231 items (Spizellomyces punctatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPPG_08112	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (366 aa)
	SPPG_07720	RING-type domain-containing protein. (439 aa)
	SPPG_00799	RING-type domain-containing protein. (721 aa)
	SPPG_00695	Uncharacterized protein. (924 aa)
	SPPG_00742	Uncharacterized protein. (431 aa)
	SPPG_00539	Uncharacterized protein. (457 aa)
	SPPG_00659	TPR_REGION domain-containing protein. (680 aa)
	SPPG_00296	Ubiquitin carboxyl-terminal hydrolase. (888 aa)
	SPPG_00697	TIP120 domain-containing protein. (1323 aa)
	SPPG_00463	WD_REPEATS_REGION domain-containing protein. (619 aa)
	SPPG_00442	U-box domain-containing protein. (1134 aa)
	SPPG_00257	DUF2062 domain-containing protein. (186 aa)
	SPPG_00643	Ubiquitin carboxyl-terminal hydrolase. (504 aa)
	SPPG_00169	RING-type domain-containing protein. (461 aa)
	SPPG_00336	RING-type domain-containing protein. (476 aa)
	SPPG_00538	Uncharacterized protein. (368 aa)
	SPPG_00094	RING-type domain-containing protein. (457 aa)
	SPPG_00210	Uncharacterized protein. (435 aa)
	SPPG_00017	Uncharacterized protein. (521 aa)
	SPPG_00377	UBN_AB domain-containing protein. (864 aa)
	SPPG_01618	Uncharacterized protein. (1503 aa)
	SPPG_01554	PCI domain-containing protein. (412 aa)
	SPPG_01649	Autophagy_act_C domain-containing protein. (235 aa)
	SPPG_01457	CSN8_PSD8_EIF3K domain-containing protein. (219 aa)
	SPPG_01646	Uncharacterized protein. (394 aa)
	SPPG_01631	RING-type domain-containing protein. (591 aa)
	SPPG_01352	Uncharacterized protein. (832 aa)
	SPPG_01327	HECT domain-containing protein. (1114 aa)
	SPPG_01279	ULP_PROTEASE domain-containing protein. (832 aa)
	SPPG_08932	WD_REPEATS_REGION domain-containing protein. (307 aa)
	SPPG_01185	CULLIN_2 domain-containing protein; Belongs to the cullin family. (849 aa)
	SPPG_01346	RING-type domain-containing protein. (315 aa)
	SPPG_01166	Uncharacterized protein. (759 aa)
	SPPG_08926	Uncharacterized protein. (601 aa)
	SPPG_01550	Ubiquitin carboxyl-terminal hydrolase. (603 aa)
	SPPG_01248	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa)
	SPPG_01204	RING-type domain-containing protein. (551 aa)
	SPPG_01180	Ubiquitinyl hydrolase 1. (652 aa)
	SPPG_01011	RING-type domain-containing protein. (321 aa)
	SPPG_00914	Uncharacterized protein. (988 aa)
	SPPG_02397	Uncharacterized protein. (511 aa)
	SPPG_01310	Uncharacterized protein. (661 aa)
	SPPG_08902	Uncharacterized protein. (912 aa)
	SPPG_00999	RING-type domain-containing protein. (910 aa)
	SPPG_02292	Uncharacterized protein. (661 aa)
	SPPG_02377	CULLIN_2 domain-containing protein; Belongs to the cullin family. (795 aa)
	SPPG_01071	MPN domain-containing protein. (260 aa)
	SPPG_08903	Ubiquitin carboxyl-terminal hydrolase. (791 aa)
	SPPG_02322	RING-box protein 1. (123 aa)
	SPPG_02028	PCI domain-containing protein. (462 aa)
	SPPG_02018	Ubiquitin carboxyl-terminal hydrolase. (388 aa)
	SPPG_02281	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family. (368 aa)
	SPPG_02138	DNA repair protein rad8. (2170 aa)
	SPPG_09016	Ubiquitin carboxyl-terminal hydrolase. (598 aa)
	SPPG_08979	CULLIN_2 domain-containing protein; Belongs to the cullin family. (808 aa)
	SPPG_01731	Uncharacterized protein. (1446 aa)
	SPPG_02214	WD_REPEATS_REGION domain-containing protein. (420 aa)
