(41 nodes) Tetrapyrrole biosynthetic process, and Cobalt ion transport network (Aneurinibacillus aneurinilyticus)

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	hemA	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (452 aa)
	ERI11563.1	Putative protein HemX; KEGG: bmq:BMQ_4685 1.3e-71 hemX; uroporphyrin-III C-methyltransferase K02497; Psort location: CytoplasmicMembrane, score: 10.00. (273 aa)
	hemC	Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (308 aa)
	ERI11565.1	uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (259 aa)
	ERI11566.1	KEGG: bco:Bcell_3126 1.4e-122 porphobilinogen synthase K01698; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. (310 aa)
	hemL	Glutamate-1-semialdehyde-2,1-aminomutase; KEGG: bbe:BBR47_18060 1.1e-175 hemL; glutamate-1-semialdehyde 2,1-aminomutase K01845; Psort location: Cytoplasmic, score: 9.97. (436 aa)
	ERI08142.1	Putative glutamate-1-semialdehyde-2,1-aminomutase; KEGG: hhd:HBHAL_1081 6.7e-171 hemL; glutamate-1-semialdehyde 2,1-aminomutase K01845; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (455 aa)
	ERI07981.1	Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (384 aa)
	cobD	Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (322 aa)
	ERI07700.1	Adenosylcobinamide amidohydrolase; KEGG: gwc:GWCH70_2210 1.9e-31 hypothetical protein; K02013 iron complex transport system ATP-binding protein. (235 aa)
	ERI07701.1	GHMP kinase protein; KEGG: dai:Desaci_2446 3.0e-26 putative kinase involved in propanediol utilization; Psort location: Cytoplasmic, score: 7.50. (289 aa)
	ERI07702.1	Phosphoglycerate mutase family protein; KEGG: bbe:BBR47_12430 4.7e-44 cobC; alpha-ribazole phosphatase K15634; Psort location: Cytoplasmic, score: 7.50. (197 aa)
	cobS	adenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (247 aa)
	ERI07704.1	KEGG: bbe:BBR47_12410 1.2e-45 cobU; bifunctional adenosylcobalamin biosynthesis protein K02231. (182 aa)
	ERI07705.1	KEGG: bbe:BBR47_12400 3.3e-107 cobD; threonine-phosphate decarboxylase; Psort location: CytoplasmicMembrane, score: 8.16. (371 aa)
	ERI07706.1	cob(I)yrinic acid a,c-diamide adenosyltransferase; KEGG: bbe:BBR47_12390 6.5e-70 btuR; BtuR protein; K00798 cob(I)alamin adenosyltransferase; Psort location: Cytoplasmic, score: 9.97. (182 aa)
	ERI07707.1	KEGG: bmq:BMQ_0968 3.9e-88 bluB; cob(II)yrinic acid a,c-diamide reductase K04719. (215 aa)
	ERI07708.1	Putative precorrin-2 dehydrogenase; KEGG: gct:GC56T3_3065 2.4e-40 siroheme synthase; K02304 precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Psort location: Cytoplasmic, score: 7.50. (216 aa)
	cobQ	Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (504 aa)
