STRINGSTRING
ileS ileS AFM39724.1 AFM39724.1 AFM39779.1 AFM39779.1 guaA guaA AFM39952.1 AFM39952.1 AFM40036.1 AFM40036.1 AFM40604.1 AFM40604.1 AFM40648.1 AFM40648.1 coaD coaD AFM40932.1 AFM40932.1 AFM41162.1 AFM41162.1 AFM41263.1 AFM41263.1 AFM41264.1 AFM41264.1 sat sat AFM41277.1 AFM41277.1 AFM41278.1 AFM41278.1 AFM41283.1 AFM41283.1 AFM41284.1 AFM41284.1 AFM41471.1 AFM41471.1 AFM41857.1 AFM41857.1 AFM41860.1 AFM41860.1 AFM41861.1 AFM41861.1 AFM42421.1 AFM42421.1 queC queC AFM42484.1 AFM42484.1 AFM42486.1 AFM42486.1 leuS leuS nadD nadD AFM43037.1 AFM43037.1 valS valS argS argS glnS glnS mnmA mnmA AFM42186.1 AFM42186.1 metG metG tilS tilS panC panC tyrS tyrS AFM39308.1 AFM39308.1 AFM39339.1 AFM39339.1 AFM39340.1 AFM39340.1 gltX gltX cysS cysS argG argG nadE nadE AFM39723.1 AFM39723.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ileSIsoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1034 aa)
AFM39724.1PFAM: Universal stress protein family. (140 aa)
AFM39779.1PFAM: Universal stress protein family. (142 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (510 aa)
AFM39952.1Osmosensitive K+ channel histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; Osmosensitive K+ channel His kinase sensor domain; Universal stress protein family. (901 aa)
AFM40036.1Uncharacterized membrane protein; PFAM: DUF218 domain. (228 aa)
AFM40604.1PFAM: Universal stress protein family. (141 aa)
AFM40648.1PFAM: Universal stress protein family. (142 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (169 aa)
AFM40932.1Osmosensitive K+ channel histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; Osmosensitive K+ channel His kinase sensor domain; Universal stress protein family. (891 aa)
AFM41162.1PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (627 aa)
AFM41263.1Electron transfer flavoprotein, beta subunit; PFAM: Electron transfer flavoprotein domain. (257 aa)
AFM41264.1Electron transfer flavoprotein, alpha subunit; PFAM: Electron transfer flavoprotein domain; Electron transfer flavoprotein FAD-binding domain. (329 aa)
satSulfate adenylyltransferase; PFAM: ATP-sulfurylase; TIGRFAM: ATP sulphurylase; Belongs to the sulfate adenylyltransferase family. (391 aa)
AFM41277.1PFAM: Universal stress protein family. (233 aa)
AFM41278.1PFAM: Universal stress protein family. (223 aa)
AFM41283.1PFAM: Universal stress protein family. (192 aa)
AFM41284.1PFAM: Universal stress protein family. (178 aa)
AFM41471.1PFAM: Universal stress protein family. (210 aa)
AFM41857.1PFAM: NAD synthase; TIGRFAM: TIGR00268 family protein. (274 aa)
AFM41860.1Electron transfer flavoprotein, alpha subunit; PFAM: Electron transfer flavoprotein domain; Electron transfer flavoprotein FAD-binding domain. (442 aa)
AFM41861.1Electron transfer flavoprotein, beta subunit; PFAM: Electron transfer flavoprotein domain. (277 aa)
AFM42421.1PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family. (307 aa)
queCQueuosine biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (231 aa)
AFM42484.1PFAM: Universal stress protein family. (177 aa)
AFM42486.1PFAM: Universal stress protein family. (219 aa)
leuSPFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family; Belongs to the class-I aminoacyl-tRNA synthetase family. (833 aa)
nadDNicotinate/nicotinamide nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (208 aa)
AFM43037.1PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (639 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (875 aa)
argSarginyl-tRNA synthetase; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R); TIGRFAM: arginyl-tRNA synthetase. (559 aa)
glnSPFAM: tRNA synthetases class I (E and Q), catalytic domain; tRNA synthetases class I (E and Q), anti-codon binding domain; TIGRFAM: glutaminyl-tRNA synthetase; glutamyl-tRNA synthetase, archaeal and eukaryotic family. (552 aa)
mnmAtRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (367 aa)
AFM42186.1PFAM: tRNA synthetases class I (W and Y); TIGRFAM: tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (324 aa)
metGProtein containing C-terminal region/beta chain of methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (650 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (471 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (281 aa)
tyrStyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (422 aa)
AFM39308.1PFAM: Universal stress protein family. (142 aa)
AFM39339.1Electron transfer flavoprotein, alpha subunit; PFAM: Electron transfer flavoprotein domain; Electron transfer flavoprotein FAD-binding domain. (402 aa)
AFM39340.1Electron transfer flavoprotein, beta subunit; PFAM: Electron transfer flavoprotein domain. (262 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (485 aa)
cysSPFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (477 aa)
argGPFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (402 aa)
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (259 aa)
AFM39723.1PFAM: Universal stress protein family. (140 aa)
Your Current Organism:
Desulfosporosinus acidiphilus
NCBI taxonomy Id: 646529
Other names: D. acidiphilus SJ4, Desulfosporosinus acidiphilus DSM 22704, Desulfosporosinus acidiphilus SJ4, Desulfosporosinus acidiphilus str. SJ4, Desulfosporosinus acidiphilus strain SJ4, Desulfosporosinus sp. SJ4
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