STRINGSTRING
murA-2 murA-2 Slip_0117 Slip_0117 tig tig engB engB Slip_0366 Slip_0366 Slip_0403 Slip_0403 Slip_0446 Slip_0446 scpA scpA scpB scpB Slip_0693 Slip_0693 minC minC Slip_0695 Slip_0695 minE minE rodA rodA ftsL ftsL Slip_0789 Slip_0789 murE murE murF murF mraY mraY murD murD Slip_0794 Slip_0794 murG murG murC murC murA murA Slip_0801 Slip_0801 Slip_0802 Slip_0802 ftsA ftsA ftsZ ftsZ sepF sepF Slip_0821 Slip_0821 Slip_0823 Slip_0823 Slip_1038 Slip_1038 Slip_1053 Slip_1053 murB murB Slip_1179 Slip_1179 Slip_1304 Slip_1304 Slip_1604 Slip_1604 Slip_1724 Slip_1724 whiA whiA Slip_1871 Slip_1871 ftsE ftsE Slip_1975 Slip_1975 Slip_2005 Slip_2005 Slip_2006 Slip_2006 Slip_2272 Slip_2272 murA-3 murA-3 Slip_2377 Slip_2377
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
murA-2UDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (434 aa)
Slip_0117Septum formation initiator; InterPro IPR007060; KEGG: dau:Daud_0082 septum formation initiator; PFAM: Septum formation initiator; SPTR: B1I189 Septum formation initiator; PFAM: Septum formation initiator; TIGRFAM: cell division protein FtsL. (109 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (442 aa)
engBRibosome biogenesis GTP-binding protein YsxC; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (198 aa)
Slip_0366Peptidoglycan glycosyltransferase; COGs: COG0768 Cell division protein FtsI/penicillin-binding protein 2; InterPro IPR018120:IPR012338:IPR005311:IPR001460; KEGG: swo:Swol_0489 peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein transpeptidase; PRIAM: Peptidoglycan glycosyltransferase; SPTR: Q0AZN0 Peptidoglycan glycosyltransferase; PFAM: Penicillin binding protein transpeptidase domain; Penicillin-binding Protein dimerisation domain. (573 aa)
Slip_0403COGs: COG4972 Tfp pilus assembly protein ATPase PilM; KEGG: afw:Anae109_0686 type IV pilus assembly protein PilM; SPTR: A1HQ14 Type IV pilus assembly protein PilM; PFAM: Competence protein A; TIGRFAM: type IV pilus assembly protein PilM. (300 aa)
Slip_0446KEGG: swo:Swol_0594 hypothetical protein; SPTR: Q0AZD1 Putative uncharacterized protein; PFAM: Glycosyl transferase family 4. (278 aa)
scpAChromosome segregation and condensation protein ScpA; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. (250 aa)
scpBChromosome segregation and condensation protein, ScpB; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (171 aa)
Slip_0693Penicillin-binding protein 2; COGs: COG0768 Cell division protein FtsI/penicillin-binding protein 2; InterProIPR012338:IPR005311:IPR014798:IPR002345:IPR 001460:IPR017790; KEGG: swo:Swol_1638 peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; PRIAM: Peptidoglycan glycosyltransferase; SPTR: Q0AWG7 Peptidoglycan glycosyltransferase; TIGRFAM: penicillin-binding protein 2; PFAM: Penicillin binding protein transpeptidase domain; Penicillin-binding Protein dimerisation domain; TIGRFAM: penicillin-binding protein 2. (688 aa)
minCSeptum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (223 aa)
Slip_0695Septum site-determining protein MinD; COGs: COG2894 Septum formation inhibitor-activating ATPase; InterPro IPR002586:IPR010223; KEGG: swo:Swol_1636 septum site-determining protein MinD; PFAM: Cobyrinic acid ac-diamide synthase; SPTR: Q0AWG9 Septum site-determining protein MinD; TIGRFAM: septum site-determining protein MinD; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain; TIGRFAM: septum site-determining protein MinD. (267 aa)
minECell division topological specificity factor MinE; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. (91 aa)
rodARod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (378 aa)
ftsLCell division protein FtsL; Essential cell division protein; Belongs to the FtsL family. (166 aa)
Slip_0789COGs: COG0768 Cell division protein FtsI/penicillin-binding protein 2; InterProIPR005543:IPR012338:IPR005311:IPR001460:IPR 011927; KEGG: swo:Swol_0820 peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; PASTA domain containing protein; PRIAM: Peptidoglycan glycosyltransferase; SMART: PASTA domain containing protein; SPTR: Q0AYR4 Peptidoglycan glycosyltransferase; TIGRFAM: stage V sporulation protein D; PFAM: Penicillin binding protein transpeptidase domain; Penicillin-binding Protein dimerisation domain; PA [...] (703 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (493 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate/ D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (459 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide-transferas e; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (324 aa)
murDUDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (456 aa)
Slip_0794COGs: COG0772 Bacterial cell division membrane protein; InterPro IPR006162:IPR018365:IPR001182:IPR013437; KEGG: swo:Swol_0825 cell cycle protein; PFAM: cell cycle protein; SPTR: Q0AYQ9 Cell cycle protein; TIGRFAM: cell division protein FtsW; PFAM: Cell cycle protein; TIGRFAM: rod shape-determining protein RodA; stage V sporulation protein E; cell division protein FtsW; Belongs to the SEDS family. (364 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (372 aa)
murCUDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (461 aa)
murAUDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (417 aa)
Slip_0801Polypeptide-transport-associated domain protein FtsQ-type; Essential cell division protein. (244 aa)
Slip_0802Protein of unknown function DUF881; COGs: COG3879 conserved hypothetical protein; InterPro IPR010273; KEGG: swo:Swol_0830 hypothetical protein; PFAM: protein of unknown function DUF881; SPTR: Q0AYQ4 Putative uncharacterized protein; PFAM: Bacterial protein of unknown function (DUF881). (234 aa)
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (413 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (352 aa)
sepFProtein of unknown function DUF552; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (146 aa)
Slip_0821InterPro IPR003425; KEGG: swo:Swol_0956 protein of unknown function YGGT; PFAM: protein of unknown function YGGT; SPTR: Q0AYD3 Putative uncharacterized protein; PFAM: YGGT family. (91 aa)
Slip_0823DivIVA domain protein; InterPro IPR007793:IPR019933; KEGG: swo:Swol_0958 cell division initiation protein; PFAM: DivIVA family protein; SPTR: Q0AYD1 Cell division initiation protein; TIGRFAM: DivIVA domain; PFAM: DivIVA protein; TIGRFAM: DivIVA domain. (165 aa)
Slip_1038Cell division protein FtsK/SpoIIIE; COGs: COG1674 DNA segregation ATPase FtsK/SpoIIIE and related protein; InterPro IPR003593:IPR002543:IPR018541; KEGG: swo:Swol_1265 DNA translocase FtsK; PFAM: cell divisionFtsK/SpoIIIE; DNA translocase ftsK gamma; SMART: AAA ATPase; SPTR: Q0AXI0 DNA translocase FtsK; PFAM: Ftsk gamma domain; FtsK/SpoIIIE family. (728 aa)
Slip_1053COGs: COG2359 conserved hypothetical protein; InterPro IPR007347; KEGG: swo:Swol_1250 stage V sporulation protein S; PFAM: Stage V sporulation protein S; SPTR: Q0AXJ5 Stage V sporulation protein S; PFAM: Stage V sporulation protein S (SpoVS). (86 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (299 aa)
Slip_1179Hypothetical protein; KEGG: cdl:CDR20291_3347 putative membrane protein; SPTR: Q181A8 Putaive membrane protein. (305 aa)
Slip_1304WD40 domain protein beta Propeller; InterPro IPR004106:IPR012854:IPR011659:IPR011042; KEGG: mta:Moth_2083 copper amine oxidase-like; PFAM: WD40 domain protein beta Propeller; SPTR: Q2RGR3 Copper amine oxidase-like; PFAM: Copper amine oxidase N-terminal domain. (586 aa)
Slip_1604InterPro IPR000305; KEGG: cli:Clim_2264 hypothetical protein; PFAM: Excinuclease ABC C subunit domain protein; SPTR: B3EHC5 Putative uncharacterized protein; PFAM: GIY-YIG catalytic domain. (189 aa)
Slip_1724Protein of unknown function DUF710; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (92 aa)
whiAProtein of unknown function DUF199; Involved in cell division and chromosome segregation. (315 aa)
Slip_1871Protein of unknown function DUF214; Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation. Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (296 aa)
ftsESigma 54 interacting domain protein; Part of the ABC transporter FtsEX involved in cellular division. (227 aa)
Slip_1975Integrase family protein; COGs: COG4974 Site-specific recombinase XerD; InterPro IPR011010:IPR010998:IPR013762:IPR002104; KEGG: ate:Athe_2026 integrase family protein; PFAM: integrase family protein; SPTR: B9MLB3 Integrase family protein; PFAM: Phage integrase family; Belongs to the 'phage' integrase family. (349 aa)
Slip_2005Dynamin family protein; InterPro IPR001401; KEGG: sfu:Sfum_2910 dynamin family protein; PFAM: Dynamin family protein; SPTR: A0LMD5 Dynamin family protein; PFAM: Dynamin family. (577 aa)
Slip_2006Integrase family protein; COGs: COG4974 Site-specific recombinase XerD; InterPro IPR011010:IPR013762:IPR002104; KEGG: drm:Dred_2783 phage integrase family protein; PFAM: integrase family protein; SPTR: A4J884 Phage integrase family protein; PFAM: Phage integrase family; Belongs to the 'phage' integrase family. (352 aa)
Slip_2272Conserved hypothetical protein; COGs: COG0849 Actin-like ATPase involved in cell division; KEGG: swo:Swol_2371 hypothetical protein; SPTR: Q0AUE4 Putative uncharacterized protein; PFAM: Cell division protein FtsA; TIGRFAM: cell division protein FtsA. (716 aa)
murA-3UDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (415 aa)
Slip_2377parB-like partition protein; COGs: COG1475 transcriptional regulator protein; InterPro IPR003115:IPR004437; KEGG: swo:Swol_2569 transcriptional regulator; PFAM: ParB domain protein nuclease; SMART: ParB domain protein nuclease; SPTR: Q0ATU8 Transcriptional regulator; TIGRFAM: parB-like partition protein; PFAM: ParB-like nuclease domain; KorB domain; TIGRFAM: ParB-like partition proteins; Belongs to the ParB family. (280 aa)
Your Current Organism:
Syntrophothermus lipocalidus
NCBI taxonomy Id: 643648
Other names: S. lipocalidus DSM 12680, Syntrophothermus lipocalidus DSM 12680, Syntrophothermus lipocalidus TGB-C1, Syntrophothermus lipocalidus str. DSM 12680, Syntrophothermus lipocalidus strain DSM 12680
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.