(74 nodes) Fatty acyl-CoA biosynthesis network (Metarhizium acridum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAC_09707	Carrier domain-containing protein. (1832 aa)
	Pks1	Polyketide synthase 1; Polyketide synthase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress. The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (By similarity). The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (By similarity). (2148 aa)
	MAC_00143	Polyketide synthase, putative. (203 aa)
	MAC_00144	Polyketide synthase, putative; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (139 aa)
	MAC_00177	Polyketide synthase. (2200 aa)
	MAC_00241	Palmitoyl-protein thioesterase, putative. (333 aa)
	MAC_00007	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. (346 aa)
	MAC_00021	WD domain, G-beta repeat containing protein. (702 aa)
	MAC_00022	Mitochondrial FOW-1 like protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (317 aa)
	MAC_00591	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (220 aa)
	MAC_00882	Short chain dehydrogenase/reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (333 aa)
	MAC_00979	Fungal specific transcription factor, putative. (349 aa)
	MAC_00870	BZIP transcription factor (Fcr3). (320 aa)
	MAC_01111	Polyketide synthase. (3864 aa)
	MAC_01115	Beta-ketoacyl synthase. (358 aa)
	MAC_01214	PKS-like enzyme, putative. (322 aa)
	MAC_01215	Polyketide synthase, putative. (2217 aa)
	MAC_01338	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (472 aa)
	MAC_01519	Polyketide synthase, putative. (472 aa)
	MAC_01522	Polyketide synthetase PksP. (1925 aa)
	MAC_01529	Uncharacterized protein. (153 aa)
	MAC_01406	Polyketide synthase, putative. (846 aa)
	MAC_01826	Short chain dehydrogenase. (237 aa)
	MAC_02298	Rhs family protein. (146 aa)
	MAC_02652	Long-chain acyl-CoA synthetases & Acyl-protein synthetase. (693 aa)
	MAC_02764	Polyketide synthase, putative. (246 aa)
	MAC_02872	Polyketide synthase/peptide synthetase. (428 aa)
	MAC_02898	Polyketide synthase, putative. (556 aa)
	MAC_03099	Elongation of fatty acids protein. (425 aa)
	MAC_03262	Uncharacterized protein. (657 aa)
	MAC_03525	AP-1-like protein. (575 aa)
	MAC_03628	ATP-citrate synthase subunit 1. (664 aa)
	MAC_03629	ATP citrate lyase. (489 aa)
	MAC_03637	Carbonyl reductase 4. (173 aa)
	MAC_04116	Polyketide synthase, putative. (1798 aa)
	MAC_09711	Polyketide synthase, putative. (2571 aa)
	MAC_04199	Putative long-chain-fatty-acid--CoA ligase FAA2. (671 aa)
	MAC_04322	BZIP domain-containing protein. (167 aa)
	MAC_04388	Elongation of fatty acids protein. (369 aa)
	MAC_04551	Polyketide synthase, putative. (2627 aa)
	MAC_05017	BTB domain-containing protein. (305 aa)
	MAC_05547	Thioesterase family protein. (291 aa)
	MAC_05645	Steroid alpha reductase family protein. (307 aa)
	MAC_05686	Putative PKS-NRPS protein. (787 aa)
	MAC_05893	Polyketide synthase, putative. (2555 aa)
	MAC_05906	PKS-like enzyme, putative. (164 aa)
	MAC_05925	Elongation of fatty acids protein. (344 aa)
	MAC_06156	F-box domain protein. (1174 aa)
	MAC_06337	Putative succinate-fumarate transporter; Belongs to the mitochondrial carrier (TC 2.A.29) family. (346 aa)
	MAC_06582	Uncharacterized protein. (112 aa)
	MAC_06587	Uncharacterized protein. (448 aa)
	MAC_06957	Hybrid PKS-NRPS protein. (262 aa)
	MAC_06964	Short-chain type dehydrogenase, putative. (172 aa)
	MAC_07388	Uncharacterized protein. (374 aa)
	MAC_08099	Fatty acid synthase S-acetyltransferase. (83 aa)
	MAC_08100	Fatty acid synthase S-acetyltransferase. (213 aa)
	MAC_08101	Polyketide synthase, putative. (159 aa)
	MAC_08207	Polyketide synthase. (2183 aa)
	MAC_08219	Phenolpthiocerol synthesis polyketide synthase ppsA. (2569 aa)
