(28 nodes) RNA Polymerase II Transcription Elongation network (Tuber melanosporum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	D5G674_TUBMM	Uncharacterized protein; Belongs to the RNA polymerase beta chain family. (620 aa)
	D5G675_TUBMM	Uncharacterized protein. (436 aa)
	D5G763_TUBMM	RPOLD domain-containing protein. (340 aa)
	D5G7P9_TUBMM	Uncharacterized protein. (1019 aa)
	D5G7Q2_TUBMM	Uncharacterized protein. (174 aa)
	D5G825_TUBMM	Uncharacterized protein. (436 aa)
	D5G8A7_TUBMM	RNA_pol_L_2 domain-containing protein. (119 aa)
	D5G9K1_TUBMM	Uncharacterized protein. (156 aa)
	D5GCT6_TUBMM	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (122 aa)
	D5GD20_TUBMM	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1419 aa)
	D5GEJ8_TUBMM	Uncharacterized protein. (1181 aa)
	D5GFS9_TUBMM	Uncharacterized protein. (232 aa)
	D5GGR7_TUBMM	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (896 aa)
	D5GJ97_TUBMM	Uncharacterized protein. (105 aa)
	D5GJ99_TUBMM	Uncharacterized protein. (110 aa)
	D5GJJ3_TUBMM	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
	D5GJX7_TUBMM	Uncharacterized protein. (471 aa)
	D5GKA9_TUBMM	TFIIS N-terminal domain-containing protein. (395 aa)
	D5GKT6_TUBMM	Uncharacterized protein. (1025 aa)
	D5GM48_TUBMM	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (1054 aa)
	D5GM63_TUBMM	S1 motif domain-containing protein. (180 aa)
	D5GMC8_TUBMM	Uncharacterized protein. (73 aa)
	D5GMM6_TUBMM	CDC73_C domain-containing protein. (415 aa)
	D5GN86_TUBMM	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (570 aa)
	D5GNK2_TUBMM	Uncharacterized protein. (76 aa)
	D5GNK6_TUBMM	Uncharacterized protein. (220 aa)
	D5GNN0_TUBMM	RPOL4c domain-containing protein. (146 aa)
	D5GPG2_TUBMM	Plus3 domain-containing protein. (567 aa)

Your Current Organism:

Tuber melanosporum

NCBI taxonomy Id: 656061
Other names: T. melanosporum Mel28, Tuber melanosporum Mel28

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D5G674_TUBMM	D5G675_TUBMM	D5G674	D5G675	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	Uncharacterized protein.	0.943
D5G674_TUBMM	D5G763_TUBMM	D5G674	D5G763	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	RPOLD domain-containing protein.	0.978
D5G674_TUBMM	D5G7P9_TUBMM	D5G674	D5G7P9	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	Uncharacterized protein.	0.943
D5G674_TUBMM	D5G7Q2_TUBMM	D5G674	D5G7Q2	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	Uncharacterized protein.	0.957
D5G674_TUBMM	D5G825_TUBMM	D5G674	D5G825	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	Uncharacterized protein.	0.814
D5G674_TUBMM	D5G8A7_TUBMM	D5G674	D5G8A7	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	RNA_pol_L_2 domain-containing protein.	0.957
D5G674_TUBMM	D5G9K1_TUBMM	D5G674	D5G9K1	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	Uncharacterized protein.	0.976
D5G674_TUBMM	D5GCT6_TUBMM	D5G674	D5GCT6	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.956
D5G674_TUBMM	D5GD20_TUBMM	D5G674	D5GD20	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	0.872
D5G674_TUBMM	D5GEJ8_TUBMM	D5G674	D5GEJ8	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	Uncharacterized protein.	0.853
D5G674_TUBMM	D5GFS9_TUBMM	D5G674	D5GFS9	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	Uncharacterized protein.	0.911
D5G674_TUBMM	D5GGR7_TUBMM	D5G674	D5GGR7	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	0.854
D5G674_TUBMM	D5GJ97_TUBMM	D5G674	D5GJ97	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	Uncharacterized protein.	0.814
D5G674_TUBMM	D5GJ99_TUBMM	D5G674	D5GJ99	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	Uncharacterized protein.	0.814
D5G674_TUBMM	D5GJJ3_TUBMM	D5G674	D5GJJ3	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.957
D5G674_TUBMM	D5GJX7_TUBMM	D5G674	D5GJX7	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	Uncharacterized protein.	0.836
D5G674_TUBMM	D5GKA9_TUBMM	D5G674	D5GKA9	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	TFIIS N-terminal domain-containing protein.	0.800
D5G674_TUBMM	D5GKT6_TUBMM	D5G674	D5GKT6	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	Uncharacterized protein.	0.966
D5G674_TUBMM	D5GM48_TUBMM	D5G674	D5GM48	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.962
D5G674_TUBMM	D5GM63_TUBMM	D5G674	D5GM63	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	S1 motif domain-containing protein.	0.957