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rplI rplI fusA fusA rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsH rpsH rplF rplF rplR rplR rpsE rpsE ADU65106.1 ADU65106.1 rplO rplO secY secY infA infA rpmJ rpmJ rpsM rpsM rpsK rpsK rpsD rpsD rplQ rplQ tig tig rpmF rpmF rpsR rpsR ADU65471.1 ADU65471.1 rpmH rpmH gltX gltX rpsU rpsU map map ADU66299.1 ADU66299.1 rpsT rpsT rpmB rpmB tsf tsf rplL rplL rplJ rplJ rplA rplA rplK rplK rpmG rpmG tuf tuf rplM rplM rplU rplU rpmA rpmA rpmE rpmE rpmI rpmI rplT rplT rpsP rpsP rplS rplS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rplIRibosomal protein L9; Binds to the 23S rRNA. (148 aa)
fusATranslation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...] (691 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (209 aa)
rplDRibosomal protein L4/L1e; Forms part of the polypeptide exit tunnel. (207 aa)
rplWRibosomal protein L25/L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (94 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (274 aa)
rpsSRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplVRibosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (109 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (230 aa)
rplPRibosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (141 aa)
rpmCRibosomal protein L29; KEGG: clj:CLJU_c40960 50S ribosomal protein L29; TIGRFAM: ribosomal protein L29; PFAM: ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (65 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (87 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplXRibosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (106 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (133 aa)
rplFRibosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (180 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (121 aa)
rpsERibosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (167 aa)
ADU65106.1KEGG: slg:SLGD_00790 LSU ribosomal protein L30p (L7e); TIGRFAM: ribosomal protein L30; PFAM: ribosomal protein L30. (62 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
secYPreprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (433 aa)
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa)
rpmJKEGG: ddf:DEFDS_1749 50S ribosomal protein L36; TIGRFAM: ribosomal protein L36; PFAM: ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (120 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (127 aa)
rpsDRibosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (208 aa)
rplQKEGG: ddf:DEFDS_1744 50S ribosomal protein L17; TIGRFAM: ribosomal protein L17; PFAM: ribosomal protein L17. (139 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (443 aa)
rpmFKEGG: pca:Pcar_1434 50S ribosomal protein L32; TIGRFAM: ribosomal protein L32; PFAM: ribosomal L32p protein; Belongs to the bacterial ribosomal protein bL32 family. (59 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (123 aa)
ADU65471.1RNA binding S1 domain protein; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (544 aa)
rpmHKEGG: bcl:ABC4121 50S ribosomal protein L34; TIGRFAM: ribosomal protein L34; PFAM: ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (45 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (480 aa)
rpsUKEGG: dap:Dacet_2801 30S ribosomal protein S21; TIGRFAM: ribosomal protein S21; PFAM: ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (70 aa)
mapMethionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (259 aa)
ADU66299.1PFAM: protein of unknown function DUF448; ribosomal protein L7Ae/L30e/S12e/Gadd45; KEGG: gem:GM21_2982 protein of unknown function DUF448. (195 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (90 aa)
rpmBRibosomal protein L28; Manually curated; TIGRFAM: ribosomal protein L28; KEGG: afw:Anae109_2515 50S ribosomal protein L28; PFAM: ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (61 aa)
tsfTranslation elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (292 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (126 aa)
rplJRibosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (175 aa)
rplARibosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (230 aa)
rplKRibosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
rpmGKEGG: dap:Dacet_0358 50S ribosomal protein L33; TIGRFAM: ribosomal protein L33; PFAM: ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
tufTranslation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (395 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (141 aa)
rplURibosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa)
rpmAKEGG: hba:Hbal_0168 ribosomal protein L27; TIGRFAM: ribosomal protein L27; PFAM: ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (90 aa)
rpmERibosomal protein L31; Binds the 23S rRNA. (68 aa)
rpmIKEGG: pca:Pcar_1420 ribosomal protein L35; TIGRFAM: ribosomal protein L35; PFAM: Ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
rplTRibosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (117 aa)
rpsPKEGG: afl:Aflv_1764 30S ribosomal protein S16; TIGRFAM: ribosomal protein S16; PFAM: ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (95 aa)
rplSRibosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (117 aa)
Your Current Organism:
Desulfurispirillum indicum
NCBI taxonomy Id: 653733
Other names: D. indicum S5, Desulfurispirillum indicum S5, Desulfurispirillum indicum str. S5, Desulfurispirillum indicum strain S5, bacterium S5, dissimilatory selenate-respiring bacterium S5
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