STRINGSTRING
trpC trpC Deba_0005 Deba_0005 Deba_0026 Deba_0026 Deba_0027 Deba_0027 Deba_0028 Deba_0028 queH queH Deba_0118 Deba_0118 Deba_0146 Deba_0146 purE purE Deba_0169 Deba_0169 Deba_0178 Deba_0178 Deba_0205 Deba_0205 thiC thiC Deba_0221 Deba_0221 purL purL Deba_0230 Deba_0230 tmk tmk Deba_0233 Deba_0233 Deba_0246 Deba_0246 Deba_0264 Deba_0264 atpF atpF atpF-2 atpF-2 atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC Deba_0291 Deba_0291 trpB trpB Deba_0305 Deba_0305 Deba_0316 Deba_0316 Deba_0317 Deba_0317 Deba_0329 Deba_0329 hemA hemA Deba_0393 Deba_0393 Deba_0419 Deba_0419 Deba_0422 Deba_0422 Deba_0423 Deba_0423 Deba_0438 Deba_0438 moaC moaC rpoZ rpoZ Deba_0465 Deba_0465 Deba_0475 Deba_0475 selA selA Deba_0573 Deba_0573 hemL hemL Deba_0578 Deba_0578 Deba_0579 Deba_0579 Deba_0585 Deba_0585 bioB bioB bioA bioA Deba_0607 Deba_0607 bioD bioD trpA trpA trpB-2 trpB-2 trpF trpF trpD trpD Deba_0652 Deba_0652 kdsB kdsB mobA mobA Deba_0703 Deba_0703 prs prs Deba_0732 Deba_0732 coaE coaE rho rho murA murA pyrH pyrH coaD coaD Deba_0763 Deba_0763 dacA dacA coaX coaX Deba_0779 Deba_0779 Deba_0788 Deba_0788 Deba_0803 Deba_0803 hemC hemC Deba_0815 Deba_0815 Deba_0817 Deba_0817 Deba_0844 Deba_0844 dinB dinB Deba_0870 Deba_0870 nusA nusA dut dut Deba_0900 Deba_0900 Deba_0915 Deba_0915 pdxJ pdxJ cbiA cbiA Deba_0994 Deba_0994 Deba_1025 Deba_1025 Deba_1026 Deba_1026 Deba_1032 Deba_1032 queA queA tgt tgt Deba_1086 Deba_1086 Deba_1099 Deba_1099 Deba_1129 Deba_1129 Deba_1143 Deba_1143 nadE nadE Deba_1174 Deba_1174 Deba_1180 Deba_1180 proC proC Deba_1219 Deba_1219 purM purM Deba_1273 Deba_1273 dnaG dnaG rpoD rpoD purA purA folD folD queE queE ectC ectC Deba_1357 Deba_1357 ectA ectA purC purC ackA ackA Deba_1380 Deba_1380 Deba_1398 Deba_1398 Deba_1399 Deba_1399 Deba_1414 Deba_1414 Deba_1437 Deba_1437 Deba_1444 Deba_1444 atpA-2 atpA-2 atpB atpB Deba_1448 Deba_1448 Deba_1450 Deba_1450 Deba_1451 Deba_1451 Deba_1464 Deba_1464 pyrG pyrG Deba_1481 Deba_1481 Deba_1514 Deba_1514 cobS cobS cobT cobT Deba_1529 Deba_1529 Deba_1636 Deba_1636 Deba_1651 Deba_1651 cas1-2 cas1-2 Deba_1725 Deba_1725 Deba_1727 Deba_1727 cobD cobD Deba_1797 Deba_1797 Deba_1830 Deba_1830 Deba_1837 Deba_1837 Deba_1872 Deba_1872 Deba_1890 Deba_1890 Deba_1897 Deba_1897 dxs dxs Deba_1939 Deba_1939 Deba_1961 Deba_1961 thi4 thi4 Deba_1988 Deba_1988 Deba_2011 Deba_2011 Deba_2032 Deba_2032 queC queC gmk gmk Deba_2080 Deba_2080 Deba_2082 Deba_2082 acsA acsA Deba_2136 Deba_2136 Deba_2138 Deba_2138 Deba_2140 Deba_2140 Deba_2144 Deba_2144 Deba_2173 Deba_2173 Deba_2210 Deba_2210 folE2 folE2 Deba_2275 Deba_2275 Deba_2276 Deba_2276 Deba_2289 Deba_2289 Deba_2291 Deba_2291 Deba_2300 Deba_2300 Deba_2322 Deba_2322 guaA guaA Deba_2373 Deba_2373 nusB nusB ribH ribH ribBA ribBA Deba_2381 Deba_2381 Deba_2382 Deba_2382 proB proB proA proA nadD nadD dnaX dnaX thiL thiL ndk ndk cbiA-2 cbiA-2 Deba_2457 Deba_2457 Deba_2458 Deba_2458 cbiD cbiD Deba_2460 Deba_2460 Deba_2461 Deba_2461 Deba_2462 Deba_2462 Deba_2463 Deba_2463 Deba_2464 Deba_2464 Deba_2469 Deba_2469 Deba_2503 Deba_2503 Deba_2506 Deba_2506 Deba_2507 Deba_2507 Deba_2516 Deba_2516 Deba_2517 Deba_2517 Deba_2519 Deba_2519 Deba_2520 Deba_2520 Deba_2561 Deba_2561 Deba_2563 Deba_2563 Deba_2565 Deba_2565 Deba_2600 Deba_2600 Deba_2602 Deba_2602 Deba_2617 Deba_2617 Deba_2623 Deba_2623 Deba_2624 Deba_2624 pyrB pyrB pyrC pyrC nadK nadK Deba_2677 Deba_2677 cobQ cobQ cmk cmk Deba_2719 Deba_2719 polA polA atpB-2 atpB-2 atpE atpE pdxA pdxA Deba_2752 Deba_2752 Deba_2773 Deba_2773 Deba_2873 Deba_2873 Deba_2876 Deba_2876 pyrD pyrD pyrF pyrF moaA moaA rpoA rpoA adk adk rpoC rpoC rpoB rpoB nusG nusG Deba_2955 Deba_2955 Deba_2958 Deba_2958 Deba_2977 Deba_2977 Deba_2978 Deba_2978 thiE thiE thiM thiM Deba_3057 Deba_3057 pyrE pyrE Deba_3072 Deba_3072 purF purF carB carB carA carA fdhD fdhD Deba_3171 Deba_3171 Deba_3176 Deba_3176 acsA-2 acsA-2 Deba_3201 Deba_3201 Deba_3202 Deba_3202 Deba_3203 Deba_3203 Deba_3204 Deba_3204 priA priA Deba_3254 Deba_3254 Deba_3269 Deba_3269 serS serS Deba_3298 Deba_3298 Deba_3302 Deba_3302
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
trpCCOGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR013785:IPR011060:IPR013798:IPR001468; KEGG: afw:Anae109_0373 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; SPTR: A7H792 Indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (265 aa)
Deba_0005COGs: COG2927 DNA polymerase III chi subunit; InterPro IPR007459; KEGG: pca:Pcar_1548 DNA polymerase III, chi subunit; PFAM: DNA polymerase III chi subunit HolC; SPTR: Q3A4B4 DNA polymerase III, chi subunit; PFAM: DNA polymerase III chi subunit, HolC. (145 aa)
Deba_0026L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (515 aa)
Deba_0027COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR002638:IPR004393:IPR013785; KEGG: bpt:Bpet0626 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); SPTR: A9I465 Nicotinate-mononucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (286 aa)
Deba_0028Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (363 aa)
queHProtein of unknown function DUF208; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (188 aa)
Deba_0118Protein of unknown function UPF0157; COGs: COG2320 conserved hypothetical protein; InterPro IPR007344; KEGG: geo:Geob_2091 protein of unknown function UPF0157; PFAM: protein of unknown function UPF0157; SPTR: B9M8V0 Putative uncharacterized protein; PFAM: Uncharacterised protein family (UPF0157). (191 aa)
Deba_0146NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509:IPR016040; KEGG: rmr:Rmar_1316 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: D0MI98 NAD-dependent epimerase/dehydratase; PFAM: NAD dependent epimerase/dehydratase family. (312 aa)
purEPhosphoribosylamine/glycine ligase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the GARS family. (589 aa)
Deba_0169Phosphoribosylaminoimidazolecarboxamideformyltra nsferase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR011607:IPR013982; KEGG: glo:Glov_2760 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SPTR: B3E7F6 Bifunctional purine biosynthesis protein purH; PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain. (200 aa)
Deba_0178RNA polymerase, sigma-24 subunit, ECF subfamily; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterProIPR007627:IPR013249:IPR013325:IPR013324:IPR 014284; KEGG: sfu:Sfum_0272 fis family transcriptional regulator; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; SPTR: A0LEX1 Transcriptional regulator, Fis family; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa)
