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AEH06006.1 AEH06006.1 cbiD cbiD cbiA cbiA AEH06107.1 AEH06107.1 AEH06128.1 AEH06128.1 AEH06148.1 AEH06148.1 cbiT cbiT AEH06249.1 AEH06249.1 AEH06372.1 AEH06372.1 AEH06508.1 AEH06508.1 cobD cobD hemC hemC AEH06629.1 AEH06629.1 AEH06630.1 AEH06630.1 AEH06650.1 AEH06650.1 AEH06651.1 AEH06651.1 AEH06682.1 AEH06682.1 cobS cobS AEH06780.1 AEH06780.1 hemL hemL AEH06892.1 AEH06892.1 AEH06944.1 AEH06944.1 hemA hemA AEH07037.1 AEH07037.1 AEH07135.1 AEH07135.1 AEH07136.1 AEH07136.1 AEH07137.1 AEH07137.1 AEH07205.1 AEH07205.1 AEH07215.1 AEH07215.1 AEH07248.1 AEH07248.1 AEH07398.1 AEH07398.1 AEH07415.1 AEH07415.1 AEH07416.1 AEH07416.1 AEH07417.1 AEH07417.1 AEH07418.1 AEH07418.1 AEH07449.1 AEH07449.1 cobQ cobQ
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
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AEH06006.1PFAM: Cobalamin (vitamin B12) biosynthesis CbiG, core; KEGG: mae:Maeo_0036 cobalamin (vitamin B12) biosynthesis CbiG protein. (340 aa)
cbiDcobalt-precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (381 aa)
cbiACobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (458 aa)
AEH06107.1KEGG: mae:Maeo_1349 geranylgeranyl reductase; TIGRFAM: Geranylgeranyl reductase, plant/prokaryotic; PFAM: Monooxygenase, FAD-binding. (401 aa)
AEH06128.1KEGG: mae:Maeo_0202 hypothetical protein; TIGRFAM: Conserved hypothetical protein CHP00454; PFAM: Nucleotidyl transferase. (192 aa)
AEH06148.1KEGG: mae:Maeo_0220 precorrin-6x reductase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobK/CbiJ, precorrin-6x reductase; PFAM: Cobalamin (vitamin B12) biosynthesis CobK/CbiJ, precorrin-6x reductase. (256 aa)
cbiTcobalt-precorrin-6Y C(15)-methyltransferase (decarboxylating); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (186 aa)
AEH06249.1Precorrin-2 C20-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobI/CbiL, precorrin-2 C20-methyltransferase, core; KEGG: mae:Maeo_0248 precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole methylase. (235 aa)
AEH06372.1precorrin-3B C17-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobJ/CibH, precorrin-3B C17-methyltransferase, core; KEGG: mae:Maeo_0830 precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole methylase. (252 aa)
AEH06508.1Porphobilinogen synthase; KEGG: mja:MJ_0643 delta-aminolevulinic acid dehydratase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; Belongs to the ALAD family. (324 aa)
cobDCobalamin biosynthesis protein cbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (328 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (311 aa)
AEH06629.1PFAM: Cobalamin (vitamin B12) biosynthesis CbiX; KEGG: mmz:MmarC7_1164 sirohydrochlorin cobaltochelatase. (109 aa)
AEH06630.1KEGG: mae:Maeo_1381 sirohydrochlorin cobaltochelatase. (35 aa)
AEH06650.1Phosphoadenosine phosphosulfate reductase; KEGG: mae:Maeo_1343 hypothetical protein; manually curated; PFAM: Phosphoadenosine phosphosulphate reductase. (432 aa)
AEH06651.1Precorrin-4 C11-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase, core; KEGG: mae:Maeo_1342 precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole methylase. (257 aa)
AEH06682.1PFAM: CobB/CobQ-like glutamine amidotransferase; KEGG: mae:Maeo_1143 cobyrinic acid a,c-diamide synthase. (515 aa)
cobSCobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (266 aa)
AEH06780.1KEGG: mae:Maeo_0120 cobaltochelatase; PFAM: CobN/magnesium chelatase. (1240 aa)
hemLKEGG: mae:Maeo_1208 glutamate-1-semialdehyde aminotransferase; manually curated; TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; PFAM: Aminotransferase class-III; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (431 aa)
AEH06892.1KEGG: mae:Maeo_1034 hypothetical protein. (404 aa)
AEH06944.1KEGG: mmz:MmarC7_1088 siroheme synthase. (207 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (385 aa)
AEH07037.1Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; KEGG: mja:MJ_1522 cobalt-precorrin-6Y C(5)-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CbiE, precorrin-6Y methyltransferase, core; PFAM: Tetrapyrrole methylase. (205 aa)
AEH07135.1KEGG: mae:Maeo_0109 cobaltochelatase subunit CobN; PFAM: CobN/magnesium chelatase. (1267 aa)
AEH07136.1Magnesium chelatase; PFAM: ATPase associated with various cellular activities, AAA-5; KEGG: mae:Maeo_0108 magnesium chelatase; SMART: ATPase, AAA+ type, core. (374 aa)
AEH07137.1SMART: von Willebrand factor, type A; KEGG: mfs:MFS40622_1250 magnesium chelatase. (333 aa)
AEH07205.1ABC-type transporter, periplasmic subunit; PFAM: Periplasmic binding protein; KEGG: mae:Maeo_0111 periplasmic binding protein. (421 aa)
AEH07215.1UPF0284 protein; TIGRFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, putative; HAMAP: UPF0284 protein; KEGG: mae:Maeo_0615 hypothetical protein; PFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like, core; Belongs to the UPF0284 family. (357 aa)
AEH07248.1TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; KEGG: mvu:Metvu_1448 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; Belongs to the precorrin methyltransferase family. (238 aa)
AEH07398.1Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (256 aa)
AEH07415.1PFAM: Cobalamin (vitamin B12) biosynthesis CbiM; KEGG: mja:MJ_1569 cobalt transport protein CbiM. (217 aa)
AEH07416.1KEGG: mja:MJ_1570 hypothetical protein. (115 aa)
AEH07417.1KEGG: mvu:Metvu_1323 cobalt ABC transporter, inner membrane subunit CbiQ; TIGRFAM: Cobalt ABC transporter CbiQ, permease subunit; PFAM: Cobalt transport protein. (281 aa)
AEH07418.1SMART: ATPase, AAA+ type, core; manually curated; KEGG: mja:MJ_1572 cobalt transport ATP-binding protein CbiO; PFAM: ABC transporter-like. (292 aa)
AEH07449.1Precorrin-8X methylmutase CbiC/CobH; PFAM: Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase, core; KEGG: mae:Maeo_0015 precorrin-8X methylmutase. (211 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (515 aa)
Your Current Organism:
Methanothermococcus okinawensis
NCBI taxonomy Id: 647113
Other names: M. okinawensis IH1, Methanothermococcus okinawensis DSM 14208, Methanothermococcus okinawensis IH1, Methanothermococcus okinawensis str. IH1, Methanothermococcus okinawensis strain IH1
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