STRINGSTRING
AEH06006.1 AEH06006.1 cbiD cbiD cbiA cbiA AEH06128.1 AEH06128.1 AEH06148.1 AEH06148.1 cbiT cbiT AEH06249.1 AEH06249.1 AEH06372.1 AEH06372.1 AEH06508.1 AEH06508.1 cobD cobD AEH06560.1 AEH06560.1 hemC hemC AEH06629.1 AEH06629.1 AEH06651.1 AEH06651.1 cobS cobS AEH06773.1 AEH06773.1 AEH06780.1 AEH06780.1 hemL hemL AEH06944.1 AEH06944.1 hemA hemA AEH07037.1 AEH07037.1 gltX gltX AEH07135.1 AEH07135.1 AEH07136.1 AEH07136.1 AEH07248.1 AEH07248.1 AEH07398.1 AEH07398.1 AEH07449.1 AEH07449.1 cobQ cobQ
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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textmining
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Your Input:
AEH06006.1PFAM: Cobalamin (vitamin B12) biosynthesis CbiG, core; KEGG: mae:Maeo_0036 cobalamin (vitamin B12) biosynthesis CbiG protein. (340 aa)
cbiDcobalt-precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (381 aa)
cbiACobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (458 aa)
AEH06128.1KEGG: mae:Maeo_0202 hypothetical protein; TIGRFAM: Conserved hypothetical protein CHP00454; PFAM: Nucleotidyl transferase. (192 aa)
AEH06148.1KEGG: mae:Maeo_0220 precorrin-6x reductase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobK/CbiJ, precorrin-6x reductase; PFAM: Cobalamin (vitamin B12) biosynthesis CobK/CbiJ, precorrin-6x reductase. (256 aa)
cbiTcobalt-precorrin-6Y C(15)-methyltransferase (decarboxylating); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (186 aa)
AEH06249.1Precorrin-2 C20-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobI/CbiL, precorrin-2 C20-methyltransferase, core; KEGG: mae:Maeo_0248 precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole methylase. (235 aa)
AEH06372.1precorrin-3B C17-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobJ/CibH, precorrin-3B C17-methyltransferase, core; KEGG: mae:Maeo_0830 precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole methylase. (252 aa)
AEH06508.1Porphobilinogen synthase; KEGG: mja:MJ_0643 delta-aminolevulinic acid dehydratase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; Belongs to the ALAD family. (324 aa)
cobDCobalamin biosynthesis protein cbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (328 aa)
AEH06560.1Methanogenesis marker 13 metalloprotein; KEGG: mae:Maeo_1313 vanadium nitrogenase-associated related protein N; TIGRFAM: Putative methanogenesis marker 13 metalloprotein; PFAM: Nitrogenase/oxidoreductase, component 1. (406 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (311 aa)
AEH06629.1PFAM: Cobalamin (vitamin B12) biosynthesis CbiX; KEGG: mmz:MmarC7_1164 sirohydrochlorin cobaltochelatase. (109 aa)
AEH06651.1Precorrin-4 C11-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase, core; KEGG: mae:Maeo_1342 precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole methylase. (257 aa)
cobSCobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (266 aa)
AEH06773.1PFAM: Mur ligase, central; KEGG: mae:Maeo_1414 Mur ligase middle domain-containing protein. (434 aa)
AEH06780.1KEGG: mae:Maeo_0120 cobaltochelatase; PFAM: CobN/magnesium chelatase. (1240 aa)
hemLKEGG: mae:Maeo_1208 glutamate-1-semialdehyde aminotransferase; manually curated; TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; PFAM: Aminotransferase class-III; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (431 aa)
AEH06944.1KEGG: mmz:MmarC7_1088 siroheme synthase. (207 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (385 aa)
AEH07037.1Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; KEGG: mja:MJ_1522 cobalt-precorrin-6Y C(5)-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CbiE, precorrin-6Y methyltransferase, core; PFAM: Tetrapyrrole methylase. (205 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (556 aa)
AEH07135.1KEGG: mae:Maeo_0109 cobaltochelatase subunit CobN; PFAM: CobN/magnesium chelatase. (1267 aa)
AEH07136.1Magnesium chelatase; PFAM: ATPase associated with various cellular activities, AAA-5; KEGG: mae:Maeo_0108 magnesium chelatase; SMART: ATPase, AAA+ type, core. (374 aa)
AEH07248.1TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; KEGG: mvu:Metvu_1448 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; Belongs to the precorrin methyltransferase family. (238 aa)
AEH07398.1Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (256 aa)
AEH07449.1Precorrin-8X methylmutase CbiC/CobH; PFAM: Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase, core; KEGG: mae:Maeo_0015 precorrin-8X methylmutase. (211 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (515 aa)
Your Current Organism:
Methanothermococcus okinawensis
NCBI taxonomy Id: 647113
Other names: M. okinawensis IH1, Methanothermococcus okinawensis DSM 14208, Methanothermococcus okinawensis IH1, Methanothermococcus okinawensis str. IH1, Methanothermococcus okinawensis strain IH1
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