STRINGSTRING
uvrB uvrB ADU64761.1 ADU64761.1 ADU64994.1 ADU64994.1 uvrA uvrA ADU64995.1 ADU64995.1 ADU64997.1 ADU64997.1 ADU65160.1 ADU65160.1 ADU65214.1 ADU65214.1 ADU65225.1 ADU65225.1 ADU65226.1 ADU65226.1 rph rph ADU65306.1 ADU65306.1 rnc rnc ADU65402.1 ADU65402.1 ADU65410.1 ADU65410.1 ADU65415.1 ADU65415.1 xseA xseA ADU65529.1 ADU65529.1 mutS2 mutS2 rnpA rnpA ADU65641.1 ADU65641.1 ADU65663.1 ADU65663.1 cas1 cas1 ADU65672.1 ADU65672.1 rnj rnj ADU67287.1 ADU67287.1 ADU65719.1 ADU65719.1 ADU65762.1 ADU65762.1 ADU65766.1 ADU65766.1 ADU65767.1 ADU65767.1 ADU67288.1 ADU67288.1 ADU65769.1 ADU65769.1 cas1-2 cas1-2 cas2 cas2 ADU65780.1 ADU65780.1 ADU65805.1 ADU65805.1 uvrC uvrC rnr rnr ruvC ruvC ybeY ybeY ADU66162.1 ADU66162.1 ADU66224.1 ADU66224.1 ADU66244.1 ADU66244.1 nfo nfo xseB xseB polA polA ADU66398.1 ADU66398.1 ADU66433.1 ADU66433.1 rnhA rnhA ADU66807.1 ADU66807.1 rnhB rnhB ADU66891.1 ADU66891.1 ADU67004.1 ADU67004.1 ADU67060.1 ADU67060.1 ADU67092.1 ADU67092.1 ADU67097.1 ADU67097.1 ADU67125.1 ADU67125.1 ADU67127.1 ADU67127.1 rny rny ADU67203.1 ADU67203.1 ADU67235.1 ADU67235.1 ADU67236.1 ADU67236.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (660 aa)
ADU64761.1DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (368 aa)
ADU64994.1Hypothetical protein; Manually curated; KEGG: mgm:Mmc1_2781 hypothetical protein. (309 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (941 aa)
ADU64995.1KEGG: mgm:Mmc1_2698 hypothetical protein. (328 aa)
ADU64997.1PFAM: protein of unknown function DUF86; KEGG: mrb:Mrub_1240 hypothetical protein. (122 aa)
ADU65160.1PFAM: protein of unknown function DUF86; KEGG: gem:GM21_1251 protein of unknown function DUF86. (115 aa)
ADU65214.1PFAM: protein of unknown function DUF523; protein of unknown function DUF1722; KEGG: nth:Nther_2140 protein of unknown function DUF1722. (308 aa)
ADU65225.1Holliday junction resolvase YqgF; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (152 aa)
ADU65226.1KEGG: neu:NE1223 putative transposase. (343 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (244 aa)
ADU65306.1Hydrolase, TatD family; KEGG: seu:SEQ_0330 TatD related DNase; TIGRFAM: hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease. (263 aa)
rncRibonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (247 aa)
ADU65402.1KEGG: aeh:Mlg_0311 hypothetical protein. (290 aa)
ADU65410.1Hypothetical protein; KEGG: saf:SULAZ_0572 cytotoxic translational repressor of toxin-antitoxin system RelE. (107 aa)
ADU65415.1KEGG: pmy:Pmen_4544 DNA polymerase III subunit epsilon; PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease. (250 aa)
xseAExodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (469 aa)
ADU65529.1KEGG: hor:Hore_12210 single-stranded-DNA-specific exonuclease RecJ; TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1. (558 aa)
mutS2MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (785 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (117 aa)
ADU65641.1KEGG: dde:Dde_2388 3'-5' exonuclease; PFAM: 3'-5' exonuclease; SMART: 3'-5' exonuclease. (213 aa)
ADU65663.1KEGG: ypb:YPTS_2599 CRISPR-associated Csy4 family protein; TIGRFAM: CRISPR-associated protein, Csy4 family; PFAM: CRISPR-associated protein Csy4. (182 aa)
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (325 aa)
ADU65672.1PFAM: Exonuclease RNase T and DNA polymerase III; KEGG: glo:Glov_2482 DNA-directed DNA polymerase; SMART: Exonuclease. (169 aa)
rnjRNA-metabolising metallo-beta-lactamase; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (581 aa)
ADU67287.1DNA polymerase III, alpha subunit; SMART: phosphoesterase PHP domain protein; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: pca:Pcar_1222 DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type. (1163 aa)