	SPPG_01783	Ubiquitin-activating enzyme E1-like; Belongs to the ubiquitin-activating E1 family. (604 aa)
	SPPG_01821	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (234 aa)
	SPPG_08956	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (168 aa)
	SPPG_02834	Ubiquitin-conjugating enzyme E2-18 kDa; Belongs to the ubiquitin-conjugating enzyme family. (169 aa)
	SPPG_02046	RING-type domain-containing protein. (326 aa)
	SPPG_02829	Uncharacterized protein. (696 aa)
	SPPG_01930	ANAPC5 domain-containing protein. (774 aa)
	SPPG_09054	Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. (251 aa)
	SPPG_02725	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (182 aa)
	SPPG_02944	Uncharacterized protein. (577 aa)
	SPPG_02706	APC1_C domain-containing protein. (1743 aa)
	SPPG_02761	Uncharacterized protein. (555 aa)
	SPPG_01814	Uncharacterized protein. (528 aa)
	SPPG_02842	RING-type domain-containing protein. (518 aa)
	SPPG_02553	E3 ubiquitin-protein ligase. (812 aa)
	SPPG_02763	Uncharacterized protein. (434 aa)
	SPPG_02752	Uncharacterized protein. (538 aa)
	SPPG_02719	RING-type domain-containing protein. (426 aa)
	SPPG_02441	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
	SPPG_02659	Josephin domain-containing protein. (326 aa)
	SPPG_09026	Peptidase_S15 domain-containing protein. (285 aa)
	SPPG_03581	RING-type domain-containing protein. (364 aa)
	SPPG_09125	NEDD8 protein. (78 aa)
	SPPG_02775	Uncharacterized protein. (512 aa)
	SPPG_03397	Ubiquitin-conjugating enzyme E2 15; Belongs to the ubiquitin-conjugating enzyme family. (167 aa)
	SPPG_03613	Polyubiquitin. (243 aa)
	SPPG_03637	Ubiquitinyl hydrolase 1. (649 aa)
	SPPG_03398	Urb2 domain-containing protein. (1634 aa)
	SPPG_09121	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (168 aa)
	SPPG_03299	RING-type domain-containing protein. (546 aa)
	SPPG_03569	Ubiquitin-conjugating enzyme E2 8; Belongs to the ubiquitin-conjugating enzyme family. (181 aa)
	NCS2	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (490 aa)
	SPPG_03411	Uncharacterized protein. (222 aa)
	SPPG_03344	RING-type domain-containing protein. (341 aa)
	SPPG_02478	Rad60-SLD domain-containing protein. (313 aa)
	SPPG_03143	SP-RING-type domain-containing protein. (1487 aa)
	SPPG_03337	Uncharacterized protein. (395 aa)
	SPPG_04246	UBIQUITIN_CONJUGAT_2 domain-containing protein. (136 aa)
	SPPG_04216	CTLH domain-containing protein. (383 aa)
	SUS1	Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of [...] (97 aa)
	SPPG_04151	Ubiquitin carboxyl-terminal hydrolase. (969 aa)
	SPPG_04181	Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
	SPPG_03111	Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. (260 aa)
	SPPG_03325	RING-CH-type domain-containing protein. (328 aa)
	SPPG_04192	Uncharacterized protein. (450 aa)
	UBA4	Adenylyltransferase and sulfurtransferase UBA4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subseque [...] (454 aa)
	SPPG_03973	Uncharacterized protein. (619 aa)
	SPPG_03906	RING-type domain-containing protein. (338 aa)
	SPPG_03892	Uncharacterized protein. (276 aa)
	SPPG_03188	Uncharacterized protein. (807 aa)
	SPPG_03893	RING-type domain-containing protein. (231 aa)
	SPPG_03106	UBIQUITIN_CONJUGAT_2 domain-containing protein. (149 aa)
