(90 nodes) Nuclease activity network (Grosmannia clavigera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CMQ_3512	Smr domain containing protein. (402 aa)
	CMQ_3724	Cleavage and polyadenylation specificity factor subunit. (857 aa)
	CMQ_4105	Flap structure-specific endonuclease. (749 aa)
	CMQ_3409	Deoxyribonuclease. (412 aa)
	CMQ_3964	Protein required for cell viability. (233 aa)
	CMQ_5212	DNA lyase. (795 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1223 aa)
	CMQ_760	Uncharacterized protein. (422 aa)
	USB1	U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (339 aa)
	CMQ_758	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (304 aa)
	CMQ_665	Nuclease s1. (339 aa)
	CMQ_469	Uncharacterized protein. (399 aa)
	CMQ_899	DNA repair protein pso2. (883 aa)
	CMQ_1119	3-5 exonuclease helicase. (525 aa)
	CMQ_654	Exodeoxyribonuclease 1. (805 aa)
	CMQ_1034	tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (318 aa)
	CMQ_680	Ribonuclease t2; Belongs to the RNase T2 family. (401 aa)
	CMQ_5390	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2353 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (856 aa)
	CMQ_2934	Xpg i-region protein. (731 aa)
	CMQ_2696	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1463 aa)
	CMQ_2647	Rpp14 protein family. (206 aa)
	CMQ_2826	Tyrosyl-DNA phosphodiesterase. (553 aa)
	CMQ_2754	Duf652 domain containing protein. (170 aa)
	CMQ_2735	Mitochondrial exoribonuclease. (1159 aa)
	CMQ_2606	Mating-type switching protein swi10. (366 aa)
	CMQ_2867	Ribonuclease p complex subunit. (827 aa)
	CMQ_2947	Rnase3 domain containing protein. (1246 aa)
	CMQ_3257	60S ribosomal protein l3. (471 aa)
	CMQ_2537	Uncharacterized protein. (286 aa)
	CMQ_2318	Translin-associated factor. (288 aa)
	CMQ_2270	Nuclease s1. (303 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (400 aa)
	CMQ_4933	Transcription factor. (888 aa)
	CMQ_4997	DNA repair protein. (1038 aa)
	CMQ_4984	Uncharacterized protein. (217 aa)
	CMQ_8304	Exosome complex exonuclease exoribonuclease; Belongs to the RNR ribonuclease family. (1030 aa)
	CMQ_8283	DNA repair protein. (614 aa)
	CMQ_8043	20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (471 aa)
	CMQ_8051	tRNA-splicing endonuclease subunit. (971 aa)
	CMQ_6001	RNA interference and gene silencing protein. (1096 aa)
	CMQ_6333	RNA exonuclease. (775 aa)
	CMQ_6035	Histidine triad nucleotide-binding protein. (311 aa)
	CMQ_6372	Endonuclease exonuclease phosphatase family protein. (314 aa)
	CMQ_5945	DNA replication helicase. (1602 aa)
	CMQ_6424	Uncharacterized protein. (433 aa)
	SLX4	Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (751 aa)
	CMQ_6466	Uv-endonuclease uve-1. (518 aa)
	CMQ_1998	Uncharacterized protein. (119 aa)
	CMQ_1914	RNA-3-phosphate cyclase family protein. (408 aa)
	CMQ_1997	DNA repair protein. (356 aa)
	CMQ_2030	Exosome complex exonuclease. (1631 aa)
	CMQ_1933	Eukaryotic translation initiation factor; Belongs to the argonaute family. (978 aa)
	CMQ_7233	Uncharacterized protein. (216 aa)
	CMQ_7586	Guanine-specific ribonuclease n1/t1. (168 aa)
	CMQ_7361	Ribonuclease p protein subunit. (379 aa)
	CMQ_7206	Transcriptional effector. (693 aa)
	CMQ_7373	Curved DNA-binding protein. (382 aa)
	CMQ_7166	Endonuclease. (346 aa)
	CMQ_7155	tRNA processing endoribonuclease. (991 aa)
	CMQ_7207	RNA interference and gene silencing protein. (608 aa)
	CMQ_87	Protein kinase and ribonuclease. (1260 aa)
	CMQ_155	Nuclease domain-containing protein 1. (396 aa)
	CMQ_220	Uncharacterized protein. (739 aa)
	CMQ_40	Las1-like protein. (367 aa)
	CMQ_183	Uncharacterized protein. (402 aa)
	CMQ_251	Dhp1-interacting protein. (388 aa)
	CMQ_7781	RNA exonuclease 4. (721 aa)
	CMQ_7864	tRNA splicing endonuclease subunit. (574 aa)
	CMQ_7987	Uncharacterized protein. (184 aa)
	CMQ_7803	DNA polymerase. (1105 aa)
	CMQ_7873	Cell wall biogenesis protein phosphatase. (1428 aa)
	CMQ_7771	RNA interference and gene silencing protein. (1004 aa)
	CMQ_7979	Caf1 family ribonuclease. (361 aa)
	CMQ_7910	DNA polymerase gamma. (1168 aa)
	CMQ_5726	Ccr4-not core complex subunit. (434 aa)
	CMQ_5589	Ribonuclease h. (113 aa)
	CMQ_5692	RNA exonuclease 4. (382 aa)
	CMQ_5634	Ribonuclease p complex subunit. (996 aa)
	CMQ_4845	RasGAP. (3016 aa)
	CMQ_4826	Nucleolar rnase. (372 aa)
	CMQ_4489	Ribonuclease. (974 aa)
	CMQ_4469	RNA helicase rnase; Belongs to the helicase family. Dicer subfamily. (2671 aa)
	CMQ_4713	DNA excision repair protein rad2. (1287 aa)
	CMQ_4585	RNA exonuclease. (205 aa)
	CMQ_6575	RNA lariat debranching protein. (551 aa)
	CMQ_6791	Alpha-mannosyltransferase. (865 aa)
	CMQ_4237	Uncharacterized protein. (570 aa)
	CMQ_3625	Meiotic recombination protein mre11. (1249 aa)
	CMQ_3784	Uncharacterized protein. (182 aa)

