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nth nth ispF ispF Arch_1565 Arch_1565 eno eno Arch_1454 Arch_1454 Arch_1430 Arch_1430 Arch_1360 Arch_1360 nnrD nnrD fumC fumC deoC deoC moaA moaA Arch_1246 Arch_1246 Arch_1177 Arch_1177 argH argH pdxS pdxS Arch_1140 Arch_1140 hemH hemH Arch_1079 Arch_1079 pyrF pyrF Arch_0959 Arch_0959 Arch_0855 Arch_0855 aroK aroK aroC aroC mltG mltG Arch_0812 Arch_0812 Arch_0796 Arch_0796 uxuA uxuA Arch_0438 Arch_0438 Arch_0428 Arch_0428 Arch_0422 Arch_0422 Arch_0402 Arch_0402 Arch_0346 Arch_0346 menC menC menB menB panD panD Arch_0254 Arch_0254 pckG pckG Arch_0192 Arch_0192 aroD aroD luxS luxS Arch_0067 Arch_0067 Arch_0046 Arch_0046
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nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (226 aa)
ispF2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (163 aa)
Arch_1565KEGG: ckl:CKL_2647 hypothetical protein; SPTR: C8RU50 Putative uncharacterized protein. (59 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
Arch_1454COGs: COG3971 2-keto-4-pentenoate hydratase; InterPro IPR002529:IPR011234; KEGG: bja:blr1240 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; PFAM: fumarylacetoacetate (FAA) hydrolase; PRIAM: 2-oxopent-4-enoate hydratase; SPTR: Q89V18 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; PFAM: Fumarylacetoacetate (FAA) hydrolase family; TIGRFAM: 2-oxo-hepta-3-ene-1,7-dioic acid hydratase. (260 aa)
Arch_1430COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054:IPR009061; KEGG: bcv:Bcav_1154 adenylate/guanylate cyclase; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; PRIAM: Adenylate cyclase; SPTR: D0WPL7 Putative adenylate cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain. (345 aa)
Arch_1360InterPro IPR002539; KEGG: drm:Dred_0577 dehydratase; PFAM: MaoC domain protein dehydratase; PRIAM:3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-ch olest-24-enoyl-CoAhydratase; SPTR: D0WP03 Putative MaoC like domain protein; PFAM: MaoC like domain. (291 aa)
nnrDProtein of unknown function UPF0031; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (283 aa)
fumCFumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (220 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (354 aa)
Arch_1246COGs: COG0315 Molybdenum cofactor biosynthesis enzyme; InterPro IPR002820; KEGG: car:cauri_1058 molybdenum cofactor biosynthesis protein; PFAM: molybdopterin cofactor biosynthesis MoaC region; SPTR: A7BBB8 Putative uncharacterized protein; TIGRFAM: molybdenum cofactor biosynthesis protein C; PFAM: MoaC family; TIGRFAM: molybdenum cofactor biosynthesis protein MoaC. (159 aa)
Arch_1177COGs: COG0015 Adenylosuccinate lyase; InterProIPR008948:IPR004769:IPR020557:IPR000362:IPR 003031; KEGG: cth:Cthe_0741 adenylosuccinate lyase; PFAM: fumarate lyase; SPTR: C0ECV4 Putative uncharacterized protein; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase. (479 aa)
argHCOGs: COG0165 Argininosuccinate lyase; InterProIPR008948:IPR009049:IPR020557:IPR000362:IPR 003031; KEGG: drm:Dred_0278 argininosuccinate lyase; PFAM: fumarate lyase; SPTR: B0MQ53 Putative uncharacterized protein; TIGRFAM: argininosuccinate lyase; PFAM: Lyase; TIGRFAM: argininosuccinate lyase. (462 aa)
pdxSPyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (292 aa)
Arch_1140COGs: COG0311 glutamine amidotransferase involved in pyridoxine biosynthesis; InterPro IPR002161; KEGG: dsy:DSY4245 glutamine amidotransferase subunit PdxT; PFAM: SNO glutamine amidotransferase; SPTR: D0WI52 Glutamine amidotransferase subunit PdxT; PFAM: SNO glutamine amidotransferase family. (210 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (317 aa)
Arch_1079formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (284 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (232 aa)
