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| | Acs | AMP-binding enzyme; KEGG: bfr:BF0528 1.8e-210 acetyl-coenzyme A synthetase K01895; Psort location: Cytoplasmic, score: 9.26. (569 aa) |
| | metA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (305 aa) |
| | thrS | threonine--tRNA ligase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (649 aa) |
| | def | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (187 aa) |
| | PhnP | Metallo-beta-lactamase domain protein; KEGG: gbe:GbCGDNIH1_1079 4.7e-31 metal-dependent hydrolase; Psort location: Cytoplasmic, score: 8.96. (255 aa) |
| | murB | UDP-N-acetylmuramate dehydrogenase; Cell wall formation. (350 aa) |
| | pheS | phenylalanine--tRNA ligase, alpha subunit; KEGG: bth:BT1669 3.8e-139 phenylalanyl-tRNA synthetase alpha chain K01889; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (346 aa) |
| | infC | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (231 aa) |
| | rpmI | Ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (65 aa) |
| | rplT | Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (114 aa) |
| | lepA | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (597 aa) |
| | pheT | phenylalanine--tRNA ligase, beta subunit; KEGG: bfr:BF2565 2.6e-291 phenylalanyl-tRNA synthetase beta chain K01890; Psort location: Cytoplasmic, score: 9.97. (822 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (535 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa) |
| | LysC | Amino acid kinase family; KEGG: bth:BT1375 2.7e-170 aspartokinase K00928; Belongs to the aspartokinase family. (440 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (386 aa) |
| | hisC | KEGG: bth:BT0202 2.0e-94 histidinol-phosphate aminotransferase K00817; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (344 aa) |
| | YvqK | ATP:cob(I)alamin adenosyltransferase; KEGG: ptr:452403 4.9e-20 LOC452403; similar to MMAB protein K00798; Psort location: Cytoplasmic, score: 8.96; Belongs to the Cob(I)alamin adenosyltransferase family. (165 aa) |
| | EFB33402.1 | Hypothetical protein; KEGG: dra:DR0966 1.2e-09 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; Psort location: Cytoplasmic, score: 8.96. (60 aa) |
| | smpB | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (159 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (194 aa) |
| | rplY | Ribosomal protein L25, Ctc-form; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (204 aa) |
| | pth | aminoacyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (190 aa) |
| | nadE | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (642 aa) |
| | QueA_1 | Putative S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (416 aa) |
| | EFB33442.1 | Von Willebrand factor type A domain protein; KEGG: eci:UTI89_C2553 1.3e-05 yfbK; hypothetical protein YfbK; Psort location: CytoplasmicMembrane, score: 9.46. (342 aa) |
| | EFB33443.1 | Von Willebrand factor type A domain protein; KEGG: mka:MK0192 0.0024 chlI, chlD; Mg-chelatase subunit ChlI and Chld (MoxR-like ATPase and vWF domain) K03404:K03405; Psort location: CytoplasmicMembrane, score: 9.46. (332 aa) |
| | rpsP | Ribosomal protein S16; KEGG: eci:UTI89_C0735 3.5e-06 tolA; membrane spanning protein TolA K03646; Belongs to the bacterial ribosomal protein bS16 family. (182 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (323 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (528 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (178 aa) |
| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (172 aa) |
| | atpE | ATP synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (80 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (348 aa) |
| | AtpC | ATP synthase, delta/epsilon subunit, beta-sandwich domain protein; KEGG: bth:BT0712 6.5e-18 ATP synthase epsilon chain K02114; Psort location: Cytoplasmic, score: 8.96. (80 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (508 aa) |
| | rplM | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (153 aa) |
| | rpsI | Ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (128 aa) |
