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| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa) |
| | pdxS | Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (295 aa) |
| | pdxT | Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (193 aa) |
| | Sgly_0021 | Phospholipase D/Transphosphatidylase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol; Belongs to the phospholipase D family. Cardiolipin synthase subfamily. (513 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D- erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (302 aa) |
| | glmU | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (453 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (313 aa) |
| | Sgly_0202 | MazG family protein; COGs: COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain; InterPro IPR004518: IPR011551; KEGG: tjr:TherJR_0182 MazG family protein; PFAM: NTP pyrophosphohydrolase MazG, putative catalytic core; SPTR: MazG family protein; TIGRFAM: NTP pyrophosphohydrolase MazG, bacterial; PFAM: MazG nucleotide pyrophosphohydrolase domain; TIGRFAM: MazG family protein. (367 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (150 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (309 aa) |
| | Sgly_0223 | COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR002638: IPR004393; KEGG: dhd:Dhaf_0158 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); SPTR: Nicotinate nucleotide pyrophosphorylase; TIGRFAM: Nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (289 aa) |
| | coaX | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (255 aa) |
| | mcsB | ATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in proteins; Belongs to the ATP:guanido phosphotransferase family. (350 aa) |
| | Sgly_0298 | KEGG: dhd:Dhaf_0391 hypothetical protein; SPTR: Putative uncharacterized protein. (130 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (238 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (158 aa) |
| | Sgly_0358 | KEGG: dhd:Dhaf_1424 hypothetical protein; SPTR: Putative uncharacterized protein. (422 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | carA | COGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR002474: IPR000991: IPR006274; KEGG: dsy:DSY2043 hypothetical protein; PFAM: Carbamoyl phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; PRIAM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing); SPTR: Putative uncharacterized protein; TIGRFAM: Carbamoyl phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (366 aa) |
| | carB | COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterPro IPR005481: IPR005479: IPR005480: IPR011607: IPR 006275; KEGG: dsy:DSY2042 hypothetical protein; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; PRIAM: Carbamoyl-phosphate synthase (ammonia); SPTR: Putative uncharacterized protein; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; PFAM: Carbamoyl-phosphate synthase L chain, ATP bind [...] (1075 aa) |
| | Sgly_0450 | COGs: COG5663 conserved hypothetical protein; KEGG: dhd:Dhaf_0800 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Belongs to the 5'(3')-deoxyribonucleotidase family. (184 aa) |
| | Sgly_0482 | InterPro IPR004518; KEGG: dhd:Dhaf_0830 MazG nucleotide pyrophosphohydrolase; PFAM: NTP pyrophosphohydrolase MazG, putative catalytic core; SPTR: Putative uncharacterized protein; PFAM: MazG nucleotide pyrophosphohydrolase domain. (107 aa) |
| | dacA | Conserved hypothetical protein CHP00159; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (275 aa) |
| | Sgly_0494 | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (205 aa) |
| | Sgly_0508 | Thiamine biosynthesis protein ThiS; InterPro IPR003749: IPR010035; KEGG: cth:Cthe_2538 thiamine biosynthesis protein ThiS; PFAM: ThiamineS; SPTR: Thiamine biosynthesis protein ThiS; TIGRFAM: ThiS, thiamine-biosynthesis; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS. (69 aa) |
| | Sgly_0509 | UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594: IPR007901; KEGG: cth:Cthe_2539 UBA/ThiF-type NAD/FAD binding fold; PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; SPTR: UBA/THIF-type NAD/FAD binding fold; PFAM: MoeZ/MoeB domain; ThiF family. (270 aa) |
