesis-like protein; PFAM: GtrA-like protein; Glycosyl transferase family 2. (948 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (636 aa) |
| | infC | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (157 aa) |
| | rpmI | Ribosomal protein L35; InterPro IPR001706:IPR018265; KEGG: swo:Swol_1091 50S ribosomal protein L35; PFAM: ribosomal protein L35; SPTR: Q0AY03 50S ribosomal protein L35; TIGRFAM: ribosomal protein L35; PFAM: Ribosomal protein L35; TIGRFAM: ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (65 aa) |
| | rplT | Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (117 aa) |
| | pheS | COGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; InterProIPR010978:IPR006195:IPR004188:IPR002319:IPR 004529; KEGG: mta:Moth_1751 phenylalanyl-tRNA synthetase, alpha subunit; PFAM: phenylalanyl-tRNA synthetase class IIc; aminoacyl tRNA synthetase class II domain protein; SPTR: Q2RHN7 Phenylalanyl-tRNA synthetase alpha chain; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: tRNA synthetases class II core domain (F); Aminoacyl tRNA synthetase class II, N-terminal domain; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthe [...] (340 aa) |
| | pheT | COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterProIPR020825:IPR005121:IPR009061:IPR005146:IPR 005147:IPR004532; KEGG: swo:Swol_1095 phenylalanine--tRNA ligase; PFAM: B3/4 domain protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; SPTR: Q0AXZ9 Phenylalanyl-tRNA synthetase beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial. (684 aa) |
| | Slip_1410 | RNA polymerase, sigma-24 subunit, ECF subfamily; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterProIPR013325:IPR013324:IPR007627:IPR013249:IPR 000838:IPR014284; KEGG: swo:Swol_1212 ECF subfamily RNA polymerase sigma-24 factor; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; SPTR: Q0AXN3 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. (199 aa) |
| | Slip_1396 | Serine-type D-Ala-D-Ala carboxypeptidase; COGs: COG1686 D-alanyl-D-alanine carboxypeptidase; InterProIPR012338:IPR015956:IPR001967:IPR012907:IPR 018044; KEGG: chy:CHY_2101 D-alanyl-D-alanine carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; PRIAM: Serine-type D-Ala-D-Ala carboxypeptidase; SPTR: Q3AAB4 D-alanyl-D-alanine carboxypeptidase; PFAM: D-alanyl-D-alanine carboxypeptidase; Penicillin-binding protein 5, C-terminal domain; Belongs to the peptidase S11 family. (427 aa) |
| | Slip_1386 | DnaB domain protein helicase domain protein; COGs: COG0305 Replicative DNA helicase; InterPro IPR007693:IPR007694:IPR016136; KEGG: swo:Swol_1201 replicative DNA helicase-like protein; PFAM: DnaB domain protein helicase domain protein; SPTR: Q0AXP4 Primary replicative DNA helicase; PFAM: DnaB-like helicase N terminal domain; DnaB-like helicase C terminal domain. (453 aa) |
| | Slip_1372 | Penicillin-binding protein, 1A family; COGs: COG0744 Membrane carboxypeptidase (penicillin-binding protein); InterPro IPR012338:IPR001264:IPR001460:IPR011816; KEGG: swo:Swol_0921 penicillin-binding protein; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; SPTR: Q0AYG7 Penicillin-binding protein; TIGRFAM: penicillin-binding protein, 1A family; PFAM: Penicillin binding protein transpeptidase domain; Transglycosylase; TIGRFAM: penicillin-binding protein 1B; penicillin-binding protein, 1A family. (646 aa) |
| | Slip_1315 | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins. (244 aa) |
| | rpmF | COGs: COG0333 Ribosomal protein L32; InterPro IPR002677; KEGG: swo:Swol_0770 50S ribosomal protein L32; PFAM: ribosomal L32p protein; SPTR: Q0AYW3 50S ribosomal protein L32; TIGRFAM: ribosomal protein L32; PFAM: Ribosomal L32p protein family; TIGRFAM: ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (57 aa) |
| | Slip_1206 | COGs: COG0480 Translation elongation factors (GTPase); InterProIPR000795:IPR004161:IPR005517:IPR000640:IPR 004540:IPR005225:IPR020568:IPR009000:IPR009022:IPR014721; KEGG: swo:Swol_1152 elongation factor G; PFAM: protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; elongation factor G domain IV; elongation factor G domain protein; SPTR: Q0AXU2 Translation elongation factor G; TIGRFAM: translation elongation factor G; small GTP-binding protein; PFAM: Elongation factor Tu domain 2; Elongation factor G C-terminus; Elongation factor Tu GTP binding domain; Elongation [...] (672 aa) |
| | ddl | D-alanine/D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (314 aa) |
| | Slip_1140 | KEGG: swo:Swol_1380 hypothetical protein; SPTR: Q0AX67 Putative uncharacterized protein. (624 aa) |
| | Slip_1100 | Penicillin-binding protein, 1A family; COGs: COG0744 Membrane carboxypeptidase (penicillin-binding protein); InterPro IPR001264:IPR001460:IPR011816:IPR012338; KEGG: drm:Dred_1803 1A family penicillin-binding protein; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; SPTR: A4J5H5 Penicillin-binding protein, 1A family; TIGRFAM: penicillin-binding protein, 1A family; PFAM: Penicillin binding protein transpeptidase domain; Transglycosylase; TIGRFAM: penicillin-binding protein, 1A family. (697 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (299 aa) |
| | uppP | Undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (259 aa) |
| | Slip_1012 | Serine-type D-Ala-D-Ala carboxypeptidase; COGs: COG1686 D-alanyl-D-alanine carboxypeptidase; InterPro IPR001967:IPR018044:IPR012338:IPR015956; KEGG: swo:Swol_0909 serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; PRIAM: Serine-type D-Ala-D-Ala carboxypeptidase; SPTR: Q0AYH9 Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: D-alanyl-D-alanine carboxypeptidase; Penicillin-binding protein 5, C-terminal domain; Belongs to the peptidase S11 family. (401 aa) |
| | rpsO | Ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa) |
| | infB | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (776 aa) |
| | nusA | Transcription termination factor NusA; Participates in both transcription termination and antitermination. (350 aa) |
| | polC | DNA polymerase III, alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1218 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (567 aa) |
| | frr | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (188 aa) |