	ERI07710.1	Drug resistance MFS transporter, drug:H+ antiporter-2 family; KEGG: ase:ACPL_1277 1.4e-69 EmrB/QacA subfamily drug resistance transporter; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the major facilitator superfamily. (492 aa)
	cobT	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (355 aa)
	hemL-2	Glutamate-1-semialdehyde-2,1-aminomutase; KEGG: bbe:BBR47_10510 1.9e-180 gsaB; glutamate-1-semialdehyde aminotransferase K01845; Psort location: Cytoplasmic, score: 9.97. (431 aa)
	ERI06655.1	KEGG: bco:Bcell_3349 4.6e-85 uroporphyrin-III C-methyltransferase; K02303 uroporphyrin-III C-methyltransferase; Psort location: Cytoplasmic, score: 7.50. (256 aa)
	ERI06155.1	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (477 aa)
	hemH	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (306 aa)
	hemE	Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (367 aa)
	cbiM	Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (251 aa)
	cbiN	Cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (103 aa)
	ERI05179.1	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00. (260 aa)
	ERI05180.1	Cobalt ABC transporter, ATP-binding protein; Part of an ABC transporter complex. Responsible for energy coupling to the transport system. (296 aa)
	ERI05181.1	precorrin-3B C(17)-methyltransferase; KEGG: bmd:BMD_2606 3.0e-191 cbiH; precorrin 3 methylase K05934; Psort location: Cytoplasmic, score: 7.50. (538 aa)
	ERI05182.1	KEGG: bbe:BBR47_12460 7.9e-113 cbiX; sirohydrochlorin cobaltochelatase; K03795 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50. (308 aa)
	ERI05183.1	precorrin-6A reductase; KEGG: bbe:BBR47_12470 1.0e-87 cbiJ; precorrin-6x reductase K05895; Psort location: Cytoplasmic, score: 7.50. (264 aa)
	ERI05184.1	KEGG: bmq:BMQ_2616 2.0e-91 cbiC; precorrin-8X methylmutase CbiC K06042; Psort location: CytoplasmicMembrane, score: 8.16. (216 aa)
	cbiD	Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (368 aa)
	ERI05186.1	KEGG: bbe:BBR47_12500 2.5e-155 cbiET; CbiET protein; K00595 precorrin-6Y C5,15-methyltransferase / precorrin-8W decarboxylase; Psort location: CytoplasmicMembrane, score: 8.16. (402 aa)
	ERI05187.1	KEGG: bmq:BMQ_2613 5.7e-87 cbiL; precorrin-2 C20-methyltransferase K03394; Psort location: Cytoplasmic, score: 7.50. (235 aa)
	ERI05188.1	KEGG: pms:KNP414_06828 1.2e-102 cbiF; CbiF; K05936 precorrin-4 C11-methyltransferase; Psort location: Cytoplasmic, score: 7.50. (258 aa)
	ERI05189.1	CbiG protein; KEGG: bbe:BBR47_12530 2.4e-143 cbiG; CbiG protein; K02189 cobalt-precorrin 5A hydrolase. (381 aa)
	cbiA	Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (472 aa)
	ERI05191.1	KEGG: bpf:BpOF4_14415 4.5e-110 nasF; methyltransferase/uroporphyrinogen-III synthase; K13542 uroporphyrinogen III methyltransferase / synthase; Psort location: Cytoplasmic, score: 7.50. (490 aa)