| | Sgly_0598 | Type III secretion system ATPase, FliI/YscN; COGs: COG1157 Flagellar biosynthesis/type III secretory pathway ATPase; InterPro IPR004100: IPR000194: IPR005714: IPR003593; KEGG: dsy:DSY2986 hypothetical protein; PFAM: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain; ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal; PRIAM: H(+)-transporting two-sector ATPase; SMART: ATPase, AAA+ type, core; SPTR: Putative uncharacterized protein; TIGRFAM: flagellar protein export ATPase FliI; ATPase, type III secretion system, FliI/YscN; PFAM: ATP synthase alpha/beta family [...] (437 aa) |
| | pyrB | COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; HAMAP: Aspartate carbamoyltransferase, eukaryotic; InterPro IPR006132: IPR006131: IPR002082; KEGG: dhd:Dhaf_4019 aspartate carbamoyltransferase catalytic subunit; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; PRIAM: Aspartate carbamoyltransferase; SPTR: Aspartate carbamoyltransferase; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbam [...] (312 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (439 aa) |
| | carA-2 | COGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR002474: IPR000991: IPR006274; KEGG: dhd:Dhaf_4017 carbamoyl-phosphate synthase, small subunit; PFAM: Glutamine amidotransferase class-I, C-terminal; Carbamoyl phosphate synthase, small subunit, N-terminal; PRIAM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing); SPTR: Carbamoyl-phosphate synthase, small subunit; TIGRFAM: Carbamoyl phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit [...] (365 aa) |
| | carB-2 | COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterPro IPR005481: IPR005479: IPR005480: IPR011607: IPR 006275; KEGG: dsy:DSY2859 hypothetical protein; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; PRIAM: Carbamoyl-phosphate synthase (ammonia); SPTR: Putative uncharacterized protein; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; PFAM: Carbamoyl-phosphate synthase L chain, ATP bind [...] (1062 aa) |
| | pyrK | Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (275 aa) |
| | pyrD | Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (304 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (241 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (192 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (199 aa) |
| | Sgly_0694 | Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (397 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (360 aa) |
| | Sgly_0718 | InterPro IPR004518; KEGG: dhd:Dhaf_4426 MazG nucleotide pyrophosphohydrolase; PFAM: NTP pyrophosphohydrolase MazG, putative catalytic core; SPTR: Putative uncharacterized protein; PFAM: MazG nucleotide pyrophosphohydrolase domain. (105 aa) |
| | glk | Glucokinase; COGs: COG0837 Glucokinase; InterPro IPR003836; KEGG: dsy:DSY2007 hypothetical protein; PFAM: Glucokinase; SPTR: Putative uncharacterized protein; TIGRFAM: Glucokinase; PFAM: Glucokinase; TIGRFAM: glucokinase, proteobacterial type. (328 aa) |
| | Sgly_0732 | RelA/SpoT domain protein; InterPro IPR007685; KEGG: fsu:Fisuc_0324 RelA/SpoT domain protein; PFAM: RelA/SpoT; SPTR: Putative uncharacterized protein; PFAM: Region found in RelA / SpoT proteins. (329 aa) |
| | Sgly_0948 | Protein of unknown function UPF0157; COGs: COG2320 conserved hypothetical protein; InterPro IPR007344; KEGG: cdl:CDR20291_0528 hypothetical protein; PFAM: Uncharacterised protein family UPF0157; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised protein family (UPF0157). (177 aa) |
| | Sgly_0953 | Metal dependent phosphohydrolase; COGs: COG1896 hydrolase of HD superfamily; KEGG: ttm:Tthe_2227 metal dependent phosphohydrolase; SPTR: Metal dependent phosphohydrolase. (176 aa) |
| | Sgly_1109 | COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: dat:HRM2_29060 SoxB2; PFAM: FAD dependent oxidoreductase; PRIAM: Glycine oxidase; SPTR: FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase. (373 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (267 aa) |
| | Sgly_1415 | Metallo-beta-lactamase family protein; COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; KEGG: cpe:CPE0924 metallo-beta-lactamase family protein; SPTR: Putative uncharacterized protein; PFAM: Metallo-beta-lactamase superfamily. (275 aa) |
| | Sgly_1424 | modD protein; COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR002638: IPR006242; KEGG: clj:CLJU_c38070 nicotinate-nucleotide diphosphorylase; PFAM: Quinolinate phosphoribosyl transferase; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); SPTR: ModD protein; TIGRFAM: Putative molybdenum utilization protein ModD; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; putative molybdenum utilization protein ModD; Belongs to the NadC/ModD family. (285 aa) |
