(71 nodes) Tryptophan metabolism network (Grosmannia clavigera)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CMQ_4626	Enoyl-hydratase isomerase family protein. (292 aa)
	CMQ_4401	Flavin-binding monooxygenase-like protein. (647 aa)
	CMQ_5160	Acetamidase. (528 aa)
	CMQ_480	Uracil-5-carboxylate decarboxylase; Belongs to the metallo-dependent hydrolases superfamily. (380 aa)
	CMQ_465	Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (523 aa)
	katG	Catalase-peroxidase; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (742 aa)
	katG-2	Catalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Confers resistance to H(2)O(2) in hyphae. May play an antioxidative role in fungal defense against the host-produced H(2)O(2) (oxidative burst) at the early stage of plant infection. (801 aa)
	CMQ_4937	Homoserine O-acetyltransferase. (530 aa)
	CMQ_5030	Cytochrome p450 monooxygenase; Belongs to the cytochrome P450 family. (521 aa)
	CMQ_2173	Amidohydrolase family protein; Belongs to the metallo-dependent hydrolases superfamily. (284 aa)
	CMQ_5905	Mitochondrial integral membrane protein. (210 aa)
	CMQ_6260	Glutaryl-mitochondrial. (450 aa)
	CMQ_5899	Cytochrome p450 monooxygenase. (437 aa)
	CMQ_2978	Aromatic-l-amino-acid decarboxylase. (531 aa)
	CMQ_2795	C6 zinc finger domain containing protein. (868 aa)
	BNA1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (183 aa)
	CMQ_2578	Aromatic aminotransferase. (626 aa)
	CMQ_321	Cytochrome p450 monooxygenase; Belongs to the cytochrome P450 family. (517 aa)
	CMQ_7108	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (571 aa)
	CMQ_174	GTP-binding protein. (1931 aa)
	CMQ_7990	Fatty-acid amide hydrolase. (736 aa)
	CMQ_7800	L-amino acid oxidase. (713 aa)
	CMQ_5667	Aminotransferase, class i/classii. (466 aa)
	CMQ_4505	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (470 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (489 aa)
	CMQ_7136	Amidase. (547 aa)
	CMQ_932	Indoleamine-dioxygenase subfamily. (515 aa)
	CMQ_6980	Fatty-acid amide hydrolase. (565 aa)
	CMQ_6532	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (493 aa)
	CMQ_6939	Aminotransferase, class i/classii. (463 aa)
	CMQ_6741	Cytochrome p450 monooxygenase; Belongs to the cytochrome P450 family. (536 aa)
	CMQ_6978	Alpha beta hydrolase fold family. (552 aa)
	CMQ_6937	Aldehyde dehydrogenase mitochondrial. (450 aa)
	CMQ_6743	C6 zinc finger domain containing protein. (632 aa)
	CMQ_6711	Amidase family protein. (479 aa)
	CMQ_6787	C6 zinc finger domain containing protein. (393 aa)
	CMQ_3907	Cytochrome p450 monooxygenase. (1169 aa)
	CMQ_3416	Gcn5-related n-acetyltransferase. (212 aa)
	CMQ_3876	Nitrilase cyanide hydratase and apolipoprotein n-acyltransferase. (1067 aa)
	CMQ_3411	Amidohydrolase 2; Belongs to the metallo-dependent hydrolases superfamily. (381 aa)
	CMQ_3701	C6 zinc finger domain containing protein. (702 aa)
	CMQ_4100	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (275 aa)
	BNA5	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (483 aa)
	CMQ_3796	Indoleamine-dioxygenase. (473 aa)
	CMQ_6070	C6 zinc finger domain containing protein. (704 aa)
	CMQ_7114	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (465 aa)
	CMQ_1967	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (395 aa)
	CMQ_2037	Dihydrolipoyl dehydrogenase. (512 aa)
	CMQ_1876	Aaa family ATPase; Belongs to the AAA ATPase family. (846 aa)
	CMQ_1982	Acetyl-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
	CMQ_1855	C6 zinc finger domain containing protein. (743 aa)
	CMQ_6196	Amidase. (566 aa)
	CMQ_6129	L-psp endoribonuclease family protein. (151 aa)
	CMQ_6149	C6 zinc finger domain containing protein. (771 aa)
	CMQ_6258	Aromatic amino acid aminotransferase. (696 aa)
	CMQ_8221	Peroxisomal catalase. (873 aa)
	CMQ_3235	Mercuric reductase. (478 aa)
	CMQ_2938	Acetyl-CoA c-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (429 aa)
	CMQ_1461	Duf395 domain containing protein. (347 aa)
	CMQ_1535	Endoribonuclease l-psp. (156 aa)
	CMQ_1684	Amidase. (539 aa)
	CMQ_1584	Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily. (70 aa)
	CMQ_1169	Catalase domain containing protein. (322 aa)
	CMQ_1353	Aldehyde dehydrogenase 1a3. (415 aa)
	CMQ_1032	Uncharacterized protein. (902 aa)
	CMQ_1660	Aldehyde dehydrogenase. (486 aa)
	CMQ_503	Cytochrome p450 monooxygenase; Belongs to the cytochrome P450 family. (554 aa)
	CMQ_1285	Amidase. (580 aa)
	CMQ_643	Uncharacterized protein. (73 aa)
	CMQ_3842	Fatty-acid amide hydrolase. (463 aa)
	CMQ_3491	Cytochrome p450 monooxygenase. (556 aa)