Deba_0205Phosphomethylpyrimidine kinase; COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR013749:IPR004399; KEGG: pla:Plav_2132 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; SPTR: A7HV13 Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase. (304 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (434 aa)
Deba_0221RNA polymerase, sigma-24 subunit, ECF subfamily; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterProIPR007627:IPR013249:IPR013325:IPR013324:IPR 002011:IPR000838:IPR014284; KEGG: sfu:Sfum_3877 ECF subfamily RNA polymerase sigma-24 factor; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; SPTR: A0LQ44 RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. (202 aa)
purLPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (1001 aa)
Deba_0230COGs: COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain; InterPro IPR010075; KEGG: dol:Dole_0483 phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: A8ZTM9 Phosphoribosylformylglycinamidine synthase. (277 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (226 aa)
Deba_0233COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: afw:Anae109_2451 DNA polymerase III, delta prime subunit; SPTR: A7HD56 DNA polymerase III, delta prime subunit; TIGRFAM: DNA polymerase III, delta' subunit. (349 aa)
Deba_0246DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (370 aa)
Deba_0264COGs: COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein; InterPro IPR004435; KEGG: ppd:Ppro_0305 molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: molybdopterin-guanine dinucleotide biosynthesis MobB region; SPTR: Q1NJ69 Molybdopterin-guanine dinucleotide biosynthesis MobB region; TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: Molybdopterin guanine dinucleotide synthesis protein B; TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein MobB. (221 aa)
atpFH+transporting two-sector ATPase B/B' subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (144 aa)
atpF-2ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (221 aa)
atpHATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (183 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (504 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (292 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (469 aa)
atpCATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (137 aa)
Deba_0291COGs: COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains); InterPro IPR001228; KEGG: ppd:Ppro_0501 UDP-N-acetylglucosamine pyrophosphorylase; PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; SPTR: A1ALB2 Bifunctional protein glmU; PFAM: Nucleotidyl transferase; TIGRFAM: UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase. (258 aa)
trpBPyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (451 aa)
Deba_0305COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873:IPR020845; KEGG: mhu:Mhun_2392 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Q2FT08 AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme. (546 aa)
Deba_0316KEGG: dol:Dole_2397 hypothetical protein; SPTR: A8ZVL4 Putative uncharacterized protein. (264 aa)
Deba_0317Response regulator receiver protein; COGs: COG1102 Cytidylate kinase; KEGG: dol:Dole_2398 response regulator receiver protein; SPTR: A8ZVL5 Response regulator receiver protein. (267 aa)
Deba_0329COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR016040:IPR006367; KEGG: sfu:Sfum_1588 siroheme synthase; SPTR: A0LIM3 Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. (232 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (425 aa)
Deba_0393Beta-lactamase; COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; KEGG: rpd:RPD_2374 beta-lactamase-like; SPTR: Q137Y3 Beta-lactamase-like; PFAM: Metallo-beta-lactamase superfamily. (326 aa)
Deba_0419NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509:IPR016040; KEGG: nth:Nther_1582 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: B2A4I0 NAD-dependent epimerase/dehydratase; PFAM: NAD dependent epimerase/dehydratase family. (322 aa)
Deba_0422KEGG: dal:Dalk_1095 hypothetical protein; SPTR: B8F952 Putative uncharacterized protein. (127 aa)
Deba_0423COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; InterPro IPR007115; KEGG: dol:Dole_1493 putative 6-pyruvoyl tetrahydropterin synthase; PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; SPTR: A8ZZE4 Putative uncharacterized protein; PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: queuosine biosynthesis protein QueD; 6-pyruvoyl tetrahydropterin synthase/QueD family protein. (122 aa)
Deba_0438Dinitrogenase iron-molybdenum cofactor biosynthesis protein; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR007197:IPR003731; KEGG: dsa:Desal_0442 dinitrogenase iron-molybdenum cofactor biosynthesis protein; PFAM: Dinitrogenase iron-molybdenum cofactor biosynthesis protein; Radical SAM domain protein; SPTR: C6BX29 Dinitrogenase iron-molybdenum cofactor biosynthesis protein; PFAM: Radical SAM superfamily; Dinitrogenase iron-molybdenum cofactor. (384 aa)
moaCMolybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (155 aa)
rpoZDNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (118 aa)
Deba_0465acetoacetyl-CoA synthase; COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873:IPR005914:IPR020845; KEGG: noc:Noc_2047 acetoacetyl-CoA synthetase; PFAM: AMP-dependent synthetase and ligase; SPTR: Q3J9I9 Acetoacetyl-CoA synthase; TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-binding enzyme; TIGRFAM: acetoacetyl-CoA synthase. (650 aa)
Deba_0475COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878:IPR014777:IPR014776; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Q1JX26 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. (274 aa)
selAL-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (466 aa)
Deba_0573GCN5-related N-acetyltransferase; InterPro IPR000182:IPR016181; KEGG: bbt:BBta_5735 hypothetical protein; PFAM: GCN5-related N-acetyltransferase; SPTR: A5ENE3 Putative uncharacterized protein; PFAM: Acetyltransferase (GNAT) family. (280 aa)