| | rpsB | Ribosomal protein S2; KEGG: cps:CPS_4524 0.0048 surA; peptidyl-prolyl cis-trans isomerase SurA K03771; Psort location: Cytoplasmic, score: 8.96; Belongs to the universal ribosomal protein uS2 family. (290 aa) |
| | tsf | Translation elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (331 aa) |
| | LYS1 | KEGG: dvu:DVU0418 1.7e-129 lys1; saccharopine dehydrogenase K00290. (412 aa) |
| | ilvA | KEGG: tma:TM0356 1.5e-103 threonine dehydratase catabolic K01754; Psort location: Cytoplasmic, score: 8.96. (407 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (335 aa) |
| | nadK | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (276 aa) |
| | EFB33112.1 | Hypothetical protein. (339 aa) |
| | ilvE | Branched-chain-amino-acid transaminase; KEGG: bth:BT3892 4.1e-142 branched-chain amino acid aminotransferase K00826. (342 aa) |
| | purT | Putative phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (387 aa) |
| | folA | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (160 aa) |
| | EFB33219.1 | Thiamine diphosphokinase; KEGG: hpa:HPAG1_1222 5.9e-24 hypothetical protein K00949. (230 aa) |
| | folB | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (126 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (857 aa) |
| | EFB33260.1 | Putative UMP kinase; KEGG: bth:BT2242 9.9e-22 uridylate kinase K00947. (64 aa) |
| | pyrH | UMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (235 aa) |
| | mrdA | Penicillin-binding protein 2; KEGG: cph:Cpha266_0817 8.7e-78 peptidoglycan glycosyltransferase K05364; Psort location: CytoplasmicMembrane, score: 8.02. (616 aa) |
| | PurH_1 | MGS-like domain protein; KEGG: bth:BT3812 7.5e-72 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase. (197 aa) |
| | GltD_2 | Putative glutamate synthase (NADPH), homotetrameric; KEGG: tte:TTE0693 1.6e-94 gltD2; NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00266; Psort location: Cytoplasmic, score: 9.97. (459 aa) |
| | ribB | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (403 aa) |
| | hpt | KEGG: bth:BT4386 5.2e-64 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (190 aa) |
| | PurH_2 | AICARFT/IMPCHase bienzyme; KEGG: dme:Dmel_CG11089 9.4e-120 CG11089 K00602:K01492. (393 aa) |
| | rplS | Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (135 aa) |
| | aroA | Putative 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (412 aa) |
| | folE | GTP cyclohydrolase I; KEGG: bfs:BF3727 1.7e-74 folE, mtrA; GTP cyclohydrolase I K01495; Psort location: Cytoplasmic, score: 8.96. (197 aa) |
| | uppP | Putative undecaprenyl-diphosphatase UppP; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (276 aa) |
| | QueA_2 | Putative S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (388 aa) |
| | folK | KEGG: bth:BT3216 5.2e-32 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine K00950. (144 aa) |
| | cbiX | KEGG: mja:MJ0970 6.6e-09 putative sirohydrochlorin cobaltochelatase K03795; Psort location: Cytoplasmic, score: 8.96. (298 aa) |
| | mtnN | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (213 aa) |
| | rpsO | Ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa) |
| | EFB32910.1 | KEGG: tel:tlr1749 7.1e-67 fus; translation elongation factor EF-G K02355; Psort location: Cytoplasmic, score: 9.97. (641 aa) |
| | EFB32913.1 | Hypothetical protein; KEGG: chu:CHU_1297 0.0066 dfr; dihydrofolate reductase family protein K00287. (137 aa) |
| | rplQ | Ribosomal protein L17. (161 aa) |
| | rpsD | Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (201 aa) |
| | rpsK | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa) |
| | rpsM | 30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (126 aa) |
| | rpmJ | Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (38 aa) |
| | infA | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa) |
| | rplO | Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (148 aa) |
| | rpmD | Ribosomal protein L30. (58 aa) |
| | rpsE | Ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (170 aa) |