	SPPG_03998	Uncharacterized protein. (294 aa)
	SPPG_03962	Uncharacterized protein. (548 aa)
	URM1	Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] (101 aa)
	SPPG_03966	SCA7 domain-containing protein. (604 aa)
	SPPG_03881	Uncharacterized protein. (614 aa)
	SPPG_09151	Ubiquitin carboxyl-terminal hydrolase. (771 aa)
	SPPG_04119	Uncharacterized protein. (778 aa)
	SPPG_04033	MINDY_DUB domain-containing protein. (660 aa)
	SPPG_04837	Uncharacterized protein. (346 aa)
	SPPG_04500	Uncharacterized protein. (493 aa)
	SPPG_04490	UBIQUITIN_CONJUGAT_2 domain-containing protein. (164 aa)
	SPPG_03879	WD_REPEATS_REGION domain-containing protein. (562 aa)
	SPPG_04681	SAGA-associated factor 11. (245 aa)
	SPPG_04388	RING-type domain-containing protein. (499 aa)
	SPPG_04532	RING-type domain-containing protein. (341 aa)
	SPPG_04414	Uncharacterized protein. (344 aa)
	SPPG_04797	Ubiquitin-activating enzyme E1; Belongs to the ubiquitin-activating E1 family. (1012 aa)
	SPPG_05144	Uncharacterized protein. (1064 aa)
	SPPG_04377	DUF4205 domain-containing protein. (574 aa)
	SPPG_05308	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme. (526 aa)
	SPPG_05186	RBR-type E3 ubiquitin transferase. (532 aa)
	SPPG_04663	CULLIN_2 domain-containing protein; Belongs to the cullin family. (810 aa)
	SPPG_04980	RING-type domain-containing protein. (418 aa)
	SPPG_04971	Uncharacterized protein. (1039 aa)
	SPPG_04957	WD_REPEATS_REGION domain-containing protein. (1068 aa)
	SPPG_05179	Myb-like DNA-binding domain, shaqkyf class. (692 aa)
	SPPG_04884	Uncharacterized protein. (568 aa)
	SPPG_05164	Uncharacterized protein. (504 aa)
	SPPG_05160	Uncharacterized protein. (295 aa)
	SPPG_05122	Uncharacterized protein; Belongs to the peptidase C19 family. (1735 aa)
	SPPG_09248	Uncharacterized protein. (464 aa)
	SPPG_04990	E2_bind domain-containing protein. (432 aa)
	SPPG_05247	Uncharacterized protein. (383 aa)
	SPPG_05609	RING-type domain-containing protein. (462 aa)
	SPPG_05152	UBIQUITIN_CONJUGAT_2 domain-containing protein. (619 aa)
	SPPG_05538	MPN domain-containing protein. (320 aa)
	SPPG_06004	Uncharacterized protein. (399 aa)
	SPPG_05465	Uncharacterized protein. (506 aa)
	SPPG_05442	WD_REPEATS_REGION domain-containing protein. (294 aa)
	SPPG_05378	26S proteasome non-ATPase regulatory subunit 14. (310 aa)
	SPPG_05872	Hemimethylated DNA binding domain-containing protein. (624 aa)
	SPPG_04968	SP-RING-type domain-containing protein. (594 aa)
	SPPG_06017	WD_REPEATS_REGION domain-containing protein. (326 aa)
	SPPG_04930	USP domain-containing protein; Belongs to the peptidase C19 family. (662 aa)
	SPPG_05969	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (211 aa)
	SPPG_04890	CUE domain-containing protein. (828 aa)
	SPPG_05367	PCI domain-containing protein. (447 aa)
	SPPG_06350	RING-type domain-containing protein. (451 aa)
	SPPG_05681	Uncharacterized protein. (3758 aa)
	SPPG_09338	Uncharacterized protein. (1218 aa)
	SPPG_05592	Uncharacterized protein. (852 aa)
	SPPG_05583	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (2182 aa)
	SPPG_09367	Uncharacterized protein. (80 aa)
	SPPG_06259	Uncharacterized protein. (453 aa)
	SPPG_06169	HECT domain-containing protein. (2365 aa)
	SPPG_06143	Uncharacterized protein. (2311 aa)
