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| | EGD56780.1 | COG0178 Excinuclease ATPase subunit. (835 aa) |
| | EGD56924.1 | DNA polymerase LigD; COG3285 Predicted eukaryotic-type DNA primase. (323 aa) |
| | ligA | NAD-dependent DNA ligase LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (692 aa) |
| | EGD56990.1 | Hypothetical protein. (201 aa) |
| | ung | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (225 aa) |
| | EGD57016.1 | Hypothetical protein; COG1466 DNA polymerase III, delta subunit. (297 aa) |
| | recO | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (273 aa) |
| | EGD57050.1 | Ferric-uptake regulator; COG0735 Fe2+/Zn2+ uptake regulation proteins; Belongs to the Fur family. (138 aa) |
| | EGD57086.1 | COG1061 DNA or RNA helicases of superfamily II. (417 aa) |
| | EGD57087.1 | Hypothetical protein; COG0419 ATPase involved in DNA repair. (794 aa) |
| | EGD57088.1 | Hypothetical protein. (111 aa) |
| | EGD57089.1 | Hypothetical protein. (698 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (636 aa) |
| | EGD56362.1 | COG0514 Superfamily II DNA helicase. (545 aa) |
| | EGD56363.1 | COG0514 Superfamily II DNA helicase. (95 aa) |
| | EGD56413.1 | DSBA oxidoreductase; COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis. (240 aa) |
| | whiB-2 | WhiB family regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (97 aa) |
| | EGD56523.1 | Hypothetical protein; COG0468 RecA/RadA recombinase. (221 aa) |
| | EGD56524.1 | Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. (541 aa) |
| | dnaE2 | Error-prone DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1096 aa) |
| | EGD56546.1 | COG0708 Exonuclease III. (281 aa) |
| | EGD56587.1 | Formamidopyrimidine-DNA glycosylase catalytic domain-containing protein; COG0266 Formamidopyrimidine-DNA glycosylase. (261 aa) |
| | EGD56588.1 | DEAD/H associated domain-containing protein; COG1201 Lhr-like helicases. (1534 aa) |
| | EGD56669.1 | COG0420 DNA repair exonuclease. (434 aa) |
| | EGD56670.1 | Hypothetical protein; COG0419 ATPase involved in DNA repair. (861 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (99 aa) |
| | priA | Primosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (676 aa) |
| | uvrC | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (681 aa) |
| | EGD56203.1 | COG0258 5'-3' exonuclease (including N-terminal domain of PolI). (313 aa) |
| | rbpA | Hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family. (114 aa) |
| | EGD56230.1 | uvrA-like protein; COG0178 Excinuclease ATPase subunit. (808 aa) |
| | EGD55825.1 | Hypothetical protein; COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (623 aa) |
| | dnaE | COG0587 DNA polymerase III, alpha subunit. (1178 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (897 aa) |
| | uvrB | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (717 aa) |
| | EGD55993.1 | COG3973 Superfamily I DNA and RNA helicases. (622 aa) |
| | uvrA | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (952 aa) |
| | EGD55590.1 | DSBA oxidoreductase; COG3531 Predicted protein-disulfide isomerase. (212 aa) |
| | EGD55593.1 | DNA-(apurinic or apyrimidinic site) lyase; COG0266 Formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (231 aa) |
| | mutM | Formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (295 aa) |
| | EGD55629.1 | COG0266 Formamidopyrimidine-DNA glycosylase. (53 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1318 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1172 aa) |
| | EGD55400.1 | Transcription factor CarD; COG1329 Transcriptional regulators, similar to M. xanthus CarD. (162 aa) |
| | radA | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (456 aa) |
| | EGD55407.1 | HhH-GPD family protein; COG1194 A/G-specific DNA glycosylase. (288 aa) |
| | EGD55470.1 | 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase-like protein; COG0366 Glycosidases. (291 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (350 aa) |
| | whiB-3 | Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (84 aa) |
| | EGD55245.1 | UvrD/REP helicase; COG0210 Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. (1101 aa) |
| | EGD55246.1 | UvrD/REP helicase; COG0210 Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. (1117 aa) |
| | EGD55250.1 | UvrD/REP helicase; COG0210 Superfamily I DNA and RNA helicases. (679 aa) |
| | whiB-4 | Transcriptional regulatory protein Whib-like WhiB7; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (88 aa) |
| | EGD54997.1 | Hypothetical protein. (445 aa) |