| | rplR | Ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (114 aa) |
| | rplF | Ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (195 aa) |
| | rpsH | Ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (131 aa) |
| | rpsN | Ribosomal protein S14p/S29e; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (100 aa) |
| | rplE | Ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (184 aa) |
| | rplX | Ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (105 aa) |
| | rplN | Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (121 aa) |
| | rpsQ | 30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (88 aa) |
| | rpmC | Ribosomal protein L29; Psort location: Cytoplasmic, score: 8.96; Belongs to the universal ribosomal protein uL29 family. (64 aa) |
| | rplP | Ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (142 aa) |
| | rpsC | Ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (252 aa) |
| | rplV | Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (134 aa) |
| | rpsS | Ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (89 aa) |
| | rplB | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (275 aa) |
| | rplW | Ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (97 aa) |
| | rplD | 50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (209 aa) |
| | rplC | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (204 aa) |
| | rpsJ | Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (101 aa) |
| | fusA | Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...] (704 aa) |
| | rpsG | Ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (158 aa) |
| | rpsL | Ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (127 aa) |
| | NanA | Dihydrodipicolinate synthetase family; KEGG: bfs:BF1712 5.5e-131 putative N-acetylneuraminate lyase K01639; Psort location: Cytoplasmic, score: 8.96; Belongs to the DapA family. (306 aa) |
| | serB | KEGG: bth:BT0832 1.6e-156 putative phosphoserine phosphatase K01079:K07166; Psort location: Cytoplasmic, score: 8.96. (414 aa) |
| | alaS | alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (887 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (494 aa) |
| | EFB32646.1 | Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (221 aa) |
| | cobU | Adenosylcobinamide kinase/adenosylcobinamidephosphate guanylyltransferase; KEGG: bfs:BF2518 4.8e-61 cobP; bifunctional cobalamin biosynthesis protein K02231; Psort location: Cytoplasmic, score: 8.96. (175 aa) |
| | cobT | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (345 aa) |
| | cobS | Cobalamin-5-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (267 aa) |
| | cobC | Alpha-ribazole phosphatase; KEGG: lil:LA4206 2.6e-21 gpmA; phosphoglycerate mutase K01834. (178 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (292 aa) |
| | TyrA | Hypothetical protein; KEGG: bth:BT3933 1.9e-98 tyrA; prephenate dehydrogenase / chorismate mutase K00210:K01850. (261 aa) |
| | DapL | Aminotransferase, class I/II; KEGG: bth:BT3935 6.9e-140 putative aminotransferase. (386 aa) |
| | PheA | Prephenate dehydratase; KEGG: bfs:BF3715 2.7e-90 putative prefrenate dehydratase K04518; Psort location: Cytoplasmic, score: 9.26. (277 aa) |
| | QueG | Putative iron-sulfur cluster-binding protein. (340 aa) |
| | purD | KEGG: bfs:BF0096 1.2e-160 purD; putative phosphoribosylamine--glycine ligase K01945; Psort location: Cytoplasmic, score: 8.96; Belongs to the GARS family. (422 aa) |
| | CysE | Putative serine O-acetyltransferase; KEGG: bth:BT3256 1.0e-106 serine acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. (313 aa) |
| | EFB32609.1 | Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (264 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (158 aa) |
| | EFB32544.1 | Hypothetical protein. (218 aa) |
| | EFB32546.1 | KEGG: bth:BT4258 6.9e-37 putative 5-formyltetrahydrofolate cyclo-ligase K01934; Psort location: Cytoplasmic, score: 8.96. (176 aa) |
| | EFB32307.1 | Bacterial transferase hexapeptide repeat protein; KEGG: ath:At1g55920 1.7e-17 F14J16.18; serine O-acetyltransferase, putative K00640; Psort location: Cytoplasmic, score: 9.26. (192 aa) |
