(92 nodes) MAPK signaling pathway - fly network (Trachymyrmex zeteki)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ALC60_02540	Kinase suppressor of Ras 2. (966 aa)
	ALC60_14636	Uncharacterized protein. (854 aa)
	ALC60_14666	Mitogen-activated protein kinase. (379 aa)
	ALC60_14348	Protein phosphatase 1B. (373 aa)
	ALC60_14039	Profilin; Belongs to the profilin family. (164 aa)
	ALC60_13955	Connector enhancer of kinase suppressor of ras 3. (1898 aa)
	ALC60_13810	Protein spitz. (450 aa)
	ALC60_13611	TNFR-Cys domain-containing protein. (399 aa)
	ALC60_13486	Tyrosine-protein phosphatase non-receptor type 11. (591 aa)
	ALC60_13327	Ras-related protein Rac1. (193 aa)
	ALC60_12818	14-3-3 protein zeta; Belongs to the 14-3-3 family. (310 aa)
	ALC60_12752	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (573 aa)
	ALC60_12374	Dual specificity mitogen-activated protein kinase kinase 1. (113 aa)
	ALC60_12191	Cyclic AMP-dependent transcription factor ATF-2. (543 aa)
	ALC60_12376	Dual specificity mitogen-activated protein kinase kinase 2. (212 aa)
	ALC60_11943	Tyrosine-protein kinase receptor. (2581 aa)
	ALC60_12105	Protein bride of sevenless. (804 aa)
	ALC60_11866	Myocyte-specific enhancer factor 2. (494 aa)
	ALC60_11825	Transcription factor AP-1. (267 aa)
	ALC60_11603	SHC-transforming protein 1. (441 aa)
	ALC60_11596	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (201 aa)
	ALC60_11141	Optomotor-blind protein. (350 aa)
	ALC60_11006	Torso-like protein. (414 aa)
	ALC60_11143	Optomotor-blind protein. (171 aa)
	ALC60_11050	Leucine-rich repeat-containing protein 4B. (575 aa)
	ALC60_10925	Transcription factor kayak. (525 aa)
	ALC60_10490	Protein daughter of sevenless. (635 aa)
	ALC60_10390	Ras-like GTP-binding protein RhoL. (187 aa)
	ALC60_10416	Ubiquitin carboxyl-terminal hydrolase CYLD. (832 aa)
	ALC60_10211	Nuclear receptor subfamily 2 group E member 1. (492 aa)
	ALC60_09832	Mitogen-activated protein kinase kinase kinase 9. (1660 aa)
	ALC60_09697	Receptor protein-tyrosine kinase. (1517 aa)
	ALC60_09534	Importin-7. (1042 aa)
	ALC60_09391	Uncharacterized protein. (1698 aa)
	ALC60_09374	Serine/threonine-protein kinase mig-15. (1290 aa)
	ALC60_09099	Ras-related C3 botulinum toxin substrate 1. (195 aa)
	ALC60_08721	Mitogen-activated protein kinase kinase kinase 15. (1363 aa)
	ALC60_08695	Docking protein 2. (558 aa)
	ALC60_08414	Protein sprouty. (448 aa)
	ALC60_08366	Ets DNA-binding protein pokkuri. (474 aa)
	ALC60_08218	TNF receptor-associated factor 6. (358 aa)
	ALC60_07739	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (520 aa)
	ALC60_07801	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
	ALC60_07738	Uncharacterized protein. (66 aa)
	ALC60_07561	Nuclear receptor subfamily 2 group E member 1. (545 aa)
	ALC60_07194	Mitogen-activated protein kinase. (366 aa)
	ALC60_06767	Striatin-4. (704 aa)
	ALC60_07004	F-box-like/WD repeat-containing protein TBL1XR1. (449 aa)
	ALC60_06929	Mitogen-activated protein kinase kinase kinase 7. (913 aa)
	ALC60_06840	Tyrosine-protein kinase. (521 aa)
	ALC60_06277	Uncharacterized protein. (1875 aa)
	ALC60_05418	Uncharacterized protein. (1051 aa)
	ALC60_05415	Ras-GEF domain-containing family member 1B. (694 aa)
	ALC60_05359	Protein lozenge. (376 aa)
	ALC60_05364	Protein lozenge. (888 aa)
	ALC60_05366	Protein lozenge. (492 aa)
	ALC60_05059	Tyrosine-protein kinase. (544 aa)
	ALC60_04738	Transforming protein p54/c-ets-1. (597 aa)
	ALC60_04519	Dual specificity mitogen-activated protein kinase kinase 6. (319 aa)
	ALC60_04274	EF-hand domain-containing protein. (503 aa)
	ALC60_04096	Dual specificity protein phosphatase 10. (410 aa)
	ALC60_04098	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (292 aa)
	ALC60_04039	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (279 aa)
	ALC60_03878	Protein son of sevenless. (1315 aa)
	ALC60_03410	Protein decapentaplegic. (401 aa)
	ALC60_03508	Serine/threonine-protein kinase A-Raf. (820 aa)
	ALC60_03491	Ras-responsive element-binding protein 1. (1709 aa)
	ALC60_03539	Dual oxidase. (1484 aa)
	ALC60_03621	Putative E3 ubiquitin-protein ligase sinah. (270 aa)
	ALC60_03356	Protein capicua like protein. (1975 aa)
	ALC60_03135	Nuclear receptor subfamily 2 group E member 1. (322 aa)
	ALC60_03145	Ubiquitin-conjugating enzyme E2-17 kDa; Belongs to the ubiquitin-conjugating enzyme family. (116 aa)
	ALC60_02690	Ras GTPase-activating protein 3. (921 aa)
	ALC60_02771	Mitogen-activated protein kinase. (375 aa)
	ALC60_02730	Protein vein. (395 aa)
	ALC60_02798	Dual specificity mitogen-activated protein kinase kinase 7. (828 aa)
	ALC60_02498	Serine/threonine-protein phosphatase. (328 aa)
	ALC60_02058	Homeobox protein prospero. (1035 aa)
	ALC60_02059	Homeobox protein prospero. (188 aa)
	ALC60_02168	Fibroblast growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1583 aa)
	ALC60_01993	Mitogen-activated protein kinase kinase kinase 4. (1315 aa)
	ALC60_01462	Uncharacterized protein. (312 aa)
	ALC60_01155	Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (438 aa)
	ALC60_00682	Transducin-like enhancer protein 4. (786 aa)
	ALC60_00702	Transducin-like enhancer protein 1. (909 aa)
	ALC60_00720	Protein E(Sev)2B. (211 aa)
	ALC60_00536	Ras-specific guanine nucleotide-releasing factor 1. (1396 aa)
	ALC60_00675	Transducin-like enhancer protein 4. (765 aa)
	ALC60_00811	Protein tramtrack, alpha isoform. (327 aa)
	ALC60_00810	C2H2-type domain-containing protein. (237 aa)
	ALC60_00812	Protein tramtrack, alpha isoform. (574 aa)
	ALC60_00141	Tyrosine-protein kinase. (523 aa)