Your Current Organism:

Grosmannia clavigera

NCBI taxonomy Id: 655863
Other names: G. clavigera kw1407, Grosmannia clavigera kw1407

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CMQ_1034	CMQ_7155	F0XFD2	F0XQB5	tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...]	tRNA processing endoribonuclease.	0.541
CMQ_1034	CMQ_7864	F0XFD2	F0XRR3	tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...]	tRNA splicing endonuclease subunit.	0.891
CMQ_1034	CMQ_8051	F0XFD2	F0XL12	tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...]	tRNA-splicing endonuclease subunit.	0.459
CMQ_1119	CMQ_1997	F0XEG4	F0XN59	3-5 exonuclease helicase.	DNA repair protein.	0.993
CMQ_1119	CMQ_1998	F0XEG4	F0XMV3	3-5 exonuclease helicase.	Uncharacterized protein.	0.544
CMQ_1119	CMQ_2030	F0XEG4	F0XN94	3-5 exonuclease helicase.	Exosome complex exonuclease.	0.644
CMQ_1119	CMQ_2606	F0XEG4	F0XHN8	3-5 exonuclease helicase.	Mating-type switching protein swi10.	0.801
CMQ_1119	CMQ_2826	F0XEG4	F0XGV8	3-5 exonuclease helicase.	Tyrosyl-DNA phosphodiesterase.	0.534
CMQ_1119	CMQ_2947	F0XEG4	F0XHZ0	3-5 exonuclease helicase.	Rnase3 domain containing protein.	0.490
CMQ_1119	CMQ_3625	F0XEG4	F0X8Q5	3-5 exonuclease helicase.	Meiotic recombination protein mre11.	0.999
CMQ_1119	CMQ_4105	F0XEG4	F0XA50	3-5 exonuclease helicase.	Flap structure-specific endonuclease.	0.999
CMQ_1119	CMQ_4469	F0XEG4	F0XTV4	3-5 exonuclease helicase.	RNA helicase rnase; Belongs to the helicase family. Dicer subfamily.	0.490
CMQ_1119	CMQ_4489	F0XEG4	F0XTP1	3-5 exonuclease helicase.	Ribonuclease.	0.544
CMQ_1119	CMQ_4713	F0XEG4	F0XU78	3-5 exonuclease helicase.	DNA excision repair protein rad2.	0.999
CMQ_1119	CMQ_4997	F0XEG4	F0XK62	3-5 exonuclease helicase.	DNA repair protein.	0.997
CMQ_1119	CMQ_5212	F0XEG4	F0XBB2	3-5 exonuclease helicase.	DNA lyase.	0.617
CMQ_1119	CMQ_5390	F0XEG4	F0XG10	3-5 exonuclease helicase.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.993
CMQ_1119	CMQ_5589	F0XEG4	F0XSN2	3-5 exonuclease helicase.	Ribonuclease h.	0.544
CMQ_1119	CMQ_5945	F0XEG4	F0XML5	3-5 exonuclease helicase.	DNA replication helicase.	0.996
CMQ_1119	CMQ_6035	F0XEG4	F0XMD7	3-5 exonuclease helicase.	Histidine triad nucleotide-binding protein.	0.523