(91 nodes) Cellular amino acid catabolic process network (Metarhizium acridum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	MAC_00129	Dihydrolipoamide succinyltransferase, putative. (433 aa)
	MAC_00216	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (440 aa)
	MAC_00231	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (494 aa)
	MAC_00416	Aldehyde dehydrogenase. (345 aa)
	MAC_00094	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (496 aa)
	MAC_00941	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (509 aa)
	MAC_00960	Succinate-semialdehyde dehydrogenase, putative. (498 aa)
	MAC_00791	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (495 aa)
	MAC_00832	Isovaleryl-CoA dehydrogenase. (401 aa)
	MAC_00833	Methylcrotonoyl-CoA carboxylase beta chain. (569 aa)
	MAC_01307	Nucleoside-diphosphate-sugar epimerase. (322 aa)
	MAC_01431	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (345 aa)
	MAC_01544	Homogentisate 1,2-dioxygenase. (468 aa)
	MAC_01648	NAD-specific glutamate dehydrogenase; NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (1038 aa)
	MAC_01736	Aminotransferase, putative. (451 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (506 aa)
	MAC_01928	Arginase; Belongs to the arginase family. (325 aa)
	MAC_02015	4-hydroxyphenylpyruvate dioxygenase. (408 aa)
	MAC_02133	Homogentisate 1,2-dioxygenase. (502 aa)
	MAC_02287	Indoleamine 2,3-dioxygenase family protein. (278 aa)
	MAC_02349	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (502 aa)
	MAC_02369	Fe-ADH domain-containing protein. (320 aa)
	MAC_02469	Indoleamine 2,3-dioxygenase subfamily. (485 aa)
	MAC_02473	L-amino-acid oxidase. (175 aa)
	MAC_02677	Chlorocatechol 1,2-dioxygenase. (340 aa)
	MAC_03288	Uncharacterized protein. (222 aa)
	MAC_03373	L-asparaginase. (462 aa)
	MAC_03390	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (450 aa)
	MAC_03404	L-galactonate dehydratase. (451 aa)
	MAC_03417	Acetyl-hydrolase. (498 aa)
	MAC_03447	Sarcosine oxidase. (427 aa)
	MAC_03466	Alanine aminotransferase, putative. (479 aa)
	MAC_03478	Fructosyl-amino acid oxidase. (469 aa)
	MAC_03510	2-oxoisovalerate dehydrogenase beta subunit. (401 aa)
	MAC_03528	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (325 aa)
	MAC_03793	Methylmalonate semialdehyde dehydrogenase. (575 aa)
	MAC_04118	Alanine racemase. (381 aa)
	MAC_04224	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (444 aa)
	MAC_04257	Aldehyde dehydrogenase ALDH; Belongs to the aldehyde dehydrogenase family. (500 aa)
	MAC_04290	Threonine aldolase, putative. (353 aa)
	MAC_04466	Phosphoglycerate mutase family protein, putative. (199 aa)
	MAC_04483	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (384 aa)
	MAC_04485	Sarcosine oxidase, putative. (322 aa)
	MAC_04626	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (481 aa)
	MAC_04846	Homogentisate 1,2-dioxygenase, putative. (523 aa)
	MAC_04913	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (476 aa)
	MAC_05007	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (503 aa)
	MAC_04997	Ornithine aminotransferase. (445 aa)
	MAC_05187	L-asparaginase, putative. (999 aa)
	MAC_05306	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (575 aa)
	MAC_05408	Ornithine aminotransferase. (443 aa)
	MAC_05456	Maleylacetate reductase, putative. (363 aa)
	MAC_05464	Indoleamine 2,3-dioxygenase pyrrole 2,3-dioxygenase. (430 aa)
	BNA5	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (496 aa)
	MAC_05520	Threonine dehydratase. (575 aa)
	MAC_05591	Cytosolic hydroxymethyltransferase, putative. (336 aa)
	MAC_05656	Hydroxymethylglutaryl-CoA lyase. (407 aa)
	MAC_05762	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (528 aa)
	MAC_05874	Uncharacterized protein. (332 aa)
	MAC_05875	Serine family amino acid catabolism-related protein. (362 aa)
	MAC_05969	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (478 aa)
	MAC_06002	Phenylalanine ammonia-lyase. (733 aa)
	MAC_06210	Succinate-semialdehyde dehydrogenase NADP+. (113 aa)
