(21 nodes) Butanoate metabolism network (Metarhizium acridum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	MAC_00631	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (290 aa)
	MAC_00682	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (430 aa)
	MAC_00941	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (509 aa)
	MAC_01637	Acetoacetyl-CoA synthase. (652 aa)
	MAC_02074	Acetoacetyl-CoA synthase. (724 aa)
	MAC_03418	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (449 aa)
	MAC_04115	Acetoacetyl-CoA synthase. (735 aa)
	MAC_04702	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (519 aa)
	MAC_05007	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (503 aa)
	MAC_05656	Hydroxymethylglutaryl-CoA lyase. (407 aa)
	MAC_05762	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (528 aa)
	MAC_05937	3-hydroxybutyryl-CoA dehydrogenase. (213 aa)
	MAC_06209	Succinate-semialdehyde dehydrogenase. (495 aa)
	MAC_06519	Acetolactate synthase small subunit. (317 aa)
	MAC_06608	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
	MAC_07450	Glutamate decarboxylase, putative. (501 aa)
	MAC_07838	Enoyl-CoA hydratase/isomerase family protein. (153 aa)
	MAC_07910	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (534 aa)
	MAC_08298	Acetolactate synthase; Belongs to the TPP enzyme family. (881 aa)
	MAC_08854	Acetolactate synthase. (670 aa)
	MAC_08898	Glutamate decarboxylase, putative. (529 aa)

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAC_00631	MAC_00682	E9DSN3	E9DST4	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.727
MAC_00631	MAC_01637	E9DSN3	E9DVI9	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	Acetoacetyl-CoA synthase.	0.426
MAC_00631	MAC_02074	E9DSN3	E9DWS6	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	Acetoacetyl-CoA synthase.	0.426
MAC_00631	MAC_03418	E9DSN3	E9E0M0	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.433
MAC_00631	MAC_04115	E9DSN3	E9E2L7	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	Acetoacetyl-CoA synthase.	0.426
MAC_00631	MAC_04702	E9DSN3	E9E4A4	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.429
MAC_00631	MAC_05656	E9DSN3	E9E720	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	Hydroxymethylglutaryl-CoA lyase.	0.507
MAC_00631	MAC_05937	E9DSN3	E9E7T9	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	3-hydroxybutyryl-CoA dehydrogenase.	0.995
MAC_00631	MAC_06608	E9DSN3	E9E9R0	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.757
MAC_00631	MAC_07838	E9DSN3	E9ED90	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	Enoyl-CoA hydratase/isomerase family protein.	0.920
MAC_00631	MAC_07910	E9DSN3	E9EDG2	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.429
MAC_00682	MAC_00631	E9DST4	E9DSN3	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.727
MAC_00682	MAC_01637	E9DST4	E9DVI9	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetoacetyl-CoA synthase.	0.952
MAC_00682	MAC_02074	E9DST4	E9DWS6	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetoacetyl-CoA synthase.	0.952
MAC_00682	MAC_03418	E9DST4	E9E0M0	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.994
MAC_00682	MAC_04115	E9DST4	E9E2L7	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetoacetyl-CoA synthase.	0.952
MAC_00682	MAC_04702	E9DST4	E9E4A4	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.956
MAC_00682	MAC_05656	E9DST4	E9E720	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Hydroxymethylglutaryl-CoA lyase.	0.939
MAC_00682	MAC_05937	E9DST4	E9E7T9	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxybutyryl-CoA dehydrogenase.	0.974
MAC_00682	MAC_06608	E9DST4	E9E9R0	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.904