STRINGSTRING
ADU64942.1 ADU64942.1 ADU65040.1 ADU65040.1 ADU65129.1 ADU65129.1 ADU65155.1 ADU65155.1 ADU65171.1 ADU65171.1 ADU65215.1 ADU65215.1 hslU hslU hslV hslV clpP clpP clpX clpX ADU65425.1 ADU65425.1 ADU65426.1 ADU65426.1 alaS alaS groS groS groL groL ADU65543.1 ADU65543.1 msrA msrA ADU65579.1 ADU65579.1 ADU65599.1 ADU65599.1 ADU65648.1 ADU65648.1 ADU65765.1 ADU65765.1 clpS clpS ADU65836.1 ADU65836.1 ADU65946.1 ADU65946.1 clpB clpB ADU66067.1 ADU66067.1 ADU66068.1 ADU66068.1 ADU66093.1 ADU66093.1 ADU66141.1 ADU66141.1 ADU66176.1 ADU66176.1 ADU66254.1 ADU66254.1 ADU66388.1 ADU66388.1 ADU66497.1 ADU66497.1 ADU66661.1 ADU66661.1 ADU66662.1 ADU66662.1 ADU66680.1 ADU66680.1 ADU66785.1 ADU66785.1 ADU66830.1 ADU66830.1 ADU67096.1 ADU67096.1 htpG htpG dnaJ dnaJ dnaK dnaK grpE grpE hrcA hrcA ADU67137.1 ADU67137.1 lon lon ADU67139.1 ADU67139.1 ADU67140.1 ADU67140.1 ADU67318.1 ADU67318.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADU64942.1KEGG: dma:DMR_21430 hypothetical protein; PFAM: heat shock protein DnaJ domain protein; SMART: heat shock protein DnaJ domain protein. (242 aa)
ADU65040.1PFAM: PhoP regulatory network protein YrbL; KEGG: dap:Dacet_2166 PhoP regulatory network protein YrbL. (221 aa)
ADU65129.1TIGRFAM: redox-active disulfide protein 2; KEGG: ank:AnaeK_4013 redox-active disulfide protein 2. (77 aa)
ADU65155.1AAA ATPase central domain protein; KEGG: psa:PST_3455 ATPase of the AAA+ class; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. (699 aa)
ADU65171.1PFAM: FxsA cytoplasmic membrane protein; KEGG: dsa:Desal_0708 FxsA cytoplasmic membrane protein. (163 aa)
ADU65215.1PFAM: Tetratricopeptide TPR_1 repeat-containing protein; KEGG: ttr:Tter_0083 tetratricopeptide TPR_2 repeat protein. (495 aa)
hslUHeat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (441 aa)
hslV20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (175 aa)
clpPATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (196 aa)
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (429 aa)
ADU65425.1PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; KEGG: srm:SRM_03035 thiol:disulfide interchange protein DsbD. (159 aa)
ADU65426.1PFAM: alpha/beta hydrolase fold; KEGG: gsu:GSU3157 alpha/beta fold family hydrolase. (257 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (893 aa)
groSChaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (96 aa)
groLChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (549 aa)
ADU65543.1PFAM: Redoxin domain protein; KEGG: tal:Thal_0395 redoxin domain protein. (185 aa)
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (188 aa)
ADU65579.1KEGG: gme:Gmet_1933 heat shock protein DnaJ-like; PFAM: heat shock protein DnaJ domain protein; SMART: heat shock protein DnaJ domain protein. (100 aa)
ADU65599.1PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Peroxiredoxin-like; KEGG: ddf:DEFDS_0018 peroxiredoxin. (193 aa)
ADU65648.1KEGG: dvm:DvMF_2121 2-alkenal reductase; PFAM: peptidase S1 and S6 chymotrypsin/Hap; SMART: PDZ/DHR/GLGF domain protein. (472 aa)
ADU65765.1Peptidylprolyl isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (186 aa)
clpSATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (100 aa)
ADU65836.1TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; Clp ATPase-like; KEGG: drt:Dret_1366 ATP-dependent Clp protease, ATP-binding subunit ClpA; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. (747 aa)
ADU65946.1KEGG: gem:GM21_3712 tetratricopeptide TPR_2 repeat protein. (274 aa)
clpBATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (862 aa)
ADU66067.1PFAM: heat shock protein Hsp20; KEGG: sfu:Sfum_1743 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family. (125 aa)
ADU66068.1PFAM: heat shock protein Hsp20; KEGG: rba:RB10279 HSP20 family protein; Belongs to the small heat shock protein (HSP20) family. (141 aa)
ADU66093.1PFAM: Heat shock protein 70; KEGG: toc:Toce_0909 chaperone protein DnaK. (499 aa)
ADU66141.1PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: gur:Gura_1595 NADH:flavin oxidoreductase/NADH oxidase. (995 aa)
ADU66176.1PFAM: StbA family protein; KEGG: sat:SYN_01836 MreB-like ATPase involved in cell division. (318 aa)
ADU66254.1TIGRFAM: methionine-R-sulfoxide reductase; KEGG: nwa:Nwat_2816 methionine-R-sulfoxide reductase; PFAM: Methionine sulfoxide reductase B; Belongs to the MsrB Met sulfoxide reductase family. (132 aa)
ADU66388.1PFAM: glutaredoxin; KEGG: bph:Bphy_5356 glutaredoxin 3. (88 aa)
ADU66497.1SMART: PDZ/DHR/GLGF domain protein; TIGRFAM: protease Do; KEGG: gur:Gura_4295 protease Do; PFAM: peptidase S1 and S6 chymotrypsin/Hap; PDZ/DHR/GLGF domain protein. (463 aa)
ADU66661.1PFAM: heat shock protein Hsp20; KEGG: wsu:WS1299 hypothetical protein; Belongs to the small heat shock protein (HSP20) family. (140 aa)
ADU66662.1PFAM: heat shock protein Hsp20; KEGG: nis:NIS_1628 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family. (148 aa)
ADU66680.1Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (725 aa)
ADU66785.1KEGG: jan:Jann_0877 hypothetical protein. (156 aa)
ADU66830.1KEGG: ttr:Tter_0083 tetratricopeptide TPR_2 repeat protein; PFAM: Tetratricopeptide TPR_1 repeat-containing protein; SMART: Tetratricopeptide repeat. (1017 aa)
ADU67096.1SMART: PDZ/DHR/GLGF domain protein; KEGG: pen:PSEEN2126 hypothetical protein. (274 aa)
htpGHeat shock protein Hsp90-like protein; Molecular chaperone. Has ATPase activity. (632 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (376 aa)
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (646 aa)
grpEGrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (174 aa)
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (340 aa)
ADU67137.1PFAM: heat shock protein Hsp20; KEGG: gbm:Gbem_0603 heat shock protein Hsp20; Belongs to the small heat shock protein (HSP20) family. (140 aa)
lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (827 aa)
ADU67139.1PFAM: Protein of unknown function DUF2062; KEGG: gbm:Gbem_3780 uncharacterized protein-like protein. (172 aa)
ADU67140.1KEGG: dak:DaAHT2_2396 ATP-binding protein. (311 aa)
ADU67318.1KEGG: dak:DaAHT2_0417 rhodanese domain protein; PFAM: Rhodanese domain protein; SMART: Rhodanese domain protein. (389 aa)
Your Current Organism:
Desulfurispirillum indicum
NCBI taxonomy Id: 653733
Other names: D. indicum S5, Desulfurispirillum indicum S5, Desulfurispirillum indicum str. S5, Desulfurispirillum indicum strain S5, bacterium S5, dissimilatory selenate-respiring bacterium S5
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