(30 nodes) Mitochondrial genome maintenance network (Metarhizium acridum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	MAC_09745	ATP-dependent DNA helicase; Belongs to the helicase family. (1946 aa)
	MAC_06898	Calcium-binding mitochondrial carrier protein Aralar2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (257 aa)
	MAC_06354	ATP-dependent DNA helicase; Belongs to the helicase family. (644 aa)
	MDM10	Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...] (544 aa)
	MAC_05393	Uncharacterized protein. (788 aa)
	MAC_05331	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1139 aa)
	MAC_05033	Uncharacterized protein. (189 aa)
	MAC_04796	Mitochondrial genome maintenance protein MGM101. (285 aa)
	MAC_04649	DNA ligase. (871 aa)
	MAC_04169	HMG box protein. (315 aa)
	MAC_03805	Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family. (401 aa)
	MDM34	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. (552 aa)
	MAC_03374	Mitochondrial import inner membrane translocase subunit TIM17. (194 aa)
	MAC_02925	Mitochondrial escape protein 2. (878 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (915 aa)
	MAC_02542	DNA polymerase gamma. (1090 aa)
	MAC_02406	Mitochondrial dynamin GTPase (Msp1), putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (920 aa)
	MMM1	Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...] (397 aa)
	MAC_01367	Mitochondrial DnaJ chaperone (Mdj1), putative. (870 aa)
	MAC_01036	MutS2 protein. (1057 aa)
	MAC_00609	SsDNA binding protein. (137 aa)
	MAC_00256	ATP-dependent RNA helicase SUV3. (717 aa)
	MAC_00170	Mitochondrial import inner membrane translocase subunit TIM17. (145 aa)
	MAC_07086	Heat shock protein 78; Belongs to the ClpA/ClpB family. (789 aa)
	MAC_07337	UV-endonuclease UVE-1. (587 aa)
	MAC_07742	Uncharacterized protein. (140 aa)
	MAC_07952	Mitochondrial carrier protein RIM2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (397 aa)
	MAC_08476	Protein kinase domain-containing protein. (634 aa)
	MAC_09570	DEAD/DEAH box helicase. (585 aa)
	MAC_09744	Putative replicase/helicase/endonuclease. (1668 aa)

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAC_00609	MAC_02542	E9DSL1	E9DY44	SsDNA binding protein.	DNA polymerase gamma.	0.682
MAC_00609	MAC_04796	E9DSL1	E9E4J8	SsDNA binding protein.	Mitochondrial genome maintenance protein MGM101.	0.524
MAC_00609	MAC_07086	E9DSL1	E9EB38	SsDNA binding protein.	Heat shock protein 78; Belongs to the ClpA/ClpB family.	0.437
MAC_01367	MAC_07086	E9DUR9	E9EB38	Mitochondrial DnaJ chaperone (Mdj1), putative.	Heat shock protein 78; Belongs to the ClpA/ClpB family.	0.765
MAC_02542	MAC_00609	E9DY44	E9DSL1	DNA polymerase gamma.	SsDNA binding protein.	0.682
MAC_04796	MAC_00609	E9E4J8	E9DSL1	Mitochondrial genome maintenance protein MGM101.	SsDNA binding protein.	0.524
MAC_04796	MDM10	E9E4J8	E9E6C2	Mitochondrial genome maintenance protein MGM101.	Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...]	0.560
MAC_04796	MDM34	E9E4J8	E9E1G8	Mitochondrial genome maintenance protein MGM101.	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	0.495
MAC_04796	MMM1	E9E4J8	E9DW90	Mitochondrial genome maintenance protein MGM101.	Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...]	0.427
MAC_05393	MDM10	E9E695	E9E6C2	Uncharacterized protein.	Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...]	0.663
MAC_05393	MDM34	E9E695	E9E1G8	Uncharacterized protein.	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	0.525
MAC_05393	MMM1	E9E695	E9DW90	Uncharacterized protein.	Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...]	0.655
MAC_07086	MAC_00609	E9EB38	E9DSL1	Heat shock protein 78; Belongs to the ClpA/ClpB family.	SsDNA binding protein.	0.437
MAC_07086	MAC_01367	E9EB38	E9DUR9	Heat shock protein 78; Belongs to the ClpA/ClpB family.	Mitochondrial DnaJ chaperone (Mdj1), putative.	0.765
MAC_07742	MDM10	E9ECZ4	E9E6C2	Uncharacterized protein.	Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...]	0.555
MAC_07742	MMM1	E9ECZ4	E9DW90	Uncharacterized protein.	Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...]	0.579
MAC_08476	MDM10	E9EF28	E9E6C2	Protein kinase domain-containing protein.	Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...]	0.663
MAC_08476	MDM34	E9EF28	E9E1G8	Protein kinase domain-containing protein.	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	0.525
MAC_08476	MMM1	E9EF28	E9DW90	Protein kinase domain-containing protein.	Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...]	0.655
MAC_09570	MDM34	E9EI72	E9E1G8	DEAD/DEAH box helicase.	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	0.416