STRINGSTRING
ARN79859.1 ARN79859.1 ARN79968.1 ARN79968.1 secE secE ARN80030.1 ARN80030.1 ARN83298.1 ARN83298.1 ARN80125.1 ARN80125.1 ARN80185.1 ARN80185.1 yidC yidC ARN80349.1 ARN80349.1 ffh ffh trpE trpE ARN80421.1 ARN80421.1 ARN80436.1 ARN80436.1 ARN80437.1 ARN80437.1 ARN80438.1 ARN80438.1 ARN83374.1 ARN83374.1 ARN83375.1 ARN83375.1 ribA-2 ribA-2 ARN80658.1 ARN80658.1 ARN80774.1 ARN80774.1 ARN80786.1 ARN80786.1 ARN83449.1 ARN83449.1 ARN81151.1 ARN81151.1 yajC yajC secD secD secA secA ARN83529.1 ARN83529.1 ARN83532.1 ARN83532.1 ARN83578.1 ARN83578.1 ARN81681.1 ARN81681.1 secB secB ARN81733.1 ARN81733.1 ARN81802.1 ARN81802.1 ARN81909.1 ARN81909.1 ARN81919.1 ARN81919.1 ARN83670.1 ARN83670.1 ARN82083.1 ARN82083.1 ARN82105.1 ARN82105.1 ARN82121.1 ARN82121.1 secY secY ARN82322.1 ARN82322.1 ARN82341.1 ARN82341.1 ARN82496.1 ARN82496.1 ARN82497.1 ARN82497.1 ARN82498.1 ARN82498.1 ARN82499.1 ARN82499.1 ARN82501.1 ARN82501.1 ARN82502.1 ARN82502.1 ARN82503.1 ARN82503.1 ARN82504.1 ARN82504.1 ARN82826.1 ARN82826.1 ARN82827.1 ARN82827.1 ARN82829.1 ARN82829.1 ARN83807.1 ARN83807.1 ARN82877.1 ARN82877.1 ARN82941.1 ARN82941.1 ARN82974.1 ARN82974.1 ftsY ftsY hfq hfq
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARN79859.1Cyclic nucleotide-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
ARN79968.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
secEPreprotein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (63 aa)
ARN80030.1Fur family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Fur family. (144 aa)
ARN83298.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (718 aa)
ARN80125.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (441 aa)
ARN80185.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
yidCMembrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (601 aa)
ARN80349.1long-chain-fatty-acid--CoA ligase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. (556 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] (516 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (504 aa)
ARN80421.1Aminodeoxychorismate/anthranilate synthase component II; Derived by automated computational analysis using gene prediction method: Protein Homology. (204 aa)
ARN80436.1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
ARN80437.1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
ARN80438.1Branched-chain amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. (355 aa)
ARN83374.1Branched-chain amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. (299 aa)
ARN83375.1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
ribA-2GTP cyclohydrolase; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (360 aa)
ARN80658.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (520 aa)
ARN80774.1ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (613 aa)
ARN80786.1RND transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (510 aa)
ARN83449.1Crp/Fnr family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
ARN81151.1Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (246 aa)
yajCPreprotein translocase subunit YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (224 aa)
secDProtein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (528 aa)
secAPreprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (940 aa)
ARN83529.1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
ARN83532.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (501 aa)
ARN83578.1RND transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (523 aa)
ARN81681.1ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (618 aa)
secBProtein-export chaperone SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (164 aa)
ARN81733.1Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (267 aa)
ARN81802.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
ARN81909.1Amino acid transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (517 aa)
ARN81919.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (246 aa)
ARN83670.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa)
ARN82083.1ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (617 aa)
ARN82105.1Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (728 aa)
ARN82121.1Long-chain fatty acid--CoA ligase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. (563 aa)
secYPreprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (446 aa)
ARN82322.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (741 aa)
ARN82341.13-deoxy-7-phosphoheptulonate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
ARN82496.1P-type conjugative transfer ATPase TrbB; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
ARN82497.1Conjugal transfer protein TrbC; Derived by automated computational analysis using gene prediction method: Protein Homology. (113 aa)
ARN82498.1Conjugal transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (91 aa)
ARN82499.1Conjugal transfer protein TrbE; Type IV secretion system VirB4 family; Derived by automated computational analysis using gene prediction method: Protein Homology. (812 aa)
ARN82501.1P-type conjugative transfer protein TrbL; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa)
ARN82502.1Conjugal transfer protein TrbF; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
ARN82503.1P-type conjugative transfer protein TrbG; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
ARN82504.1Conjugal transfer protein TraI; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
ARN82826.1Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (449 aa)
ARN82827.1DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
ARN82829.1DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
ARN83807.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
ARN82877.1Crp/Fnr family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
ARN82941.1Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (371 aa)
ARN82974.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa)
ftsYSignal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (363 aa)
hfqRNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (86 aa)
Your Current Organism:
Methylocystis bryophila
NCBI taxonomy Id: 655015
Other names: DSM 21852, M. bryophila, Methylocystis bryophila Belova et al. 2013, Methylocystis sp. H2s, Methylocystis sp. S284, VKM B-2545, strain H2s
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