(30 nodes) Telomere maintenance network (Grosmannia clavigera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CMQ_899	DNA repair protein pso2. (883 aa)
	CMQ_1365	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (354 aa)
	CMQ_4773	ATP-dependent DNA helicase; Belongs to the helicase family. (973 aa)
	CMQ_4653	DNA repair protein rad50. (1301 aa)
	CMQ_7794	Phosphotidylinositol kinase; Belongs to the PI3/PI4-kinase family. (3892 aa)
	CMQ_1379	HD domain-containing protein. (257 aa)
	CMQ_546	Telomere_reg-2 domain-containing protein. (1006 aa)
	CMQ_1349	Translation initiation protein sua5. (452 aa)
	CMQ_728	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (631 aa)
	CMQ_3100	Rnp domain containing protein. (351 aa)
	CMQ_2773	Ubiquitin conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (819 aa)
	CMQ_2475	DNA damage response protein. (833 aa)
	CMQ_2071	C6 zinc finger domain containing protein. (371 aa)
	CMQ_5044	Inositol kinase kinase; Belongs to the PI3/PI4-kinase family. (2089 aa)
	CMQ_8096	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1100 aa)
	CMQ_5934	Telomere-binding alpha subunit central domain containing protein. (716 aa)
	CMQ_5945	DNA replication helicase. (1602 aa)
	CMQ_6364	Cgi121 protein; Belongs to the CGI121/TPRKB family. (202 aa)
	CMQ_7431	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (636 aa)
	CMQ_7482	Ku family DNA-binding protein. (734 aa)
	CMQ_7374	Rnapii degradation factor. (982 aa)
	CMQ_6626	Myb DNA-binding protein. (834 aa)
	CMQ_4120	Apses transcription factor. (446 aa)
	CMQ_3625	Meiotic recombination protein mre11. (1249 aa)
	CMQ_3710	DNA/RNA helicase. (1854 aa)
	CMQ_3289	Dsb repair complex subunit. (685 aa)
	CMQ_3837	Uncharacterized protein. (951 aa)
	CMQ_1680	Cell cycle checkpoint protein. (579 aa)
	CMQ_1175	Telomere length regulator protein. (1716 aa)

Your Current Organism:

Grosmannia clavigera

NCBI taxonomy Id: 655863
Other names: G. clavigera kw1407, Grosmannia clavigera kw1407

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CMQ_1175	CMQ_2475	F0XDI6	F0XIR8	Telomere length regulator protein.	DNA damage response protein.	0.599
CMQ_1175	CMQ_3289	F0XDI6	F0XAB8	Telomere length regulator protein.	Dsb repair complex subunit.	0.557
CMQ_1175	CMQ_3625	F0XDI6	F0X8Q5	Telomere length regulator protein.	Meiotic recombination protein mre11.	0.625
CMQ_1175	CMQ_3837	F0XDI6	F0XAB9	Telomere length regulator protein.	Uncharacterized protein.	0.557
CMQ_1175	CMQ_4653	F0XDI6	F0XU67	Telomere length regulator protein.	DNA repair protein rad50.	0.592
CMQ_1175	CMQ_7794	F0XDI6	F0XS95	Telomere length regulator protein.	Phosphotidylinositol kinase; Belongs to the PI3/PI4-kinase family.	0.674
CMQ_1349	CMQ_4653	F0XEB5	F0XU67	Translation initiation protein sua5.	DNA repair protein rad50.	0.541
CMQ_1349	CMQ_6364	F0XEB5	F0XMR2	Translation initiation protein sua5.	Cgi121 protein; Belongs to the CGI121/TPRKB family.	0.509
CMQ_1365	CMQ_1379	F0XDU4	F0XDX5	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	HD domain-containing protein.	0.463
CMQ_1365	CMQ_1680	F0XDU4	F0XD01	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Cell cycle checkpoint protein.	0.704
CMQ_1365	CMQ_2071	F0XDU4	F0XJW7	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	C6 zinc finger domain containing protein.	0.463
CMQ_1365	CMQ_2475	F0XDU4	F0XIR8	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	DNA damage response protein.	0.825
CMQ_1365	CMQ_2773	F0XDU4	F0XGP9	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Ubiquitin conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family.	0.610
CMQ_1365	CMQ_3289	F0XDU4	F0XAB8	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Dsb repair complex subunit.	0.653
CMQ_1365	CMQ_3625	F0XDU4	F0X8Q5	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Meiotic recombination protein mre11.	0.942
CMQ_1365	CMQ_3710	F0XDU4	F0X942	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	DNA/RNA helicase.	0.991
CMQ_1365	CMQ_3837	F0XDU4	F0XAB9	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.602
CMQ_1365	CMQ_4653	F0XDU4	F0XU67	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	DNA repair protein rad50.	0.912
CMQ_1365	CMQ_4773	F0XDU4	F0XUJ8	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	ATP-dependent DNA helicase; Belongs to the helicase family.	0.718
CMQ_1365	CMQ_5044	F0XDU4	F0XK13	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Inositol kinase kinase; Belongs to the PI3/PI4-kinase family.	0.900