hemLGlutamate-1-semialdehyde-2,1-aminomutase; COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR005814:IPR015424:IPR015421:IPR004639; KEGG: pca:Pcar_0266 glutamate-1-semialdehyde aminotransferase; PFAM: aminotransferase class-III; SPTR: Q3A7W5 Glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. (427 aa)
Deba_0578Putative transcriptional regulator, AsnC family; COGs: COG1522 Transcriptional regulators; InterPro IPR011991; KEGG: dal:Dalk_4278 putative transcriptional regulator, AsnC family; SPTR: B8FMC0 Putative transcriptional regulator, AsnC family. (164 aa)
Deba_0579Formyl transferase domain protein; COGs: COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN; InterPro IPR002376; KEGG: sss:SSUSC84_0029 phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein; SPTR: A6PR94 Putative uncharacterized protein; PFAM: Formyl transferase. (260 aa)
Deba_0585COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: dol:Dole_1973 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: A8ZT94 AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme. (572 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (331 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoateaminotr ansferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (445 aa)
Deba_06078-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (399 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (246 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa)
trpB-2Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (408 aa)
trpFN-(5'phosphoribosyl)anthranilate isomerase (PRAI); COGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR013785:IPR011060:IPR001240; KEGG: gme:Gmet_2492 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); SPTR: Q39SQ9 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (205 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa)
Deba_0652COGs: COG0015 Adenylosuccinate lyase; InterProIPR004769:IPR008948:IPR000362:IPR003031:IPR 019468:IPR020557; KEGG: dal:Dalk_1188 adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; SPTR: B8F9E5 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (439 aa)
kdsB3-deoxy-D-manno- octulosonatecytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (244 aa)
mobAMolybdenum cofactor guanylyltransferase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (223 aa)
Deba_0703Molybdopterin binding domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (359 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (313 aa)
Deba_0732Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (317 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (468 aa)
murAUDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (424 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa)
Deba_0763Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (289 aa)
dacAProtein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (280 aa)
coaXTranscriptional activator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (255 aa)
Deba_0779Radical SAM domain protein; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR007197:IPR017200; KEGG: sfu:Sfum_3058 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SPTR: A0LMT0 Radical SAM domain protein; PFAM: Radical SAM superfamily. (370 aa)
Deba_0788Putative transcriptional regulator, AsnC family; COGs: COG1522 Transcriptional regulators; InterPro IPR019888:IPR000485:IPR011991:IPR011008; KEGG: dal:Dalk_4142 putative transcriptional regulator, AsnC family; SMART: Transcription regulator, AsnC-type; SPTR: B8FMV6 Putative transcriptional regulator, AsnC family; PFAM: AsnC family. (148 aa)
Deba_0803COGs: COG2176 DNA polymerase III alpha subunit (gram-positive type); InterPro IPR006054:IPR006055:IPR012337:IPR013520; KEGG: cte:CT1039 DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; PRIAM: DNA-directed DNA polymerase; SMART: Exonuclease; SPTR: Q8KDK8 DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. (240 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (310 aa)
Deba_0815uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterProIPR006366:IPR014777:IPR014776:IPR000878:IPR 003754:IPR003043; KEGG: sfu:Sfum_3201 uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; SPTR: A0LN72 Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin-III C-methyltransferase. (509 aa)
Deba_0817FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR001645:IPR013221:IPR004101; KEGG: sfu:Sfum_1671 FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; PRIAM: Tetrahydrofolate synthase; SPTR: A0LIV6 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase. (432 aa)
Deba_0844Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (447 aa)
dinBDNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (409 aa)
Deba_0870cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (170 aa)
nusATranscription termination factor NusA; Participates in both transcription termination and antitermination. (436 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (149 aa)
Deba_0900Beta-lactamase; COGs: COG1235 Metal-dependent hydrolase of the beta-lactamase superfamily I; KEGG: gme:Gmet_1944 beta-lactamase-like; SPTR: C8QYE7 Beta-lactamase domain protein; PFAM: Metallo-beta-lactamase superfamily. (268 aa)
Deba_0915Flagellar protein export ATPase FliI; COGs: COG1157 Flagellar biosynthesis/type III secretory pathway ATPase; InterProIPR004100:IPR000194:IPR005714:IPR020005:IPR 003593; KEGG: dma:DMR_45080 flagellum-specific ATP synthase; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; H+transporting two-sector ATPase alpha/beta subunit domain protein; SMART: AAA ATPase; SPTR: Q1NVG3 ATPase FliI/YscN; TIGRFAM: flagellar protein export ATPase FliI; ATPase, FliI/YscN family; PFAM: ATP synthase alpha/beta family, beta-barrel domain; ATP synthase alpha/beta family, nucleotide-bin [...] (438 aa)
pdxJPyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (252 aa)
cbiACobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (470 aa)
Deba_0994NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR016040:IPR001509; KEGG: dvm:DvMF_2922 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: B9BAZ3 UDP-glucose 4-epimerase; PFAM: NAD dependent epimerase/dehydratase family. (344 aa)
Deba_1025Aminotransferase class-III; COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR015424:IPR005814:IPR015421; KEGG: nwi:Nwi_2388 aminotransferase class-III; PFAM: aminotransferase class-III; SPTR: Q3SPZ9 Aminotransferase; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (442 aa)
Deba_1026NAD-dependent epimerase/dehydratase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (282 aa)