| | Sgly_1427 | COGs: COG0232 dGTP triphosphohydrolase; InterPro IPR006674: IPR006261: IPR003607; KEGG: bgl:bglu_1g01530 deoxyguanosinetriphosphate triphosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: Deoxyguanosinetriphosphate triphosphohydrolase; TIGRFAM: Deoxyguanosinetriphosphate triphosphohydrolase; PFAM: HD domain; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase, putative; Belongs to the dGTPase family. Type 2 subfamily. (471 aa) |
| | Sgly_1470 | COGs: COG5015 conserved hypothetical protein; InterPro IPR011576; KEGG: clj:CLJU_c37110 putative pyridoxamine 5'-phosphate oxidase-like, FMN-binding protein; PFAM: Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain; SPTR: Putative pyridoxamine 5'-phosphate oxidase-related, FMN-binding protein; PFAM: Pyridoxamine 5'-phosphate oxidase. (130 aa) |
| | Sgly_1516 | Sugar isomerase (SIS); COGs: COG0279 Phosphoheptose isomerase; InterPro IPR001347; KEGG: ssm:Spirs_3065 sugar isomerase (SIS); PFAM: Sugar isomerase (SIS); SPTR: Putative uncharacterized protein; PFAM: SIS domain. (222 aa) |
| | Sgly_1527 | InterPro IPR000462; KEGG: aoe:Clos_2686 CDP-alcohol phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; SPTR: CDP-alcohol phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (179 aa) |
| | Sgly_1558 | Sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; COGs: COG1044 UDP-3-O-(3-hydroxymyristoyl); InterPro IPR001451: IPR020019; KEGG: tte:TTE0666 acetyltransferase; SPTR: Putative uncharacterized protein; TIGRFAM: Sialic acid O-acyltransferase, NeuD; TIGRFAM: sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family. (217 aa) |
| | Sgly_1623 | Metallophosphoesterase; COGs: COG1408 phosphohydrolase; InterPro IPR004843; KEGG: tjr:TherJR_2869 metallophosphoesterase; PFAM: Metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. (390 aa) |
| | Sgly_1642 | COGs: COG5542 integral membrane protein; KEGG: tmt:Tmath_0950 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: ALG3 protein. (403 aa) |
| | thiG | Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (257 aa) |
| | thiE | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (216 aa) |
| | thiC | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (433 aa) |
| | Sgly_1657 | Thiamine biosynthesis protein ThiS; InterPro IPR010035: IPR003749; KEGG: cth:Cthe_0597 thiamine biosynthesis protein ThiS; PFAM: ThiamineS; SPTR: Thiamine biosynthesis protein ThiS; TIGRFAM: ThiS, thiamine-biosynthesis; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS. (65 aa) |
| | Sgly_1658 | UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594: IPR007901; KEGG: mta:Moth_1970 UBA/ThiF-type NAD/FAD binding fold; PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; SPTR: UBA/THIF-type NAD/FAD binding fold; PFAM: MoeZ/MoeB domain; ThiF family. (269 aa) |
| | Sgly_1675 | Cardiolipin synthetase 2; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (483 aa) |
| | cmk | COGs: COG0283 Cytidylate kinase; HAMAP: Cytidylate kinase; InterPro IPR003136: IPR000623: IPR011994; KEGG: dhd:Dhaf_3387 cytidylate kinase; PFAM: Cytidylate kinase domain; Shikimate kinase; SPTR: Cytidylate kinase; TIGRFAM: Cytidylate kinase; PFAM: Cytidylate kinase; Shikimate kinase; TIGRFAM: cytidylate kinase. (218 aa) |
| | Sgly_1691 | COGs: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; InterPro IPR002123; KEGG: dhd:Dhaf_3386 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase; SPTR: Putative uncharacterized protein; PFAM: Acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferases. (194 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (662 aa) |
| | plsY | Acyl-phosphate glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (202 aa) |
| | gpsA | COGs: COG0240 Glycerol-3-phosphate dehydrogenase; HAMAP: Glycerol-3-phosphate dehydrogenase [NAD(P)+]; InterPro IPR011128: IPR006109; KEGG: dhd:Dhaf_3379 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal; NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal; SPTR: Glycerol-3-phosphate dehydrogenase [NAD(P)+]; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (336 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (158 aa) |
| | Sgly_1777 | COGs: COG0469 Pyruvate kinase; InterPro IPR001697: IPR015793: IPR015794: IPR008279; KEGG: dhd:Dhaf_2755 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; PEP-utilising enzyme, mobile domain; PRIAM: Pyruvate kinase., Pyruvate, water dikinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (575 aa) |