| | EGD55055.1 | DNA polymerase III subunit delta; COG0470 ATPase involved in DNA replication. (416 aa) |
| | topA | DNA topoisomerase I subunit omega; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus rem [...] (1012 aa) |
| | EGD55076.1 | Colicin V production protein; COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain. (400 aa) |
| | EGD55077.1 | NUDIX hydrolase; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. (268 aa) |
| | EGD55078.1 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG0526 Thiol-disulfide isomerase and thioredoxins. (230 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (250 aa) |
| | EGD55080.1 | Hypothetical protein. (84 aa) |
| | EGD55088.1 | Hypothetical protein. (39 aa) |
| | EGD55106.1 | Helix-turn-helix type 11 domain-containing protein; COG2378 Predicted transcriptional regulator. (325 aa) |
| | recR | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (203 aa) |
| | dnaX | DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (790 aa) |
| | EGD54812.1 | COG3285 Predicted eukaryotic-type DNA primase. (346 aa) |
| | ligC | COG1793 ATP-dependent DNA ligase. (358 aa) |
| | ku | Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (290 aa) |
| | EGD54862.1 | ATP-dependent DNA ligase; COG3285 Predicted eukaryotic-type DNA primase. (649 aa) |
| | EGD54645.1 | COG0266 Formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (294 aa) |
| | EGD54654.1 | COG0210 Superfamily I DNA and RNA helicases. (834 aa) |
| | EGD54767.1 | COG1393 Arsenate reductase and related proteins, glutaredoxin family; Belongs to the ArsC family. (113 aa) |
| | EGD54494.1 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (737 aa) |
| | EGD54499.1 | COG0629 Single-stranded DNA-binding protein. (186 aa) |
| | dinB-2 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (403 aa) |
| | EGD54559.1 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (400 aa) |
| | EGD54560.1 | 6-phosphogluconate dehydrogenase-like protein; COG1023 Predicted 6-phosphogluconate dehydrogenase. (306 aa) |
| | recF | Recombination protein F; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (405 aa) |
| | EGD54562.1 | Hypothetical protein; COG5512 Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives; Belongs to the UPF0232 family. (183 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (832 aa) |
| | EGD54565.1 | Hypothetical protein. (288 aa) |
| | EGD54364.1 | DEAD/DEAH box helicase domain-containing protein; COG0514 Superfamily II DNA helicase. (699 aa) |
| | EGD54236.1 | Hypothetical protein. (783 aa) |
| | EGD54237.1 | Helicase domain-containing protein; COG1061 DNA or RNA helicases of superfamily II. (550 aa) |
| | EGD54247.1 | Hypothetical protein; COG1055 Na+/H+ antiporter NhaD and related arsenite permeases. (390 aa) |
| | EGD54275.1 | Exodeoxyribonuclease III Xth; COG0708 Exonuclease III. (294 aa) |
| | sigA | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (466 aa) |
| | EGD54002.1 | RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (332 aa) |
| | lexA | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (239 aa) |
| | recX | Recombination regulator RecX; Modulates RecA activity; Belongs to the RecX family. (138 aa) |
| | recA | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (347 aa) |
| | EGD53776.1 | COG0648 Endonuclease IV. (255 aa) |
| | EGD53799.1 | COG1393 Arsenate reductase and related proteins, glutaredoxin family; Belongs to the ArsC family. (120 aa) |
| | EGD53823.1 | COG0708 Exonuclease III. (291 aa) |
| | ligB | COG1793 ATP-dependent DNA ligase. (514 aa) |
| | EGD53664.1 | Redox-sensitive transcriptional activator SoxR; COG0789 Predicted transcriptional regulators. (153 aa) |
| | recD | Exodeoxyribonuclease V subunit alpha; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and re [...] (627 aa) |
| | recB | Exodeoxyribonuclease V; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzy [...] (1123 aa) |
| | recC | Exodeoxyribonuclease V, gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] (1121 aa) |
| | EGD53538.1 | Thioesterase superfamily protein; COG0824 Predicted thioesterase. (143 aa) |
| | EGD53539.1 | GCN5-like N-acetyltransferase; COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins. (205 aa) |
| | EGD53540.1 | COG1252 NADH dehydrogenase, FAD-containing subunit. (475 aa) |
| | EGD53453.1 | Helicase c2; COG1199 Rad3-related DNA helicases. (669 aa) |
| | EGD53289.1 | COG0323 DNA mismatch repair enzyme (predicted ATPase). (500 aa) |
| | EGD53290.1 | COG0210 Superfamily I DNA and RNA helicases. (337 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1193 aa) |
