(66 nodes) Autophagy - yeast network (Metarhizium acridum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAC_00124	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. (255 aa)
	MAC_00117	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (404 aa)
	MAC_00907	G1/S-specific cyclin Pcl5. (721 aa)
	MAC_00809	Serine/threonine-protein kinase PRKX. (385 aa)
	MAC_00820	Phosphatidylinositol 3-kinase VPS34. (1047 aa)
	MAC_00869	TORC1 growth control complex subunit Kog1. (1384 aa)
	MAC_00993	Vacuolar protein sorting 33A-like protein; Belongs to the STXBP/unc-18/SEC1 family. (1739 aa)
	MAC_01122	WD-repeat protein pop3. (319 aa)
	MAC_01300	Eukaryotic translation initiation factor 2 alpha subunit. (315 aa)
	MAC_01355	Ras-like protein. (182 aa)
	MAC_01466	Vacuolar protease A; Belongs to the peptidase A1 family. (395 aa)
	MAC_01551	TOR kinase; Belongs to the PI3/PI4-kinase family. (2422 aa)
	MAC_01636	Serine palmitoyltransferase 2. (673 aa)
	MAC_01689	Serine palmitoyltransferase 1. (516 aa)
	MAC_01855	AvaB protein. (1059 aa)
	MAC_01883	Amino acid transporter, putative. (603 aa)
	MAC_01889	Vacuolar protein sorting-associated protein 45; Belongs to the STXBP/unc-18/SEC1 family. (558 aa)
	MAC_02566	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (586 aa)
	MAC_02739	Autophagy-related ubiquitin-like modifier atg-12. (121 aa)
	MAC_02777	Putative PEP5 protein. (1209 aa)
	MAC_02843	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (390 aa)
	MAC_03072	Autophagy-related protein 10. (203 aa)
	MAC_03159	TipA protein. (318 aa)
	MAC_03218	Autophagy-related protein 11. (1347 aa)
	MAC_03431	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily. (909 aa)
	MAC_03557	Actin-like protein 3; Belongs to the actin family. (436 aa)
	MAC_03566	Vesicle transport SNARE complex subunit protein. (198 aa)
	MAC_03602	Vesicle fusion factor NSFI. (840 aa)
	MAC_03778	Non-specific serine/threonine protein kinase. (913 aa)
	MAC_03903	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. (254 aa)
	MAC_03816	Ras-2 protein. (181 aa)
	MAC_03915	Protein kinase (Gcn2), putative. (1595 aa)
	MAC_03924	Putative Ras-related protein Rab7. (187 aa)
	MAC_03931	Amino acid transporter, putative. (698 aa)
	MAC_04131	Vacuolar protein sorting-associated protein. (741 aa)
	MAC_04144	Autophagy-related protein; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation; Belongs to the ATG22 family. (633 aa)
	MAC_04385	Subtilisin-like serine protease PR1H; Belongs to the peptidase S8 family. (533 aa)
	MAC_05047	Vacuolar protein sorting protein DigA. (966 aa)
	MAC_04998	Serine/threonine-protein kinase. (948 aa)
	MAC_05361	Autophagy-related protein 3. (387 aa)
	MAC_05760	Autophagy-related protein 27. (323 aa)
	MAC_05792	Serine/threonine protein kinase, putative. (1242 aa)
	MAC_05799	Kinase; Belongs to the inositol phosphokinase (IPK) family. (1418 aa)
	MAC_06161	Vacuolar fusion protein mon-1. (599 aa)
	MAC_06191	Non-specific serine/threonine protein kinase. (732 aa)
	MAC_06233	Golgi complex component. (1550 aa)
	MAC_06303	Autophagy-related protein 17. (503 aa)
	MAC_06396	SNARE Ykt6; Belongs to the synaptobrevin family. (216 aa)
	MAC_06412	Serine/threonine-protein phosphatase. (309 aa)
	MAC_06426	TOR signaling pathway regulator (TapA), putative. (352 aa)
	MAC_06483	Negative regulator of the PHO system; Belongs to the protein kinase superfamily. (327 aa)
	MAC_06535	Uncharacterized protein. (390 aa)
	MAC_06688	Autophagy related lipase. (546 aa)
	MAC_06749	Phosphoinositide 3-kinase regulatory subunit 4. (1535 aa)
	MAC_07146	Putative response regulator receiver RIM15p. (1917 aa)
	MAC_07287	Autophagy-related protein 6. (407 aa)
	MAC_08018	Autophagy-related protein 2. (2148 aa)
	MAC_08024	Mitogen-activated protein kinase. (429 aa)
	MAC_08346	Protein phosphatase. (696 aa)
	MAC_08574	Putative TGF beta receptor associated protein 1. (771 aa)
	MAC_08643	cAMP-dependent protein kinase catalytic subunit. (523 aa)
	MAC_08764	Autophagy-related protein. (108 aa)
	MAC_09129	Autophagy-related protein 18. (331 aa)
	MAC_09459	CAMK family protein kinase. (772 aa)
	MAC_09484	Vacuolar assembly protein, putative. (1313 aa)
	MAC_09804	SNARE complex subunit (Vam7), putative. (366 aa)

Your Current Organism:

Metarhizium acridum

NCBI taxonomy Id: 655827
Other names: M. acridum CQMa 102, Metarhizium acridum CQMa 102, Metarhizium anisopliae var. acridum CQMa 102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAC_00117	MAC_00124	E9DS44	E9DQV5	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy.	0.703
MAC_00117	MAC_00820	E9DS44	E9DTI2	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Phosphatidylinositol 3-kinase VPS34.	0.897
MAC_00117	MAC_02566	E9DS44	E9DY68	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...]	0.712
MAC_00117	MAC_02739	E9DS44	E9DYP2	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy-related ubiquitin-like modifier atg-12.	0.712
MAC_00117	MAC_03072	E9DS44	E9DZM4	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy-related protein 10.	0.636
MAC_00117	MAC_03218	E9DS44	E9E020	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy-related protein 11.	0.983
MAC_00117	MAC_03431	E9DS44	E9E0N3	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily.	0.968
MAC_00117	MAC_03566	E9DS44	E9E118	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Vesicle transport SNARE complex subunit protein.	0.416
MAC_00117	MAC_03903	E9DS44	E9E1T5	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.	0.670
MAC_00117	MAC_03924	E9DS44	E9E226	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Putative Ras-related protein Rab7.	0.470
MAC_00117	MAC_04144	E9DS44	E9E2P6	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy-related protein; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation; Belongs to the ATG22 family.	0.632
MAC_00117	MAC_04998	E9DS44	E9E5C2	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Serine/threonine-protein kinase.	0.998
MAC_00117	MAC_05361	E9DS44	E9E663	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy-related protein 3.	0.636
MAC_00117	MAC_05760	E9DS44	E9E7B2	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy-related protein 27.	0.911
MAC_00117	MAC_06161	E9DS44	E9E8G3	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Vacuolar fusion protein mon-1.	0.511
MAC_00117	MAC_06303	E9DS44	E9E8V5	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy-related protein 17.	0.983
MAC_00117	MAC_06396	E9DS44	E9E948	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	SNARE Ykt6; Belongs to the synaptobrevin family.	0.543
MAC_00117	MAC_06688	E9DS44	E9E9Z0	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy related lipase.	0.644
MAC_00117	MAC_06749	E9DS44	E9EA51	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Phosphoinositide 3-kinase regulatory subunit 4.	0.895
MAC_00117	MAC_07287	E9DS44	E9EBN9	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy-related protein 6.	0.910