| | Sgly_1780 | 1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; COGs: COG1691 NCAIR mutase (PurE)-related protein; InterPro IPR000031; KEGG: chy:CHY_1282 hypothetical protein; PFAM: 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; SPTR: Putative uncharacterized protein; PFAM: AIR carboxylase. (250 aa) |
| | Sgly_1833 | Metal dependent phosphohydrolase; COGs: COG1896 hydrolase of HD superfamily; KEGG: ttm:Tthe_2227 metal dependent phosphohydrolase; SPTR: Metal dependent phosphohydrolase. (198 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (395 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (271 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (632 aa) |
| | Sgly_1888 | COGs: COG0142 Geranylgeranyl pyrophosphate synthase; InterPro IPR000092; KEGG: dhd:Dhaf_3491 polyprenyl synthetase; PFAM: Polyprenyl synthetase; SPTR: Polyprenyl synthetase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (289 aa) |
| | folD | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa) |
| | Sgly_1893 | COGs: COG5015 conserved hypothetical protein; InterPro IPR011576; KEGG: cth:Cthe_2635 pyridoxamine 5'-phosphate oxidase-related, FMN-binding; PFAM: Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain; SPTR: Pyridoxamine 5'-phosphate oxidase-related, FMN-binding; PFAM: Pyridoxamine 5'-phosphate oxidase. (144 aa) |
| | Sgly_1896 | Oxidoreductase FAD/NAD(P)-binding domain protein; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterPro IPR008333: IPR001433: IPR019480; KEGG: mta:Moth_0816 oxidoreductase FAD/NAD(P)-binding; PFAM: Oxidoreductase FAD/NAD(P)-binding; Oxidoreductase, FAD-binding domain; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; SPTR: Oxidoreductase FAD/NAD(P)-binding; PFAM: Oxidoreductase FAD-binding domain; Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B; Oxidoreductase NAD-binding domain. (281 aa) |
| | Sgly_2016 | COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR000644: IPR001093; KEGG: cce:Ccel_0394 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; PRIAM: IMP dehydrogenase; SPTR: IMP dehydrogenase/GMP reductase; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase. (496 aa) |
| | surE | 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (258 aa) |
| | folE | COGs: COG0302 GTP cyclohydrolase I; HAMAP: GTP cyclohydrolase I; InterPro IPR001474: IPR020602; KEGG: dsy:DSY1825 hypothetical protein; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: Putative uncharacterized protein; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. (188 aa) |
| | Sgly_2067 | Hypothetical protein; COGs: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase; KEGG: dsy:DSY1832 hypothetical protein; SPTR: Putative uncharacterized protein. (340 aa) |
| | pfkA-2 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (322 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa) |
| | Sgly_2094 | CDP-diacylglycerol--serine O-phosphatidyltransferase; COGs: COG1183 Phosphatidylserine synthase; InterPro IPR004533: IPR000462; KEGG: dhd:Dhaf_3028 CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; SPTR: Putative uncharacterized protein; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (174 aa) |
| | Sgly_2107 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (718 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (196 aa) |
| | Sgly_2191 | COGs: COG2301 Citrate lyase beta subunit; InterPro IPR005000; KEGG: dhd:Dhaf_3086 citryl-CoA lyase; PFAM: HpcH/HpaI aldolase; PRIAM: Citryl-CoA lyase; SPTR: Putative uncharacterized protein; PFAM: HpcH/HpaI aldolase/citrate lyase family; Belongs to the HpcH/HpaI aldolase family. (299 aa) |
| | Sgly_2201 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873: IPR011904; KEGG: dhd:Dhaf_0467 acetate/CoA ligase; PFAM: AMP-dependent synthetase/ligase; PRIAM: Acetate--CoA ligase; SPTR: Putative uncharacterized protein; TIGRFAM: Acetate--CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme; TIGRFAM: acetate--CoA ligase. (653 aa) |
| | cinA | Competence/damage-inducible protein cinA; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; InterPro IPR001453: IPR008136: IPR008135; KEGG: dhd:Dhaf_3119 competence/damage-inducible protein CinA; PFAM: CinA, C-terminal; Molybdopterin binding; SPTR: Competence/damage-inducible protein CinA; TIGRFAM: Competence-induced protein CinA; CinA, C-terminal; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-terminal doma [...] (411 aa) |
