(86 nodes) Folate biosynthesis network (Gaeumannomyces tritici)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GGTG_13384	ANK_REP_REGION domain-containing protein. (989 aa)
	GGTG_00214	HET domain-containing protein. (627 aa)
	GGTG_00278	Uncharacterized protein. (369 aa)
	GGTG_00629	ZT_dimer domain-containing protein. (470 aa)
	GGTG_00655	MSF1 domain-containing protein. (187 aa)
	GGTG_00695	Uncharacterized protein. (280 aa)
	GGTG_01101	Alkaline phosphatase. (593 aa)
	GGTG_01125	Uncharacterized protein. (635 aa)
	GGTG_01339	Uncharacterized protein. (1771 aa)
	GGTG_01537	FolB domain-containing protein. (321 aa)
	GGTG_01553	GTP_cyclohydroI domain-containing protein. (293 aa)
	GGTG_01557	Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (850 aa)
	GGTG_01619	Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. (800 aa)
	GGTG_01668	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. (263 aa)
	GGTG_02415	Alkaline phosphatase D. (636 aa)
	GGTG_02639	Uncharacterized protein. (625 aa)
	GGTG_02700	ANK_REP_REGION domain-containing protein. (1178 aa)
	GGTG_02890	Uncharacterized protein. (70 aa)
	GGTG_02980	FSH1 domain-containing protein. (275 aa)
	GGTG_03123	Elongation factor G. (862 aa)
	GGTG_03164	FSH1 domain-containing protein. (253 aa)
	GGTG_03577	MFS domain-containing protein. (550 aa)
	GGTG_04018	Folylpolyglutamate synthase. (712 aa)
	GGTG_04019	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (585 aa)
	GGTG_04093	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (681 aa)
	GGTG_05455	Uncharacterized protein. (268 aa)
	GGTG_05716	Uncharacterized protein. (690 aa)
	GGTG_06114	Alkaline phosphatase; Belongs to the alkaline phosphatase family. (669 aa)
	GGTG_06179	GTP cyclohydrolase II. (446 aa)
	GGTG_06346	Uncharacterized protein. (147 aa)
	GGTG_06605	ANK_REP_REGION domain-containing protein. (656 aa)
	GGTG_06950	MFS domain-containing protein. (610 aa)
	GGTG_07183	HET domain-containing protein. (612 aa)
	GGTG_07239	FSH1 domain-containing protein. (256 aa)
	GGTG_07315	HET domain-containing protein. (710 aa)
	GGTG_07745	F-box domain-containing protein. (693 aa)
	GGTG_07825	Uncharacterized protein. (1224 aa)
	GGTG_07869	Aminodeoxychorismate synthase. (922 aa)
	GGTG_07963	Cation diffusion facilitator 1. (546 aa)
	GGTG_08058	RibD_C domain-containing protein. (192 aa)
	GGTG_08128	Elp3 domain-containing protein. (720 aa)
	GGTG_08347	MFS domain-containing protein. (549 aa)
	GGTG_08383	Uncharacterized protein. (213 aa)
	GGTG_08488	MFS domain-containing protein. (557 aa)
	GGTG_08505	Folic acid synthesis protein. (481 aa)
	GGTG_08539	N2,N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (695 aa)
	GGTG_08836	MFS domain-containing protein. (553 aa)
	GGTG_09312	Alkaline phosphatase. (498 aa)
	GGTG_09377	MFS domain-containing protein. (576 aa)
	GGTG_09504	Mitochondrial metal transporter 2. (494 aa)
	GGTG_09560	ANK_REP_REGION domain-containing protein. (1123 aa)
	GGTG_09601	Molybdenum cofactor sulfurase. (634 aa)
	GGTG_09634	Cation efflux family protein. (549 aa)
	GGTG_09790	Inner membrane protein yicO. (612 aa)
	GGTG_09819	Myb-like domain-containing protein. (347 aa)
	GGTG_09886	ANK_REP_REGION domain-containing protein. (882 aa)
	GGTG_09905	Folylpolyglutamate synthase. (416 aa)
	GGTG_09996	Uncharacterized protein. (354 aa)
	GGTG_10337	Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. (166 aa)
	GGTG_10377	Short-chain dehydrogenase/reductase SDR. (105 aa)
	GGTG_10512	Inner membrane protein yieG. (597 aa)
	GGTG_10732	HET domain-containing protein. (745 aa)
	GGTG_10833	Uncharacterized protein. (522 aa)
	GGTG_11269	Uncharacterized protein. (277 aa)
	GGTG_11346	FSH1 domain-containing protein. (266 aa)
	GGTG_11506	MFS domain-containing protein. (463 aa)
	GGTG_11720	Short-chain dehydrogenase. (251 aa)
	GGTG_11824	FSH1 domain-containing protein. (324 aa)
	GGTG_11958	Vacuolar membrane PQ loop repeat protein. (361 aa)
	GGTG_12032	HET domain-containing protein. (919 aa)
	GGTG_12125	MFS domain-containing protein. (661 aa)
	GGTG_12290	GTP cyclohydrolase 1. (308 aa)
	GGTG_12568	MSF1 domain-containing protein. (247 aa)
	GGTG_12810	Uncharacterized protein. (730 aa)
	GGTG_13078	HET domain-containing protein. (964 aa)
	GGTG_13101	F-box domain-containing protein. (632 aa)
	GGTG_13238	HeLo domain-containing protein. (269 aa)
	GGTG_13243	ANK_REP_REGION domain-containing protein. (1373 aa)
	GGTG_13381	Uncharacterized protein. (1169 aa)
	GGTG_13407	ANK_REP_REGION domain-containing protein. (1050 aa)
	GGTG_13421	PNP_UDP_1 domain-containing protein. (447 aa)
	GGTG_13506	Uncharacterized protein. (1063 aa)
	GGTG_13579	ANK_REP_REGION domain-containing protein. (1098 aa)
	GGTG_13589	ANK_REP_REGION domain-containing protein. (1052 aa)
	GGTG_13834	GTP cyclohydrolase-2. (442 aa)
	GGTG_14067	Citrinin biosynthesis oxydoreductase CtnB. (269 aa)

