STRINGSTRING
pyrD pyrD AFM40860.1 AFM40860.1 AFM40847.1 AFM40847.1 AFM40841.1 AFM40841.1 AFM40811.1 AFM40811.1 AFM40793.1 AFM40793.1 cutD cutD AFM40247.1 AFM40247.1 AFM40207.1 AFM40207.1 AFM40185.1 AFM40185.1 rlmN rlmN leuA leuA AFM40123.1 AFM40123.1 AFM40048.1 AFM40048.1 AFM40044.1 AFM40044.1 AFM39995.1 AFM39995.1 hisF hisF hisA hisA trpA trpA trpF trpF trpC trpC moaA moaA AFM39802.1 AFM39802.1 AFM39794.1 AFM39794.1 AFM39783.1 AFM39783.1 AFM39605.1 AFM39605.1 AFM39471.1 AFM39471.1 AFM39378.1 AFM39378.1 AFM39375.1 AFM39375.1 AFM39323.1 AFM39323.1 AFM39206.1 AFM39206.1 pdxS pdxS AFM42610.1 AFM42610.1 AFM42611.1 AFM42611.1 AFM42720.1 AFM42720.1 pdxS-2 pdxS-2 deoC deoC AFM42881.1 AFM42881.1 AFM42885.1 AFM42885.1 AFM42893.1 AFM42893.1 AFM42894.1 AFM42894.1 AFM43169.1 AFM43169.1 AFM43176.1 AFM43176.1 tpiA tpiA AFM43412.1 AFM43412.1 AFM43424.1 AFM43424.1 tal tal AFM43494.1 AFM43494.1 AFM43504.1 AFM43504.1 mqnC mqnC AFM40910.1 AFM40910.1 AFM40911.1 AFM40911.1 AFM41020.1 AFM41020.1 AFM41137.1 AFM41137.1 AFM41307.1 AFM41307.1 thiE thiE AFM41417.1 AFM41417.1 thiG thiG AFM41434.1 AFM41434.1 thiE-2 thiE-2 AFM41448.1 AFM41448.1 AFM41634.1 AFM41634.1 AFM41681.1 AFM41681.1 queE queE guaB guaB AFM42242.1 AFM42242.1 AFM42398.1 AFM42398.1 dapA-2 dapA-2 AFM42534.1 AFM42534.1 AFM42538.1 AFM42538.1 AFM42557.1 AFM42557.1 rlmN-2 rlmN-2 pyrF pyrF mqnE-2 mqnE-2 mqnE mqnE dapA dapA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pyrDDihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (306 aa)
AFM40860.1Nicotinate-nucleotide pyrophosphorylase (carboxylating); PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (288 aa)
AFM40847.1PFAM: Lysine-2,3-aminomutase; Radical SAM superfamily; TIGRFAM: KamA family protein; lysine-2,3-aminomutase. (414 aa)
AFM40841.1PFAM: Prokaryotic protein of unknown function (DUF849). (269 aa)
AFM40811.1Fe-S oxidoreductase; PFAM: Protein of unknown function (DUF512); TIGRFAM: putative FeS-containing Cyanobacterial-specific oxidoreductase. (443 aa)
AFM40793.13-deoxy-D-arabinoheptulosonate-7-phosphate synthase; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (342 aa)
cutDGlycyl-radical enzyme activator family protein; Catalyzes activation of the choline trimethylamine-lyase CutC under anaerobic conditions by generation of an organic free radical on a glycine residue, via an homolytic cleavage of S-adenosyl-L-methionine (SAM). (328 aa)
AFM40247.1PFAM: HMGL-like; TIGRFAM: homocitrate synthase NifV; Belongs to the alpha-IPM synthase/homocitrate synthase family. (376 aa)
AFM40207.1PFAM: Radical SAM superfamily; TIGRFAM: glycyl-radical enzyme activating protein family. (393 aa)
AFM40185.1PFAM: KDPG and KHG aldolase; TIGRFAM: Entner-Doudoroff aldolase. (217 aa)
rlmN23S rRNA m(2)A-2503 methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (357 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (507 aa)
AFM40123.13-deoxy-D-arabinoheptulosonate-7-phosphate synthase; PFAM: Chorismate mutase type II; DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (378 aa)
AFM40048.13-deoxy-D-arabinoheptulosonate-7-phosphate synthase; PFAM: Chorismate mutase type II; DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (378 aa)
AFM40044.1PFAM: Radical SAM superfamily; TIGRFAM: radical SAM additional 4Fe4S-binding domain; radical SAM protein, BA_1875 family. (384 aa)
AFM39995.1PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (467 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; manually curated. (253 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (259 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (198 aa)
trpCPFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (323 aa)
AFM39802.1PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. (1521 aa)
AFM39794.1PFAM: Lysine-2,3-aminomutase; TIGRFAM: KamA family protein. (416 aa)
AFM39783.1Pyruvate-formate lyase-activating enzyme; PFAM: Radical SAM superfamily. (318 aa)
AFM39605.1Putative nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (486 aa)
AFM39471.1PFAM: NADH:flavin oxidoreductase / NADH oxidase family. (331 aa)
AFM39378.1Iron-only hydrogenase maturation protein HydE; PFAM: Radical SAM superfamily; TIGRFAM: [FeFe] hydrogenase H-cluster radical SAM maturase HydE. (399 aa)
AFM39375.1Iron-only hydrogenase maturation protein HydG; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: [FeFe] hydrogenase H-cluster radical SAM maturase HydG; thiazole biosynthesis protein ThiH. (471 aa)
AFM39323.1PFAM: IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase. (498 aa)
AFM39206.1tRNA-U20-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (321 aa)
pdxSPyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (294 aa)