ADU65719.1Addiction module toxin, RelE/StbE family; KEGG: abc:ACICU_p0010 cytotoxic translational repressor of toxin-antitoxin stability system; TIGRFAM: addiction module toxin, RelE/StbE family; PFAM: plasmid stabilization system. (99 aa)
ADU65762.1TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; nucleic acid binding OB-fold tRNA/helicase-type; KEGG: sat:SYN_02192 HD-superfamily hydrolase; SMART: metal-dependent phosphohydrolase HD region. (375 aa)
ADU65766.1KEGG: dol:Dole_0747 hypothetical protein. (273 aa)
ADU65767.1TIGRFAM: CRISPR-associated protein, Csm1 family; KEGG: tye:THEYE_A0633 CRISPR-associated protein, Csm1 family. (922 aa)
ADU67288.1KEGG: rsk:RSKD131_4108 3'-5' exonuclease; PFAM: Tetratricopeptide TPR_1 repeat-containing protein; SMART: Tetratricopeptide repeat. (372 aa)
ADU65769.1KEGG: tye:THEYE_A0635 CRISPR-associated RAMP protein, Csm3 family; TIGRFAM: CRISPR-associated RAMP protein, Csm3 family; PFAM: protein of unknown function DUF324. (245 aa)
cas1-2CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (333 aa)
cas2CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (91 aa)
ADU65780.1KEGG: ava:Ava_4177 hypothetical protein. (90 aa)
ADU65805.1KEGG: wsu:WS0596 DNA polymerase III subunit epsilon; PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease. (206 aa)
uvrCExcinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (604 aa)
rnrRibonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (747 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (171 aa)
ybeYProtein of unknown function UPF0054; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (152 aa)
ADU66162.1KEGG: noc:Noc_0626 hypothetical protein. (184 aa)
ADU66224.1KEGG: ppu:PP_3375 deoxyribonuclease I; PFAM: Endonuclease I. (312 aa)
ADU66244.1Ribonuclease, Rne/Rng family; KEGG: gur:Gura_0301 ribonuclease; TIGRFAM: ribonuclease, Rne/Rng family; PFAM: RNA-binding protein AU-1/Ribonuclease E/G; RNA binding S1 domain protein. (501 aa)
nfoApurinic endonuclease Apn1; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (283 aa)
xseBExonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (77 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (881 aa)
ADU66398.1KEGG: alv:Alvin_2062 exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase. (272 aa)
ADU66433.1KEGG: dol:Dole_2728 hypothetical protein. (364 aa)
rnhARibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (152 aa)
ADU66807.1PFAM: Smr protein/MutS2; KEGG: fnu:FN1563 hypothetical protein. (149 aa)
rnhBRibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (201 aa)
ADU66891.1KEGG: oih:OB1057 hypothetical protein; PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease. (166 aa)
ADU67004.1KEGG: rcp:RCAP_rcc00930 hypothetical protein. (93 aa)
ADU67060.1KEGG: dhd:Dhaf_0643 protein of unknown function DUF262; manually curated; PFAM: protein of unknown function DUF262. (349 aa)
ADU67092.1KEGG: syp:SYNPCC7002_A1133 hypothetical protein. (248 aa)
ADU67097.1PFAM: HNH endonuclease; KEGG: avn:Avin_48770 hypothetical protein. (251 aa)
ADU67125.1KEGG: hha:Hhal_2065 hypothetical protein. (426 aa)
ADU67127.1PFAM: domain of unknown function DUF1732; YicC-like domain-containing protein; KEGG: dal:Dalk_1930 YicC domain protein. (297 aa)
rnyYmdA/YtgF protein; Endoribonuclease that initiates mRNA decay. (518 aa)
ADU67203.1KEGG: mgm:Mmc1_2863 hypothetical protein. (327 aa)
ADU67235.1PFAM: UvrD/REP helicase; KEGG: noc:Noc_0988 UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1123 aa)
ADU67236.1TIGRFAM: putative DNA repair protein; KEGG: nwa:Nwat_2049 putative DNA repair protein. (915 aa)
Your Current Organism:
Desulfurispirillum indicum
NCBI taxonomy Id: 653733
Other names: D. indicum S5, Desulfurispirillum indicum S5, Desulfurispirillum indicum str. S5, Desulfurispirillum indicum strain S5, bacterium S5, dissimilatory selenate-respiring bacterium S5
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