(84 nodes) Pyridoxal phosphate binding network (Metarhizium acridum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAC_00213	Cystathionine beta-lyase, putative. (577 aa)
	MAC_00338	Tyrosine decarboxylase, putative. (544 aa)
	MAC_00121	Cystathionine gamma-synthase. (597 aa)
	MAC_00580	Mitochondrial carrier protein, putative; Belongs to the mitochondrial carrier (TC 2.A.29) family. (450 aa)
	MAC_00606	5-aminolevulinate synthase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (603 aa)
	MAC_00667	Aspartate aminotransferase. (449 aa)
	MAC_00700	MOSC domain containing protein. (340 aa)
	MAC_00941	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (509 aa)
	MAC_00791	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (495 aa)
	MAC_01099	Cysteine desulfurase. (499 aa)
	MAC_01109	Cystathionine gamma-synthase, putative. (535 aa)
	MAC_01386	MOSC domain containing protein. (348 aa)
	MAC_01412	Uncharacterized protein. (131 aa)
	MAC_01636	Serine palmitoyltransferase 2. (673 aa)
	MAC_01689	Serine palmitoyltransferase 1. (516 aa)
	MAC_01735	Uncharacterized protein. (651 aa)
	MAC_01736	Aminotransferase, putative. (451 aa)
	MAC_01795	Sphingosine-1-phosphate lyase. (566 aa)
	MAC_01877	Aminotransferase, putative. (414 aa)
	MAC_02916	Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. (287 aa)
	MAC_03039	Uncharacterized protein. (696 aa)
	MAC_03466	Alanine aminotransferase, putative. (479 aa)
	MAC_03583	Threonine synthase. (537 aa)
	MAC_03761	Cystathionine beta-lyase. (410 aa)
	MAC_03820	Threonine dehydratase catabolic. (379 aa)
	MAC_03973	Aspartate aminotransferase. (553 aa)
	MAC_04021	Fungal specific transcription factor, putative. (710 aa)
	MAC_04023	Aminotransferase, putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (423 aa)
	MAC_04189	Glutamate-1-semialdehyde 2,1-aminomutase, putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (437 aa)
	MAC_04206	Cystathionine gamma-lyase. (418 aa)
	MAC_04466	Phosphoglycerate mutase family protein, putative. (199 aa)
	MAC_04497	Aminotransferase, putative. (424 aa)
	MAC_04626	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (481 aa)
	MAC_04900	Aminotran_1_2 domain-containing protein. (412 aa)
	MAC_05007	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (503 aa)
	MAC_04997	Ornithine aminotransferase. (445 aa)
	MAC_05075	Threonine dehydratase, putative. (325 aa)
	hxB	Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (777 aa)
	MAC_05400	Aspartate aminotransferase, putative. (376 aa)
	MAC_05408	Ornithine aminotransferase. (443 aa)
	BNA5	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (496 aa)
	MAC_05520	Threonine dehydratase. (575 aa)
	MAC_05549	Amidohydrolase. (485 aa)
	MAC_05591	Cytosolic hydroxymethyltransferase, putative. (336 aa)
	MAC_05608	Aminotransferase. (474 aa)
	MAC_05761	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
	MAC_05762	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (528 aa)
	MAC_05770	Aminotran_1_2 domain-containing protein. (452 aa)
	MAC_05845	Amidohydrolase. (463 aa)
	MAC_05865	Phosphoserine aminotransferase. (410 aa)
	MAC_05874	Uncharacterized protein. (332 aa)
	MAC_05875	Serine family amino acid catabolism-related protein. (362 aa)
	MAC_05903	Cysteine desulfurase. (482 aa)
	MAC_05945	1-aminocyclopropane-1-carboxylate deaminase. (380 aa)
	MAC_06189	Uncharacterized protein. (149 aa)
	MAC_06295	Penicillin-binding protein, putative. (144 aa)
	MAC_06385	Histidinol-phosphate aminotransferase. (506 aa)
	MAC_06403	Amidohydrolase. (370 aa)
	MAC_06666	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1068 aa)
	MAC_06737	Aromatic-L-amino-acid decarboxylase. (606 aa)
	MAC_06809	Phosphoglycerate mutase family protein, putative. (166 aa)