| | Sgly_2213 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; COGs: COG0558 Phosphatidylglycerophosphate synthase; InterPro IPR000462: IPR004570; KEGG: dhd:Dhaf_3123 CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; PRIAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; SPTR: CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--glycerol-3-ph [...] (206 aa) |
| | pgi | COGs: COG0166 Glucose-6-phosphate isomerase; HAMAP: Phosphoglucose isomerase (PGI); InterPro IPR001672; KEGG: dsy:DSY2034 glucose-6-phosphate isomerase; PFAM: Phosphoglucose isomerase (PGI); SPTR: Glucose-6-phosphate isomerase; PFAM: Phosphoglucose isomerase; Belongs to the GPI family. (565 aa) |
| | Sgly_2241 | deoxyUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (165 aa) |
| | Sgly_2247 | Riboflavin kinase; COGs: COG0196 FAD synthase; InterPro IPR015864: IPR015865: IPR004821: IPR002606; KEGG: dhd:Dhaf_3672 riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; PRIAM: FAD synthetase., Riboflavin kinase; SPTR: FAD synthase; TIGRFAM: Riboflavin kinase/FAD synthetase; Cytidyltransferase-related; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family. (310 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (364 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (384 aa) |
| | Sgly_2262 | Phosphatidate cytidylyltransferase; COGs: COG0575 CDP-diglyceride synthetase; InterPro IPR000374; KEGG: dsy:DSY2541 hypothetical protein; PFAM: Phosphatidate cytidylyltransferase; SPTR: Phosphatidate cytidylyltransferase; PFAM: Cytidylyltransferase family; Belongs to the CDS family. (264 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (238 aa) |
| | fdhD | Protein fdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (263 aa) |
| | plsX | Phosphate:acyl-(acyl carrier protein) acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (337 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (421 aa) |
| | Sgly_2331 | COGs: COG1564 Thiamine pyrophosphokinase; InterPro IPR007371: IPR006282; KEGG: dhd:Dhaf_3841 thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, catalytic domain; SPTR: Thiamine pyrophosphokinase; TIGRFAM: Thiamin pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, vitamin B1 binding domain; Thiamin pyrophosphokinase, catalytic domain; TIGRFAM: thiamine pyrophosphokinase. (219 aa) |
| | Sgly_2332 | COGs: COG0036 Pentose-5-phosphate-3-epimerase; InterPro IPR000056; KEGG: dhd:Dhaf_3842 ribulose-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; SPTR: Putative uncharacterized protein; TIGRFAM: Ribulose-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase. (218 aa) |
| | purD | COGs: COG0151 Phosphoribosylamine-glycine ligase; HAMAP: Phosphoribosylglycinamide synthetase; InterPro IPR020562: IPR020561: IPR020560: IPR000115; KEGG: dhd:Dhaf_1480 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, A [...] (426 aa) |
| | Sgly_2352 | COGs: COG1456 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein); KEGG: geo:Geob_2483 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein)-like protein; SPTR: CO dehydrogenase/acetyl-CoA synthase gamma subunit (Corrinoid Fe-S protein)-like protein; PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit. (352 aa) |
| | purH | IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); HAMAP: Bifunctional purine biosynthesis protein purH; InterPro IPR011607: IPR013982: IPR002695; KEGG: dhd:Dhaf_1478 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; MGS-like; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain; SPTR: Bifunctional purine biosynthesis protein purH; TIGRFAM: AICARFT/IMPCHase bienzyme; [...] (513 aa) |
| | purN | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (205 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR000728: IPR010918: IPR004733; KEGG: dhd:Dhaf_1476 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein, C-terminal; AIR synthase related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylaminoimid [...] (338 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (466 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (730 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (235 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa) |
| | purC | COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; HAMAP: SAICAR synthetase; InterPro IPR001636; KEGG: dsy:DSY3931 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: SAICAR synthetase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (239 aa) |