| | thiL | Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (372 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. (514 aa) |
| | trpC | KEGG: bfs:BF2676 5.1e-57 trpC; indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 8.96. (272 aa) |
| | trpF | KEGG: bfr:BF2655 3.4e-35 putative N-(5'-phosphoribosyl)anthranilate isomerase K01817; Psort location: Cytoplasmic, score: 8.96; Belongs to the TrpF family. (237 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (326 aa) |
| | prfC | Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (528 aa) |
| | serC | Putative phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (357 aa) |
| | pdxB | 4-phosphoerythronate dehydrogenase; KEGG: bfs:BF2073 6.2e-116 serA; putative D-3-phosphoglycerate dehydrogenase K00058; Psort location: Cytoplasmic, score: 9.97; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (307 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (375 aa) |
| | glnS | glutamine--tRNA ligase; KEGG: bfs:BF2773 6.7e-229 glnS; glutaminyl-tRNA synthetase K01886; Psort location: Cytoplasmic, score: 8.96. (573 aa) |
| | mltG | YceG family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (399 aa) |
| | ribE | KEGG: bth:BT1317 3.9e-82 riboflavin synthase alpha chain K00793. (250 aa) |
| | CoaW | Putative pantothenate kinase; Similar to putative CG5725-PE protein; KEGG: saa:SAUSA300_2084 4.7e-15 coaA; pantothenate kinase K00867. (275 aa) |
| | ileS | isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1211 aa) |
| | coaBC | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (396 aa) |
| | rpmA | Ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (95 aa) |
| | rplU | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (105 aa) |
| | EFB32499.1 | Metallo-beta-lactamase domain protein; KEGG: fnu:FN0900 2.5e-32 metal dependent hydrolase; Psort location: Cytoplasmic, score: 8.96. (290 aa) |
| | PurF | Class II glutamine amidotransferase; KEGG: chu:CHU_2612 6.2e-155 purF; amidophosphoribosyltransferase K00764; Psort location: Cytoplasmic, score: 8.96. (628 aa) |
| | carA | Carbamoyl-phosphate synthase, small subunit; KEGG: bfr:BF2636 1.0e-161 glutamine-hydrolyzing carbamoyl phosphate synthetase III K01956; Psort location: Cytoplasmic, score: 8.96; Belongs to the CarA family. (358 aa) |
| | HemN_2 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (350 aa) |
| | FusA_1 | KEGG: bth:BT2167 0. elongation factor EF-G K02355; Psort location: Cytoplasmic, score: 9.97. (720 aa) |
| | rpsF | Ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (114 aa) |
| | rpsR | Ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (90 aa) |
| | rplI | Ribosomal protein L9; Binds to the 23S rRNA. (172 aa) |
| | ThiD | KEGG: bth:BT0790 1.0e-39 phosphomethylpyrimidine kinase K00877:K00941; Psort location: Cytoplasmic, score: 8.96. (317 aa) |
| | pdxS | Pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (293 aa) |
| | pdxT | Pyridoxal 5'-phosphate synthase, glutaminase subunit Pdx2; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (189 aa) |
| | aspS | aspartate--tRNA ligase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (585 aa) |
| | EFB32218.1 | Hypothetical protein. (404 aa) |
| | metG | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (687 aa) |
| | hemN | Coproporphyrinogen dehydrogenase; KEGG: bfr:BF1914 2.9e-141 putative oxygen-independent coproporphyrinogen III oxidase K02495; Psort location: Cytoplasmic, score: 9.97; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (454 aa) |
| | hemG | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (461 aa) |
| | tyrS | tyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (443 aa) |
| | hemD | KEGG: chu:CHU_0169 1.0e-58 hemD; uroporphyrinogen-III synthase K01719. (248 aa) |
| | ribD | Riboflavin biosynthesis protein RibD; KEGG: bth:BT3728 7.3e-81 ribD; 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase K00082:K01498; Psort location: Cytoplasmic, score: 8.96. (318 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (399 aa) |
