node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALC60_00190 | ALC60_01629 | A0A151XJZ8 | A0A151XG11 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | E3 SUMO-protein ligase PIAS3. | 0.897 |
ALC60_00190 | ALC60_03063 | A0A151XJZ8 | A0A151XCB9 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | DNA repair protein XRCC3. | 0.506 |
ALC60_00190 | ALC60_04562 | A0A151XJZ8 | A0A151X7X4 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Serine/threonine-protein kinase atr; Belongs to the PI3/PI4-kinase family. | 0.540 |
ALC60_00190 | ALC60_06025 | A0A151XJZ8 | A0A151X3P9 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.502 |
ALC60_00190 | ALC60_07105 | A0A151XJZ8 | A0A151X0P6 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Histone deacetylase Rpd3. | 0.502 |
ALC60_00190 | ALC60_08830 | A0A151XJZ8 | A0A151WX28 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Protein MCM10 like protein. | 0.524 |
ALC60_00190 | ALC60_09109 | A0A151XJZ8 | A0A151WV55 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Cell division control protein 45 like protein. | 0.657 |
ALC60_00190 | ALC60_13803 | A0A151XJZ8 | A0A151WH58 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Structural maintenance of chromosomes protein. | 0.413 |
ALC60_00596 | ALC60_01664 | A0A151XIG5 | A0A151XG44 | Structural maintenance of chromosomes protein. | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. | 0.999 |
ALC60_00596 | ALC60_04562 | A0A151XIG5 | A0A151X7X4 | Structural maintenance of chromosomes protein. | Serine/threonine-protein kinase atr; Belongs to the PI3/PI4-kinase family. | 0.599 |
ALC60_00596 | ALC60_05556 | A0A151XIG5 | A0A151X597 | Structural maintenance of chromosomes protein. | DNA helicase; Belongs to the MCM family. | 0.826 |
ALC60_00596 | ALC60_06015 | A0A151XIG5 | A0A151X3P1 | Structural maintenance of chromosomes protein. | CNDH2_C domain-containing protein. | 0.990 |
ALC60_00596 | ALC60_06025 | A0A151XIG5 | A0A151X3P9 | Structural maintenance of chromosomes protein. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.597 |
ALC60_00596 | ALC60_07105 | A0A151XIG5 | A0A151X0P6 | Structural maintenance of chromosomes protein. | Histone deacetylase Rpd3. | 0.597 |
ALC60_00596 | ALC60_08830 | A0A151XIG5 | A0A151WX28 | Structural maintenance of chromosomes protein. | Protein MCM10 like protein. | 0.476 |
ALC60_00596 | ALC60_09109 | A0A151XIG5 | A0A151WV55 | Structural maintenance of chromosomes protein. | Cell division control protein 45 like protein. | 0.699 |
ALC60_00596 | ALC60_09406 | A0A151XIG5 | A0A151WUK5 | Structural maintenance of chromosomes protein. | Condensin complex subunit 3. | 0.999 |
ALC60_00596 | ALC60_11325 | A0A151XIG5 | A0A151WP32 | Structural maintenance of chromosomes protein. | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. | 0.536 |
ALC60_00596 | ALC60_11616 | A0A151XIG5 | A0A151WNS2 | Structural maintenance of chromosomes protein. | DNA helicase; Belongs to the MCM family. | 0.762 |
ALC60_00596 | ALC60_11802 | A0A151XIG5 | A0A151WN03 | Structural maintenance of chromosomes protein. | Condensin-2 complex subunit D3. | 0.986 |