(28 nodes) Histone methylation, and Structural constituent of chromatin network (Tuber melanosporum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	D5G4G8_TUBMM	Uncharacterized protein. (146 aa)
	D5G561_TUBMM	Histone H2A; Belongs to the histone H2A family. (134 aa)
	D5G562_TUBMM	Histone H2B; Belongs to the histone H2B family. (138 aa)
	D5G566_TUBMM	H15 domain-containing protein. (228 aa)
	D5G6N7_TUBMM	PH domain-containing protein. (685 aa)
	D5G7G8_TUBMM	Uncharacterized protein. (1134 aa)
	D5G7U3_TUBMM	Uncharacterized protein. (901 aa)
	D5G9C4_TUBMM	SET domain-containing protein. (355 aa)
	D5G9H9_TUBMM	Uncharacterized protein. (586 aa)
	D5GAU8_TUBMM	PHD domain-containing protein. (673 aa)
	D5GBC0_TUBMM	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	D5GCV3_TUBMM	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (143 aa)
	D5GDB9_TUBMM	Histone domain-containing protein. (152 aa)
	D5GEI8_TUBMM	Uncharacterized protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (892 aa)
	D5GF07_TUBMM	Histone domain-containing protein. (136 aa)
	D5GFN9_TUBMM	SET domain-containing protein. (593 aa)
	D5GHA6_TUBMM	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (377 aa)
	D5GHJ7_TUBMM	B30.2/SPRY domain-containing protein. (376 aa)
	D5GI24_TUBMM	WD_REPEATS_REGION domain-containing protein. (334 aa)
	D5GIC1_TUBMM	BAH domain-containing protein. (411 aa)
	D5GID0_TUBMM	Uncharacterized protein. (846 aa)
	D5GIN5_TUBMM	WD_REPEATS_REGION domain-containing protein. (460 aa)
	D5GJS2_TUBMM	PHD-type domain-containing protein. (534 aa)
	D5GKI6_TUBMM	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. (1200 aa)
	D5GKT7_TUBMM	WD_REPEATS_REGION domain-containing protein. (472 aa)
	D5GM40_TUBMM	Uncharacterized protein. (489 aa)
	D5GNG2_TUBMM	Uncharacterized protein. (258 aa)
	D5GP65_TUBMM	Uncharacterized protein. (1697 aa)

Your Current Organism:

Tuber melanosporum

NCBI taxonomy Id: 656061
Other names: T. melanosporum Mel28, Tuber melanosporum Mel28

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D5G4G8_TUBMM	D5G561_TUBMM	D5G4G8	D5G561	Uncharacterized protein.	Histone H2A; Belongs to the histone H2A family.	0.734
D5G4G8_TUBMM	D5G562_TUBMM	D5G4G8	D5G562	Uncharacterized protein.	Histone H2B; Belongs to the histone H2B family.	0.881
D5G4G8_TUBMM	D5G566_TUBMM	D5G4G8	D5G566	Uncharacterized protein.	H15 domain-containing protein.	0.624
D5G4G8_TUBMM	D5G6N7_TUBMM	D5G4G8	D5G6N7	Uncharacterized protein.	PH domain-containing protein.	0.681
D5G4G8_TUBMM	D5G7G8_TUBMM	D5G4G8	D5G7G8	Uncharacterized protein.	Uncharacterized protein.	0.887
D5G4G8_TUBMM	D5G7U3_TUBMM	D5G4G8	D5G7U3	Uncharacterized protein.	Uncharacterized protein.	0.718
D5G4G8_TUBMM	D5G9C4_TUBMM	D5G4G8	D5G9C4	Uncharacterized protein.	SET domain-containing protein.	0.550
D5G4G8_TUBMM	D5G9H9_TUBMM	D5G4G8	D5G9H9	Uncharacterized protein.	Uncharacterized protein.	0.537
D5G4G8_TUBMM	D5GAU8_TUBMM	D5G4G8	D5GAU8	Uncharacterized protein.	PHD domain-containing protein.	0.595
D5G4G8_TUBMM	D5GBC0_TUBMM	D5G4G8	D5GBC0	Uncharacterized protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.734
D5G4G8_TUBMM	D5GCV3_TUBMM	D5G4G8	D5GCV3	Uncharacterized protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.912
D5G4G8_TUBMM	D5GEI8_TUBMM	D5G4G8	D5GEI8	Uncharacterized protein.	Uncharacterized protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	0.822
D5G4G8_TUBMM	D5GHA6_TUBMM	D5G4G8	D5GHA6	Uncharacterized protein.	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	0.819
D5G4G8_TUBMM	D5GHJ7_TUBMM	D5G4G8	D5GHJ7	Uncharacterized protein.	B30.2/SPRY domain-containing protein.	0.744
D5G4G8_TUBMM	D5GIC1_TUBMM	D5G4G8	D5GIC1	Uncharacterized protein.	BAH domain-containing protein.	0.995
D5G4G8_TUBMM	D5GID0_TUBMM	D5G4G8	D5GID0	Uncharacterized protein.	Uncharacterized protein.	0.560
D5G4G8_TUBMM	D5GIN5_TUBMM	D5G4G8	D5GIN5	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.639
D5G4G8_TUBMM	D5GJS2_TUBMM	D5G4G8	D5GJS2	Uncharacterized protein.	PHD-type domain-containing protein.	0.435
D5G4G8_TUBMM	D5GKI6_TUBMM	D5G4G8	D5GKI6	Uncharacterized protein.	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.	0.681
D5G4G8_TUBMM	D5GKT7_TUBMM	D5G4G8	D5GKT7	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.810