| | Sgly_2362 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR019468: IPR004769; KEGG: dhd:Dhaf_1473 adenylosuccinate lyase; PFAM: Fumarate lyase; Adenylosuccinate lyase, C-terminal; SPTR: Putative uncharacterized protein; TIGRFAM: Adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (433 aa) |
| | purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (167 aa) |
| | thiM-2 | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (270 aa) |
| | thiE-2 | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (207 aa) |
| | Sgly_2389 | COGs: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; InterPro IPR002123: IPR004552; KEGG: cbt:CLH_3257 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase; SPTR: 1-acyl-sn-glycerol-3-phosphate acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: Acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferases; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (237 aa) |
| | Sgly_2403 | COGs: COG0232 dGTP triphosphohydrolase; InterPro IPR006674: IPR003607: IPR006261; KEGG: dsy:DSY3050 deoxyguanosinetriphosphate triphosphohydrolase-like protein; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: Putative uncharacterized protein; TIGRFAM: Deoxyguanosinetriphosphate triphosphohydrolase; PFAM: HD domain; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase, putative; Belongs to the dGTPase family. Type 2 subfamily. (331 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (216 aa) |
| | Sgly_2423 | COGs: COG0818 Diacylglycerol kinase; InterPro IPR000829; KEGG: lsg:lse_1381 hypothetical protein; PFAM: Diacylglycerol kinase, prokaryotic; SPTR: DgkA protein; PFAM: Prokaryotic diacylglycerol kinase. (132 aa) |
| | Sgly_2431 | Histidine triad (HIT) protein; COGs: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase; InterPro IPR001310; KEGG: dhd:Dhaf_4293 histidine triad (HIT) protein; PFAM: Histidine triad (HIT) protein; SPTR: Putative uncharacterized protein; PFAM: HIT domain. (114 aa) |
| | Sgly_2454 | Metal dependent phosphohydrolase; COGs: COG1713 HD superfamily hydrolase involved in NAD metabolism; InterPro IPR006674: IPR003607: IPR005249; KEGG: dsy:DSY3160 hypothetical protein; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: Putative uncharacterized protein; TIGRFAM: Conserved hypothetical protein CHP00488; PFAM: HD domain; TIGRFAM: putative HD superfamily hydrolase of NAD metabolism. (205 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (213 aa) |
| | Sgly_2474 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (200 aa) |
| | Sgly_2527 | UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594: IPR007901; KEGG: eel:EUBELI_00643 thiamine biosynthesis protein ThiF; PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; SPTR: Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2; PFAM: MoeZ/MoeB domain; ThiF family. (268 aa) |
| | Sgly_2528 | Thiamine biosynthesis protein ThiS; InterPro IPR003749: IPR010035; KEGG: eel:EUBELI_00642 thiamine biosynthesis ThiS; PFAM: ThiamineS; SPTR: Thiamine biosynthesis protein ThiS; TIGRFAM: ThiS, thiamine-biosynthesis; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS. (68 aa) |
| | Sgly_2571 | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (201 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (510 aa) |
| | Sgly_2670 | COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR000836: IPR005904; KEGG: dhd:Dhaf_1437 hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: Putative uncharacterized protein; TIGRFAM: Hypoxanthine phosphoribosyl transferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (210 aa) |
| | nnrE | YjeF-related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (523 aa) |
| | pdxS-2 | Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (294 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (661 aa) |
| | Sgly_2881 | COGs: COG3635 phosphoglycerate mutase AP superfamily; InterPro IPR019304: IPR006124; KEGG: apo:Arcpr_1280 proposed homoserine kinase; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Metalloenzyme; PRIAM: Phosphoglycerate mutase; SPTR: Proposed homoserine kinase; PFAM: Metalloenzyme superfamily; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TIGRFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archaeal form. (376 aa) |
| | psd | Phosphatidylserine decarboxylase proenzyme; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (298 aa) |
| | Sgly_3017 | Metallophosphoesterase; InterPro IPR004843; KEGG: sun:SUN_0863 hypothetical protein; PFAM: Metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. (658 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa) |