	SPPG_05794	USP domain-containing protein; Belongs to the peptidase C19 family. (1390 aa)
	SPPG_05379	E3 ubiquitin-protein ligase PEP5. (993 aa)
	SPPG_06595	Uncharacterized protein. (450 aa)
	SPPG_09398	Uncharacterized protein. (1098 aa)
	SPPG_05905	HECT domain-containing protein. (683 aa)
	SPPG_06664	USP domain-containing protein. (388 aa)
	SPPG_06553	Uncharacterized protein. (689 aa)
	SPPG_06555	UBIQUITIN_CONJUGAT_2 domain-containing protein. (338 aa)
	NCS6	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (351 aa)
	SPPG_05759	RING-type domain-containing protein. (627 aa)
	SPPG_05721	Uncharacterized protein. (273 aa)
	SPPG_06337	Uncharacterized protein. (602 aa)
	SPPG_06665	Ubiquitin carboxyl-terminal hydrolase. (944 aa)
	SPPG_06286	Ubiquitin-conjugating enzyme E2 2, variant; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	SPPG_06608	Ubiquitin-conjugating enzyme E2-16 kDa; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	SPPG_06227	Polyubiquitin. (381 aa)
	SPPG_06950	Uncharacterized protein. (251 aa)
	SPPG_07072	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (160 aa)
	SPPG_06799	ULP_PROTEASE domain-containing protein. (249 aa)
	SPPG_06897	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
	SPPG_06149	Uncharacterized protein. (321 aa)
	SPPG_07019	WD_REPEATS_REGION domain-containing protein. (485 aa)
	SPPG_06078	HECT domain-containing protein. (1103 aa)
	SPPG_06951	HECT domain-containing protein. (446 aa)
	SPPG_07108	Uncharacterized protein; Belongs to the peptidase C19 family. (1150 aa)
	SPPG_07168	YDG domain-containing protein. (331 aa)
	SPPG_07158	WD_REPEATS_REGION domain-containing protein. (1187 aa)
	SPPG_06574	RING-type domain-containing protein. (1586 aa)
	SPPG_07070	UBIQUITIN_CONJUGAT_2 domain-containing protein. (243 aa)
	SPPG_07065	FHA domain-containing protein. (1540 aa)
	SPPG_09386	Uncharacterized protein. (85 aa)
	SPPG_06474	Uncharacterized protein. (453 aa)
	SPPG_07565	RING-type domain-containing protein. (399 aa)
	SPPG_07111	RING-type domain-containing protein. (381 aa)
	SPPG_09429	E3 ubiquitin protein ligase. (860 aa)
	SPPG_07766	Uncharacterized protein. (799 aa)
	SPPG_07541	RING-type domain-containing protein. (318 aa)
	SPPG_09449	RING-type domain-containing protein. (527 aa)
	SPPG_07439	Uncharacterized protein. (441 aa)
	SPPG_07831	Ubiquitin carboxyl-terminal hydrolase. (647 aa)
	SPPG_06996	RING-type domain-containing protein. (236 aa)
	SPPG_07861	WD_REPEATS_REGION domain-containing protein. (686 aa)
	SPPG_07998	RING-type domain-containing protein. (212 aa)
	SPPG_07264	Uncharacterized protein. (497 aa)
	SPPG_07888	ULP_PROTEASE domain-containing protein. (470 aa)
	SPPG_08097	Uncharacterized protein. (217 aa)
	SPPG_07626	Uncharacterized protein. (433 aa)
	SPPG_07772	RING-type domain-containing protein. (325 aa)
	SPPG_07540	UBIQUITIN_CONJUGAT_2 domain-containing protein. (267 aa)
	SPPG_08287	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	SPPG_08168	Uncharacterized protein. (897 aa)
	SPPG_08594	COP9 signalosome complex subunit 5. (332 aa)
	SPPG_09562	DNA repair protein rad18. (388 aa)
	SPPG_08737	RING-type domain-containing protein. (386 aa)
	SPPG_08667	WD_REPEATS_REGION domain-containing protein. (889 aa)
	SPPG_08568	B30.2/SPRY domain-containing protein. (1183 aa)
	SPPG_08072	RING-type domain-containing protein. (348 aa)