Your Current Organism:

Aneurinibacillus aneurinilyticus

NCBI taxonomy Id: 649747
Other names: A. aneurinilyticus ATCC 12856, Aneurinibacillus aneurinilyticus ATCC 12856, Aneurinibacillus aneurinilyticus DSM 5562, Aneurinibacillus aneurinilyticus str. ATCC 12856, Aneurinibacillus aneurinilyticus strain ATCC 12856

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERI05179.1	ERI05180.1	HMPREF0083_05752	HMPREF0083_05753	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	Cobalt ABC transporter, ATP-binding protein; Part of an ABC transporter complex. Responsible for energy coupling to the transport system.	0.999
ERI05179.1	ERI05181.1	HMPREF0083_05752	HMPREF0083_05754	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	precorrin-3B C(17)-methyltransferase; KEGG: bmd:BMD_2606 3.0e-191 cbiH; precorrin 3 methylase K05934; Psort location: Cytoplasmic, score: 7.50.	0.871
ERI05179.1	ERI05182.1	HMPREF0083_05752	HMPREF0083_05755	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	KEGG: bbe:BBR47_12460 7.9e-113 cbiX; sirohydrochlorin cobaltochelatase; K03795 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50.	0.703
ERI05179.1	ERI05183.1	HMPREF0083_05752	HMPREF0083_05756	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	precorrin-6A reductase; KEGG: bbe:BBR47_12470 1.0e-87 cbiJ; precorrin-6x reductase K05895; Psort location: Cytoplasmic, score: 7.50.	0.839
ERI05179.1	ERI05184.1	HMPREF0083_05752	HMPREF0083_05757	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	KEGG: bmq:BMQ_2616 2.0e-91 cbiC; precorrin-8X methylmutase CbiC K06042; Psort location: CytoplasmicMembrane, score: 8.16.	0.843
ERI05179.1	ERI05186.1	HMPREF0083_05752	HMPREF0083_05759	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	KEGG: bbe:BBR47_12500 2.5e-155 cbiET; CbiET protein; K00595 precorrin-6Y C5,15-methyltransferase / precorrin-8W decarboxylase; Psort location: CytoplasmicMembrane, score: 8.16.	0.868
ERI05179.1	ERI05187.1	HMPREF0083_05752	HMPREF0083_05760	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	KEGG: bmq:BMQ_2613 5.7e-87 cbiL; precorrin-2 C20-methyltransferase K03394; Psort location: Cytoplasmic, score: 7.50.	0.817
ERI05179.1	ERI05188.1	HMPREF0083_05752	HMPREF0083_05761	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	KEGG: pms:KNP414_06828 1.2e-102 cbiF; CbiF; K05936 precorrin-4 C11-methyltransferase; Psort location: Cytoplasmic, score: 7.50.	0.793
ERI05179.1	ERI05189.1	HMPREF0083_05752	HMPREF0083_05762	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	CbiG protein; KEGG: bbe:BBR47_12530 2.4e-143 cbiG; CbiG protein; K02189 cobalt-precorrin 5A hydrolase.	0.858
ERI05179.1	ERI05191.1	HMPREF0083_05752	HMPREF0083_05764	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	KEGG: bpf:BpOF4_14415 4.5e-110 nasF; methyltransferase/uroporphyrinogen-III synthase; K13542 uroporphyrinogen III methyltransferase / synthase; Psort location: Cytoplasmic, score: 7.50.	0.692
ERI05179.1	ERI07701.1	HMPREF0083_05752	HMPREF0083_04241	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	GHMP kinase protein; KEGG: dai:Desaci_2446 3.0e-26 putative kinase involved in propanediol utilization; Psort location: Cytoplasmic, score: 7.50.	0.537
ERI05179.1	ERI07705.1	HMPREF0083_05752	HMPREF0083_04245	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	KEGG: bbe:BBR47_12400 3.3e-107 cobD; threonine-phosphate decarboxylase; Psort location: CytoplasmicMembrane, score: 8.16.	0.416
ERI05179.1	cbiA	HMPREF0083_05752	HMPREF0083_05763	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	0.798
ERI05179.1	cbiD	HMPREF0083_05752	HMPREF0083_05758	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.	0.876
ERI05179.1	cbiM	HMPREF0083_05752	HMPREF0083_05750	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.	0.999
ERI05179.1	cbiN	HMPREF0083_05752	HMPREF0083_05751	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	Cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family.	0.998
ERI05179.1	cobT	HMPREF0083_05752	HMPREF0083_04251	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).	0.754
ERI05180.1	ERI05179.1	HMPREF0083_05753	HMPREF0083_05752	Cobalt ABC transporter, ATP-binding protein; Part of an ABC transporter complex. Responsible for energy coupling to the transport system.	KEGG: rcp:RCAP_rcc02035 1.1e-19 cbiQ2; cobalt ABC transporter permease CbiQ K02008; Psort location: CytoplasmicMembrane, score: 10.00.	0.999
ERI05180.1	ERI05181.1	HMPREF0083_05753	HMPREF0083_05754	Cobalt ABC transporter, ATP-binding protein; Part of an ABC transporter complex. Responsible for energy coupling to the transport system.	precorrin-3B C(17)-methyltransferase; KEGG: bmd:BMD_2606 3.0e-191 cbiH; precorrin 3 methylase K05934; Psort location: Cytoplasmic, score: 7.50.	0.870
ERI05180.1	ERI05182.1	HMPREF0083_05753	HMPREF0083_05755	Cobalt ABC transporter, ATP-binding protein; Part of an ABC transporter complex. Responsible for energy coupling to the transport system.	KEGG: bbe:BBR47_12460 7.9e-113 cbiX; sirohydrochlorin cobaltochelatase; K03795 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50.	0.726

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