node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Deba_1481 | fhs | Deba_1481 | Deba_2227 | COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: hbu:Hbut_0038 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: C8QWH8 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase family. | Formate--tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR020628:IPR000559; KEGG: dat:HRM2_16700 Fhs; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: C0QAX9 Formate--tetrahydrofolate ligase; PFAM: Formate--tetrahydrofolate ligase. | 0.935 |
Deba_1481 | folD | Deba_1481 | Deba_1327 | COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: hbu:Hbut_0038 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: C8QWH8 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.930 |
Deba_2149 | Deba_2153 | Deba_2149 | Deba_2153 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_3267 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FJ30 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_2779 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FKU9 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.963 |
Deba_2149 | Deba_2224 | Deba_2149 | Deba_2224 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_3267 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FJ30 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dol:Dole_0458 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: A8ZTK4 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.918 |
Deba_2149 | fhs | Deba_2149 | Deba_2227 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_3267 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FJ30 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Formate--tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR020628:IPR000559; KEGG: dat:HRM2_16700 Fhs; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: C0QAX9 Formate--tetrahydrofolate ligase; PFAM: Formate--tetrahydrofolate ligase. | 0.923 |
Deba_2149 | folD | Deba_2149 | Deba_1327 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_3267 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FJ30 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.919 |
Deba_2149 | glyA | Deba_2149 | Deba_3071 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_3267 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FJ30 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.943 |
Deba_2153 | Deba_2149 | Deba_2153 | Deba_2149 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_2779 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FKU9 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_3267 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FJ30 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.963 |
Deba_2153 | Deba_2224 | Deba_2153 | Deba_2224 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_2779 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FKU9 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dol:Dole_0458 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: A8ZTK4 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.901 |
Deba_2153 | fhs | Deba_2153 | Deba_2227 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_2779 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FKU9 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Formate--tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR020628:IPR000559; KEGG: dat:HRM2_16700 Fhs; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: C0QAX9 Formate--tetrahydrofolate ligase; PFAM: Formate--tetrahydrofolate ligase. | 0.932 |
Deba_2153 | folD | Deba_2153 | Deba_1327 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_2779 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FKU9 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.920 |
Deba_2153 | glyA | Deba_2153 | Deba_3071 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_2779 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FKU9 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.943 |
Deba_2224 | Deba_2149 | Deba_2224 | Deba_2149 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dol:Dole_0458 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: A8ZTK4 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_3267 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FJ30 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.918 |
Deba_2224 | Deba_2153 | Deba_2224 | Deba_2153 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dol:Dole_0458 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: A8ZTK4 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_2779 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FKU9 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.901 |
Deba_2224 | fhs | Deba_2224 | Deba_2227 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dol:Dole_0458 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: A8ZTK4 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Formate--tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR020628:IPR000559; KEGG: dat:HRM2_16700 Fhs; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: C0QAX9 Formate--tetrahydrofolate ligase; PFAM: Formate--tetrahydrofolate ligase. | 0.952 |
Deba_2224 | folD | Deba_2224 | Deba_1327 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dol:Dole_0458 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: A8ZTK4 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.920 |
Deba_2224 | glyA | Deba_2224 | Deba_3071 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dol:Dole_0458 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: A8ZTK4 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.943 |
fhs | Deba_1481 | Deba_2227 | Deba_1481 | Formate--tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR020628:IPR000559; KEGG: dat:HRM2_16700 Fhs; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: C0QAX9 Formate--tetrahydrofolate ligase; PFAM: Formate--tetrahydrofolate ligase. | COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: hbu:Hbut_0038 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: C8QWH8 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase family. | 0.935 |
fhs | Deba_2149 | Deba_2227 | Deba_2149 | Formate--tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR020628:IPR000559; KEGG: dat:HRM2_16700 Fhs; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: C0QAX9 Formate--tetrahydrofolate ligase; PFAM: Formate--tetrahydrofolate ligase. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_3267 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FJ30 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.923 |
fhs | Deba_2153 | Deba_2227 | Deba_2153 | Formate--tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR020628:IPR000559; KEGG: dat:HRM2_16700 Fhs; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: C0QAX9 Formate--tetrahydrofolate ligase; PFAM: Formate--tetrahydrofolate ligase. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_2779 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FKU9 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.932 |