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pfp pfp nifJ nifJ MaeB MaeB purU purU hisC hisC pfkA pfkA EFB33499.1 EFB33499.1 pflB pflB pflA pflA FumA FumA GltD_2 GltD_2 EFB33029.1 EFB33029.1 EFB33058.1 EFB33058.1 EFB33059.1 EFB33059.1 fba fba tpiA tpiA NagB_1 NagB_1 nagB nagB AnsB AnsB AspA_3 AspA_3 manA manA PheA PheA gap gap rpe rpe GlkA GlkA gdhA gdhA AspC AspC AnsA AnsA glmS glmS glnA glnA ScpC ScpC IolC_2 IolC_2 FrdB FrdB EFB31978.1 EFB31978.1 sdhA sdhA sdhC sdhC EFB31995.1 EFB31995.1 deoC deoC IolC_1 IolC_1 gpmI gpmI ackA ackA pta pta dacA dacA Acs Acs PuuR PuuR EFB31784.1 EFB31784.1 argR argR prs prs pgk pgk PorC PorC EFB31422.1 EFB31422.1 PorA_1 PorA_1 EFB31424.1 EFB31424.1 pgi pgi asnA asnA Mdh Mdh gltA gltA EFB31009.1 EFB31009.1 pyk pyk rpiB rpiB Tkt Tkt ppdK ppdK PgcA PgcA pckA pckA eno eno
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pfpDiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (573 aa)
nifJPyruvate synthase; KEGG: bfs:BF3168 0. nifJ; putative pyruvate-flavodoxin oxidoreductase K03737; Psort location: Cytoplasmic, score: 8.96. (1196 aa)
MaeBPhosphate acetyl/butyryl transferase; KEGG: bfs:BF3408 0. maeB; putative NADP-dependent malic enzyme K00029; Psort location: Cytoplasmic, score: 8.96. (762 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa)
hisCKEGG: bth:BT0202 2.0e-94 histidinol-phosphate aminotransferase K00817; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (344 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa)
EFB33499.1HMGL-like protein; KEGG: bfr:BF2937 1.6e-172 pyruvate carboxylase subunit B K01960; Psort location: CytoplasmicMembrane, score: 9.96. (616 aa)
pflBKEGG: efa:EF1613 5.7e-271 pflB; formate acetyltransferase K00656; Psort location: Cytoplasmic, score: 9.26. (749 aa)
pflAPyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (261 aa)
FumAHydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (551 aa)
GltD_2Putative glutamate synthase (NADPH), homotetrameric; KEGG: tte:TTE0693 1.6e-94 gltD2; NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00266; Psort location: Cytoplasmic, score: 9.97. (459 aa)
EFB33029.1Aminotransferase, class I/II; KEGG: bfr:BF0595 3.0e-155 aspartate aminotransferase K00812. (379 aa)
EFB33058.12-oxoacid:acceptor oxidoreductase, alpha subunit; KEGG: bth:BT2836 1.2e-208 korA; 2-oxoglutarate synthase subunit korA K00174; Psort location: Cytoplasmic, score: 8.96. (615 aa)
EFB33059.1Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; KEGG: bth:BT2837 2.9e-141 korB; 2-oxoglutarate synthase subunit korB K00175. (334 aa)
fbaKEGG: bth:BT1691 1.9e-128 fructose-bisphosphate aldolase, class II K01624; Psort location: Cytoplasmic, score: 8.96. (336 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (687 aa)
NagB_1Putative glucosamine-6-phosphate deaminase; KEGG: bfr:BF3116 1.8e-267 glucosamine-6-phosphate isomerase K02564. (662 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. (262 aa)
AnsBL-asparaginase, type II; KEGG: aha:AHA_3828 4.6e-104 L-asparaginase, type II K01424; Psort location: Periplasmic, score: 9.44; Belongs to the asparaginase 1 family. (349 aa)
AspA_3KEGG: psp:PSPPH_5133 2.7e-145 aspA; aspartate ammonia-lyase K01744; Psort location: Cytoplasmic, score: 9.26. (470 aa)
manAKEGG: bth:BT0373 5.7e-81 mannose-6-phosphate isomerase K01809; Psort location: Cytoplasmic, score: 8.96. (330 aa)
PheAPrephenate dehydratase; KEGG: bfs:BF3715 2.7e-90 putative prefrenate dehydratase K04518; Psort location: Cytoplasmic, score: 9.26. (277 aa)
gapKEGG: fth:FTH_1121 6.9e-117 gapA; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) K00134; Psort location: Cytoplasmic, score: 9.97. (342 aa)
rpeKEGG: pgi:PG1595 1.9e-73 rpe; ribulose-phosphate 3-epimerase K01783; Psort location: Cytoplasmic, score: 8.96. (217 aa)
GlkAROK family protein; KEGG: bfs:BF0512 2.6e-108 putative ROK family transcriptional repressor K00845; Psort location: Cytoplasmic, score: 9.26. (344 aa)
gdhAKEGG: bth:BT1970 4.9e-194 glutamate dehydrogenase K00262; Psort location: Cytoplasmic, score: 9.26; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (443 aa)
AspCAminotransferase, class I/II; KEGG: bth:BT1476 4.8e-187 aspartate aminotransferase K00812. (402 aa)
AnsAL-asparaginase, type I; KEGG: bth:BT0526 5.8e-104 L-asparaginase I K01424; Psort location: Cytoplasmic, score: 9.97. (351 aa)
glmSGlutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (614 aa)
glnAGlutamate--ammonia ligase, catalytic domain protein; KEGG: bth:BT0543 1.4e-301 glutamine synthetase K01915; Psort location: Cytoplasmic, score: 8.96. (729 aa)
ScpCKEGG: bfs:BF0025 1.7e-136 putative CoA transferase K01041; Psort location: Cytoplasmic, score: 8.96. (496 aa)
IolC_2Kinase, PfkB family; KEGG: bth:BT1757 9.2e-106 fructokinase K00847. (293 aa)
FrdBKEGG: bfs:BF4341 1.0e-106 fumarate reductase iron-sulfur protein K00240; Psort location: Cytoplasmic, score: 8.96. (252 aa)
EFB31978.1S23 ribosomal protein. (117 aa)
sdhAKEGG: bth:BT3054 0. succinate dehydrogenase flavoprotein subunit K00239. (660 aa)
sdhCSuccinate dehydrogenase cytochrome B subunit, b558 family; KEGG: bfs:BF4339 1.2e-73 fumarate reductase transmembrane cytochrome b subunit K00241; Psort location: CytoplasmicMembrane, score: 10.00. (234 aa)
EFB31995.1Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (123 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (313 aa)
IolC_1Kinase, PfkB family; KEGG: bfr:BF0171 4.1e-87 fructokinase K00847. (311 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (507 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa)
ptaKEGG: bth:BT3692 3.3e-124 phosphate acetyltransferase K00625; Psort location: Cytoplasmic, score: 8.96. (340 aa)
dacATIGR00159 family protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (259 aa)
AcsAMP-binding enzyme; KEGG: bfr:BF0528 1.8e-210 acetyl-coenzyme A synthetase K01895; Psort location: Cytoplasmic, score: 9.26. (569 aa)
PuuRCupin domain protein; KEGG: psp:PSPPH_2917 5.0e-11 DNA-binding protein K00517. (184 aa)
EFB31784.1PspC domain protein. (71 aa)
argRArginine repressor, C-terminal domain protein; Regulates arginine biosynthesis genes. (157 aa)
prsRibose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (312 aa)
pgkKEGG: bfr:BF3269 1.3e-156 phosphoglycerate kinase K00927; Psort location: Cytoplasmic, score: 9.26. (444 aa)
PorC2-oxoacid:ferredoxin/flavodoxin oxidoreductase, gamma subunit; KEGG: bth:BT0329 1.4e-70 vorA; ketoisovalerate oxidoreductase subunit vorA K00186. (178 aa)
EFB31422.1Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; KEGG: bth:BT0330 1.3e-104 vorA; ketoisovalerate oxidoreductase subunit vorA K00186. (255 aa)
PorA_13-methyl-2-oxobutanoate dehydrogenase (ferredoxin); KEGG: bfr:BF1648 6.7e-142 vorB; ketoisovalerate oxidoreductase subunit VorB K00174; Psort location: Cytoplasmic, score: 8.96. (363 aa)
EFB31424.14Fe-4S binding domain protein; KEGG: bfr:BF1649 2.3e-22 hypothetical protein K00176. (76 aa)
pgiKEGG: bfr:BF3812 7.3e-184 glucose-6-phosphate isomerase K01810; Psort location: Cytoplasmic, score: 9.26; Belongs to the GPI family. (448 aa)
asnAAspartate--ammonia ligase; KEGG: bfs:BF3607 6.2e-139 asnA; asparagine synthetase AsnA K01914; Psort location: Cytoplasmic, score: 9.97. (346 aa)
MdhLactate/malate dehydrogenase, NAD binding domain protein; KEGG: pgi:PG1949 1.1e-107 mdh; malate dehydrogenase K00026; Psort location: Cytoplasmic, score: 9.26; Belongs to the LDH/MDH superfamily. (358 aa)
gltAKEGG: bth:BT4310 1.2e-291 NADPH-dependent glutamate synthase small chain K00266; Psort location: Cytoplasmic, score: 9.97. (767 aa)
EFB31009.1Proposed homoserine kinase; KEGG: bth:BT2402 1.8e-134 phosphoglycerate mutase K01834. (409 aa)
pykPyruvate kinase; KEGG: bth:BT2841 9.7e-150 pyruvate kinase K00873; Psort location: Cytoplasmic, score: 8.96. (495 aa)
rpiBKEGG: bth:BT0346 6.4e-50 ribose 5-phosphate isomerase B K01808; Psort location: Cytoplasmic, score: 8.96. (147 aa)
TktTransketolase, thiamine diphosphate binding domain protein; KEGG: bth:BT0347 1.4e-276 transketolase K00615; Belongs to the transketolase family. (674 aa)
ppdKKEGG: bfs:BF2567 0. ppdK; pyruvate phosphate dikinase K01006; Psort location: Cytoplasmic, score: 9.97; Belongs to the PEP-utilizing enzyme family. (906 aa)
PgcAPhosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; KEGG: bth:BT1548 1.4e-228 phosphoglucomutase phosphomannomutase K01840. (602 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (537 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (435 aa)
Your Current Organism:
Prevotella oris
NCBI taxonomy Id: 649760
Other names: P. oris F0302, Prevotella oris F0302, Prevotella oris str. F0302, Prevotella oris strain F0302
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