Your Current Organism:

Gaeumannomyces tritici

NCBI taxonomy Id: 644352
Other names: G. tritici R3-111a-1, Gaeumannomyces graminis var. tritici R3-111a-1, Gaeumannomyces tritici R3-111a-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GGTG_00278	GGTG_01537	J3NG85	J3NJV6	Uncharacterized protein.	FolB domain-containing protein.	0.749
GGTG_00278	GGTG_01553	J3NG85	J3NJX1	Uncharacterized protein.	GTP_cyclohydroI domain-containing protein.	0.474
GGTG_00278	GGTG_01668	J3NG85	J3NK87	Uncharacterized protein.	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.	0.699
GGTG_00278	GGTG_04018	J3NG85	J3NRX0	Uncharacterized protein.	Folylpolyglutamate synthase.	0.828
GGTG_00278	GGTG_04019	J3NG85	J3NRX1	Uncharacterized protein.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.821
GGTG_00278	GGTG_06179	J3NG85	J3NY24	Uncharacterized protein.	GTP cyclohydrolase II.	0.447
GGTG_00278	GGTG_07745	J3NG85	J3P2J9	Uncharacterized protein.	F-box domain-containing protein.	0.447
GGTG_00278	GGTG_07869	J3NG85	J3P2X8	Uncharacterized protein.	Aminodeoxychorismate synthase.	0.489
GGTG_00278	GGTG_08058	J3NG85	J3P3H2	Uncharacterized protein.	RibD_C domain-containing protein.	0.534
GGTG_00278	GGTG_08505	J3NG85	J3P4R9	Uncharacterized protein.	Folic acid synthesis protein.	0.888
GGTG_00278	GGTG_09905	J3NG85	J3P8S0	Uncharacterized protein.	Folylpolyglutamate synthase.	0.666
GGTG_00278	GGTG_11824	J3NG85	J3PEA1	Uncharacterized protein.	FSH1 domain-containing protein.	0.830
GGTG_00278	GGTG_12290	J3NG85	J3PFL5	Uncharacterized protein.	GTP cyclohydrolase 1.	0.474
GGTG_00278	GGTG_13834	J3NG85	J3PJZ3	Uncharacterized protein.	GTP cyclohydrolase-2.	0.447
GGTG_00655	GGTG_12568	J3NHB8	J3PGE3	MSF1 domain-containing protein.	MSF1 domain-containing protein.	0.858
GGTG_00655	GGTG_13101	J3NHB8	J3PHX0	MSF1 domain-containing protein.	F-box domain-containing protein.	0.874
GGTG_00695	GGTG_07869	J3NHF8	J3P2X8	Uncharacterized protein.	Aminodeoxychorismate synthase.	0.941
GGTG_00695	GGTG_08505	J3NHF8	J3P4R9	Uncharacterized protein.	Folic acid synthesis protein.	0.925
GGTG_01101	GGTG_02415	J3NIM3	J3NMB1	Alkaline phosphatase.	Alkaline phosphatase D.	0.903
GGTG_01101	GGTG_08505	J3NIM3	J3P4R9	Alkaline phosphatase.	Folic acid synthesis protein.	0.514