	MAC_06815	Molybdopterin cofactor sulfurase, putative. (479 aa)
	MAC_06869	Cystathionine gamma-synthase, putative. (287 aa)
	MAC_07121	L-kynurenine/alpha-aminoadipate aminotransferase, putative. (557 aa)
	MAC_07303	Uncharacterized protein. (153 aa)
	MAC_07350	Aminotransferase, putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
	MAC_07450	Glutamate decarboxylase, putative. (501 aa)
	MAC_07481	ACC synthase. (425 aa)
	MAC_07506	Serine family amino acid catabolism-related protein. (321 aa)
	MAC_07551	DUF4396 domain-containing protein. (178 aa)
	MAC_07664	DAO domain-containing protein. (496 aa)
	MAC_07898	Cystathionine beta-lyase. (448 aa)
	MAC_07927	Phosphoserine aminotransferase. (426 aa)
	MAC_08083	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (899 aa)
	MAC_08102	Fungal_trans domain-containing protein. (526 aa)
	MAC_08182	Aminotransferase. (487 aa)
	MAC_08292	1-aminocyclopropane-1-carboxylate deaminase, putative. (383 aa)
	MAC_08769	Aspartate aminotransferase. (417 aa)
	MAC_08898	Glutamate decarboxylase, putative. (529 aa)
	MAC_08901	Aspartate aminotransferase, putative. (429 aa)
	MAC_09112	Cystathionine beta-lyase, putative. (237 aa)
	MAC_09440	O-acetylhomoserin (Thiol)-lyase. (434 aa)
	MAC_09521	Pyridoxal-dependent decarboxylase domain protein. (1034 aa)
	MAC_09554	Aromatic amino acid aminotransferase. (500 aa)

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA5	MAC_01877	E9E6G7	E9DW79	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Aminotransferase, putative.	0.502
BNA5	MAC_03466	E9E6G7	E9E0R8	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Alanine aminotransferase, putative.	0.411
BNA5	MAC_03973	E9E6G7	E9E275	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Aspartate aminotransferase.	0.454
BNA5	MAC_04497	E9E6G7	E9E3Q3	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Aminotransferase, putative.	0.411
BNA5	MAC_04900	E9E6G7	E9E4V2	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Aminotran_1_2 domain-containing protein.	0.411
BNA5	MAC_05400	E9E6G7	E9E6A2	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Aspartate aminotransferase, putative.	0.502
BNA5	MAC_05549	E9E6G7	E9E6Q1	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Amidohydrolase.	0.411
BNA5	MAC_05608	E9E6G7	E9E6W0	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Aminotransferase.	0.481
BNA5	MAC_05770	E9E6G7	E9E7C2	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Aminotran_1_2 domain-containing protein.	0.948
BNA5	MAC_05845	E9E6G7	E9E7J7	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Amidohydrolase.	0.411
BNA5	MAC_06189	E9E6G7	E9E8J1	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Uncharacterized protein.	0.411
BNA5	MAC_06403	E9E6G7	E9E955	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Amidohydrolase.	0.411
BNA5	MAC_07481	E9E6G7	E9EC83	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	ACC synthase.	0.411
BNA5	MAC_08102	E9E6G7	E9EE04	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Fungal_trans domain-containing protein.	0.411
BNA5	MAC_08901	E9E6G7	E9EGA3	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Aspartate aminotransferase, putative.	0.411
MAC_00121	MAC_00213	E9DS48	E9DR44	Cystathionine gamma-synthase.	Cystathionine beta-lyase, putative.	0.908
MAC_00121	MAC_01109	E9DS48	E9DU11	Cystathionine gamma-synthase.	Cystathionine gamma-synthase, putative.	0.910
MAC_00121	MAC_03761	E9DS48	E9E1L3	Cystathionine gamma-synthase.	Cystathionine beta-lyase.	0.459
MAC_00121	MAC_03820	E9DS48	E9E1W5	Cystathionine gamma-synthase.	Threonine dehydratase catabolic.	0.817
MAC_00121	MAC_04206	E9DS48	E9E2V8	Cystathionine gamma-synthase.	Cystathionine gamma-lyase.	0.938