(43 nodes) Mixed, incl. PKMTs methylate histone lysines, and Nucleosome network (Tuber melanosporum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	D5G4G8_TUBMM	Uncharacterized protein. (146 aa)
	D5G561_TUBMM	Histone H2A; Belongs to the histone H2A family. (134 aa)
	D5G562_TUBMM	Histone H2B; Belongs to the histone H2B family. (138 aa)
	D5G566_TUBMM	H15 domain-containing protein. (228 aa)
	D5G6N7_TUBMM	PH domain-containing protein. (685 aa)
	D5G7G8_TUBMM	Uncharacterized protein. (1134 aa)
	D5G7U3_TUBMM	Uncharacterized protein. (901 aa)
	D5G9C4_TUBMM	SET domain-containing protein. (355 aa)
	D5G9H9_TUBMM	Uncharacterized protein. (586 aa)
	D5GAU8_TUBMM	PHD domain-containing protein. (673 aa)
	D5GBC0_TUBMM	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	D5GBR5_TUBMM	SHNi-TPR domain-containing protein. (496 aa)
	D5GBZ0_TUBMM	Uncharacterized protein. (370 aa)
	D5GCV3_TUBMM	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (143 aa)
	D5GD24_TUBMM	Chromo domain-containing protein. (225 aa)
	D5GDB9_TUBMM	Histone domain-containing protein. (152 aa)
	D5GEB8_TUBMM	SET domain-containing protein. (217 aa)
	D5GED3_TUBMM	C2H2-type domain-containing protein. (619 aa)
	D5GEI8_TUBMM	Uncharacterized protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (892 aa)
	D5GEX1_TUBMM	Fe2OG dioxygenase domain-containing protein. (431 aa)
	D5GF07_TUBMM	Histone domain-containing protein. (136 aa)
	D5GFN9_TUBMM	SET domain-containing protein. (593 aa)
	D5GH94_TUBMM	BHLH domain-containing protein. (363 aa)
	D5GHA6_TUBMM	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (377 aa)
	D5GHJ7_TUBMM	B30.2/SPRY domain-containing protein. (376 aa)
	D5GI24_TUBMM	WD_REPEATS_REGION domain-containing protein. (334 aa)
	D5GIA7_TUBMM	Uncharacterized protein. (667 aa)
	D5GIC1_TUBMM	BAH domain-containing protein. (411 aa)
	D5GID0_TUBMM	Uncharacterized protein. (846 aa)
	D5GIN5_TUBMM	WD_REPEATS_REGION domain-containing protein. (460 aa)
	D5GJS2_TUBMM	PHD-type domain-containing protein. (534 aa)
	D5GK47_TUBMM	Uncharacterized protein. (132 aa)
	D5GKC7_TUBMM	Uncharacterized protein. (561 aa)
	D5GKI6_TUBMM	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. (1200 aa)
	D5GKT7_TUBMM	WD_REPEATS_REGION domain-containing protein. (472 aa)
	D5GLJ2_TUBMM	Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (412 aa)
	D5GLQ4_TUBMM	Uncharacterized protein. (328 aa)
	D5GM40_TUBMM	Uncharacterized protein. (489 aa)
	D5GNG2_TUBMM	Uncharacterized protein. (258 aa)
	D5GNS7_TUBMM	Uncharacterized protein. (1063 aa)
	D5GP65_TUBMM	Uncharacterized protein. (1697 aa)
	D5GP67_TUBMM	WD_REPEATS_REGION domain-containing protein. (436 aa)
	D5GPG9_TUBMM	Uncharacterized protein. (1480 aa)

Your Current Organism:

Tuber melanosporum

NCBI taxonomy Id: 656061
Other names: T. melanosporum Mel28, Tuber melanosporum Mel28

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D5G4G8_TUBMM	D5G561_TUBMM	D5G4G8	D5G561	Uncharacterized protein.	Histone H2A; Belongs to the histone H2A family.	0.734
D5G4G8_TUBMM	D5G562_TUBMM	D5G4G8	D5G562	Uncharacterized protein.	Histone H2B; Belongs to the histone H2B family.	0.881
D5G4G8_TUBMM	D5G566_TUBMM	D5G4G8	D5G566	Uncharacterized protein.	H15 domain-containing protein.	0.624
D5G4G8_TUBMM	D5G6N7_TUBMM	D5G4G8	D5G6N7	Uncharacterized protein.	PH domain-containing protein.	0.681
D5G4G8_TUBMM	D5G7G8_TUBMM	D5G4G8	D5G7G8	Uncharacterized protein.	Uncharacterized protein.	0.887
D5G4G8_TUBMM	D5G7U3_TUBMM	D5G4G8	D5G7U3	Uncharacterized protein.	Uncharacterized protein.	0.718
D5G4G8_TUBMM	D5G9C4_TUBMM	D5G4G8	D5G9C4	Uncharacterized protein.	SET domain-containing protein.	0.550
D5G4G8_TUBMM	D5G9H9_TUBMM	D5G4G8	D5G9H9	Uncharacterized protein.	Uncharacterized protein.	0.537
D5G4G8_TUBMM	D5GAU8_TUBMM	D5G4G8	D5GAU8	Uncharacterized protein.	PHD domain-containing protein.	0.595
D5G4G8_TUBMM	D5GBC0_TUBMM	D5G4G8	D5GBC0	Uncharacterized protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.734
D5G4G8_TUBMM	D5GBR5_TUBMM	D5G4G8	D5GBR5	Uncharacterized protein.	SHNi-TPR domain-containing protein.	0.667
D5G4G8_TUBMM	D5GBZ0_TUBMM	D5G4G8	D5GBZ0	Uncharacterized protein.	Uncharacterized protein.	0.550
D5G4G8_TUBMM	D5GCV3_TUBMM	D5G4G8	D5GCV3	Uncharacterized protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.912
D5G4G8_TUBMM	D5GD24_TUBMM	D5G4G8	D5GD24	Uncharacterized protein.	Chromo domain-containing protein.	0.604
D5G4G8_TUBMM	D5GEB8_TUBMM	D5G4G8	D5GEB8	Uncharacterized protein.	SET domain-containing protein.	0.550
D5G4G8_TUBMM	D5GEI8_TUBMM	D5G4G8	D5GEI8	Uncharacterized protein.	Uncharacterized protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	0.822
D5G4G8_TUBMM	D5GHA6_TUBMM	D5G4G8	D5GHA6	Uncharacterized protein.	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	0.819
D5G4G8_TUBMM	D5GHJ7_TUBMM	D5G4G8	D5GHJ7	Uncharacterized protein.	B30.2/SPRY domain-containing protein.	0.744
D5G4G8_TUBMM	D5GIA7_TUBMM	D5G4G8	D5GIA7	Uncharacterized protein.	Uncharacterized protein.	0.422
D5G4G8_TUBMM	D5GIC1_TUBMM	D5G4G8	D5GIC1	Uncharacterized protein.	BAH domain-containing protein.	0.995