STRINGSTRING
EGD56729.1 EGD56729.1 EGD56747.1 EGD56747.1 EGD56802.1 EGD56802.1 EGD56857.1 EGD56857.1 ligA ligA ung ung EGD57168.1 EGD57168.1 EGD56546.1 EGD56546.1 EGD56587.1 EGD56587.1 EGD56203.1 EGD56203.1 polA polA EGD55544.1 EGD55544.1 EGD55546.1 EGD55546.1 EGD55549.1 EGD55549.1 EGD55550.1 EGD55550.1 EGD55593.1 EGD55593.1 mutM mutM EGD55629.1 EGD55629.1 EGD55407.1 EGD55407.1 EGD55470.1 EGD55470.1 EGD55266.1 EGD55266.1 EGD55018.1 EGD55018.1 nth nth EGD54631.1 EGD54631.1 EGD54645.1 EGD54645.1 EGD54694.1 EGD54694.1 EGD54275.1 EGD54275.1 EGD53776.1 EGD53776.1 EGD53823.1 EGD53823.1 EGD53734.1 EGD53734.1 ligB ligB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGD56729.1Pancreatic ribonuclease. (362 aa)
EGD56747.1Hypothetical protein. (429 aa)
EGD56802.1methylated-DNA/protein- cysteinemethyltransferase; COG0350 Methylated DNA-protein cysteine methyltransferase. (181 aa)
EGD56857.1HhH-GPD family protein; COG0177 Predicted EndoIII-related endonuclease. (187 aa)
ligANAD-dependent DNA ligase LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (692 aa)
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (225 aa)
EGD57168.1P4 family phage/plasmid primase; COG3378 Predicted ATPase. (706 aa)
EGD56546.1COG0708 Exonuclease III. (281 aa)
EGD56587.1Formamidopyrimidine-DNA glycosylase catalytic domain-containing protein; COG0266 Formamidopyrimidine-DNA glycosylase. (261 aa)
EGD56203.1COG0258 5'-3' exonuclease (including N-terminal domain of PolI). (313 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (897 aa)
EGD55544.1O6-methylguanine-DNA methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (163 aa)
EGD55546.1methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (199 aa)
EGD55549.1COG2818 3-methyladenine DNA glycosylase. (202 aa)
EGD55550.1COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase. (285 aa)
EGD55593.1DNA-(apurinic or apyrimidinic site) lyase; COG0266 Formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (231 aa)
mutMFormamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (295 aa)
EGD55629.1COG0266 Formamidopyrimidine-DNA glycosylase. (53 aa)
EGD55407.1HhH-GPD family protein; COG1194 A/G-specific DNA glycosylase. (288 aa)
EGD55470.13-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase-like protein; COG0366 Glycosidases. (291 aa)
EGD55266.1Beta-lactamase domain-containing protein; COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing. (455 aa)
EGD55018.1Exodeoxyribonuclease III Xth; COG0708 Exonuclease III. (260 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (250 aa)
EGD54631.1COG2094 3-methyladenine DNA glycosylase; Belongs to the DNA glycosylase MPG family. (200 aa)
EGD54645.1COG0266 Formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (294 aa)
EGD54694.1Uracil-DNA glycosylase superfamily protein; COG3663 G:T/U mismatch-specific DNA glycosylase. (192 aa)
EGD54275.1Exodeoxyribonuclease III Xth; COG0708 Exonuclease III. (294 aa)
EGD53776.1COG0648 Endonuclease IV. (255 aa)
EGD53823.1COG0708 Exonuclease III. (291 aa)
EGD53734.1Hypothetical protein; COG1573 Uracil-DNA glycosylase. (246 aa)
ligBCOG1793 ATP-dependent DNA ligase. (514 aa)
Your Current Organism:
Gordonia neofelifaecis
NCBI taxonomy Id: 644548
Other names: G. neofelifaecis NRRL B-59395, Gordonia neofelifaecis AD-6, Gordonia neofelifaecis NRRL B-59395, Gordonia neofelifaecis str. NRRL B-59395, Gordonia neofelifaecis strain NRRL B-59395, Gordonia sp. AD-6
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