(83 nodes) Tryptophan metabolism network (Gaeumannomyces tritici)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	GGTG_06332	Amino transferase. (593 aa)
	GGTG_03889	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Belongs to the metallo-dependent hydrolases superfamily. (380 aa)
	GGTG_04124	Uncharacterized protein. (464 aa)
	GGTG_04293	Amidase domain-containing protein. (603 aa)
	GGTG_04413	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (497 aa)
	GGTG_04473	Catalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Confers resistance to H(2)O(2) in hyphae. May play an antioxidative role in fungal defense against the host-produced H(2)O(2) (oxidative burst) at the early stage of plant infection. (788 aa)
	GGTG_04544	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (343 aa)
	GGTG_04546	Uncharacterized protein. (583 aa)
	GGTG_04549	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (487 aa)
	GGTG_04978	Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily. (191 aa)
	GGTG_05208	Dihydrolipoyllysine-residue succinyltransferase. (416 aa)
	GGTG_05225	Dihydrolipoyl dehydrogenase. (508 aa)
	GGTG_05251	Vacuolar protein sorting-associated protein 4; Belongs to the AAA ATPase family. (752 aa)
	GGTG_05913	Uncharacterized protein. (426 aa)
	GGTG_06001	Uncharacterized protein. (98 aa)
	GGTG_06434	Nitrilase 2. (517 aa)
	GGTG_06555	Uncharacterized protein. (586 aa)
	GGTG_06567	Amino_oxidase domain-containing protein. (695 aa)
	GGTG_06591	Amidase domain-containing protein. (535 aa)
	GGTG_06619	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (546 aa)
	GGTG_06620	Uncharacterized protein. (507 aa)
	GGTG_06686	N-acetyltransferase domain-containing protein. (163 aa)
	GGTG_06694	Uncharacterized protein. (579 aa)
	GGTG_06708	Cytochrome P450 2C31; Belongs to the cytochrome P450 family. (577 aa)
	GGTG_06855	Indoleamine 2,3-dioxygenase. (493 aa)
	GGTG_07007	Uncharacterized protein. (232 aa)
	GGTG_07169	Amidase domain-containing protein. (538 aa)
	GGTG_07291	Glutamyl-tRNA(Gln) amidotransferase subunit A. (555 aa)
	GGTG_07350	Amine oxidase. (497 aa)
	GGTG_07353	Bifunctional cytochrome P450/NADPH--P450 reductase; In the N-terminal section; belongs to the cytochrome P450 family. (1088 aa)
	GGTG_07399	Uncharacterized protein. (241 aa)
	GGTG_07463	Amidase domain-containing protein. (554 aa)
	GGTG_07479	CN hydrolase domain-containing protein. (346 aa)
	GGTG_07512	Enoyl-CoA hydratase/isomerase. (278 aa)
	GGTG_07590	AB hydrolase-1 domain-containing protein. (537 aa)
	GGTG_08665	Uncharacterized protein. (237 aa)
	GGTG_08981	Glutamyl-tRNA(Gln) amidotransferase subunit A. (449 aa)
	GGTG_09019	Bifunctional cytochrome P450/NADPH--P450 reductase; In the N-terminal section; belongs to the cytochrome P450 family. (1113 aa)
	GGTG_09030	Amidase domain-containing protein. (398 aa)
	GGTG_09069	Uncharacterized protein. (633 aa)
	GGTG_09128	Uncharacterized protein. (238 aa)
	GGTG_09721	Indoleamine 2,3-dioxygenase subfamily. (553 aa)
	GGTG_09851	Endoribonuclease L-PSP. (141 aa)
	GGTG_10011	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (715 aa)
	GGTG_10071	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (553 aa)
	GGTG_10266	Integral membrane protein. (516 aa)
	GGTG_10942	Catalase-peroxidase; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (819 aa)
	GGTG_11046	Uncharacterized protein. (483 aa)
	GGTG_11075	Betaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (541 aa)
	GGTG_11905	Zn(2)-C6 fungal-type domain-containing protein. (840 aa)
	GGTG_12122	AB hydrolase-1 domain-containing protein. (529 aa)
	GGTG_12252	Betaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (480 aa)
	GGTG_12253	Kynurenine-oxoglutarate transaminase 1. (493 aa)
	GGTG_12411	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (312 aa)
	GGTG_12698	Cytochrome P450 3A24; Belongs to the cytochrome P450 family. (562 aa)
	GGTG_12822	Uncharacterized protein. (641 aa)
	GGTG_13039	Methyltransf_2 domain-containing protein. (192 aa)
	GGTG_13538	Amidase domain-containing protein. (586 aa)
	GGTG_13793	Cytochrome P450; Belongs to the cytochrome P450 family. (535 aa)
	GGTG_13819	Amino_oxidase domain-containing protein. (731 aa)
	GGTG_14134	2,3-dihydroxybenzoic acid decarboxylase; Belongs to the metallo-dependent hydrolases superfamily. (391 aa)
	GGTG_14190	Uncharacterized protein. (546 aa)
	GGTG_00100	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (525 aa)
	GGTG_00246	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (319 aa)
	GGTG_00524	Aromatic amino acid aminotransferase. (655 aa)
	GGTG_00620	Transcriptional activator protein DAL81. (814 aa)
	GGTG_00963	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
	GGTG_01161	Tr-type G domain-containing protein. (671 aa)
	GGTG_01354	Uncharacterized protein. (175 aa)
	GGTG_01497	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (180 aa)
	GGTG_01621	Aminotran_1_2 domain-containing protein. (432 aa)
	GGTG_02123	Uncharacterized protein. (199 aa)
	GGTG_02321	Uncharacterized protein. (505 aa)
	GGTG_02379	Uncharacterized protein. (546 aa)
	GGTG_02739	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (434 aa)
	GGTG_02773	Uncharacterized protein. (175 aa)
	GGTG_02895	Polyamine acetyltransferase. (278 aa)
	GGTG_02972	Aminotran_1_2 domain-containing protein. (480 aa)
	GGTG_02982	Catalase domain-containing protein. (310 aa)
	GGTG_03447	Uncharacterized protein. (146 aa)
	GGTG_03448	YeeE/YedE family protein. (389 aa)
	GGTG_03818	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (743 aa)
	GGTG_03873	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (291 aa)

