(47 nodes) Ubiquitin-dependent ERAD pathway network (Metarhizium acridum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAC_06708	Proteasome-activating nucleotidase. (528 aa)
	MAC_06507	Ubiquitin fusion degradation protein Ufd1, putative. (358 aa)
	MAC_06459	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (222 aa)
	MAC_06445	N-acetyltransferase 5. (133 aa)
	MAC_05765	Putative ubiquitin fusion degradation protein 2. (1045 aa)
	MAC_04919	DnaJ domain containing protein. (415 aa)
	MAC_04639	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (1009 aa)
	MAC_04447	Uncharacterized protein. (405 aa)
	MAC_04323	ATP-dependent Zn protease. (489 aa)
	MAC_01557	Ubiquitin fusion degradation protein (Ufd1), putative. (757 aa)
	MAC_01742	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (582 aa)
	MAC_01766	Cytoskeleton assembly control protein Sla1, putative. (537 aa)
	MAC_01976	Ubiquitin conjugating enzyme (UbcA), putative; Belongs to the ubiquitin-conjugating enzyme family. (234 aa)
	MAC_02215	Dna-J like membrane chaperone protein. (360 aa)
	MAC_02364	Hsp40 co-chaperone Jid1, putative. (244 aa)
	MAC_02399	Putative non-canonical ubiquitin conjugating enzyme 1. (327 aa)
	MAC_02504	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (579 aa)
	MAC_02555	Cell division control protein Cdc48; Belongs to the AAA ATPase family. (818 aa)
	MAC_02661	Glucose-regulated protein; Belongs to the heat shock protein 70 family. (662 aa)
	MAC_03073	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (695 aa)
	MAC_03255	Uncharacterized protein. (582 aa)
	MAC_03256	Uncharacterized protein. (457 aa)
	MAC_03409	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (519 aa)
	MAC_03483	E3 ubiquitin-protein ligase. (1169 aa)
	MAC_03701	UV excision repair protein (RadW), putative. (400 aa)
	MAC_04153	NPL4 family protein. (650 aa)
	MAC_04178	Proteasome regulatory particle subunit Rpt4; Belongs to the AAA ATPase family. (391 aa)
	MAC_00132	OTU-like cysteine protease, putative. (368 aa)
	MAC_00442	E3 ubiquitin-protein ligase MARCH6. (1640 aa)
	MAC_00530	UBX domain protein, putative. (504 aa)
	MAC_00683	Ubiquitin-conjugating enzyme E2; Belongs to the ubiquitin-conjugating enzyme family. (351 aa)
	MAC_00988	Ankyrin repeat and zinc finger domain containing protein 1. (641 aa)
	MAC_00754	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (142 aa)
	MAC_01164	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (828 aa)
	MAC_01538	Ubiquitin-conjugating enzyme. (265 aa)
	MAC_09392	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (531 aa)
	MAC_08572	RING finger protein. (838 aa)
	MAC_08305	TPR Domain containing protein. (427 aa)
	MAC_07948	UBX domain protein. (537 aa)
	MAC_07887	Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
	MAC_07586	UBX domain-containing protein. (436 aa)
	MAC_07498	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (1058 aa)
	MAC_07477	Proteasome component ECM29. (1829 aa)
	MAC_07401	Ubiquitin-protein ligase Sel1/Ubx2, putative. (1047 aa)
	MAC_07352	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (600 aa)
	MAC_07341	Long chronological lifespan protein 2; Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway. (119 aa)
	MAC_07314	Protein transport protein SEC61 alpha subunit. (476 aa)

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAC_00132	MAC_00530	E9DQW3	E9DSD2	OTU-like cysteine protease, putative.	UBX domain protein, putative.	0.566
MAC_00132	MAC_01557	E9DQW3	E9DVA9	OTU-like cysteine protease, putative.	Ubiquitin fusion degradation protein (Ufd1), putative.	0.870
MAC_00132	MAC_02555	E9DQW3	E9DY57	OTU-like cysteine protease, putative.	Cell division control protein Cdc48; Belongs to the AAA ATPase family.	0.929
MAC_00132	MAC_03701	E9DQW3	E9E1F3	OTU-like cysteine protease, putative.	UV excision repair protein (RadW), putative.	0.481
MAC_00132	MAC_04153	E9DQW3	E9E2Q5	OTU-like cysteine protease, putative.	NPL4 family protein.	0.975
MAC_00132	MAC_04323	E9DQW3	E9E375	OTU-like cysteine protease, putative.	ATP-dependent Zn protease.	0.929
MAC_00132	MAC_05765	E9DQW3	E9E7B7	OTU-like cysteine protease, putative.	Putative ubiquitin fusion degradation protein 2.	0.974
MAC_00132	MAC_06507	E9DQW3	E9E9F9	OTU-like cysteine protease, putative.	Ubiquitin fusion degradation protein Ufd1, putative.	0.979
MAC_00132	MAC_06708	E9DQW3	E9EA10	OTU-like cysteine protease, putative.	Proteasome-activating nucleotidase.	0.897
MAC_00442	MAC_00754	E9DRS3	E9DTB6	E3 ubiquitin-protein ligase MARCH6.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.666
MAC_00442	MAC_01538	E9DRS3	E9DV90	E3 ubiquitin-protein ligase MARCH6.	Ubiquitin-conjugating enzyme.	0.627
MAC_00442	MAC_01766	E9DRS3	E9DVW8	E3 ubiquitin-protein ligase MARCH6.	Cytoskeleton assembly control protein Sla1, putative.	0.680
MAC_00442	MAC_01976	E9DRS3	E9DWH8	E3 ubiquitin-protein ligase MARCH6.	Ubiquitin conjugating enzyme (UbcA), putative; Belongs to the ubiquitin-conjugating enzyme family.	0.486
MAC_00442	MAC_02555	E9DRS3	E9DY57	E3 ubiquitin-protein ligase MARCH6.	Cell division control protein Cdc48; Belongs to the AAA ATPase family.	0.795
MAC_00442	MAC_03483	E9DRS3	E9E0T5	E3 ubiquitin-protein ligase MARCH6.	E3 ubiquitin-protein ligase.	0.502
MAC_00442	MAC_04153	E9DRS3	E9E2Q5	E3 ubiquitin-protein ligase MARCH6.	NPL4 family protein.	0.660
MAC_00442	MAC_04323	E9DRS3	E9E375	E3 ubiquitin-protein ligase MARCH6.	ATP-dependent Zn protease.	0.795
MAC_00442	MAC_05765	E9DRS3	E9E7B7	E3 ubiquitin-protein ligase MARCH6.	Putative ubiquitin fusion degradation protein 2.	0.499
MAC_00442	MAC_06459	E9DRS3	E9E9B1	E3 ubiquitin-protein ligase MARCH6.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.558
MAC_00442	MAC_06507	E9DRS3	E9E9F9	E3 ubiquitin-protein ligase MARCH6.	Ubiquitin fusion degradation protein Ufd1, putative.	0.675