(19 nodes) Mixed, incl. Vitamin B6 metabolism, and Uracil/uridine/allantoin permease network (Metarhizium acridum)

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Your Input:
	MAC_01186	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] (350 aa)
	MAC_01187	Fungal specific transcription factor domain-containing protein. (541 aa)
	MAC_01423	Uracil permease. (393 aa)
	MAC_01565	Nmt1 protein. (342 aa)
	MAC_01787	Thiamin pyrophosphokinase-related protein. (322 aa)
	MAC_02895	Uracil permease. (550 aa)
	MAC_02916	Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. (287 aa)
	MAC_03178	Aldo/keto reductase, putative. (332 aa)
	MAC_03210	Thiamine pyrophosphokinase. (333 aa)
	MAC_03808	Aldo/keto reductase, putative. (332 aa)
	MAC_05278	Uncharacterized protein. (274 aa)
	MAC_05514	Uncharacterized protein. (157 aa)
	MAC_05709	Uracil permease, putative. (324 aa)
	MAC_06382	Pyridoxamine 5'-phosphate oxidase. (249 aa)
	MAC_06751	Pyridox_oxase_2 domain-containing protein. (264 aa)
	MAC_07473	Pyridoxine. (228 aa)
	MAC_07474	Pyridoxine biosynthesis protein PDX1; Belongs to the PdxS/SNZ family. (310 aa)
	MAC_08993	Uncharacterized protein. (154 aa)
	MAC_09554	Aromatic amino acid aminotransferase. (500 aa)

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAC_01186	MAC_01565	E9DU88	E9DVB7	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	Nmt1 protein.	0.840
MAC_01186	MAC_03210	E9DU88	E9E012	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	Thiamine pyrophosphokinase.	0.654
MAC_01186	MAC_05278	E9DU88	E9E5Y0	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	Uncharacterized protein.	0.863
MAC_01186	MAC_07473	E9DU88	E9EC75	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	Pyridoxine.	0.497
MAC_01187	MAC_05709	E9DU89	E9E761	Fungal specific transcription factor domain-containing protein.	Uracil permease, putative.	0.742
MAC_01565	MAC_01186	E9DVB7	E9DU88	Nmt1 protein.	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	0.840
MAC_01565	MAC_06382	E9DVB7	E9E934	Nmt1 protein.	Pyridoxamine 5'-phosphate oxidase.	0.800
MAC_01565	MAC_06751	E9DVB7	E9EA53	Nmt1 protein.	Pyridox_oxase_2 domain-containing protein.	0.800
MAC_01565	MAC_07473	E9DVB7	E9EC75	Nmt1 protein.	Pyridoxine.	0.811
MAC_01565	MAC_07474	E9DVB7	E9EC76	Nmt1 protein.	Pyridoxine biosynthesis protein PDX1; Belongs to the PdxS/SNZ family.	0.858
MAC_01787	MAC_05278	E9DVY9	E9E5Y0	Thiamin pyrophosphokinase-related protein.	Uncharacterized protein.	0.419
MAC_02916	MAC_06382	E9DZ68	E9E934	Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6.	Pyridoxamine 5'-phosphate oxidase.	0.633
MAC_02916	MAC_09554	E9DZ68	E9EI56	Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6.	Aromatic amino acid aminotransferase.	0.438
MAC_03178	MAC_03808	E9DZY0	E9E1V3	Aldo/keto reductase, putative.	Aldo/keto reductase, putative.	0.904
MAC_03178	MAC_06382	E9DZY0	E9E934	Aldo/keto reductase, putative.	Pyridoxamine 5'-phosphate oxidase.	0.901
MAC_03178	MAC_06751	E9DZY0	E9EA53	Aldo/keto reductase, putative.	Pyridox_oxase_2 domain-containing protein.	0.900
MAC_03210	MAC_01186	E9E012	E9DU88	Thiamine pyrophosphokinase.	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	0.654
MAC_03210	MAC_05278	E9E012	E9E5Y0	Thiamine pyrophosphokinase.	Uncharacterized protein.	0.778
MAC_03808	MAC_03178	E9E1V3	E9DZY0	Aldo/keto reductase, putative.	Aldo/keto reductase, putative.	0.904
MAC_03808	MAC_06382	E9E1V3	E9E934	Aldo/keto reductase, putative.	Pyridoxamine 5'-phosphate oxidase.	0.901