STRINGSTRING
EGD56780.1 EGD56780.1 EGD57016.1 EGD57016.1 recO recO dnaG dnaG EGD56362.1 EGD56362.1 EGD56363.1 EGD56363.1 EGD56669.1 EGD56669.1 EGD56670.1 EGD56670.1 priA priA uvrC uvrC EGD56203.1 EGD56203.1 EGD56230.1 EGD56230.1 EGD55825.1 EGD55825.1 dnaE dnaE polA polA uvrB uvrB uvrA uvrA radA radA EGD55245.1 EGD55245.1 EGD55246.1 EGD55246.1 EGD55250.1 EGD55250.1 EGD55055.1 EGD55055.1 topA topA recR recR dnaX dnaX EGD54654.1 EGD54654.1 EGD54494.1 EGD54494.1 EGD54499.1 EGD54499.1 EGD54559.1 EGD54559.1 EGD54364.1 EGD54364.1 recX recX recA recA EGD53289.1 EGD53289.1 EGD53290.1 EGD53290.1 mfd mfd
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGD56780.1COG0178 Excinuclease ATPase subunit. (835 aa)
EGD57016.1Hypothetical protein; COG1466 DNA polymerase III, delta subunit. (297 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (273 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (636 aa)
EGD56362.1COG0514 Superfamily II DNA helicase. (545 aa)
EGD56363.1COG0514 Superfamily II DNA helicase. (95 aa)
EGD56669.1COG0420 DNA repair exonuclease. (434 aa)
EGD56670.1Hypothetical protein; COG0419 ATPase involved in DNA repair. (861 aa)
priAPrimosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (676 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (681 aa)
EGD56203.1COG0258 5'-3' exonuclease (including N-terminal domain of PolI). (313 aa)
EGD56230.1uvrA-like protein; COG0178 Excinuclease ATPase subunit. (808 aa)
EGD55825.1Hypothetical protein; COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (623 aa)
dnaECOG0587 DNA polymerase III, alpha subunit. (1178 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (897 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (717 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (952 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (456 aa)
EGD55245.1UvrD/REP helicase; COG0210 Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. (1101 aa)
EGD55246.1UvrD/REP helicase; COG0210 Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. (1117 aa)
EGD55250.1UvrD/REP helicase; COG0210 Superfamily I DNA and RNA helicases. (679 aa)
EGD55055.1DNA polymerase III subunit delta; COG0470 ATPase involved in DNA replication. (416 aa)
topADNA topoisomerase I subunit omega; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus rem [...] (1012 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (203 aa)
dnaXDNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (790 aa)
EGD54654.1COG0210 Superfamily I DNA and RNA helicases. (834 aa)
EGD54494.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (737 aa)
EGD54499.1COG0629 Single-stranded DNA-binding protein. (186 aa)
EGD54559.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (400 aa)
EGD54364.1DEAD/DEAH box helicase domain-containing protein; COG0514 Superfamily II DNA helicase. (699 aa)
recXRecombination regulator RecX; Modulates RecA activity; Belongs to the RecX family. (138 aa)
recARecombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (347 aa)
EGD53289.1COG0323 DNA mismatch repair enzyme (predicted ATPase). (500 aa)
EGD53290.1COG0210 Superfamily I DNA and RNA helicases. (337 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1193 aa)
Your Current Organism:
Gordonia neofelifaecis
NCBI taxonomy Id: 644548
Other names: G. neofelifaecis NRRL B-59395, Gordonia neofelifaecis AD-6, Gordonia neofelifaecis NRRL B-59395, Gordonia neofelifaecis str. NRRL B-59395, Gordonia neofelifaecis strain NRRL B-59395, Gordonia sp. AD-6
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