(42 nodes) Phosphopantetheine binding ACP domain network (Metarhizium acridum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAC_04406	Nonribosomal peptide synthase. (10285 aa)
	Pks1	Polyketide synthase 1; Polyketide synthase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress. The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (By similarity). The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (By similarity). (2148 aa)
	MAC_00177	Polyketide synthase. (2200 aa)
	MAC_01111	Polyketide synthase. (3864 aa)
	MAC_01215	Polyketide synthase, putative. (2217 aa)
	MAC_01519	Polyketide synthase, putative. (472 aa)
	MAC_01522	Polyketide synthetase PksP. (1925 aa)
	MAC_01697	Peptide synthetase. (2804 aa)
	MAC_01723	Transferase family protein. (2241 aa)
	MAC_01861	Peptide synthetase. (1644 aa)
	MAC_02762	Nonribosomal peptide synthase. (10186 aa)
	MAC_02881	Peptide synthetase. (5435 aa)
	MAC_04116	Polyketide synthase, putative. (1798 aa)
	MAC_04462	NRPS-like enzyme, putative. (273 aa)
	MAC_04551	Polyketide synthase, putative. (2627 aa)
	MAC_04974	Peptide synthetase. (5358 aa)
	MAC_05398	Nonribosomal peptide synthase, putative. (3530 aa)
	MAC_05687	Nonribosomal peptide synthase. (1879 aa)
	MAC_05893	Polyketide synthase, putative. (2555 aa)
	MAC_06316	Nonribosomal peptide synthetase 10. (1281 aa)
	MAC_06764	Fatty acid synthase subunit alpha; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family. (1859 aa)
	MAC_06860	Nonribosomal peptide synthase, putative. (1173 aa)
	MAC_06980	Peptide synthetase 3. (1793 aa)
	MAC_06982	Peptide synthetase. (889 aa)
	MAC_07604	Nonribosomal peptide synthase, putative. (2607 aa)
	MAC_07714	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (131 aa)
	MAC_07911	NRPS-like enzyme, putative. (1064 aa)
	MAC_07977	Peptide synthetase. (4838 aa)
	MAC_08207	Polyketide synthase. (2183 aa)
	MAC_08214	Nonribosomal peptide synthase GliP-like, putative. (1693 aa)
	MAC_08219	Phenolpthiocerol synthesis polyketide synthase ppsA. (2569 aa)
	MAC_08372	Polyketide synthase. (2378 aa)
	MAC_08860	Amino acid adenylation domain protein. (1605 aa)
	MAC_08899	Nonribosomal peptide synthase, putative. (9390 aa)
	MAC_09298	Carrier domain-containing protein. (1592 aa)
	Pks2	Polyketide synthase 2; Polyketide synthase; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster (Probable). The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified (Probable). (1861 aa)
	MAC_09497	Polyketide synthase, putative. (2454 aa)
	MAC_09498	Aminoadipate-semialdehyde dehydrogenase, putative. (1616 aa)
	MAC_09549	Polyketide synthase. (2488 aa)
	MAC_09675	Aminoadipate reductase enzyme. (1178 aa)
	MAC_09707	Carrier domain-containing protein. (1832 aa)
	MAC_09711	Polyketide synthase, putative. (2571 aa)

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAC_00177	MAC_01519	E9DR08	E9DUY6	Polyketide synthase.	Polyketide synthase, putative.	0.759
MAC_00177	MAC_02881	E9DR08	E9DZ33	Polyketide synthase.	Peptide synthetase.	0.421
MAC_00177	MAC_04974	E9DR08	E9E526	Polyketide synthase.	Peptide synthetase.	0.417
MAC_00177	MAC_05398	E9DR08	E9E6A0	Polyketide synthase.	Nonribosomal peptide synthase, putative.	0.417
MAC_00177	MAC_05687	E9DR08	E9E739	Polyketide synthase.	Nonribosomal peptide synthase.	0.448
MAC_00177	MAC_06980	E9DR08	E9EAT2	Polyketide synthase.	Peptide synthetase 3.	0.421
MAC_00177	MAC_07604	E9DR08	E9ECK6	Polyketide synthase.	Nonribosomal peptide synthase, putative.	0.675
MAC_00177	MAC_09498	E9DR08	E9EI00	Polyketide synthase.	Aminoadipate-semialdehyde dehydrogenase, putative.	0.408
MAC_01215	MAC_06980	E9DUB7	E9EAT2	Polyketide synthase, putative.	Peptide synthetase 3.	0.421
MAC_01215	MAC_06982	E9DUB7	E9EAT4	Polyketide synthase, putative.	Peptide synthetase.	0.413
MAC_01215	MAC_07604	E9DUB7	E9ECK6	Polyketide synthase, putative.	Nonribosomal peptide synthase, putative.	0.419
MAC_01519	MAC_00177	E9DUY6	E9DR08	Polyketide synthase, putative.	Polyketide synthase.	0.759
MAC_01519	MAC_01522	E9DUY6	E9DUY9	Polyketide synthase, putative.	Polyketide synthetase PksP.	0.898
MAC_01519	MAC_04116	E9DUY6	E9E2L8	Polyketide synthase, putative.	Polyketide synthase, putative.	0.899
MAC_01519	MAC_09549	E9DUY6	E9EI51	Polyketide synthase, putative.	Polyketide synthase.	0.837
MAC_01519	Pks1	E9DUY6	A0A2U8NEV6	Polyketide synthase, putative.	Polyketide synthase 1; Polyketide synthase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress. The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (By similarity). The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (By similarity).	0.849
MAC_01519	Pks2	E9DUY6	E9EHG2	Polyketide synthase, putative.	Polyketide synthase 2; Polyketide synthase; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster (Probable). The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified (Probable).	0.888
MAC_01522	MAC_01519	E9DUY9	E9DUY6	Polyketide synthetase PksP.	Polyketide synthase, putative.	0.898
MAC_01522	MAC_02881	E9DUY9	E9DZ33	Polyketide synthetase PksP.	Peptide synthetase.	0.419
MAC_01522	MAC_05398	E9DUY9	E9E6A0	Polyketide synthetase PksP.	Nonribosomal peptide synthase, putative.	0.438