| | lgt | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (306 aa) |
| | dapB | KEGG: bth:BT3320 3.1e-89 dihydrodipicolinate reductase K00215; Belongs to the DapB family. (251 aa) |
| | EFB31969.1 | WbqC-like protein. (216 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (144 aa) |
| | EFB31995.1 | Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (123 aa) |
| | apt | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (176 aa) |
| | EFB32040.1 | Ketopantoate reductase PanE/ApbA; KEGG: pho:PH1390 9.1e-07 2-dehydropantoate 2-reductase K00077; Psort location: Cytoplasmic, score: 8.96. (321 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (175 aa) |
| | speA | Arginine 2-monooxygenase; Catalyzes the biosynthesis of agmatine from arginine. (630 aa) |
| | ribF | Riboflavin biosynthesis protein RibF; KEGG: bfr:BF4346 8.0e-75 putative riboflavin kinase K00861:K00953; Belongs to the ribF family. (313 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (153 aa) |
| | YafQ | Addiction module toxin, RelE/StbE family. (91 aa) |
| | murC | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (459 aa) |
| | murG | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (368 aa) |
| | murD | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (443 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (422 aa) |
| | murE | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (483 aa) |
| | PenA | Penicillin-binding protein, transpeptidase domain protein; KEGG: bfr:BF0311 7.8e-196 penicillin-binding protein K03587; Psort location: CytoplasmicMembrane, score: 8.02. (719 aa) |
| | infB | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (916 aa) |
| | rpsT | Ribosomal protein S20; Binds directly to 16S ribosomal RNA. (84 aa) |
| | dut | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (146 aa) |
| | prfB | Putative peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (378 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa) |
| | dacA | TIGR00159 family protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (259 aa) |
| | folP | KEGG: bth:BT3646 3.4e-76 dihydropteroate synthase K00796; Psort location: Cytoplasmic, score: 8.96. (325 aa) |
| | murF | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (438 aa) |
| | efp | Translation elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (188 aa) |
| | ddl | D-ala D-ala ligase N-terminal domain protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (331 aa) |
| | argR | Arginine repressor, C-terminal domain protein; Regulates arginine biosynthesis genes. (157 aa) |
| | rplL | Ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (125 aa) |
| | rplJ | Ribosomal protein L10; Psort location: Cytoplasmic, score: 8.96. (172 aa) |
| | rplA | Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (230 aa) |
| | rplK | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (146 aa) |
| | tuf | Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (398 aa) |
| | rpsU | Ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (63 aa) |
| | gltX | glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (505 aa) |
| | nspC | KEGG: hpa:HPAG1_0020 6.4e-82 carboxynorspermidine decarboxylase K01618. (388 aa) |
| | queC | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (217 aa) |
| | EFB31481.1 | Hypothetical protein. (304 aa) |
| | RpsA | Putative ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (593 aa) |
| | YihX | HAD hydrolase, family IA, variant 3; KEGG: xla:447032 2.0e-10 ephx2-prov; epoxide hydrolase 2, cytoplasmic K08726. (211 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (272 aa) |
| | EFB31544.1 | Hypothetical protein. (506 aa) |
| | lysS | lysine--tRNA ligase; KEGG: bth:BT2122 7.1e-241 lysyl-tRNA synthetase K04567; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-II aminoacyl-tRNA synthetase family. (579 aa) |
| | YhhQ | Putative membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (242 aa) |
| | queF | preQ(1) synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (155 aa) |
| | EFB31437.1 | Hypothetical protein. (550 aa) |