	MAC_08372	Polyketide synthase. (2378 aa)
	MAC_08410	Polyketide synthase, putative. (438 aa)
	MAC_08536	Thioesterase family protein. (338 aa)
	MAC_08860	Amino acid adenylation domain protein. (1605 aa)
	MAC_08897	Thioesterase family protein. (284 aa)
	MAC_09037	Polyketide synthase. (382 aa)
	MAC_09039	Polyketide synthase, putative. (138 aa)
	Pks2	Polyketide synthase 2; Polyketide synthase; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster (Probable). The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified (Probable). (1861 aa)
	MAC_09389	Uncharacterized protein. (146 aa)
	MAC_09442	Putative long-chain-fatty-acid--CoA ligase FAA2. (705 aa)
	MAC_09497	Polyketide synthase, putative. (2454 aa)
	MAC_09549	Polyketide synthase. (2488 aa)
	MAC_09609	Uncharacterized protein. (561 aa)
	MAC_09673	Thioesterase family protein. (333 aa)
	MAC_09678	Putative tricarboxylate transporter mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (324 aa)

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAC_00007	MAC_00591	E9DRT4	E9DSJ3	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...]	0.950
MAC_00007	MAC_00870	E9DRT4	E9DTN2	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	BZIP transcription factor (Fcr3).	0.500
MAC_00007	MAC_00882	E9DRT4	E9DT00	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Short chain dehydrogenase/reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.900
MAC_00007	MAC_01338	E9DRT4	E9DUP0	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.942
MAC_00007	MAC_01529	E9DRT4	E9DUZ6	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Uncharacterized protein.	0.529
MAC_00007	MAC_03525	E9DRT4	E9E0X7	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	AP-1-like protein.	0.500
MAC_00007	MAC_03637	E9DRT4	E9E189	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Carbonyl reductase 4.	0.919
MAC_00007	MAC_04322	E9DRT4	E9E374	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	BZIP domain-containing protein.	0.500
MAC_00007	MAC_05645	E9DRT4	E9E709	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Steroid alpha reductase family protein.	0.977
MAC_00007	MAC_05925	E9DRT4	E9E7S7	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Elongation of fatty acids protein.	0.929
MAC_00007	MAC_06582	E9DRT4	E9E9N4	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Uncharacterized protein.	0.529
MAC_00007	MAC_06587	E9DRT4	E9E9N9	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Uncharacterized protein.	0.484
MAC_00021	MAC_01338	E9DRU8	E9DUP0	WD domain, G-beta repeat containing protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.564
MAC_00021	MAC_02652	E9DRU8	E9DYF5	WD domain, G-beta repeat containing protein.	Long-chain acyl-CoA synthetases & Acyl-protein synthetase.	0.420
MAC_00021	MAC_04199	E9DRU8	E9E2V1	WD domain, G-beta repeat containing protein.	Putative long-chain-fatty-acid--CoA ligase FAA2.	0.465
MAC_00143	MAC_00144	E9DQX4	E9DQX5	Polyketide synthase, putative.	Polyketide synthase, putative; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.596
MAC_00144	MAC_00143	E9DQX5	E9DQX4	Polyketide synthase, putative; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Polyketide synthase, putative.	0.596
MAC_00144	MAC_01115	E9DQX5	E9DU17	Polyketide synthase, putative; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Beta-ketoacyl synthase.	0.421
MAC_00144	MAC_08101	E9DQX5	E9EE03	Polyketide synthase, putative; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Polyketide synthase, putative.	0.499
MAC_00144	MAC_08219	E9DQX5	E9EEC1	Polyketide synthase, putative; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Phenolpthiocerol synthesis polyketide synthase ppsA.	0.519