(36 nodes) RNA Polymerase II Promoter Escape network (Spizellomyces punctatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	SPPG_08799	WD_REPEATS_REGION domain-containing protein. (91 aa)
	SPPG_08550	Cyclin ccl1; Belongs to the cyclin family. (354 aa)
	SPPG_08563	DNA repair helicase (Rad3). (841 aa)
	SPPG_07472	TAFII28 domain-containing protein. (190 aa)
	SPPG_09468	DNA repair helicase rad25. (934 aa)
	SPPG_07298	Uncharacterized protein. (300 aa)
	SPPG_07395	BSD domain-containing protein. (548 aa)
	SPPG_06733	Uncharacterized protein. (640 aa)
	SPPG_07252	BTP domain-containing protein. (214 aa)
	SPPG_07183	HTH TFE/IIEalpha-type domain-containing protein. (206 aa)
	SPPG_06988	BTP domain-containing protein. (328 aa)
	SPPG_06255	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (432 aa)
	SPPG_05960	Peptidase_M1 domain-containing protein. (1027 aa)
	SPPG_06261	TFIID_20kDa domain-containing protein. (386 aa)
	SPPG_05912	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (111 aa)
	SPPG_05569	DUF3591 domain-containing protein. (805 aa)
	SPPG_05568	Bromo domain-containing protein. (367 aa)
	SPPG_04720	Uncharacterized protein. (101 aa)
	SPPG_03982	CMGC/CDK/CDK7 protein kinase. (353 aa)
	SPPG_09152	Uncharacterized protein. (256 aa)
	SPPG_09096	TAF domain-containing protein. (448 aa)
	SPPG_09181	DNA repair helicase (Rad3). (1252 aa)
	SPPG_03497	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (203 aa)
	SPPG_03285	TATA-box-binding protein. (201 aa)
	SPPG_03559	TAFII55_N domain-containing protein. (364 aa)
	SPPG_01784	TFIID_20kDa domain-containing protein. (709 aa)
	SPPG_03008	TAF4 domain-containing protein. (720 aa)
	SPPG_01883	TFIIB-type domain-containing protein. (330 aa)
	SPPG_01972	CMGC/CDK protein kinase; Belongs to the protein kinase superfamily. (339 aa)
	SPPG_02356	DNA repair helicase rad25. (827 aa)
	SPPG_01151	Uncharacterized protein. (621 aa)
	SPPG_01512	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (477 aa)
	SPPG_00345	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (259 aa)
	SPPG_00548	Transcription factor tfb4. (288 aa)
	SPPG_00518	CDK-activating kinase assembly factor MAT1. (309 aa)
	SPPG_00731	Uncharacterized protein. (330 aa)

Your Current Organism:

Spizellomyces punctatus

NCBI taxonomy Id: 645134
Other names: S. punctatus DAOM BR117, Spizellomyces punctatus DAOM BR117

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SPPG_00345	SPPG_00518	A0A0L0HU53	A0A0L0HV92	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	CDK-activating kinase assembly factor MAT1.	0.995
SPPG_00345	SPPG_00548	A0A0L0HU53	A0A0L0HUP0	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	Transcription factor tfb4.	0.993
SPPG_00345	SPPG_00731	A0A0L0HU53	A0A0L0HVX9	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	Uncharacterized protein.	0.991
SPPG_00345	SPPG_01151	A0A0L0HU53	A0A0L0HS56	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	Uncharacterized protein.	0.990
SPPG_00345	SPPG_01512	A0A0L0HU53	A0A0L0HT65	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.992
SPPG_00345	SPPG_01784	A0A0L0HU53	A0A0L0HMP7	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	TFIID_20kDa domain-containing protein.	0.850
SPPG_00345	SPPG_01883	A0A0L0HU53	A0A0L0HNY3	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	TFIIB-type domain-containing protein.	0.984
SPPG_00345	SPPG_01972	A0A0L0HU53	A0A0L0HP69	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	CMGC/CDK protein kinase; Belongs to the protein kinase superfamily.	0.938
SPPG_00345	SPPG_02356	A0A0L0HU53	A0A0L0HQG7	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	DNA repair helicase rad25.	0.943
SPPG_00345	SPPG_03008	A0A0L0HU53	A0A0L0HNM6	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	TAF4 domain-containing protein.	0.909
SPPG_00345	SPPG_03285	A0A0L0HU53	A0A0L0HKX1	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	TATA-box-binding protein.	0.927
SPPG_00345	SPPG_03497	A0A0L0HU53	A0A0L0HKS7	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...]	0.855
SPPG_00345	SPPG_03559	A0A0L0HU53	A0A0L0HL38	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	TAFII55_N domain-containing protein.	0.887
SPPG_00345	SPPG_03982	A0A0L0HU53	A0A0L0HHD1	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	CMGC/CDK/CDK7 protein kinase.	0.938
SPPG_00345	SPPG_04720	A0A0L0HU53	A0A0L0HH46	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	Uncharacterized protein.	0.913
SPPG_00345	SPPG_05568	A0A0L0HU53	A0A0L0HEX2	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	Bromo domain-containing protein.	0.825
SPPG_00345	SPPG_05569	A0A0L0HU53	A0A0L0HEA9	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	DUF3591 domain-containing protein.	0.825
SPPG_00345	SPPG_05912	A0A0L0HU53	A0A0L0HDV8	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	0.982
SPPG_00345	SPPG_05960	A0A0L0HU53	A0A0L0HBP4	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	Peptidase_M1 domain-containing protein.	0.869
SPPG_00345	SPPG_06255	A0A0L0HU53	A0A0L0HAK2	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family.	0.994