(39 nodes) Fatty acid metabolism network (Metarhizium acridum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAC_00212	AMP-binding enzyme, putative. (563 aa)
	MAC_00241	Palmitoyl-protein thioesterase, putative. (333 aa)
	MAC_00440	Acetyl-CoA carboxylase. (2285 aa)
	MAC_00007	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. (346 aa)
	MAC_00591	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (220 aa)
	MAC_00631	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (290 aa)
	MAC_00682	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (430 aa)
	MAC_00882	Short chain dehydrogenase/reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (333 aa)
	MAC_00823	PKS_ER domain-containing protein. (419 aa)
	MAC_01176	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (502 aa)
	MAC_01338	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (472 aa)
	MAC_02269	3-oxoacyl-(Acyl-carrier-protein) reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (293 aa)
	MAC_02652	Long-chain acyl-CoA synthetases & Acyl-protein synthetase. (693 aa)
	MAC_02697	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
	MAC_02878	Fatty acid synthase subunit beta dehydratase; Belongs to the fungal fatty acid synthetase subunit beta family. (2115 aa)
	MAC_02884	Fatty acid synthase subunit alpha reductase; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family. (1598 aa)
	MAC_03561	Nonspecific lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family. (459 aa)
	MAC_03637	Carbonyl reductase 4. (173 aa)
	MAC_03868	Malonyl CoA-acyl carrier protein transacylase. (425 aa)
	MAC_03923	(R)-benzylsuccinyl-CoA dehydrogenase. (455 aa)
	MAC_04199	Putative long-chain-fatty-acid--CoA ligase FAA2. (671 aa)
	MAC_04770	Uncharacterized protein. (439 aa)
	MAC_04820	Uncharacterized protein. (575 aa)
	MAC_04821	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (324 aa)
	MAC_05128	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (683 aa)
	MAC_05407	AMP-binding enzyme, putative. (358 aa)
	MAC_05529	AMP-binding enzyme, putative. (484 aa)
	MAC_05645	Steroid alpha reductase family protein. (307 aa)
	MAC_05925	Elongation of fatty acids protein. (344 aa)
	MAC_06608	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
	MAC_06628	Delta12 fatty acid desaturase. (478 aa)
	MAC_06764	Fatty acid synthase subunit alpha; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family. (1859 aa)
	MAC_06765	Fatty acid synthase beta subunit dehydratase; Belongs to the fungal fatty acid synthetase subunit beta family. (2110 aa)
	MAC_07602	Fatty acid synthase subunit alpha reductase; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family. (1593 aa)
	MAC_07838	Enoyl-CoA hydratase/isomerase family protein. (153 aa)
	MAC_08668	3-oxoacyl-[acyl-carrier-protein]-synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (389 aa)
	Arp2	Hydroxynaphthalene reductase-like protein Arp2; Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified. (267 aa)
	MAC_09347	3-ketoacyl-acyl carrier protein reductase, putative; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa)
	MAC_09442	Putative long-chain-fatty-acid--CoA ligase FAA2. (705 aa)

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Arp2	MAC_00007	E9EHG1	E9DRT4	Hydroxynaphthalene reductase-like protein Arp2; Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	0.920
Arp2	MAC_00882	E9EHG1	E9DT00	Hydroxynaphthalene reductase-like protein Arp2; Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.	Short chain dehydrogenase/reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.920
Arp2	MAC_02269	E9EHG1	E9DXC1	Hydroxynaphthalene reductase-like protein Arp2; Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.	3-oxoacyl-(Acyl-carrier-protein) reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.908
Arp2	MAC_02878	E9EHG1	E9DZ30	Hydroxynaphthalene reductase-like protein Arp2; Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.	Fatty acid synthase subunit beta dehydratase; Belongs to the fungal fatty acid synthetase subunit beta family.	0.909
Arp2	MAC_02884	E9EHG1	E9DZ36	Hydroxynaphthalene reductase-like protein Arp2; Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.	Fatty acid synthase subunit alpha reductase; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.	0.909
Arp2	MAC_03637	E9EHG1	E9E189	Hydroxynaphthalene reductase-like protein Arp2; Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.	Carbonyl reductase 4.	0.908
Arp2	MAC_03868	E9EHG1	E9E213	Hydroxynaphthalene reductase-like protein Arp2; Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.	Malonyl CoA-acyl carrier protein transacylase.	0.930
Arp2	MAC_06764	E9EHG1	E9EA66	Hydroxynaphthalene reductase-like protein Arp2; Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.	Fatty acid synthase subunit alpha; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.	0.909
Arp2	MAC_06765	E9EHG1	E9EA67	Hydroxynaphthalene reductase-like protein Arp2; Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.	Fatty acid synthase beta subunit dehydratase; Belongs to the fungal fatty acid synthetase subunit beta family.	0.909
Arp2	MAC_07602	E9EHG1	E9ECK4	Hydroxynaphthalene reductase-like protein Arp2; Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.	Fatty acid synthase subunit alpha reductase; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.	0.909
Arp2	MAC_08668	E9EHG1	E9EFM0	Hydroxynaphthalene reductase-like protein Arp2; Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.	3-oxoacyl-[acyl-carrier-protein]-synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.932
Arp2	MAC_09347	E9EHG1	E9EHJ9	Hydroxynaphthalene reductase-like protein Arp2; Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.	3-ketoacyl-acyl carrier protein reductase, putative; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.908
MAC_00007	Arp2	E9DRT4	E9EHG1	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Hydroxynaphthalene reductase-like protein Arp2; Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.	0.920
MAC_00007	MAC_00591	E9DRT4	E9DSJ3	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...]	0.950
MAC_00007	MAC_00882	E9DRT4	E9DT00	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Short chain dehydrogenase/reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.900
MAC_00007	MAC_01338	E9DRT4	E9DUP0	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.942
MAC_00007	MAC_02269	E9DRT4	E9DXC1	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	3-oxoacyl-(Acyl-carrier-protein) reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.919
MAC_00007	MAC_03637	E9DRT4	E9E189	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Carbonyl reductase 4.	0.919
MAC_00007	MAC_05645	E9DRT4	E9E709	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Steroid alpha reductase family protein.	0.977
MAC_00007	MAC_05925	E9DRT4	E9E7S7	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.	Elongation of fatty acids protein.	0.929