| | Sgly_3029 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | fabZ | (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (141 aa) |
| | Sgly_3075 | COGs: COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein; InterPro IPR004435; KEGG: dae:Dtox_3499 molybdopterin-guanine dinucleotide biosynthesis protein B; SPTR: Molybdopterin-guanine dinucleotide biosynthesis protein B; TIGRFAM: Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB), conserved domain; PFAM: Molybdopterin guanine dinucleotide synthesis protein B; TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein MobB. (165 aa) |
| | Sgly_3076 | COGs: COG0521 Molybdopterin biosynthesis protein; InterPro IPR001453: IPR020817; KEGG: hmo:HM1_0061 molybdenum cofactor biosynthesis protein, putative; PFAM: Molybdopterin binding; SPTR: Molybdenum cofactor biosynthesis protein, putative; TIGRFAM: Molybdenum cofactor synthesis; PFAM: Probable molybdopterin binding domain; TIGRFAM: molybdenum cofactor synthesis domain. (166 aa) |
| | moaC | GTP cyclohydrolase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (158 aa) |
| | moaA | GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (318 aa) |
| | Sgly_3349 | KEGG: dhd:Dhaf_4933 hypothetical protein; SPTR: Putative uncharacterized protein. (105 aa) |
| | Sgly_3079 | Molybdopterin binding domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (341 aa) |
| | Sgly_3080 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (446 aa) |
| | Sgly_3081 | Metal dependent phosphohydrolase, HD region; COGs: COG0317 Guanosine polyphosphate pyrophosphohydrolase/synthetase; KEGG: pfo:Pfl01_2133 metal dependent phosphohydrolase, HD region; SPTR: Putative uncharacterized protein. (161 aa) |
| | Sgly_3093 | Phosphoglycerate mutase; COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR013078; KEGG: adg:Adeg_1465 alpha-ribazole phosphatase; PFAM: Histidine phosphatase superfamily, clade-1; SPTR: Alpha-ribazole phosphatase; PFAM: Phosphoglycerate mutase family. (186 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa) |
| | gpmI | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (542 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | pgk | COGs: COG0126 3-phosphoglycerate kinase; HAMAP: Phosphoglycerate kinase; InterPro IPR001576; KEGG: dhd:Dhaf_4718 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa) |
| | Sgly_3229 | COGs: COG3051 Citrate lyase alpha subunit; InterPro IPR006472; KEGG: dsy:DSY3038 hypothetical protein; PFAM: Citrate lyase, alpha subunit; PRIAM: Citrate CoA-transferase; SPTR: Putative uncharacterized protein; TIGRFAM: Citrate lyase, alpha subunit; manually curated; PFAM: Citrate lyase, alpha subunit (CitF); TIGRFAM: citrate lyase, alpha subunit. (528 aa) |
| | Sgly_3230 | COGs: COG2301 Citrate lyase beta subunit; InterPro IPR005000; KEGG: clj:CLJU_c40570 citrate lyase subunit beta; PFAM: HpcH/HpaI aldolase; PRIAM: Citryl-CoA lyase; SPTR: Citrate lyase beta chain; PFAM: HpcH/HpaI aldolase/citrate lyase family; Belongs to the HpcH/HpaI aldolase family. (235 aa) |
| | Sgly_3246 | KEGG: dsy:DSY4860 hypothetical protein; SPTR: Putative uncharacterized protein. (338 aa) |
| | atpC | ATP synthase F1 subcomplex epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (136 aa) |
| | atpD | ATP synthase F1 subcomplex beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (467 aa) |
| | atpG | ATP synthase F1 subcomplex gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (282 aa) |
| | atpA | ATP synthase F1 subcomplex alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (502 aa) |
| | atpH | ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (189 aa) |
| | atpF | ATP synthase F0 subcomplex B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (185 aa) |
| | atpE | ATP synthase F0 subcomplex C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (76 aa) |
| | atpB | ATP synthase F0 subcomplex A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (246 aa) |
| | Sgly_3281 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125; KEGG: dbr:Deba_2384 CMP/dCMP deaminase zinc-binding protein; PFAM: CMP/dCMP deaminase, zinc-binding; SPTR: CMP/dCMP deaminase zinc-binding; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. (148 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (212 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa) |
| | deoC-2 | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (225 aa) |