Your Current Organism:

Grosmannia clavigera

NCBI taxonomy Id: 655863
Other names: G. clavigera kw1407, Grosmannia clavigera kw1407

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA1	BNA4	F0XHH1	F0XUP5	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.827
BNA1	BNA5	F0XHH1	F0XA19	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.952
BNA1	CMQ_1169	F0XHH1	F0XES5	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Catalase domain containing protein.	0.793
BNA1	CMQ_2173	F0XHH1	F0XIQ3	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydrolase family protein; Belongs to the metallo-dependent hydrolases superfamily.	0.835
BNA1	CMQ_3411	F0XHH1	F0X9X1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydrolase 2; Belongs to the metallo-dependent hydrolases superfamily.	0.748
BNA1	CMQ_3796	F0XHH1	F0XA20	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Indoleamine-dioxygenase.	0.486
BNA1	CMQ_4505	F0XHH1	F0XU99	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.690
BNA1	CMQ_480	F0XHH1	F0XC18	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Uracil-5-carboxylate decarboxylase; Belongs to the metallo-dependent hydrolases superfamily.	0.890
BNA1	CMQ_8221	F0XHH1	F0XL66	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Peroxisomal catalase.	0.690
BNA1	CMQ_932	F0XHH1	F0XDK5	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Indoleamine-dioxygenase subfamily.	0.486
BNA1	katG	F0XHH1	F0XCK7	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Catalase-peroxidase; Belongs to the peroxidase family. Peroxidase/catalase subfamily.	0.666
BNA1	katG-2	F0XHH1	F0XL63	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Catalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Confers resistance to H(2)O(2) in hyphae. May play an antioxidative role in fungal defense against the host-produced H(2)O(2) (oxidative burst) at the early stage of plant infection.	0.666
BNA4	BNA1	F0XUP5	F0XHH1	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.827
BNA4	BNA5	F0XUP5	F0XA19	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.983
BNA4	CMQ_2173	F0XUP5	F0XIQ3	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Amidohydrolase family protein; Belongs to the metallo-dependent hydrolases superfamily.	0.442
BNA4	CMQ_2578	F0XUP5	F0XHG5	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aromatic aminotransferase.	0.671
BNA4	CMQ_321	F0XUP5	F0XQT5	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Cytochrome p450 monooxygenase; Belongs to the cytochrome P450 family.	0.410
BNA4	CMQ_3491	F0XUP5	F0XAS9	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Cytochrome p450 monooxygenase.	0.410
BNA4	CMQ_3796	F0XUP5	F0XA20	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Indoleamine-dioxygenase.	0.402
BNA4	CMQ_4100	F0XUP5	F0XA18	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.790