| | PyrC | Amidohydrolase family protein; KEGG: bth:BT0250 4.0e-128 dihydroorotase (DHOase) K01465; Psort location: Cytoplasmic, score: 8.96. (443 aa) |
| | asnA | Aspartate--ammonia ligase; KEGG: bfs:BF3607 6.2e-139 asnA; asparagine synthetase AsnA K01914; Psort location: Cytoplasmic, score: 9.97. (346 aa) |
| | purB | Adenylosuccinate lyase; KEGG: bfs:BF3792 5.8e-191 purB; adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 8.96. (448 aa) |
| | asnS | asparagine--tRNA ligase; KEGG: bfs:BF3790 2.1e-179 asnS, tss; asparaginyl-tRNA synthetase K01893; Psort location: Cytoplasmic, score: 9.26. (463 aa) |
| | trpS | tryptophan--tRNA ligase; KEGG: bfs:BF3809 3.3e-133 trpS; tryptophanyl-tRNA synthetase K01867; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-I aminoacyl-tRNA synthetase family. (361 aa) |
| | cysK | Cysteine synthase A; KEGG: bth:BT3080 7.9e-116 cysteine synthase A K01738; Belongs to the cysteine synthase/cystathionine beta- synthase family. (315 aa) |
| | udk | Uridine kinase; KEGG: bth:BT0184 1.8e-70 uridine kinase K00876; Psort location: Cytoplasmic, score: 8.96. (212 aa) |
| | rpmE | Ribosomal protein L31. (83 aa) |
| | TrpB | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (452 aa) |
| | greA | Prokaryotic transcription elongation factor, GreA/GreB domain protein; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (156 aa) |
| | frr | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (186 aa) |
| | YgaD | Competence/damage-inducible domain protein CinA; Belongs to the CinA family. (166 aa) |
| | rpmB | Ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (87 aa) |
| | rpmG | Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (62 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (285 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (114 aa) |
| | gltA | KEGG: bth:BT4310 1.2e-291 NADPH-dependent glutamate synthase small chain K00266; Psort location: Cytoplasmic, score: 9.97. (767 aa) |
| | serS | serine--tRNA ligase; KEGG: bfs:BF0928 1.8e-157 serS; seryl-tRNA synthetase K01875; Psort location: Cytoplasmic, score: 9.97. (430 aa) |
| | EFB31098.1 | Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; KEGG: hch:HCH_06267 1.6e-07 folK2; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950; Psort location: Cytoplasmic, score: 8.96. (126 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (425 aa) |
| | hisS | histidine--tRNA ligase; KEGG: bfr:BF3416 4.4e-193 histidyl-tRNA synthetase K01892; Psort location: Cytoplasmic, score: 9.97. (454 aa) |
| | folC | Bifunctional protein FolC; KEGG: bfs:BF2850 8.2e-121 putative folylpolyglutamate synthase K01930; Belongs to the folylpolyglutamate synthase family. (428 aa) |
| | thrC | Threonine synthase; KEGG: bfs:BF0560 8.7e-165 thrC; threonine synthase K01733. (433 aa) |
| | ThrA | Homoserine dehydrogenase; KEGG: bfs:BF0558 3.1e-295 thrA; putative aspartokinase I-homoserine dehydrogenase K00003:K00928. (811 aa) |
| | valS | valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (898 aa) |
| | mtgA | Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (244 aa) |
| | proS | proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (493 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (163 aa) |
| | pyrB | KEGG: bth:BT0742 3.4e-131 aspartate carbamoyltransferase catalytic chain K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (333 aa) |
| | MrcA_1 | Transglycosylase; KEGG: bfs:BF2276 2.4e-256 putative penicillin-binding peptidoglycan biosynthesis-related exported protein K05366; Psort location: CytoplasmicMembrane, score: 9.98. (770 aa) |
| | EFB30879.1 | Hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (294 aa) |
| | EFB30885.1 | Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (364 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (349 aa) |
| | pyrF | KEGG: bfr:BF0909 1.4e-107 orotidine 5'-phosphate decarboxylase K01591; Psort location: Cytoplasmic, score: 8.96; Belongs to the OMP decarboxylase family. Type 2 subfamily. (274 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (370 aa) |
