(34 nodes) Regulation of TP53 Activity through Phosphorylation network (Metarhizium acridum)

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	MAC_00148	Uncharacterized protein. (215 aa)
	MAC_00264	Uncharacterized protein. (361 aa)
	MAC_00386	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (689 aa)
	MAC_01056	Checkpoint kinase 2-like protein. (662 aa)
	MAC_01088	FACT complex subunit spt-16. (1033 aa)
	MAC_01092	Putative MNORI-2 protein. (259 aa)
	MAC_01314	Protein kinase domain-containing protein. (773 aa)
	MAC_01609	BRCT domain-containing protein. (855 aa)
	MAC_01946	Ubiquitin. (153 aa)
	MAC_02617	Serine/threonine protein kinase. (1353 aa)
	MAC_02642	Ubiquitin. (343 aa)
	MAC_02830	Serine/threonine protein kinase. (237 aa)
	MAC_03019	QDE3 protein. (1698 aa)
	MAC_03136	Serine/threonine-protein kinase hal4; Belongs to the protein kinase superfamily. (487 aa)
	MDM34	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. (552 aa)
	MAC_03823	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (595 aa)
	MAC_03917	Serine/threonine protein kinase, putative. (559 aa)
	MAC_04577	PHD finger domain-containing protein. (622 aa)
	MAC_04644	RMI1_N domain-containing protein. (247 aa)
	MAC_04729	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (343 aa)
	MAC_04744	Fungal specific transcription factor, putative. (696 aa)
	MAC_05365	Kinase domain containing protein. (782 aa)
	MAC_05524	Ribosome assembly protein Noc2, putative. (784 aa)
	MAC_05930	Putative Werner syndrome helicase. (551 aa)
	MAC_06687	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (605 aa)
	MAC_06913	APH domain-containing protein. (274 aa)
	MAC_07123	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (256 aa)
	MAC_07285	Casein kinase II, alpha chain (CK II alpha subunit); Belongs to the protein kinase superfamily. (427 aa)
	MAC_07613	Serine/threonine protein kinase, putative. (535 aa)
	MAC_08284	BZIP domain-containing protein. (257 aa)
	MAC_08581	CAMK family protein kinase. (604 aa)
	MAC_09304	Calcium/calmodulin-dependent protein kinase. (535 aa)
	MAC_09425	Putative recQ DNA helicase. (297 aa)
	MAC_09841	Complex I intermediate-associated protein 30. (227 aa)

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAC_00148	MAC_00264	E9DQX9	E9DR95	Uncharacterized protein.	Uncharacterized protein.	0.726
MAC_00148	MAC_00386	E9DQX9	E9DRL7	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.913
MAC_00148	MAC_01609	E9DQX9	E9DVG1	Uncharacterized protein.	BRCT domain-containing protein.	0.650
MAC_00148	MAC_03823	E9DQX9	E9E1W8	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.872
MAC_00148	MAC_04644	E9DQX9	E9E446	Uncharacterized protein.	RMI1_N domain-containing protein.	0.858
MAC_00148	MAC_05930	E9DQX9	E9E7T2	Uncharacterized protein.	Putative Werner syndrome helicase.	0.407
MAC_00148	MAC_07613	E9DQX9	E9ECL5	Uncharacterized protein.	Serine/threonine protein kinase, putative.	0.640
MAC_00264	MAC_00148	E9DR95	E9DQX9	Uncharacterized protein.	Uncharacterized protein.	0.726
MAC_00264	MAC_01609	E9DR95	E9DVG1	Uncharacterized protein.	BRCT domain-containing protein.	0.545
MAC_00264	MAC_03019	E9DR95	E9DZH1	Uncharacterized protein.	QDE3 protein.	0.726
MAC_00264	MAC_03823	E9DR95	E9E1W8	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.865
MAC_00264	MAC_04644	E9DR95	E9E446	Uncharacterized protein.	RMI1_N domain-containing protein.	0.949
MAC_00264	MAC_05930	E9DR95	E9E7T2	Uncharacterized protein.	Putative Werner syndrome helicase.	0.998
MAC_00264	MAC_09425	E9DR95	E9EHS7	Uncharacterized protein.	Putative recQ DNA helicase.	0.726
MAC_00386	MAC_00148	E9DRL7	E9DQX9	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Uncharacterized protein.	0.913
MAC_00386	MAC_01609	E9DRL7	E9DVG1	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	BRCT domain-containing protein.	0.683
MAC_00386	MAC_03019	E9DRL7	E9DZH1	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	QDE3 protein.	0.948
MAC_00386	MAC_03823	E9DRL7	E9E1W8	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.985
MAC_00386	MAC_04644	E9DRL7	E9E446	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	RMI1_N domain-containing protein.	0.964
MAC_00386	MAC_05930	E9DRL7	E9E7T2	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	Putative Werner syndrome helicase.	0.998