Uncharacterized protein.

Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.

Uncharacterized protein.

Telomere-binding alpha subunit central domain-containing protein.

Uncharacterized protein.

Putative RAD50 protein.

Uncharacterized protein.

NhRAD6-like protein; Belongs to the ubiquitin-conjugating enzyme family.

Uncharacterized protein.

HD domain-containing protein.

Uncharacterized protein.

DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.

Uncharacterized protein.

Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.

Uncharacterized protein.

Phosphatidylinositol 3; Belongs to the PI3/PI4-kinase family.

Uncharacterized protein.

Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.

Uncharacterized protein.

DNA helicase; Belongs to the MCM family.

Uncharacterized protein.

HD domain-containing protein.

Uncharacterized protein.

Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.

Uncharacterized protein.

ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase.

Uncharacterized protein.

DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.

Uncharacterized protein.

DNA replication factor Dna2.

Uncharacterized protein.

Checkpoint protein; Belongs to the HUS1 family.

Uncharacterized protein.

Ku70 protein.

Uncharacterized protein.

Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.

Uncharacterized protein.

Uncharacterized protein.

Uncharacterized protein.

DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]