(99 nodes) Nuclear chromosome segregation network (Metarhizium acridum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAC_07209	Uncharacterized protein. (66 aa)
	MAC_00386	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (689 aa)
	MAC_00430	Uncharacterized protein. (127 aa)
	MAC_00497	Putative nuclear protein SA-1. (1150 aa)
	MAC_00502	Uncharacterized protein. (192 aa)
	MAC_00701	Condensin subunit. (1127 aa)
	MAC_00702	Inner centromere protein. (1238 aa)
	MAC_00910	MUS38-like protein. (1227 aa)
	MAC_00807	Casein kinase I isoform epsilon; Belongs to the protein kinase superfamily. (390 aa)
	MAC_00843	Uncharacterized protein. (282 aa)
	MAC_01010	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (909 aa)
	MAC_01028	TLG2-vesicle protein of 38 kDa. (293 aa)
	MAC_01029	Uncharacterized protein. (79 aa)
	MAC_01050	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (851 aa)
	MAC_01105	Uncharacterized protein. (724 aa)
	MAC_01140	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (464 aa)
	MAC_01360	Sister chromatid cohesion protein. (1875 aa)
	MAC_01430	Putative transcription factor G6G8.4. (420 aa)
	MAC_01462	Kinetochore protein mis14, putative. (241 aa)
	MAC_01679	DASH complex component Dam1, putative. (113 aa)
	MAC_01925	Proteasome regulatory particle subunit (RpnC), putative. (581 aa)
	MAC_01931	Anucleate primary sterigmata protein B. (1439 aa)
	MAC_01949	Structural maintenance of chromosomes protein. (1488 aa)
	MAC_02000	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (813 aa)
	MAC_02001	Uncharacterized protein. (258 aa)
	MAC_02037	Spindle pole body-associated protein sad1. (924 aa)
	MAC_02052	Mitotic spindle biogenesis protein Spc19, putative. (168 aa)
	MAC_02072	Putative anaphase control protein cut9. (613 aa)
	MAC_02209	FAD dependent oxidoreductase superfamily. (173 aa)
	MAC_02270	Uncharacterized protein. (393 aa)
	MAC_02294	Serine/threonine protein phosphatase 2A. (293 aa)
	MAC_02527	Cell division-associated protein bimb. (2107 aa)
	MAC_02746	Metalloprotease. (416 aa)
	MAC_02747	Meiotic helicase. (456 aa)
	MAC_02924	Putative neurofilament triplet H1 protein. (631 aa)
	MAC_02982	Double-strand-break repair protein rad21. (619 aa)
	MAC_03011	Tyrosine-protein phosphatase CDC14. (619 aa)
	MAC_03102	WD40 domain-containing protein. (535 aa)
	MAC_03149	Putative SPO76 protein. (1506 aa)
	MAC_03185	GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (300 aa)
	MAC_03314	20S cyclosome subunit (APC8), putative. (964 aa)
	MAC_03275	Uncharacterized protein. (253 aa)
	MAC_03277	Uncharacterized protein. (309 aa)
	MAC_03415	Putative kinetochore protein ndc-80. (782 aa)
	MAC_03465	Proteasome regulatory particle, non-ATPase-like protein. (488 aa)
	MAC_03588	Uncharacterized protein. (426 aa)
	MAC_03624	Uncharacterized protein. (186 aa)
	MAC_03734	Structural maintenance of chromosomes protein. (1202 aa)
	MAC_03831	Uncharacterized protein. (698 aa)
	MAC_03843	Mis12-Mtw1 family protein. (474 aa)
	MAC_03943	Cleft lip and palate transmembrane protein 1. (704 aa)
	MAC_04103	Microtubule associated protein (Ase1), putative. (767 aa)
	MAC_04505	Kinetochore protein fta4, putative. (253 aa)
	MAC_04593	Kinase domain containing protein. (1165 aa)
	MAC_04644	RMI1_N domain-containing protein. (247 aa)
	MAC_04894	Rec8. (563 aa)
	MAC_05016	APH domain-containing protein. (403 aa)
	MAC_05106	Mis6 domain-containing protein. (698 aa)
	MAC_05303	Checkpoint protein kinase, putative. (884 aa)
	MAC_05369	Sister chromatid cohesion protein Eso1. (585 aa)
	MAC_05460	DASH complex subunit Ask1. (156 aa)
	MAC_05651	Sister chromatid cohesion protein Ctf8, putative. (146 aa)
	MAC_05666	Uncharacterized protein. (88 aa)
	MAC_05741	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (769 aa)
	MAC_05778	Shugoshin. (632 aa)
	MAC_05779	Uncharacterized protein. (137 aa)
	MAC_05975	Putative cell division control protein CDC23. (647 aa)
	MAC_06034	Uncharacterized protein. (842 aa)
	MAC_06039	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (680 aa)
	MAC_06425	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1653 aa)