Deba_1032Radical SAM domain protein; InterPro IPR007197; KEGG: cbh:CLC_2585 hypothetical protein; PFAM: Radical SAM domain protein; SPTR: A7FQ13 Putative uncharacterized protein; PFAM: Radical SAM superfamily. (414 aa)
queAS-adenosylmethionine/tRNA-ribosyltransferase-iso merase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (365 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (371 aa)
Deba_1086COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR000836:IPR005904; KEGG: sfu:Sfum_1422 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: A0LI61 Hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (183 aa)
Deba_1099Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR015424:IPR004839:IPR015421; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: Q39YE4 L-threonine O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II; TIGRFAM: L-threonine-O-3-phosphate decarboxylase. (377 aa)
Deba_1129Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (385 aa)
Deba_1143Competence/damage-inducible protein CinA; COGs: COG1546 Uncharacterized protein (competence- and mitomycin-induced); InterPro IPR001453:IPR008136:IPR008135; KEGG: gme:Gmet_0196 competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; SPTR: C8QYB6 Competence/damage-inducible protein CinA; TIGRFAM: competence/damage-inducible protein CinA; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-terminal domain; molybden [...] (416 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (565 aa)
Deba_1174Methyltransferase FkbM family; InterPro IPR006342; KEGG: cyt:cce_0521 hypothetical protein; SPTR: B5JGB3 Methyltransferase, FkbM family protein; TIGRFAM: methyltransferase FkbM family; TIGRFAM: methyltransferase, FkbM family. (303 aa)
Deba_11802-phosphosulfolactate phosphatase; COGs: COG2045 Phosphosulfolactate phosphohydrolase; InterPro IPR005238; KEGG: ttu:TERTU_0169 putative 2-phosphosulfolactate phosphatase; PFAM: 2-phosphosulfolactate phosphatase; SPTR: C5BLF2 Putative 2-phosphosulfolactate phosphatase; PFAM: 2-phosphosulpholactate phosphatase; TIGRFAM: 2-phosphosulfolactate phosphatase; Belongs to the ComB family. (225 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa)
Deba_1219Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR000728:IPR010918:IPR004733:IPR016188; KEGG: pca:Pcar_1293 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: Q3A515 Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosp [...] (349 aa)
Deba_1273rfaE bifunctional protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. (176 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (586 aa)
rpoDRNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (590 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (435 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa)
queERadical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (212 aa)
ectCEctoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (130 aa)
Deba_1357Diaminobutyrate/2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa)
ectAL-2,4-diaminobutyric acid acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. (169 aa)
purCCOGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR001636:IPR018236:IPR013816; KEGG: glo:Glov_3047 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: B3E940 Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (298 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (403 aa)
Deba_1380Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (708 aa)
Deba_1398COGs: COG1239 Mg-chelatase subunit ChlI; InterPro IPR011704:IPR003593; KEGG: adg:Adeg_0556 magnesium chelatase; PFAM: ATPase associated with various cellular activities AAA_5; PRIAM: Magnesium chelatase; SMART: AAA ATPase; SPTR: C9RBS7 Magnesium chelatase; PFAM: Magnesium chelatase, subunit ChlI. (345 aa)
Deba_1399COGs: COG1239 Mg-chelatase subunit ChlI; InterPro IPR000523:IPR002035:IPR003593; KEGG: dau:Daud_1209 magnesium chelatase; PFAM: von Willebrand factor type A; magnesium chelatase ChlI subunit; PRIAM: Magnesium chelatase; SMART: von Willebrand factor type A; AAA ATPase; SPTR: B1I3V2 Magnesium chelatase; PFAM: Magnesium chelatase, subunit ChlI; von Willebrand factor type A domain. (680 aa)
Deba_1414COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372:IPR005790:IPR008921; KEGG: gur:Gura_3132 DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; SPTR: A5G675 DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit. (349 aa)
Deba_1437Bifunctional GlmU protein; COGs: COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains); InterPro IPR001451:IPR011004; KEGG: dps:DP2923 bifunctional GlmU protein; SPTR: C0GCM6 Bifunctional GlmU protein. (268 aa)
Deba_1444H+transporting two-sector ATPase E subunit; InterPro IPR002842; KEGG: bfs:BF2749 putative V-type ATP synthase subunit E; PFAM: H+transporting two-sector ATPase E subunit; SPTR: D0TNN5 ATP synthase subunit E. (210 aa)
atpA-2H+transporting two-sector ATPase alpha/beta subunit central region; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (581 aa)
atpBH+transporting two-sector ATPase alpha/beta subunit central region; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (439 aa)
Deba_1448COGs: COG1394 H+-ATPase subunit D; InterPro IPR002699; KEGG: fsu:Fisuc_2839 V-type ATPase, D subunit; PFAM: H+transporting two-sector ATPase D subunit; SPTR: Q1Q3P2 Putative uncharacterized protein; TIGRFAM: V-type ATPase, D subunit; PFAM: ATP synthase subunit D; TIGRFAM: H(+)-transporting ATP synthase, vacuolar type, subunit D. (204 aa)
Deba_1450H+transporting two-sector ATPase C subunit; InterPro IPR002379; KEGG: pcu:pc1676 V-type ATP synthase subunit K; PFAM: H+transporting two-sector ATPase C subunit; SPTR: Q6MAJ9 Putative V-type sodium ATP synthase subunit K (NtpK); PFAM: ATP synthase subunit C. (145 aa)
Deba_1451KEGG: dal:Dalk_4915 hypothetical protein; SPTR: B8FDG0 Putative uncharacterized protein. (205 aa)
Deba_1464Serine/threonine protein kinase PpkA; InterPro IPR002035; KEGG: dat:HRM2_08320 predicted serine/threonine protein kinase PpkA; SPTR: C0QJU2 Predicted serine/threonine protein kinase PpkA. (719 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (546 aa)
Deba_1481COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: hbu:Hbut_0038 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: C8QWH8 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase family. (233 aa)