AFM42610.1Biotin synthase-related enzyme; PFAM: Radical SAM superfamily. (327 aa)
AFM42611.1Biotin synthetase-like uncharacterized protein; PFAM: Radical SAM superfamily. (293 aa)
AFM42720.1Pseudaminic acid synthase; PFAM: SAF domain; NeuB family; TIGRFAM: pseudaminic acid synthase. (350 aa)
pdxS-2Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (294 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (214 aa)
AFM42881.1Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (403 aa)
AFM42885.1Putative molybdenum utilization protein ModD; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; putative molybdenum utilization protein ModD; Belongs to the NadC/ModD family. (281 aa)
AFM42893.1PFAM: HMGL-like; TIGRFAM: homocitrate synthase NifV; Belongs to the alpha-IPM synthase/homocitrate synthase family. (371 aa)
AFM42894.1Putative Fe-S oxidoreductase; PFAM: Radical SAM superfamily; TIGRFAM: nitrogenase cofactor biosynthesis protein NifB. (277 aa)
AFM43169.1PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (530 aa)
AFM43176.1PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (477 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (274 aa)
AFM43412.1PFAM: Glycerol-3-phosphate responsive antiterminator. (192 aa)
AFM43424.1Alpha-hydroxyacid dehydrogenase, FMN-dependent L-lactate dehydrogenase; PFAM: FMN-dependent dehydrogenase. (334 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (214 aa)
AFM43494.1Fe-S oxidoreductase; PFAM: Radical SAM superfamily. (291 aa)
AFM43504.1six-Cys-in-45 modification radical SAM protein; PFAM: Radical SAM superfamily; TIGRFAM: radical SAM additional 4Fe4S-binding domain; SCIFF radical SAM maturase. (484 aa)
mqnCDe-hypoxanthine futalosine cyclase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (362 aa)
AFM40910.1PFAM: Radical SAM superfamily; TIGRFAM: putative heme d1 biosynthesis radical SAM protein NirJ1; radical SAM additional 4Fe4S-binding domain. (392 aa)
AFM40911.1PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (324 aa)
AFM41020.1PFAM: Dihydroorotate dehydrogenase; TIGRFAM: dihydroorotate dehydrogenase (subfamily 1) family protein. (402 aa)
AFM41137.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1150 aa)
AFM41307.1PFAM: Pyridine nucleotide-disulphide oxidoreductase; NADH:flavin oxidoreductase / NADH oxidase family. (669 aa)
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (209 aa)
AFM41417.1PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (453 aa)
thiGPutative enzyme of thiazole biosynthesis; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (268 aa)
AFM41434.1Tyrosine lyase ThiH; PFAM: Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH. (373 aa)
thiE-2Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (207 aa)
AFM41448.1Anaerobic sulfatase-maturating enzyme; PFAM: Radical SAM superfamily; SEC-C motif; TIGRFAM: anaerobic sulfatase-maturating enzyme; radical SAM additional 4Fe4S-binding domain. (417 aa)
AFM41634.1Putative Fe-S oxidoreductase; PFAM: Radical SAM superfamily. (447 aa)
AFM41681.1PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases; fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist. (308 aa)
queEOrganic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (243 aa)
guaBInosine-5''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (483 aa)
AFM42242.1PFAM: HMGL-like; Biotin-requiring enzyme; Conserved carboxylase domain; TIGRFAM: acetyl-CoA carboxylase, biotin carboxyl carrier protein. (646 aa)
AFM42398.1TIGRFAM: putative DNA modification/repair radical SAM protein. (438 aa)
dapA-2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (317 aa)
AFM42534.12-nitropropane dioxygenase-like enzyme; PFAM: 2-nitropropane dioxygenase. (314 aa)
AFM42538.1PFAM: 2-nitropropane dioxygenase; TIGRFAM: putative enoyl-[acyl-carrier-protein] reductase II. (316 aa)
AFM42557.1Ribulose-5-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (222 aa)
rlmN-223S rRNA m(2)A-2503 methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (355 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (236 aa)
mqnE-2De-hypoxanthine futalosine cyclase; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (364 aa)
mqnEPutative menaquinone biosynthesis protein, SCO4494 family; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (369 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa)
Your Current Organism:
Desulfosporosinus acidiphilus
NCBI taxonomy Id: 646529
Other names: D. acidiphilus SJ4, Desulfosporosinus acidiphilus DSM 22704, Desulfosporosinus acidiphilus SJ4, Desulfosporosinus acidiphilus str. SJ4, Desulfosporosinus acidiphilus strain SJ4, Desulfosporosinus sp. SJ4
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.