Your Current Organism:

Gaeumannomyces tritici

NCBI taxonomy Id: 644352
Other names: G. tritici R3-111a-1, Gaeumannomyces graminis var. tritici R3-111a-1, Gaeumannomyces tritici R3-111a-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GGTG_00100	GGTG_00246	J3NFQ5	J3NG53	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.806
GGTG_00100	GGTG_00524	J3NFQ5	J3NGY8	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aromatic amino acid aminotransferase.	0.723
GGTG_00100	GGTG_01497	J3NFQ5	J3NJR7	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.846
GGTG_00100	GGTG_01621	J3NFQ5	J3NK39	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aminotran_1_2 domain-containing protein.	0.780
GGTG_00100	GGTG_02972	J3NFQ5	J3NNW6	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aminotran_1_2 domain-containing protein.	0.723
GGTG_00100	GGTG_03889	J3NFQ5	J3NRI5	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Belongs to the metallo-dependent hydrolases superfamily.	0.416
GGTG_00100	GGTG_06332	J3NFQ5	J3NYI0	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Amino transferase.	0.723
GGTG_00100	GGTG_06619	J3NFQ5	J3NZC0	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.983
GGTG_00100	GGTG_06620	J3NFQ5	J3NZC1	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.434
GGTG_00100	GGTG_06686	J3NFQ5	J3NZI8	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	N-acetyltransferase domain-containing protein.	0.416
GGTG_00100	GGTG_09721	J3NFQ5	J3P886	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Indoleamine 2,3-dioxygenase subfamily.	0.434
GGTG_00100	GGTG_12253	J3NFQ5	J3PFH8	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynurenine-oxoglutarate transaminase 1.	0.859
GGTG_00100	GGTG_12411	J3NFQ5	J3PFY6	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.416
GGTG_00246	GGTG_00100	J3NG53	J3NFQ5	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.806
GGTG_00246	GGTG_06619	J3NG53	J3NZC0	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.918
GGTG_00246	GGTG_06620	J3NG53	J3NZC1	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Uncharacterized protein.	0.901
GGTG_00246	GGTG_09721	J3NG53	J3P886	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Indoleamine 2,3-dioxygenase subfamily.	0.901
GGTG_00524	GGTG_00100	J3NGY8	J3NFQ5	Aromatic amino acid aminotransferase.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.723
GGTG_00524	GGTG_01621	J3NGY8	J3NK39	Aromatic amino acid aminotransferase.	Aminotran_1_2 domain-containing protein.	0.590
GGTG_00524	GGTG_05225	J3NGY8	J3NVB2	Aromatic amino acid aminotransferase.	Dihydrolipoyl dehydrogenase.	0.475