| | PurM | KEGG: bfr:BF0911 6.7e-174 putative phosphoribosylformylglycinamidine cyclo-ligase K01933; Psort location: Cytoplasmic, score: 8.96. (405 aa) |
| | AroE | KEGG: bfs:BF0838 4.4e-83 aroE; putative shikimate 5-dehydrogenase K00014; Psort location: Cytoplasmic, score: 8.96. (248 aa) |
| | purC | KEGG: bth:BT4217 2.6e-124 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 8.96; Belongs to the SAICAR synthetase family. (316 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa) |
| | EFB30930.1 | Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (472 aa) |
| | Upp | KEGG: bth:BT2791 2.7e-74 uracil phosphoribosyltransferase K00761. (219 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (278 aa) |
| | ilvD | KEGG: bfs:BF3551 3.1e-247 ilvD; dihydroxy-acid dehydratase K01687; Belongs to the IlvD/Edd family. (623 aa) |
| | ilvB | Acetolactate synthase, large subunit, biosynthetic type; KEGG: bfs:BF3550 3.0e-203 ilvB; putative acetolactate synthase large subunit K01652; Psort location: Cytoplasmic, score: 8.96. (571 aa) |
| | ilvN | KEGG: bth:BT2076 1.9e-50 acetohydroxyacid synthase small subunit K01653; Psort location: Cytoplasmic, score: 8.96. (185 aa) |
| | ilvC | KEGG: bfs:BF3546 5.1e-144 putative reductoisomerase K00053. (347 aa) |
| | argS | arginine--tRNA ligase; KEGG: bfr:BF4421 2.7e-234 arginyl-tRNA synthetase K01887; Psort location: Cytoplasmic, score: 9.26. (641 aa) |
| | cysS | cysteine--tRNA ligase; KEGG: bfr:BF0196 1.4e-164 cysteinyl-tRNA synthetase K01883; Psort location: Cytoplasmic, score: 9.97. (421 aa) |
| | EFB30733.1 | HAD phosphoserine phosphatase-like hydrolase, family IB; KEGG: ctc:CTC01739 7.6e-15 phosphoserine phosphatase K01079; Psort location: Cytoplasmic, score: 8.96. (195 aa) |
| | PdxK | KEGG: cac:CAC1622 6.3e-43 pyridoxal kinase related protein K00868. (272 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (210 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (204 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (436 aa) |
| | leuS | leucine--tRNA ligase; KEGG: bfr:BF4586 0. leucyl-tRNA synthetase K01869; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-I aminoacyl-tRNA synthetase family. (968 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (359 aa) |
| | pyrD | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate. (301 aa) |
| | PyrK | Oxidoreductase NAD-binding domain protein; KEGG: bcl:ABC2332 1.8e-36 pyrDII; dihydroorotate dehydrogenase electron transfer subunit K02823; Psort location: Cytoplasmic, score: 9.97. (258 aa) |
| | nrdG | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (171 aa) |
| | AguA_2 | Putative phage virion morphogenesis protein; KEGG: spd:SPD_0814 2.9e-47 agmatine deiminase; Psort location: Cytoplasmic, score: 8.96. (342 aa) |
| | EFB30540.1 | Hypothetical protein. (205 aa) |
| | pdxA | Pyridoxal phosphate biosynthetic protein PdxA; KEGG: bth:BT4374 1.1e-93 4-hydroxythreonine-4-phosphate dehydrogenase K00097; Psort location: Cytoplasmic, score: 8.96; Belongs to the PdxA family. (361 aa) |
| | QueD | Putative queuosine biosynthesis protein QueD; KEGG: bth:BT4453 1.7e-35 6-pyruvoyl-tetrahydropterin synthase K01737; Psort location: Cytoplasmic, score: 8.96. (111 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (190 aa) |
| | purL | Putative phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1242 aa) |
| | Ddh | Diaminopimelate dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. (299 aa) |
| | YjiA | CobW/P47K family protein; KEGG: ftf:FTF1000c 3.9e-59 cobS; cobalamin (vitamin B12) synthesis protein/P47K family protein; Psort location: Cytoplasmic, score: 8.96. (416 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (626 aa) |
| | glyS | glycine--tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (517 aa) |
| | EFB30426.1 | Hypothetical protein; KEGG: sce:YNL250W 8.5e-05 RAD50; coiled-coil protein, contains a purine-binding domain, two heptad repeats and a hydrophobic tail; Psort location: CytoplasmicMembrane, score: 9.46. (558 aa) |