Arch_0959COGs: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; InterPro IPR020625:IPR013785:IPR002220; KEGG: ckp:ckrop_1871 dihydrodipicolinate synthase; PFAM: dihydrodipicolinate synthetase; SPTR: C0W1Z6 Possible dihydrodipicolinate synthase; PFAM: Dihydrodipicolinate synthetase family; Belongs to the DapA family. (305 aa)
Arch_0855Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (433 aa)
aroK3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (515 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (405 aa)
mltGAminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (373 aa)
Arch_0812COGs: COG1760 L-serine deaminase; InterPro IPR004644:IPR005131:IPR005130; KEGG: aau:AAur_3830 L-serine ammonia-lyase; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; PRIAM: L-serine ammonia-lyase; SPTR: A1RB97 L-serine ammonia-lyase; TIGRFAM: L-serine dehydratase 1; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form. (460 aa)
Arch_0796Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (892 aa)
uxuAMannonate dehydratase; Catalyzes the dehydration of D-mannonate. (359 aa)
Arch_0438COGs: COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase; InterPro IPR013785:IPR000887; KEGG: tau:Tola_0229 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase; SPTR: D0YQL3 Khg/kdpg aldolase; TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase; TIGRFAM: Entner-Doudoroff aldolase. (214 aa)
Arch_0428COGs: COG1027 Aspartate ammonia-lyase; InterProIPR020557:IPR000362:IPR003031:IPR018951:IPR 004708:IPR008948; KEGG: hsm:HSM_0765 aspartate ammonia-lyase; PFAM: fumarate lyase; Fumarase C-like; SPTR: B0USK4 Aspartate ammonia-lyase; TIGRFAM: aspartate ammonia-lyase; PFAM: Lyase; Fumarase C C-terminus; TIGRFAM: aspartate ammonia-lyase. (481 aa)
Arch_0422Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR016040:IPR015884:IPR012301:IPR012302; KEGG: nca:Noca_2034 malate dehydrogenase; PFAM: malic protein NAD-binding; malic protein domain protein; SPTR: D0WL78 NADP-dependent malic enzyme; PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain. (466 aa)
Arch_0402KEGG: kse:Ksed_00360 pyrimidine dimer DNA glycosylase/DNA-(apurinic or apyrimidinic site) lyase; SPTR: C7NIG2 Pyrimidine dimer DNA glycosylase. (147 aa)
Arch_0346COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); InterPro IPR001078:IPR001017:IPR005475:IPR011603; KEGG: bcv:Bcav_1274 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase central region; dehydrogenase E1 component; catalytic domain of components of various dehydrogenase complexes; SPTR: D0WRR3 Oxoglutarate dehydrogenase (Succinyl-transferring), E1 component; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Dehydrogenase E1 component; Transketolase, pyrimidine binding domain; TIGRFAM: 2- [...] (1238 aa)
menCMandelate racemase/muconate lactonizing protein; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (327 aa)
menBNaphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. (329 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (151 aa)
Arch_02542-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (291 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (616 aa)
Arch_0192Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (242 aa)
luxSQuorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (153 aa)
Arch_0067dTDP-glucose 4,6-dehydratase; COGs: COG1088 dTDP-D-glucose 4 6-dehydratase; InterPro IPR001509:IPR016040:IPR005888; KEGG: xce:Xcel_2563 dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: D0WPK4 dTDP-glucose 4,6-dehydratase; TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (330 aa)
Arch_0046KEGG: sro:Sros_5538 hypothetical protein; SPTR: D0YPL4 Deoxyribose-phosphate aldolase superfamily protein. (287 aa)
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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