Deba_1514Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (228 aa)
cobSCobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (245 aa)
cobTNicotinate-nucleotide/dimethylbenzimidazolephosp horibosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (351 aa)
Deba_1529Adenosylcobinamide-phosphateguanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (187 aa)
Deba_1636COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878:IPR014777:IPR014776; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A1ANF1 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. (546 aa)
Deba_1651Conserved hypothetical protein; COGs: COG0407 Uroporphyrinogen-III decarboxylase; KEGG: dal:Dalk_4908 hypothetical protein; SPTR: B8FDF3 Putative uncharacterized protein; PFAM: Uroporphyrinogen decarboxylase (URO-D). (444 aa)
cas1-2CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (655 aa)
Deba_1725Riboflavin biosynthesis protein RibF; COGs: COG0196 FAD synthase; InterProIPR002606:IPR015865:IPR015864:IPR014729:IPR 001412; KEGG: dba:Dbac_2972 riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; SPTR: C7LV43 Riboflavin biosynthesis protein RibF; TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (316 aa)
Deba_1727Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (463 aa)
cobDCobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (321 aa)
Deba_1797KEGG: sfu:Sfum_3819 hypothetical protein; SPTR: A0LPY6 Putative uncharacterized protein. (103 aa)
Deba_1830DNA primase catalytic core domain protein; COGs: COG0358 DNA primase; InterPro IPR002694:IPR013264; KEGG: sfu:Sfum_3790 DNA primase catalytic core; PFAM: DNA primase catalytic core domain; SMART: zinc finger CHC2-family protein; SPTR: A0LPV7 DNA primase catalytic core, N-terminal domain; PFAM: DNA primase catalytic core, N-terminal domain; CHC2 zinc finger; TIGRFAM: DNA primase, catalytic core. (1104 aa)
Deba_1837RNA polymerase, sigma-24 subunit, ECF subfamily; InterPro IPR018170:IPR014284; KEGG: dde:Dde_1928 sigma-24 (FecI-like); SPTR: C6MK24 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. (194 aa)
Deba_18722-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: xac:XAC1784 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR: B7A5Y7 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFA [...] (165 aa)
Deba_1890Molybdenum cofactor synthesis domain protein; COGs: COG0521 Molybdopterin biosynthesis protein; InterPro IPR008284:IPR001453:IPR020817; KEGG: sfu:Sfum_0070 molybdenum cofactor synthesis domain-containing protein; PFAM: molybdopterin binding domain; SPTR: A0LEC1 Molybdopterin adenylyltransferase; TIGRFAM: molybdenum cofactor synthesis domain protein; manually curated; PFAM: Probable molybdopterin binding domain; TIGRFAM: molybdenum cofactor synthesis domain. (163 aa)
Deba_1897RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (346 aa)
dxsDeoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (635 aa)
Deba_1939COGs: COG3830 ACT domain-containing protein; InterPro IPR002912; KEGG: mvu:Metvu_1156 ACT domain-containing protein; PFAM: amino acid-binding ACT domain protein; SPTR: C9RHG2 ACT domain-containing protein; PFAM: ACT domain. (92 aa)
Deba_1961RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (503 aa)
thi4Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (260 aa)
Deba_1988KEGG: dps:DP1532 hypothetical protein; SPTR: Q6AN13 Putative uncharacterized protein; PFAM: Predicted membrane protein (DUF2134). (342 aa)
Deba_2011Hypothetical protein; InterPro IPR015424; KEGG: ttj:TTHA0934 glutamate-1-semialdehyde 2,1-aminomutase (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-AT); SPTR: Q5SJS4 Glutamate-1-semialdehyde 2,1-aminomutase; PFAM: Aminotransferase class-III. (344 aa)
Deba_2032COGs: COG0422 Thiamine biosynthesis protein ThiC; InterPro IPR002817; KEGG: geo:Geob_0543 thiamine biosynthesis protein ThiC; PFAM: thiamine biosynthesis protein ThiC; SPTR: B9LZU6 Thiamine biosynthesis protein ThiC; TIGRFAM: thiamine biosynthesis protein ThiC; PFAM: ThiC family; TIGRFAM: thiamine biosynthesis protein ThiC. (436 aa)
queCexsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (234 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (202 aa)
Deba_2080Nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterProIPR001732:IPR014026:IPR014027:IPR016040:IPR 008927:IPR013328:IPR017476; KEGG: tye:THEYE_A0998 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: B5YKR5 UDP-glucose 6-dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domai [...] (434 aa)
Deba_2082rfaE bifunctional protein; COGs: COG2870 ADP-heptose synthase bifunctional sugar kinase/adenylyltransferase; InterPro IPR011611:IPR011913; KEGG: sfu:Sfum_3634 ribokinase-like domain-containing protein; PFAM: PfkB domain protein; SPTR: A0LPF2 PfkB domain protein; TIGRFAM: rfaE bifunctional protein; PFAM: pfkB family carbohydrate kinase; TIGRFAM: rfaE bifunctional protein, domain I. (344 aa)
acsAacetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (662 aa)
Deba_2136Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain protein; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterProIPR017938:IPR001834:IPR017927:IPR012165:IPR 008333:IPR001433:IPR019480; KEGG: sfu:Sfum_1970 oxidoreductase FAD/NAD(P)-binding subunit; PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; SPTR: A0LJQ2 Oxidoreductase FAD/NAD(P)-binding domain protein; PFAM: Ox [...] (279 aa)
Deba_2138COGs: COG1239 Mg-chelatase subunit ChlI; KEGG: dau:Daud_1208 magnesium chelatase; PRIAM: Magnesium chelatase; SPTR: B1I3V1 Magnesium chelatase. (142 aa)
Deba_2140NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR016040:IPR008089:IPR002198:IPR001509; KEGG: sfu:Sfum_2190 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: C0GQ58 NAD-dependent epimerase/dehydratase; PFAM: NAD dependent epimerase/dehydratase family. (302 aa)
Deba_2144COGs: COG0777 Acetyl-CoA carboxylase beta subunit; InterPro IPR000438:IPR011762:IPR011763:IPR000022; KEGG: gsu:GSU2370 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; PFAM: carboxyl transferase; SPTR: Q74AI4 Acetyl-CoA carboxylase, carboxyl transferase, beta subunit; PFAM: Carboxyl transferase domain; TIGRFAM: acetyl-CoA carboxylase, carboxyl transferase, beta subunit. (630 aa)
Deba_2173WbqC-like family protein; InterPro IPR014985; KEGG: psb:Psyr_1578 hypothetical protein; PFAM: WbqC-like family protein; SPTR: Q4ZW46 Putative uncharacterized protein; PFAM: WbqC-like protein family. (235 aa)