	MAC_06209	Succinate-semialdehyde dehydrogenase. (495 aa)
	MAC_06424	APSES transcription factor Xbp1, putative. (465 aa)
	MAC_06592	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (508 aa)
	MAC_06621	Dehydrogenase; Belongs to the aldehyde dehydrogenase family. (321 aa)
	MAC_06666	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1068 aa)
	MAC_06798	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (176 aa)
	MAC_06809	Phosphoglycerate mutase family protein, putative. (166 aa)
	MAC_06834	Sarcosine oxidase. (446 aa)
	MAC_06861	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (508 aa)
	MAC_07082	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (504 aa)
	MAC_07358	Fumarylacetoacetase. (428 aa)
	MAC_07506	Serine family amino acid catabolism-related protein. (321 aa)
	MAC_07564	Fungal specific transcription factor domain protein. (645 aa)
	MAC_07808	L-allo-threonine aldolase. (355 aa)
	BNA1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (183 aa)
	MAC_08199	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa)
	MAC_08380	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. (475 aa)
	MAC_08769	Aspartate aminotransferase. (417 aa)
	MAC_08887	Esterase, putative. (352 aa)
	MAC_08888	Zn(2)-C6 fungal-type domain-containing protein. (659 aa)
	MAC_09256	Alpha/beta hydrolase domain-containing protein. (132 aa)
	MAC_09274	DAO domain-containing protein. (421 aa)
	MAC_09278	Amino_oxidase domain-containing protein. (591 aa)
	MAC_09662	Nucleoside-diphosphate-sugar epimerase, putative. (315 aa)
	MAC_09733	NAD_binding_9 domain-containing protein. (663 aa)
	MAC_09734	Uncharacterized protein. (608 aa)
	MAC_09736	Sarcosine oxidase, putative. (379 aa)
	MAC_09849	Uncharacterized protein. (199 aa)

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA1	BNA4	E9EE38	E9DW74	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.871
BNA1	BNA5	E9EE38	E9E6G7	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.990
BNA1	MAC_02469	E9EE38	E9DXX1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Indoleamine 2,3-dioxygenase subfamily.	0.497
BNA1	MAC_03528	E9EE38	E9E0Y0	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.485
BNA1	MAC_05464	E9EE38	E9E6G6	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Indoleamine 2,3-dioxygenase pyrrole 2,3-dioxygenase.	0.497
BNA4	BNA1	E9DW74	E9EE38	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.871
BNA4	BNA5	E9DW74	E9E6G7	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.996
BNA4	MAC_02469	E9DW74	E9DXX1	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Indoleamine 2,3-dioxygenase subfamily.	0.465
BNA4	MAC_03528	E9DW74	E9E0Y0	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.491
BNA4	MAC_05464	E9DW74	E9E6G6	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Indoleamine 2,3-dioxygenase pyrrole 2,3-dioxygenase.	0.465
BNA4	MAC_07358	E9DW74	E9EBW0	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Fumarylacetoacetase.	0.435
BNA5	BNA1	E9E6G7	E9EE38	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.990
BNA5	BNA4	E9E6G7	E9DW74	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.996
BNA5	MAC_01544	E9E6G7	E9DV96	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Homogentisate 1,2-dioxygenase.	0.493
BNA5	MAC_01928	E9E6G7	E9DWD0	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Arginase; Belongs to the arginase family.	0.606
BNA5	MAC_02015	E9E6G7	E9DWL7	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	4-hydroxyphenylpyruvate dioxygenase.	0.491
BNA5	MAC_02133	E9E6G7	E9DWY5	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Homogentisate 1,2-dioxygenase.	0.493
BNA5	MAC_02469	E9E6G7	E9DXX1	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Indoleamine 2,3-dioxygenase subfamily.	0.946
BNA5	MAC_03417	E9E6G7	E9E0L9	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Acetyl-hydrolase.	0.413
BNA5	MAC_03466	E9E6G7	E9E0R8	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Alanine aminotransferase, putative.	0.411