(51 nodes) Integral component of endoplasmic reticulum membrane network (Metarhizium acridum)

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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protein homology

Your Input:
	MAC_03436	Tubulin-tyrosine ligase. (381 aa)
	MAC_00369	Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (79 aa)
	MAC_00042	Ankyrin repeat protein. (1389 aa)
	MAC_00517	Dolichyl pyrophosphate phosphatase. (237 aa)
	MAC_00591	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (220 aa)
	MAC_00664	ER membrane protein complex subunit 4; Belongs to the EMC4 family. (167 aa)
	MAC_00743	Protein translocation protein, Sec62 family protein. (394 aa)
	MAC_01149	Delta(24(24(1)))-sterol reductase. (573 aa)
	MAC_01201	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1310 aa)
	MAC_01338	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (472 aa)
	MAC_01529	Uncharacterized protein. (153 aa)
	MAC_01690	Rhomboid protein 2. (603 aa)
	MAC_01887	CaaX prenyl proteinase Rce1. (326 aa)
	MMM1	Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...] (397 aa)
	MAC_02418	Uncharacterized protein. (251 aa)
	MAC_02426	Tetratricopeptide repeat domain-containing protein. (340 aa)
	MAC_03099	Elongation of fatty acids protein. (425 aa)
	MAC_03246	Membrane-tethered transcription factor (SPT23), putative. (471 aa)
	MAC_03345	GPI transamidase component GPI16. (585 aa)
	MAC_03350	Cytomegalovirus gH-receptor family protein, putative. (991 aa)
	MAC_03607	Phosphatidate cytidylyltransferase family protein. (626 aa)
	MAC_03679	UDP-Glc/Gal endoplasmic reticulum nucleotide sugar transporter. (413 aa)
	MAC_03698	DUF1183 domain protein. (310 aa)
	MAC_04388	Elongation of fatty acids protein. (369 aa)
	MAC_04422	EMC1_C domain-containing protein. (968 aa)
	MAC_04782	Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (85 aa)
	MAC_04925	COPII-coated vesicle protein (Erv41), putative. (372 aa)
	MAC_04939	ER membrane protein. (429 aa)
	MAC_04943	Integral ER membrane protein Scs2. (320 aa)
	MAC_05658	Uncharacterized protein. (126 aa)
	MAC_05911	Serine/threonine kinase IREI. (1259 aa)
	MAC_05925	Elongation of fatty acids protein. (344 aa)
	MAC_06032	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (456 aa)
	MAC_06156	F-box domain protein. (1174 aa)
	MAC_06373	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (389 aa)
	MAC_06374	Uncharacterized protein. (720 aa)
	MAC_06467	SUN domain-containing protein. (902 aa)
	MAC_06582	Uncharacterized protein. (112 aa)
	MAC_06970	Delta(24(24(1)))-sterol reductase, putative. (469 aa)
	MAC_07266	Putative cell division control protein CDC91. (421 aa)
	MAC_07271	Phosphoinositide phosphatase. (709 aa)
	MAC_07484	Uncharacterized protein. (212 aa)
	MAC_08293	C-14 sterol reductase, putative. (427 aa)
	MAC_08355	Intramembrane protease. (571 aa)
	MAC_08528	C-14 sterol reductase. (492 aa)
	MAC_08533	Alpha-galactosidase. (611 aa)
	MAC_08812	Endoplasmic reticulum-Golgi intermediate compartment protein 3. (356 aa)
	MAC_08936	Phosphatidate cytidylyltransferase, putative. (772 aa)
	MAC_09048	GPI transamidase component PIG-S, putative. (566 aa)
	MAC_09323	ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family. (234 aa)
	MAC_09439	DUF2012 domain-containing protein. (236 aa)

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAC_00042	MAC_01338	E9DRW9	E9DUP0	Ankyrin repeat protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.784
MAC_00369	MAC_00517	E9DRK0	E9DSB9	Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family.	Dolichyl pyrophosphate phosphatase.	0.918
MAC_00369	MAC_03607	E9DRK0	E9E159	Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family.	Phosphatidate cytidylyltransferase family protein.	0.537
MAC_00369	MAC_04782	E9DRK0	E9E4I4	Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family.	Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family.	0.992
MAC_00369	MAC_08936	E9DRK0	E9EGD8	Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family.	Phosphatidate cytidylyltransferase, putative.	0.705
MAC_00517	MAC_00369	E9DSB9	E9DRK0	Dolichyl pyrophosphate phosphatase.	Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family.	0.918
MAC_00517	MAC_04782	E9DSB9	E9E4I4	Dolichyl pyrophosphate phosphatase.	Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family.	0.928
MAC_00517	MAC_08936	E9DSB9	E9EGD8	Dolichyl pyrophosphate phosphatase.	Phosphatidate cytidylyltransferase, putative.	0.659
MAC_00591	MAC_01338	E9DSJ3	E9DUP0	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...]	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.905
MAC_00591	MAC_05925	E9DSJ3	E9E7S7	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...]	Elongation of fatty acids protein.	0.911
MAC_00664	MAC_02426	E9DSR6	E9DXS8	ER membrane protein complex subunit 4; Belongs to the EMC4 family.	Tetratricopeptide repeat domain-containing protein.	0.995
MAC_00664	MAC_04422	E9DSR6	E9E3H4	ER membrane protein complex subunit 4; Belongs to the EMC4 family.	EMC1_C domain-containing protein.	0.995
MAC_00664	MAC_09323	E9DSR6	E9EHH5	ER membrane protein complex subunit 4; Belongs to the EMC4 family.	ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family.	0.996
MAC_00664	MAC_09439	E9DSR6	E9EHU1	ER membrane protein complex subunit 4; Belongs to the EMC4 family.	DUF2012 domain-containing protein.	0.964
MAC_00743	MAC_03679	E9DSZ5	E9E1D1	Protein translocation protein, Sec62 family protein.	UDP-Glc/Gal endoplasmic reticulum nucleotide sugar transporter.	0.457
MAC_01149	MAC_06970	E9DU51	E9EAS2	Delta(24(24(1)))-sterol reductase.	Delta(24(24(1)))-sterol reductase, putative.	0.901
MAC_01149	MAC_08293	E9DU51	E9EEJ5	Delta(24(24(1)))-sterol reductase.	C-14 sterol reductase, putative.	0.788
MAC_01149	MAC_08528	E9DU51	E9EF80	Delta(24(24(1)))-sterol reductase.	C-14 sterol reductase.	0.791
MAC_01338	MAC_00042	E9DUP0	E9DRW9	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	Ankyrin repeat protein.	0.784
MAC_01338	MAC_00591	E9DUP0	E9DSJ3	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...]	0.905