Deba_2210Radical SAM domain protein; COGs: COG2896 Molybdenum cofactor biosynthesis protein; InterPro IPR007197; KEGG: sfu:Sfum_1766 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SPTR: A0LJ51 Radical SAM domain protein; PFAM: Radical SAM superfamily. (423 aa)
folE2GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. (262 aa)
Deba_2275Radical SAM domain protein; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR007197; KEGG: tye:THEYE_A1314 AstB/ChuR-related protein; PFAM: Radical SAM domain protein; SPTR: B5YFS6 AstB/chuR-related protein; PFAM: Radical SAM superfamily. (396 aa)
Deba_2276KEGG: tye:THEYE_A1819 hypothetical protein; SPTR: B5YHM4 Putative uncharacterized protein. (109 aa)
Deba_2289dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (315 aa)
Deba_2291COGs: COG1898 dTDP-4-dehydrorhamnose 3 5-epimerase; InterPro IPR011051:IPR014710:IPR000888; KEGG: sat:SYN_00576 dTDP-4-dehydrorhamnose 3,5-epimerase; SPTR: Q2LVW0 DTDP-4-dehydrorhamnose 3,5-epimerase; PFAM: WxcM-like, C-terminal. (153 aa)
Deba_23001-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; COGs: COG1691 NCAIR mutase (PurE)-related protein; InterPro IPR000031; KEGG: gem:GM21_3730 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; SPTR: C6E6X1 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; PFAM: AIR carboxylase. (250 aa)
Deba_2322RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; COGs: COG1191 DNA-directed RNA polymerase specialized sigma subunit; InterProIPR013325:IPR013324:IPR000943:IPR011991:IPR 007627:IPR007624:IPR007630:IPR014284:IPR012845; KEGG: mgm:Mmc1_3037 FliA/WhiG family RNA polymerase sigma factor; PFAM: sigma-70 region 4 domain protein; sigma-70 region 2 domain protein; sigma-70 region 3 domain protein; SPTR: A0LC35 RNA polymerase, sigma 28 subunit, FliA/WhiG family; TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; S [...] (260 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (517 aa)
Deba_2373COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR016195:IPR003141:IPR004013:IPR011708:IPR 004365:IPR004805; KEGG: pca:Pcar_1222 DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: phosphoesterase PHP domain protein; SPTR: Q3A586 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; OB-fold nucleic acid binding domain; TIGRFAM: DNA-directed DNA polymerase III [...] (1152 aa)
nusBNusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (142 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa)
ribBAGTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (403 aa)
Deba_2381COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR017938:IPR001783; KEGG: glo:Glov_1750 riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: B3EB72 Riboflavin synthase, alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. (219 aa)
Deba_2382Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (377 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (388 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa)
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (220 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (532 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (342 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (153 aa)
cbiA-2Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (460 aa)
Deba_2457Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. (213 aa)
Deba_2458COGs: COG2243 Precorrin-2 methylase; InterPro IPR006364:IPR014777:IPR000878:IPR012382; KEGG: sfu:Sfum_2135 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A0LK65 Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. (244 aa)
cbiDCobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (370 aa)
Deba_2460precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; COGs: COG2242 Precorrin-6B methylase 2; InterPro IPR012818:IPR014008:IPR000878:IPR006365; KEGG: dvl:Dvul_0558 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); SPTR: A1VAW5 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; precorrin-6y C5,15-methyltransferase (d [...] (407 aa)
Deba_2461COGs: COG2875 Precorrin-4 methylase; InterProIPR006362:IPR003043:IPR014777:IPR014776:IPR 000878; KEGG: dat:HRM2_02280 CobM; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: C0GRK4 Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. (266 aa)
Deba_2462COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR002750; KEGG: dma:DMR_02540 cobalamin biosynthesis protein CbiG; PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; SPTR: C4XGG5 Cobalamin biosynthesis protein CbiG; PFAM: Cobalamin biosynthesis central region; Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. (355 aa)
Deba_2463COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR014777:IPR000878; KEGG: gtn:GTNG_1694 precorrin-3 methylase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-3B C(17)-methyltransferase; SPTR: A4IP04 Precorrin-3 methylase; TIGRFAM: precorrin-3B C17-methyltransferase; manually curated; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. (261 aa)
Deba_2464Anaerobic cobalt chelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. (297 aa)
Deba_2469Cobaltochelatase; COGs: COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatase; InterPro IPR003672; KEGG: dal:Dalk_4060 cobaltochelatase; PFAM: CobN/magnesium chelatase; PRIAM: Cobaltochelatase; SPTR: B8FM12 Cobaltochelatase; PFAM: CobN/Magnesium Chelatase; TIGRFAM: cobaltochelatase, CobN subunit. (1264 aa)
Deba_2503COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR020845:IPR000873; KEGG: mhu:Mhun_2392 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Q2FT08 AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme. (544 aa)
Deba_2506Radical SAM domain protein; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR006638:IPR007197; KEGG: mex:Mext_2406 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: C7IBZ9 Radical SAM domain protein; PFAM: Radical SAM superfamily. (337 aa)
Deba_2507Radical SAM domain protein; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR006638:IPR007197; KEGG: mpo:Mpop_2365 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: C7IBZ9 Radical SAM domain protein; PFAM: Radical SAM superfamily. (338 aa)
Deba_2516Magnesium chelatase; COGs: COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatase; InterPro IPR003672; KEGG: cts:Ctha_2441 cobaltochelatase; PFAM: CobN/magnesium chelatase; PRIAM: Magnesium chelatase; SPTR: B3QX80 Cobaltochelatase; PFAM: CobN/Magnesium Chelatase. (1240 aa)