Your Current Organism:

Trachymyrmex zeteki

NCBI taxonomy Id: 64791
Other names: T. zeteki

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALC60_00141	ALC60_00536	A0A151XK61	A0A151XIT7	Tyrosine-protein kinase.	Ras-specific guanine nucleotide-releasing factor 1.	0.650
ALC60_00141	ALC60_00720	A0A151XK61	A0A151XIS8	Tyrosine-protein kinase.	Protein E(Sev)2B.	0.799
ALC60_00141	ALC60_01155	A0A151XK61	A0A151XHS8	Tyrosine-protein kinase.	Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.911
ALC60_00141	ALC60_02498	A0A151XK61	A0A151XDL3	Tyrosine-protein kinase.	Serine/threonine-protein phosphatase.	0.435
ALC60_00141	ALC60_02540	A0A151XK61	A0A151XDQ0	Tyrosine-protein kinase.	Kinase suppressor of Ras 2.	0.549
ALC60_00141	ALC60_02771	A0A151XK61	A0A151XDA4	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.812
ALC60_00141	ALC60_02798	A0A151XK61	A0A151XDE1	Tyrosine-protein kinase.	Dual specificity mitogen-activated protein kinase kinase 7.	0.862
ALC60_00141	ALC60_03145	A0A151XK61	A0A151XCL1	Tyrosine-protein kinase.	Ubiquitin-conjugating enzyme E2-17 kDa; Belongs to the ubiquitin-conjugating enzyme family.	0.755
ALC60_00141	ALC60_03410	A0A151XK61	A0A151XAT1	Tyrosine-protein kinase.	Protein decapentaplegic.	0.547
ALC60_00141	ALC60_03508	A0A151XK61	A0A151XB10	Tyrosine-protein kinase.	Serine/threonine-protein kinase A-Raf.	0.546
ALC60_00141	ALC60_03539	A0A151XK61	A0A151XB50	Tyrosine-protein kinase.	Dual oxidase.	0.616
ALC60_00141	ALC60_03878	A0A151XK61	A0A151XA05	Tyrosine-protein kinase.	Protein son of sevenless.	0.650
ALC60_00141	ALC60_04096	A0A151XK61	A0A151X950	Tyrosine-protein kinase.	Dual specificity protein phosphatase 10.	0.449
ALC60_00141	ALC60_04098	A0A151XK61	A0A151X986	Tyrosine-protein kinase.	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.449
ALC60_00141	ALC60_04519	A0A151XK61	A0A151X7T9	Tyrosine-protein kinase.	Dual specificity mitogen-activated protein kinase kinase 6.	0.840
ALC60_00141	ALC60_05059	A0A151XK61	A0A151X6R4	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.807
ALC60_00141	ALC60_05359	A0A151XK61	A0A151X5S5	Tyrosine-protein kinase.	Protein lozenge.	0.400
ALC60_00141	ALC60_05364	A0A151XK61	A0A151X5U0	Tyrosine-protein kinase.	Protein lozenge.	0.400
ALC60_00141	ALC60_05366	A0A151XK61	A0A151X5V6	Tyrosine-protein kinase.	Protein lozenge.	0.400
ALC60_00141	ALC60_06767	A0A151XK61	A0A151X1D0	Tyrosine-protein kinase.	Striatin-4.	0.529