	SPPG_08401	SP-RING-type domain-containing protein. (200 aa)
	SPPG_08411	Uncharacterized protein; Belongs to the SKP1 family. (158 aa)
	SPPG_08614	CULLIN_2 domain-containing protein; Belongs to the cullin family. (737 aa)
	SPPG_08120	ULP_PROTEASE domain-containing protein. (237 aa)
	SPPG_08647	Uncharacterized protein. (731 aa)
	SPPG_08225	RING-type domain-containing protein. (1156 aa)
	SPPG_08166	RING-type domain-containing protein. (382 aa)
	SPPG_09495	SP-RING-type domain-containing protein. (621 aa)
	SPPG_08312	OTU domain-containing protein. (305 aa)

Your Current Organism:

Spizellomyces punctatus

NCBI taxonomy Id: 645134
Other names: S. punctatus DAOM BR117, Spizellomyces punctatus DAOM BR117

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NCS2	NCS6	A0A0L0HKS2	A0A0L0HB31	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	0.714
NCS2	SPPG_03613	A0A0L0HKS2	A0A0L0HL87	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	Polyubiquitin.	0.452
NCS2	SPPG_06227	A0A0L0HKS2	A0A0L0HAE3	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	Polyubiquitin.	0.452
NCS2	SPPG_09367	A0A0L0HKS2	A0A0L0HCN0	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	Uncharacterized protein.	0.714
NCS2	SPPG_09386	A0A0L0HKS2	A0A0L0H989	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	Uncharacterized protein.	0.714
NCS2	SPPG_09562	A0A0L0HKS2	A0A0L0H525	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	DNA repair protein rad18.	0.473
NCS2	UBA4	A0A0L0HKS2	A0A0L0HJ14	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	Adenylyltransferase and sulfurtransferase UBA4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subseque [...]	0.449
NCS6	NCS2	A0A0L0HB31	A0A0L0HKS2	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	0.714
NCS6	UBA4	A0A0L0HB31	A0A0L0HJ14	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	Adenylyltransferase and sulfurtransferase UBA4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subseque [...]	0.597
SPPG_00017	SPPG_02214	A0A0L0HTQ1	A0A0L0HP24	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.584
SPPG_00017	SPPG_02478	A0A0L0HTQ1	A0A0L0HKH5	Uncharacterized protein.	Rad60-SLD domain-containing protein.	0.595
SPPG_00017	SPPG_02775	A0A0L0HTQ1	A0A0L0HLJ1	Uncharacterized protein.	Uncharacterized protein.	0.828
SPPG_00017	SPPG_05152	A0A0L0HTQ1	A0A0L0HE90	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.643
SPPG_00094	SPPG_00463	A0A0L0HTY3	A0A0L0HUG9	RING-type domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.582
SPPG_00094	SPPG_00659	A0A0L0HTY3	A0A0L0HV34	RING-type domain-containing protein.	TPR_REGION domain-containing protein.	0.552
SPPG_00094	SPPG_01185	A0A0L0HTY3	A0A0L0HS47	RING-type domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.546
SPPG_00094	SPPG_01248	A0A0L0HTY3	A0A0L0HRS6	RING-type domain-containing protein.	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family.	0.684
SPPG_00094	SPPG_01821	A0A0L0HTY3	A0A0L0HNV2	RING-type domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.480
SPPG_00094	SPPG_02322	A0A0L0HTY3	A0A0L0HQ82	RING-type domain-containing protein.	RING-box protein 1.	0.553
SPPG_00094	SPPG_02441	A0A0L0HTY3	A0A0L0HM91	RING-type domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.470

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