Deba_2517Cobaltochelatase; COGs: COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatase; InterPro IPR003006:IPR003672; KEGG: ppd:Ppro_1259 cobaltochelatase; PFAM: CobN/magnesium chelatase; PRIAM: Cobaltochelatase; SPTR: A1ANG0 Hydrogenobyrinic acid a,c-diamide cobaltochelatase; PFAM: CobN/Magnesium Chelatase; TIGRFAM: cobaltochelatase, CobN subunit. (1240 aa)
Deba_2519COGs: COG1239 Mg-chelatase subunit ChlI; InterPro IPR003593:IPR000523; KEGG: cli:Clim_1021 magnesium chelatase; PFAM: magnesium chelatase ChlI subunit; PRIAM: Magnesium chelatase; SMART: AAA ATPase; SPTR: B3EC21 Magnesium chelatase; PFAM: Magnesium chelatase, subunit ChlI. (342 aa)
Deba_2520COGs: COG1239 Mg-chelatase subunit ChlI; InterPro IPR002035:IPR000523; KEGG: ppd:Ppro_1261 magnesium chelatase; PFAM: von Willebrand factor type A; magnesium chelatase ChlI subunit; PRIAM: Magnesium chelatase; SMART: von Willebrand factor type A; SPTR: A1ANG2 Protoporphyrin IX magnesium-chelatase; PFAM: Magnesium chelatase, subunit ChlI; von Willebrand factor type A domain; TIGRFAM: cobaltochelatase subunit. (697 aa)
Deba_2561Phage/plasmid primase, P4 family; COGs: COG3378 ATPase; InterPro IPR006500:IPR014818:IPR014015; KEGG: dvl:Dvul_0879 hypothetical protein; PFAM: primase P4; SPTR: A1VBT4 Plasmid/phage primase, P4 family; TIGRFAM: phage/plasmid primase, P4 family; PFAM: D5 N terminal like; TIGRFAM: phage/plasmid primase, P4 family, C-terminal domain. (744 aa)
Deba_2563KEGG: dvl:Dvul_0880 sigma-24 (FecI-like); SPTR: A1VBT5 Sigma-24 (FecI-like); PFAM: Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. (194 aa)
Deba_2565KEGG: dsh:Dshi_3225 hypothetical protein; SPTR: C6MK22 Putative uncharacterized protein. (696 aa)
Deba_2600Phage/plasmid primase, P4 family; COGs: COG3378 ATPase; InterPro IPR006500:IPR014818:IPR014015; KEGG: dvl:Dvul_0879 hypothetical protein; PFAM: primase P4; SPTR: A1VBT4 Plasmid/phage primase, P4 family; TIGRFAM: phage/plasmid primase, P4 family; PFAM: D5 N terminal like; TIGRFAM: phage/plasmid primase, P4 family, C-terminal domain. (749 aa)
Deba_2602KEGG: dvl:Dvul_0880 sigma-24 (FecI-like); SPTR: A1VBT5 Sigma-24 (FecI-like); PFAM: Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. (194 aa)
Deba_2617Phosphoribosylaminoimidazolecarboxamideformyltra nsferase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR013982:IPR002695; KEGG: sfu:Sfum_3083 AICARFT/IMPCHase bienzyme, formylation region; PFAM: AICARFT/IMPCHase bienzyme formylation region; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme formylation region; SPTR: C8QXJ9 IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme. (428 aa)
Deba_2623Aldehyde oxidase and xanthine dehydrogenase molybdopterin binding protein; COGs: COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL/CutL homologs; InterPro IPR000674:IPR008274; KEGG: tro:trd_A0400 xanthine dehydrogenase molybdenum-binding subunit; PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; SPTR: B9L3N6 Xanthine dehydrogenase molybdenum-binding subunit; PFAM: Molybdopterin-binding domain of aldehyde dehydrogenase; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain. (623 aa)
Deba_2624Molybdopterin dehydrogenase FAD-binding protein; COGs: COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM/CutM homologs; InterProIPR016167:IPR016169:IPR005107:IPR016166:IPR 002346; KEGG: smd:Smed_4005 molybdopterin dehydrogenase FAD-binding; PFAM: molybdopterin dehydrogenase FAD-binding; CO dehydrogenase flavoprotein domain protein; SPTR: Q565X8 Carbon monoxide dehydrogenase medium chain; PFAM: FAD binding domain in molybdopterin dehydrogenase; CO dehydrogenase flavoprotein C-terminal domain. (294 aa)
pyrBCOGs: COG0540 Aspartate carbamoyltransferase catalytic chain; InterProIPR002082:IPR006130:IPR019825:IPR006132:IPR 006131; KEGG: dol:Dole_0514 aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; PRIAM: Aspartate carbamoyltransferase; SPTR: A8ZU12 Aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: as [...] (308 aa)
pyrCDihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (434 aa)
nadKATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (285 aa)
Deba_2677Beta-lactamase domain protein; COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; KEGG: adg:Adeg_1793 beta-lactamase domain protein; SPTR: C9R9A2 Beta-lactamase domain protein; PFAM: Metallo-beta-lactamase superfamily. (274 aa)
cobQCobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (508 aa)
cmkCOGs: COG0283 Cytidylate kinase; InterPro IPR003136:IPR011994; KEGG: gbm:Gbem_3257 cytidylate kinase; PFAM: cytidylate kinase region; SPTR: C8R0Z9 Cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase. (222 aa)
Deba_2719COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR020845:IPR000873; KEGG: rce:RC1_1843 propionate--CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: B6INQ5 Propionate--CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. (634 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (890 aa)
atpB-2ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (229 aa)
atpEATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (121 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (322 aa)
Deba_2752Anaerobic cobalt chelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. (285 aa)
Deba_2773NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509:IPR016040:IPR008089; KEGG: rba:RB9168 nucleotide sugar epimerase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: Q7ULZ7 Nucleotide sugar epimerase; PFAM: NAD dependent epimerase/dehydratase family. (330 aa)
Deba_2873Amine oxidase; COGs: COG1232 Protoporphyrinogen oxidase; InterPro IPR002937; KEGG: gsu:GSU1512 amine oxidase, flavin-containing; PFAM: amine oxidase; SPTR: Q74D07 Amine oxidase, flavin-containing; PFAM: Flavin containing amine oxidoreductase. (456 aa)
Deba_2876Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain protein; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterProIPR008333:IPR001433:IPR019480:IPR012165:IPR 017927:IPR017938; KEGG: dps:DP3016 dihydroorotate dehydrogenase, electron transfer subunit; PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; Oxidoreductase FAD-binding domain protein; oxidoreductase FAD/NAD(P)-binding domain protein; SPTR: Q1NN17 Oxidoreductase FAD/NAD(P)-binding:Oxidoreductase FAD-bind [...] (259 aa)
pyrDDihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (307 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (230 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (348 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (334 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (213 aa)
rpoCDNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1399 aa)
rpoBDNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1386 aa)
nusGNusG antitermination factor; Participates in transcription elongation, termination and antitermination. (177 aa)
Deba_2955Radical SAM domain protein; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR007197:IPR017200:IPR006638; KEGG: sfu:Sfum_3056 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: A0LMS8 Radical SAM domain protein; PFAM: Radical SAM superfamily. (394 aa)
Deba_2958Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731:IPR013785; KEGG: dol:Dole_1224 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: A8ZY23 Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (327 aa)
Deba_2977ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (337 aa)
Deba_2978Dehydrogenase E1 component; COGs: COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type alpha subunit; InterPro IPR001017:IPR018370; KEGG: rxy:Rxyl_0348 pyruvate dehydrogenase (lipoamide); PFAM: dehydrogenase E1 component; SPTR: B7S016 Dehydrogenase E1 component superfamily protein; PFAM: Dehydrogenase E1 component. (326 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (268 aa)
Deba_3057RNA polymerase, sigma-24 subunit, ECF subfamily; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterProIPR014284:IPR013325:IPR013324:IPR007627:IPR 013249; KEGG: dma:DMR_42310 RNA polymerase ECF-type sigma factor; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; SPTR: C4XQ23 RNA polymerase ECF-type sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. (209 aa)
pyrEPhosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (251 aa)
Deba_3072Metal dependent phosphohydrolase; COGs: COG1896 hydrolase of HD superfamily; InterPro IPR006674:IPR003607; KEGG: dba:Dbac_3189 metal dependent phosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; SPTR: Q1K3X2 Metal dependent phosphohydrolase. (196 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (471 aa)
carBCOGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR006275:IPR016185:IPR005480:IPR005481:IPR 005479:IPR011607:IPR011761:IPR005483:IPR013817:IPR013816; KEGG: sfu:Sfum_0008 carbamoyl phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; SPTR: C8R2N3 Carbamoyl-phosphate synthase, large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase [...] (1084 aa)
carACOGs: COG0505 Carbamoylphosphate synthase small subunit; InterProIPR006274:IPR002474:IPR000991:IPR017926:IPR 001317:IPR011702:IPR006220; KEGG: sfu:Sfum_0009 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: A0LE61 Carbamoyl-phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (394 aa)
fdhDFormate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Belongs to the FdhD family. (260 aa)
Deba_3171UBA/THIF-type NAD/FAD binding protein; COGs: COG1179 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 1; InterPro IPR009036:IPR000594:IPR016040; KEGG: reh:H16_A1870 ThiF/MoeB/HesA family protein; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: A1HS23 UBA/THIF-type NAD/FAD binding protein; PFAM: ThiF family. (270 aa)
Deba_3176Creatininase; COGs: COG1402 Uncharacterized protein putative amidase; InterPro IPR003785; KEGG: sfu:Sfum_0661 creatininase; PFAM: Creatininase; SPTR: A0LG08 Creatininase; PFAM: Creatinine amidohydrolase. (240 aa)
acsA-2acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (665 aa)
Deba_3201Thiamine pyrophosphate protein domain protein TPP-binding protein; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: sfu:Sfum_2795 thiamine pyrophosphate binding domain-containing protein; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; SPTR: A0LM21 Pyruvate ferredoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (320 aa)
Deba_3202Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR009014:IPR002880:IPR015941; KEGG: sfu:Sfum_2794 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; SPTR: A0LM20 Pyruvate ferredoxin oxidoreductase, alpha subunit; PFAM: domain. (391 aa)
Deba_3203COGs: COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase delta subunit; InterPro IPR011898:IPR001450:IPR017896:IPR017900; KEGG: sfu:Sfum_2793 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: A0LM19 Pyruvate ferredoxin oxidoreductase, delta subunit; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family. (109 aa)
Deba_3204Pyruvate/ketoisovalerate oxidoreductase, gamma subunit; COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR011894:IPR002869:IPR019752; KEGG: sat:SYN_00157 pyruvate:ferredoxin oxidoreductase gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; SPTR: Q2LYF2 Pyruvate:ferredoxin oxidoreductase gamma subunit; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate [...] (182 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (750 aa)
Deba_3254Carbamoyl-phosphate synthase L chain ATP-binding protein; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterProIPR016185:IPR011054:IPR005481:IPR005479:IPR 005482:IPR011761:IPR011764:IPR013817:IPR013816; KEGG: dol:Dole_2179 carbamoyl-phosphate synthase L chain ATP-binding; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; SPTR: A8ZUF1 Carbamoyl-phosphate synthase L chain ATP-binding; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-term [...] (495 aa)
Deba_3269RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (363 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa)
Deba_3298Adenylate/guanylate cyclase with Chase sensor; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054:IPR007890; KEGG: sfu:Sfum_2382 adenylate/guanylate cyclase; PFAM: CHASE2 domain protein; adenylyl cyclase class-3/4/guanylyl cyclase; SMART: adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: A0LKW1 Adenylate/guanylate cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain; CHASE2 domain. (705 aa)
Deba_3302COGs: COG1234 Metal-dependent hydrolase of the beta-lactamase superfamily III; KEGG: sat:SYN_00175 metal-dependent hydrolase; SPTR: Q2LQ10 Metal-dependent hydrolase. (274 aa)
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.