	MAC_06441	Structural maintenance of chromosomes protein. (1196 aa)
	MAC_06595	RING-6 like protein. (297 aa)
	MAC_09285	Uncharacterized protein. (129 aa)
	MAC_09803	Microtubule-associated protein EB1. (199 aa)
	MAC_09789	Putative neurofilament triplet H1 protein. (236 aa)
	MAC_09723	Uncharacterized protein. (259 aa)
	MAC_09721	Uncharacterized protein. (309 aa)
	MAC_09664	Alpha-1,2-mannosyltransferase (Alg2), putative. (693 aa)
	MAC_09567	Uncharacterized protein. (1390 aa)
	MAC_09536	Uncharacterized protein. (105 aa)
	MAC_06605	Short-chain dehydrogenases/reductase, putative; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
	MAC_06682	Nuclear condensin complex subunit 3, putative. (1039 aa)
	MAC_06694	Uncharacterized protein. (343 aa)
	MAC_06741	GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (357 aa)
	MAC_07192	Casein kinase 1 epsilon. (220 aa)
	MAC_07257	Kinesin related protein 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1156 aa)
	MAC_07280	Chromosome segregation protein. (1398 aa)
	MAC_07505	Apoptosis-inducing TAF9-like domain 1 family protein, putative. (114 aa)
	MAC_07512	Serine/threonine protein kinase. (994 aa)
	MAC_07584	CENP-T_C domain-containing protein. (490 aa)
	MAC_07606	Casein kinase I isoform delta; Belongs to the protein kinase superfamily. (314 aa)
	MAC_07698	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1182 aa)
	MAC_07699	Cell cycle protein kinase, putative. (475 aa)
	MAC_07701	DEAD-2 domain-containing protein. (891 aa)
	MAC_07772	CCCH zinc finger and RRM domain-containing protein. (662 aa)
	MAC_07900	Chromosome segregation protein (Pcs1), putative. (356 aa)
	MAC_08661	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (325 aa)
	MAC_08664	Uncharacterized protein. (303 aa)
	MAC_08997	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (980 aa)

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAC_00386	MAC_00910	E9DRL7	E9DT28	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	MUS38-like protein.	0.895
MAC_00386	MAC_01010	E9DRL7	E9DTR2	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.667
MAC_00386	MAC_04644	E9DRL7	E9E446	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	RMI1_N domain-containing protein.	0.964
MAC_00386	MAC_05369	E9DRL7	E9E671	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Sister chromatid cohesion protein Eso1.	0.632
MAC_00386	MAC_06425	E9DRL7	E9E977	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.638
MAC_00386	MAC_07701	E9DRL7	E9ECV3	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	DEAD-2 domain-containing protein.	0.534
MAC_00386	MAC_09664	E9DRL7	E9EIG6	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Alpha-1,2-mannosyltransferase (Alg2), putative.	0.686
MAC_00430	MAC_03734	E9DRR1	E9E1I6	Uncharacterized protein.	Structural maintenance of chromosomes protein.	0.665
MAC_00430	MAC_05303	E9DRR1	E9E605	Uncharacterized protein.	Checkpoint protein kinase, putative.	0.422
MAC_00430	MAC_05369	E9DRR1	E9E671	Uncharacterized protein.	Sister chromatid cohesion protein Eso1.	0.698
MAC_00430	MAC_05651	E9DRR1	E9E715	Uncharacterized protein.	Sister chromatid cohesion protein Ctf8, putative.	0.999
MAC_00430	MAC_07701	E9DRR1	E9ECV3	Uncharacterized protein.	DEAD-2 domain-containing protein.	0.692
MAC_00497	MAC_00502	E9DS99	E9DSA4	Putative nuclear protein SA-1.	Uncharacterized protein.	0.957
MAC_00497	MAC_00701	E9DS99	E9DSV3	Putative nuclear protein SA-1.	Condensin subunit.	0.851
MAC_00497	MAC_01360	E9DS99	E9DUR2	Putative nuclear protein SA-1.	Sister chromatid cohesion protein.	0.993
MAC_00497	MAC_01949	E9DS99	E9DWF1	Putative nuclear protein SA-1.	Structural maintenance of chromosomes protein.	0.877
MAC_00497	MAC_02527	E9DS99	E9DY29	Putative nuclear protein SA-1.	Cell division-associated protein bimb.	0.984
MAC_00497	MAC_02982	E9DS99	E9DZD4	Putative nuclear protein SA-1.	Double-strand-break repair protein rad21.	0.999
MAC_00497	MAC_03149	E9DS99	E9DZV1	Putative nuclear protein SA-1.	Putative SPO76 protein.	0.994
MAC_00497	MAC_03734	E9DS99	E9E1I6	Putative nuclear protein SA-1.	Structural maintenance of chromosomes protein.	0.999