(18 nodes) Anaphase-promoting complex, and Inactivation of APC/C via direct inhibition of the APC/C complex network (Tuber melanosporum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	D5G3U0_TUBMM	Uncharacterized protein. (637 aa)
	D5G3V5_TUBMM	Uncharacterized protein. (560 aa)
	D5G684_TUBMM	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (171 aa)
	D5G9S9_TUBMM	WD_REPEATS_REGION domain-containing protein. (587 aa)
	D5GBI8_TUBMM	Uncharacterized protein. (335 aa)
	D5GCK2_TUBMM	Uncharacterized protein. (507 aa)
	D5GCN6_TUBMM	Uncharacterized protein. (236 aa)
	D5GCN7_TUBMM	RING-type domain-containing protein. (86 aa)
	D5GE48_TUBMM	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (231 aa)
	D5GF92_TUBMM	Uncharacterized protein. (1100 aa)
	D5GFB7_TUBMM	CULLIN_2 domain-containing protein; Belongs to the cullin family. (565 aa)
	D5GGN1_TUBMM	Uncharacterized protein. (1892 aa)
	D5GHI9_TUBMM	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (302 aa)
	D5GKD6_TUBMM	Uncharacterized protein. (793 aa)
	D5GKR4_TUBMM	WD_REPEATS_REGION domain-containing protein. (539 aa)
	D5GM16_TUBMM	Uncharacterized protein. (659 aa)
	D5GM99_TUBMM	ANAPC5 domain-containing protein. (739 aa)
	D5GPI5_TUBMM	HORMA domain-containing protein. (216 aa)

Your Current Organism:

Tuber melanosporum

NCBI taxonomy Id: 656061
Other names: T. melanosporum Mel28, Tuber melanosporum Mel28

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D5G3U0_TUBMM	D5G3V5_TUBMM	D5G3U0	D5G3V5	Uncharacterized protein.	Uncharacterized protein.	0.999
D5G3U0_TUBMM	D5G684_TUBMM	D5G3U0	D5G684	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.987
D5G3U0_TUBMM	D5G9S9_TUBMM	D5G3U0	D5G9S9	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.985
D5G3U0_TUBMM	D5GBI8_TUBMM	D5G3U0	D5GBI8	Uncharacterized protein.	Uncharacterized protein.	0.961
D5G3U0_TUBMM	D5GCK2_TUBMM	D5G3U0	D5GCK2	Uncharacterized protein.	Uncharacterized protein.	0.830
D5G3U0_TUBMM	D5GCN6_TUBMM	D5G3U0	D5GCN6	Uncharacterized protein.	Uncharacterized protein.	0.957
D5G3U0_TUBMM	D5GCN7_TUBMM	D5G3U0	D5GCN7	Uncharacterized protein.	RING-type domain-containing protein.	0.999
D5G3U0_TUBMM	D5GE48_TUBMM	D5G3U0	D5GE48	Uncharacterized protein.	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	0.999
D5G3U0_TUBMM	D5GF92_TUBMM	D5G3U0	D5GF92	Uncharacterized protein.	Uncharacterized protein.	0.988
D5G3U0_TUBMM	D5GFB7_TUBMM	D5G3U0	D5GFB7	Uncharacterized protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.999
D5G3U0_TUBMM	D5GGN1_TUBMM	D5G3U0	D5GGN1	Uncharacterized protein.	Uncharacterized protein.	0.999
D5G3U0_TUBMM	D5GHI9_TUBMM	D5G3U0	D5GHI9	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.966
D5G3U0_TUBMM	D5GKD6_TUBMM	D5G3U0	D5GKD6	Uncharacterized protein.	Uncharacterized protein.	0.999
D5G3U0_TUBMM	D5GKR4_TUBMM	D5G3U0	D5GKR4	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.992
D5G3U0_TUBMM	D5GM16_TUBMM	D5G3U0	D5GM16	Uncharacterized protein.	Uncharacterized protein.	0.926
D5G3U0_TUBMM	D5GM99_TUBMM	D5G3U0	D5GM99	Uncharacterized protein.	ANAPC5 domain-containing protein.	0.999
D5G3U0_TUBMM	D5GPI5_TUBMM	D5G3U0	D5GPI5	Uncharacterized protein.	HORMA domain-containing protein.	0.999
D5G3V5_TUBMM	D5G3U0_TUBMM	D5G3V5	D5G3U0	Uncharacterized protein.	Uncharacterized protein.	0.999
D5G3V5_TUBMM	D5G684_TUBMM	D5G3V5	D5G684	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.978
D5G3V5_TUBMM	D5G9S9_TUBMM	D5G3V5	D5G9S9	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.984